SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VPR'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEE_A_30BA500_1 (GENOME POLYPROTEIN)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 12	HIS A 374 ASP A 348 GLY A 116 ALA A 376 ALA A 377	VPR A 1 ( 4.6A) VPR A 1 ( 4.5A) None None None	1.12A	3keeA-3g0iA: undetectable	3keeA-3g0iA: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUE_B_SUEB1201_1 (NS3 PROTEASE, NS4A PROTEIN)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 12	HIS A 374 ASP A 348 GLY A 116 ALA A 376 ALA A 377	VPR A 1 ( 4.6A) VPR A 1 ( 4.5A) None None None	1.07A	3sueB-3g0iA: undetectable	3sueB-3g0iA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUE_C_SUEC1201_1 (NS3 PROTEASE, NS4A PROTEIN)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 12	HIS A 374 ASP A 348 GLY A 116 ALA A 376 ALA A 377	VPR A 1 ( 4.6A) VPR A 1 ( 4.5A) None None None	1.11A	3sueC-3g0iA: undetectable	3sueC-3g0iA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUF_A_SUEA1201_1 (NS3 PROTEASE, NS4A PROTEIN)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 12	HIS A 374 ASP A 348 GLY A 116 ALA A 376 ALA A 377	VPR A 1 ( 4.6A) VPR A 1 ( 4.5A) None None None	1.03A	3sufA-3g0iA: undetectable	3sufA-3g0iA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUF_C_SUEC1201_1 (NS3 PROTEASE, NS4A PROTEIN)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 11	HIS A 374 ASP A 348 GLY A 116 ALA A 376 ALA A 377	VPR A 1 ( 4.6A) VPR A 1 ( 4.5A) None None None	1.20A	3sufC-3g0iA: undetectable	3sufC-3g0iA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_B_CLMB221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 12	TYR A 251 LEU A 215 PHE A 196 PHE A 244 CYH A 350	VPR A 1 (-4.2A) VPR A 1 ( 4.4A) VPR A 1 (-4.3A) VPR A 1 ( 4.7A) VPR A 1 ( 4.4A)	1.37A	3u9fB-3g0iA: undetectable 3u9fC-3g0iA: undetectable	3u9fB-3g0iA: 19.89 3u9fC-3g0iA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_D_CLMD221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 12	TYR A 251 LEU A 215 PHE A 196 PHE A 244 CYH A 350	VPR A 1 (-4.2A) VPR A 1 ( 4.4A) VPR A 1 (-4.3A) VPR A 1 ( 4.7A) VPR A 1 ( 4.4A)	1.34A	3u9fD-3g0iA: undetectable 3u9fE-3g0iA: undetectable	3u9fD-3g0iA: 19.89 3u9fE-3g0iA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_G_CLMG221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 12	TYR A 251 LEU A 215 PHE A 196 PHE A 244 CYH A 350	VPR A 1 (-4.2A) VPR A 1 ( 4.4A) VPR A 1 (-4.3A) VPR A 1 ( 4.7A) VPR A 1 ( 4.4A)	1.36A	3u9fG-3g0iA: undetectable 3u9fH-3g0iA: undetectable	3u9fG-3g0iA: 19.89 3u9fH-3g0iA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_H_CLMH221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 12	TYR A 251 LEU A 215 PHE A 196 PHE A 244 CYH A 350	VPR A 1 (-4.2A) VPR A 1 ( 4.4A) VPR A 1 (-4.3A) VPR A 1 ( 4.7A) VPR A 1 ( 4.4A)	1.41A	3u9fH-3g0iA: undetectable 3u9fI-3g0iA: undetectable	3u9fH-3g0iA: 19.89 3u9fI-3g0iA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_L_CLML221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 12	PHE A 244 CYH A 350 TYR A 251 LEU A 215 PHE A 196	VPR A 1 ( 4.7A) VPR A 1 ( 4.4A) VPR A 1 (-4.2A) VPR A 1 ( 4.4A) VPR A 1 (-4.3A)	1.36A	3u9fJ-3g0iA: undetectable 3u9fL-3g0iA: undetectable	3u9fJ-3g0iA: 19.89 3u9fL-3g0iA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_S_CLMS221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	5 / 12	PHE A 244 CYH A 350 TYR A 251 LEU A 215 PHE A 196	VPR A 1 ( 4.7A) VPR A 1 ( 4.4A) VPR A 1 (-4.2A) VPR A 1 ( 4.4A) VPR A 1 (-4.3A)	1.39A	3u9fP-3g0iA: undetectable 3u9fS-3g0iA: undetectable	3u9fP-3g0iA: 19.89 3u9fS-3g0iA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AWU_A_4CHA502_0 (OXIDOREDUCTASE, FMN-BINDING)	3g0i	EPOXIDE HYDROLASE (Aspergillus niger)	4 / 7	HIS A 255 TYR A 251 LEU A 249 PHE A 196	None VPR A 1 (-4.2A) None VPR A 1 (-4.3A)	1.32A	4awuA-3g0iA: 2.6	4awuA-3g0iA: 22.97

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3KEE_A_30BA500_1","GENOME POLYPROTEIN","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"HIS A 374;ASP A 348;GLY A 116;ALA A 376;ALA A 377","VPR A   1 ( 4.6A);VPR A   1 ( 4.5A);None;None;None","1.12A","3keeA-3g0iA:undetectable",null],["3SUE_B_SUEB1201_1","NS3 PROTEASE, NS4A PROTEIN","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"HIS A 374;ASP A 348;GLY A 116;ALA A 376;ALA A 377","VPR A   1 ( 4.6A);VPR A   1 ( 4.5A);None;None;None","1.07A","3sueB-3g0iA:undetectable","3keeA-3g0iA:18.84"],["3SUE_C_SUEC1201_1","NS3 PROTEASE, NS4A PROTEIN","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"HIS A 374;ASP A 348;GLY A 116;ALA A 376;ALA A 377","VPR A   1 ( 4.6A);VPR A   1 ( 4.5A);None;None;None","1.11A","3sueC-3g0iA:undetectable","3sueB-3g0iA:19.50"],["3SUF_A_SUEA1201_1","NS3 PROTEASE, NS4A PROTEIN","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"HIS A 374;ASP A 348;GLY A 116;ALA A 376;ALA A 377","VPR A   1 ( 4.6A);VPR A   1 ( 4.5A);None;None;None","1.03A","3sufA-3g0iA:undetectable","3sueC-3g0iA:19.50"],["3SUF_C_SUEC1201_1","NS3 PROTEASE, NS4A PROTEIN","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"HIS A 374;ASP A 348;GLY A 116;ALA A 376;ALA A 377","VPR A   1 ( 4.6A);VPR A   1 ( 4.5A);None;None;None","1.20A","3sufC-3g0iA:undetectable","3sufA-3g0iA:19.50"],["3U9F_B_CLMB221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"TYR A 251;LEU A 215;PHE A 196;PHE A 244;CYH A 350","VPR A   1 (-4.2A);VPR A   1 ( 4.4A);VPR A   1 (-4.3A);VPR A   1 ( 4.7A);VPR A   1 ( 4.4A)","1.37A","3u9fB-3g0iA:undetectable;3u9fC-3g0iA:undetectable","3sufC-3g0iA:19.50"],["3U9F_D_CLMD221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"TYR A 251;LEU A 215;PHE A 196;PHE A 244;CYH A 350","VPR A   1 (-4.2A);VPR A   1 ( 4.4A);VPR A   1 (-4.3A);VPR A   1 ( 4.7A);VPR A   1 ( 4.4A)","1.34A","3u9fD-3g0iA:undetectable;3u9fE-3g0iA:undetectable","3u9fB-3g0iA:19.89;3u9fC-3g0iA:19.89"],["3U9F_G_CLMG221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"TYR A 251;LEU A 215;PHE A 196;PHE A 244;CYH A 350","VPR A   1 (-4.2A);VPR A   1 ( 4.4A);VPR A   1 (-4.3A);VPR A   1 ( 4.7A);VPR A   1 ( 4.4A)","1.36A","3u9fG-3g0iA:undetectable;3u9fH-3g0iA:undetectable","3u9fD-3g0iA:19.89;3u9fE-3g0iA:19.89"],["3U9F_H_CLMH221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"TYR A 251;LEU A 215;PHE A 196;PHE A 244;CYH A 350","VPR A   1 (-4.2A);VPR A   1 ( 4.4A);VPR A   1 (-4.3A);VPR A   1 ( 4.7A);VPR A   1 ( 4.4A)","1.41A","3u9fH-3g0iA:undetectable;3u9fI-3g0iA:undetectable","3u9fG-3g0iA:19.89;3u9fH-3g0iA:19.89"],["3U9F_L_CLML221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"PHE A 244;CYH A 350;TYR A 251;LEU A 215;PHE A 196","VPR A   1 ( 4.7A);VPR A   1 ( 4.4A);VPR A   1 (-4.2A);VPR A   1 ( 4.4A);VPR A   1 (-4.3A)","1.36A","3u9fJ-3g0iA:undetectable;3u9fL-3g0iA:undetectable","3u9fH-3g0iA:19.89;3u9fI-3g0iA:19.89"],["3U9F_S_CLMS221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",5,"PHE A 244;CYH A 350;TYR A 251;LEU A 215;PHE A 196","VPR A   1 ( 4.7A);VPR A   1 ( 4.4A);VPR A   1 (-4.2A);VPR A   1 ( 4.4A);VPR A   1 (-4.3A)","1.39A","3u9fP-3g0iA:undetectable;3u9fS-3g0iA:undetectable","3u9fJ-3g0iA:19.89;3u9fL-3g0iA:19.89"],["4AWU_A_4CHA502_0","OXIDOREDUCTASE, FMN-BINDING","3g0i","EPOXIDE HYDROLASE","Aspergillus niger",4,"HIS A 255;TYR A 251;LEU A 249;PHE A 196","None;VPR A   1 (-4.2A);None;VPR A   1 (-4.3A)","1.32A","4awuA-3g0iA:2.6","3u9fP-3g0iA:19.89;3u9fS-3g0iA:19.89"]]