SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'WAI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1y2f CELL DIVISION
PROTEIN ZIPA
(Escherichia
coli) 		5 / 12 ILE A  12
ILE A  11
MET A 101
ALA A 105
LEU A 129
 WAI  A 300 ( 4.9A)
None
None
None
None
 1.11A 1bsxA-1y2fA:
undetectable		 1bsxA-1y2fA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1y2f CELL DIVISION
PROTEIN ZIPA
(Escherichia
coli) 		5 / 12 ILE A  12
ILE A  11
MET A 101
ALA A 105
LEU A 129
 WAI  A 300 ( 4.9A)
None
None
None
None
 1.11A 1bsxB-1y2fA:
undetectable		 1bsxB-1y2fA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1y2f CELL DIVISION
PROTEIN ZIPA
(Escherichia
coli) 		5 / 12 GLY A  40
LEU A  28
LEU A  61
ALA A  62
LEU A  29
 None
None
None
WAI  A 300 (-3.5A)
None
 1.12A 1jipA-1y2fA:
undetectable		 1jipA-1y2fA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1y2f CELL DIVISION
PROTEIN ZIPA
(Escherichia
coli) 		5 / 8 LEU A  23
THR A  79
GLY A  68
ALA A  62
ILE A  84
 None
None
WAI  A 300 ( 4.2A)
WAI  A 300 (-3.5A)
None
 1.35A 3jusB-1y2fA:
undetectable		 3jusB-1y2fA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1y2f CELL DIVISION
PROTEIN ZIPA
(Escherichia
coli) 		5 / 9 LEU A  23
THR A  79
GLY A  68
ALA A  62
ILE A  84
 None
None
WAI  A 300 ( 4.2A)
WAI  A 300 (-3.5A)
None
 1.35A 3jusB-1y2fA:
undetectable		 3jusB-1y2fA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1y2f CELL DIVISION
PROTEIN ZIPA
(Escherichia
coli) 		4 / 7 ILE A 108
LEU A  28
PHE A  70
GLY A  68
 None
None
None
WAI  A 300 ( 4.2A)
 0.95A 4hajA-1y2fA:
undetectable		 4hajA-1y2fA:
18.66