SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VPF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		3 / 3 LEU A 169
HIS A  39
ILE A  40
 VPF  A 201 (-4.3A)
VPF  A 201 (-3.8A)
None
 0.68A 1s9pB-3ufaA:
undetectable		 1s9pB-3ufaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 9 ALA A 171
SER A 154
GLY A 152
SER A 178
ALA A 149
 VPF  A 201 (-4.9A)
VPF  A 201 (-1.7A)
VPF  A 201 (-3.3A)
VPF  A 201 ( 4.7A)
VPF  A 201 (-3.4A)
 1.46A 2vh3A-3ufaA:
undetectable		 2vh3A-3ufaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 6 LEU A 169
SER A 154
THR A  25
VAL A  18
 VPF  A 201 (-4.3A)
VPF  A 201 (-1.7A)
None
None
 1.03A 3d2tB-3ufaA:
undetectable		 3d2tB-3ufaA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.81A 3keeB-3ufaA:
13.0		 3keeB-3ufaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.83A 3keeC-3ufaA:
12.4		 3keeC-3ufaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.83A 3keeD-3ufaA:
12.8		 3keeD-3ufaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.83A 3sueA-3ufaA:
11.8		 3sueA-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.83A 3sueC-3ufaA:
11.4		 3sueC-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 11 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.88A 3sufC-3ufaA:
11.1		 3sufC-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.78A 3sufD-3ufaA:
11.5		 3sufD-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 5 HIS A  39
ALA A 171
SER A 154
GLY A 155
 VPF  A 201 (-3.8A)
VPF  A 201 (-4.9A)
VPF  A 201 (-1.7A)
None
 1.08A 5yodB-3ufaA:
10.7		 5yodB-3ufaA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 5 HIS A  39
ALA A 171
SER A 154
GLY A 155
 VPF  A 201 (-3.8A)
VPF  A 201 (-4.9A)
VPF  A 201 (-1.7A)
None
 1.25A 5yodD-3ufaA:
10.7		 5yodD-3ufaA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.80A 6c2mC-3ufaA:
11.7		 6c2mC-3ufaA:
20.21