SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'WAN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 8 PHE A 820
HIS A 653
THR A 621
HIS A 617
 WAN  A 901 (-3.7A)
ZN  A 876 (-3.3A)
None
ZN  A 876 (-3.3A)
 0.94A 1bzmA-3bjcA:
undetectable		 1bzmA-3bjcA:
13.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		7 / 9 TYR A 612
LEU A 725
LEU A 765
VAL A 782
ALA A 783
GLN A 817
PHE A 820
 None
None
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.28A 1tbfA-3bjcA:
48.3		 1tbfA-3bjcA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		7 / 9 TYR A 612
LEU A 725
LEU A 765
VAL A 782
MET A 816
GLN A 817
PHE A 820
 None
None
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.71A 1tbfA-3bjcA:
48.3		 1tbfA-3bjcA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		8 / 12 TYR A 612
HIS A 613
ALA A 767
ILE A 768
VAL A 782
ALA A 783
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.34A 1udtA-3bjcA:
47.8		 1udtA-3bjcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		8 / 12 TYR A 612
HIS A 613
ALA A 767
ILE A 768
VAL A 782
MET A 816
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.61A 1udtA-3bjcA:
47.8		 1udtA-3bjcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		9 / 11 TYR A 612
ILE A 778
VAL A 782
ALA A 783
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
 None
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.8A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.65A 1uduA-3bjcA:
44.6		 1uduA-3bjcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		11 / 12 TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
ALA A 783
PHE A 786
MET A 816
GLN A 817
PHE A 820
 None
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.6A)
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.8A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.63A 1uduB-3bjcA:
44.7		 1uduB-3bjcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		7 / 10 TYR A 612
HIS A 613
ALA A 783
PHE A 786
GLN A 817
GLY A 819
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
None
WAN  A 901 (-3.7A)
 0.36A 1uhoA-3bjcA:
47.5		 1uhoA-3bjcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		7 / 10 TYR A 612
HIS A 613
PHE A 786
MET A 816
GLN A 817
GLY A 819
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 (-4.8A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
None
WAN  A 901 (-3.7A)
 0.72A 1uhoA-3bjcA:
47.5		 1uhoA-3bjcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 10 TYR A 612
HIS A 617
GLN A 817
GLY A 819
PHE A 820
 None
ZN  A 876 (-3.3A)
WAN  A 901 (-3.1A)
None
WAN  A 901 (-3.7A)
 1.42A 1uhoA-3bjcA:
47.5		 1uhoA-3bjcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
HIS A 657
LEU A 765
GLN A 775
 None
MG  A 877 (-4.4A)
MG  A 877 (-4.3A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.6A)
 1.23A 1xlxA-3bjcA:
33.6		 1xlxA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 613
HIS A 657
LEU A 765
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
MG  A 877 (-4.3A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.60A 1xlxA-3bjcA:
33.6		 1xlxA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 613
HIS A 657
PHE A 786
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
MG  A 877 (-4.3A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.52A 1xlxB-3bjcA:
33.5		 1xlxB-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
PHE A 820
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.7A)
 0.68A 1xmuA-3bjcA:
33.7		 1xmuA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-4.8A)
 0.57A 1xmuB-3bjcA:
33.7		 1xmuB-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.6A)
 0.89A 1xomA-3bjcA:
34.2		 1xomA-3bjcA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		7 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.66A 1xomA-3bjcA:
34.2		 1xomA-3bjcA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 613
LEU A 765
PHE A 786
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.71A 1xomB-3bjcA:
34.3		 1xomB-3bjcA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.7A)
 0.65A 1xoqA-3bjcA:
34.3		 1xoqA-3bjcA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.7A)
 0.67A 1xoqB-3bjcA:
34.3		 1xoqB-3bjcA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.6A)
 0.84A 1xosA-3bjcA:
33.9		 1xosA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		8 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
GLN A 817
PHE A 820
ILE A 824
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
None
 0.57A 1xosA-3bjcA:
33.9		 1xosA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 617
GLN A 817
PHE A 820
ILE A 824
 None
ZN  A 876 (-3.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
None
 1.33A 1xosA-3bjcA:
33.9		 1xosA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 613
LEU A 765
GLN A 817
PHE A 820
ILE A 824
 None
MG  A 877 (-4.4A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
None
 0.55A 1xotA-3bjcA:
33.7		 1xotA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 617
GLN A 817
PHE A 820
ILE A 824
 None
ZN  A 876 (-3.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
None
 1.33A 1xotA-3bjcA:
33.7		 1xotA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
LEU A 765
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.53A 1xotB-3bjcA:
33.8		 1xotB-3bjcA:
17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		11 / 12 TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
 None
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.6A)
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-4.8A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.68A 1xozA-3bjcA:
48.2		 1xozA-3bjcA:
46.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		9 / 10 TYR A 612
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ALA A 783
MET A 816
GLN A 817
PHE A 820
 None
WAN  A 901 ( 4.7A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.35A 1xp0A-3bjcA:
48.5		 1xp0A-3bjcA:
46.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		9 / 11 TYR A 612
HIS A 613
ALA A 767
ILE A 768
VAL A 782
PHE A 786
ILE A 813
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-4.8A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.35A 2h42A-3bjcA:
48.4		 2h42A-3bjcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		10 / 12 TYR A 612
HIS A 613
ALA A 767
ILE A 768
VAL A 782
ALA A 783
ILE A 813
MET A 816
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.47A 2h42B-3bjcA:
48.2		 2h42B-3bjcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		11 / 12 TYR A 612
LEU A 725
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ALA A 783
PHE A 786
ILE A 813
GLN A 817
PHE A 820
 None
None
WAN  A 901 ( 4.7A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.8A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.31A 2h42C-3bjcA:
48.1		 2h42C-3bjcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 11 ASP A 654
HIS A 653
ASP A 764
LEU A 765
HIS A 617
 MG  A 877 ( 2.5A)
ZN  A 876 (-3.3A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
ZN  A 876 (-3.3A)
 1.27A 2q0jB-3bjcA:
undetectable		 2q0jB-3bjcA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		8 / 12 TYR A 612
HIS A 613
LEU A 725
LEU A 765
GLU A 785
PHE A 786
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
None
WAN  A 901 ( 4.7A)
None
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.82A 2weyA-3bjcA:
39.0		 2weyA-3bjcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 8 LEU A 725
PHE A 786
GLN A 817
PHE A 820
 None
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.39A 2weyB-3bjcA:
38.6		 2weyB-3bjcA:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		11 / 12 TYR A 612
HIS A 613
LEU A 765
ALA A 767
ILE A 768
VAL A 782
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-4.8A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.58A 3b2rA-3bjcA:
46.0		 3b2rA-3bjcA:
38.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 617
LEU A 765
ILE A 768
GLN A 817
PHE A 820
 None
ZN  A 876 (-3.3A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 1.40A 3b2rA-3bjcA:
46.0		 3b2rA-3bjcA:
38.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		10 / 11 TYR A 612
HIS A 613
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ILE A 813
MET A 816
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.41A 3b2rB-3bjcA:
45.7		 3b2rB-3bjcA:
38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ASP A 764
LEU A 765
GLN A 775
 ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.6A)
 0.61A 3g4lA-3bjcA:
34.1		 3g4lA-3bjcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ASP A 764
LEU A 765
GLN A 817
 ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.1A)
 0.48A 3g4lA-3bjcA:
34.1		 3g4lA-3bjcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.7A)
 0.59A 3g4lB-3bjcA:
34.3		 3g4lB-3bjcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.6A)
 0.90A 3g4lD-3bjcA:
34.7		 3g4lD-3bjcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 817
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.1A)
 0.53A 3g4lD-3bjcA:
34.7		 3g4lD-3bjcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 TYR A 612
PHE A 786
GLN A 817
PHE A 820
ILE A 824
 None
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
None
 0.42A 3iakA-3bjcA:
33.5		 3iakA-3bjcA:
17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 9 TYR A 612
HIS A 613
LEU A 725
VAL A 782
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.38A 3jwqA-3bjcA:
47.8		 3jwqA-3bjcA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 11 TYR A 612
HIS A 613
ASN A 661
ALA A 767
VAL A 782
GLN A 817
 None
MG  A 877 (-4.4A)
None
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.1A)
 1.39A 3jwqB-3bjcA:
47.6
3jwqC-3bjcA:
47.4		 3jwqB-3bjcA:
35.69
3jwqC-3bjcA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		7 / 11 TYR A 612
HIS A 613
LEU A 725
ALA A 767
VAL A 782
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
None
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.38A 3jwqB-3bjcA:
47.6
3jwqC-3bjcA:
47.4		 3jwqB-3bjcA:
35.69
3jwqC-3bjcA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 TYR A 612
HIS A 613
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.37A 3jwqC-3bjcA:
47.4		 3jwqC-3bjcA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		7 / 11 TYR A 612
HIS A 613
LEU A 725
ALA A 767
PHE A 786
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
None
WAN  A 901 ( 3.9A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.44A 3jwqA-3bjcA:
47.8
3jwqD-3bjcA:
47.3		 3jwqA-3bjcA:
35.69
3jwqD-3bjcA:
35.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 TYR A 612
PHE A 786
GLN A 817
PHE A 820
 None
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.40A 3tvxB-3bjcA:
34.4		 3tvxB-3bjcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 7 GLY A 819
VAL A 818
GLN A 817
ILE A 813
PHE A 787
 None
None
WAN  A 901 (-3.1A)
WAN  A 901 ( 4.3A)
None
 1.46A 4fglC-3bjcA:
undetectable		 4fglC-3bjcA:
13.39