SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'WCA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 12 PHE A 378
ILE A 310
ILE A 346
GLU A 192
GLY A 168
 None
WCA  A 801 ( 4.1A)
None
None
None
 1.03A 3nxuA-6co0A:
undetectable		 3nxuA-6co0A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 9 ILE A 255
GLY A 257
GLN A 162
GLY A 163
ARG A 172
 WCA  A 801 (-3.7A)
None
None
None
None
 1.41A 4acaB-6co0A:
undetectable
4acaC-6co0A:
undetectable		 4acaB-6co0A:
undetectable
4acaC-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 12 GLY A 375
CYH A 164
GLY A 166
GLY A 168
VAL A 276
 None
WCA  A 801 (-3.6A)
None
None
None
 1.11A 4b17A-6co0A:
undetectable		 4b17A-6co0A:
undetectable