SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VOR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 SER A 283
PHE A 149
VAL A 134
ALA A 303
ASP A 276
 None
None
None
VOR  A 590 ( 4.4A)
None
 1.25A 2avdB-4uymA:
undetectable		 2avdB-4uymA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 126
TYR A 140
THR A 318
LEU A 380
VAL A 510
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.92A 2wuzA-5hs1A:
40.0		 2wuzA-5hs1A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 126
TYR A 140
THR A 318
LEU A 380
VAL A 510
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.92A 2wuzB-5hs1A:
40.0		 2wuzB-5hs1A:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		4 / 7 PHE A 130
TYR A 136
ALA A 303
ALA A 307
 VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
 0.55A 2wx2A-4uymA:
40.0		 2wx2A-4uymA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.51A 2wx2A-5hs1A:
38.0		 2wx2A-5hs1A:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 8 TYR A 122
PHE A 130
TYR A 136
ALA A 303
ALA A 307
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
 0.58A 2wx2B-4uymA:
38.1		 2wx2B-4uymA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 8 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.40A 2wx2B-5hs1A:
36.5		 2wx2B-5hs1A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
PHE A 241
TYR A 140
PRO A 238
THR A 318
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
None
HEM  A 601 (-3.4A)
 1.31A 2x2nA-5hs1A:
39.3		 2x2nA-5hs1A:
29.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 ILE A  62
TYR A 122
TYR A 136
ALA A 303
ALA A 307
 None
VOR  A 590 (-3.8A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
 1.18A 2x2nD-4uymA:
36.8		 2x2nD-4uymA:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
PHE A 241
TYR A 140
LEU A 380
MET A 509
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.20A 2x2nD-5hs1A:
39.6		 2x2nD-5hs1A:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
PHE A 241
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.96A 2x2nD-5hs1A:
39.6		 2x2nD-5hs1A:
29.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		4 / 8 TYR A 122
LEU A 125
TYR A 136
ILE A 373
 VOR  A 590 (-3.8A)
None
HEM  A 580 (-4.6A)
HEM  A 580 (-4.1A)
 0.72A 3jusA-4uymA:
48.0		 3jusA-4uymA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 8 TYR A 122
THR A 126
TYR A 136
ALA A 307
ILE A 373
 VOR  A 590 (-3.8A)
None
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.0A)
HEM  A 580 (-4.1A)
 0.77A 3jusA-4uymA:
48.0		 3jusA-4uymA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 8 TYR A 126
THR A 130
TYR A 140
GLY A 310
THR A 318
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
 0.59A 3jusA-5hs1A:
45.4		 3jusA-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		4 / 8 TYR A 122
LEU A 125
TYR A 136
ILE A 373
 VOR  A 590 (-3.8A)
None
HEM  A 580 (-4.6A)
HEM  A 580 (-4.1A)
 0.72A 3jusA-4uymA:
48.0		 3jusA-4uymA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 8 TYR A 122
THR A 126
TYR A 136
ALA A 307
ILE A 373
 VOR  A 590 (-3.8A)
None
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.0A)
HEM  A 580 (-4.1A)
 0.77A 3jusA-4uymA:
48.0		 3jusA-4uymA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 8 TYR A 126
THR A 130
TYR A 140
GLY A 310
THR A 318
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
 0.59A 3jusA-5hs1A:
45.4		 3jusA-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		6 / 9 TYR A 122
LEU A 125
THR A 126
TYR A 136
ALA A 307
ILE A 373
 VOR  A 590 (-3.8A)
None
None
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.0A)
HEM  A 580 (-4.1A)
 0.86A 3jusB-4uymA:
47.9		 3jusB-4uymA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 126
THR A 130
TYR A 140
GLY A 310
THR A 318
 VOR  A 602 ( 3.8A)
None
HEM  A 601 (-4.3A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
 0.49A 3jusB-5hs1A:
45.0		 3jusB-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 8 TYR A 122
PHE A 130
TYR A 136
ALA A 303
ALA A 307
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
 0.65A 3khmA-4uymA:
41.4		 3khmA-4uymA:
31.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.51A 3khmA-5hs1A:
39.3		 3khmA-5hs1A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 126
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.66A 3khmA-5hs1A:
39.3		 3khmA-5hs1A:
29.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		4 / 8 TYR A 122
TYR A 136
ALA A 303
ALA A 307
 VOR  A 590 (-3.8A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
 0.69A 3l4dA-4uymA:
41.4		 3l4dA-4uymA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 126
TYR A 140
THR A 318
LEU A 380
MET A 509
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.19A 3l4dB-5hs1A:
39.8		 3l4dB-5hs1A:
28.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 9 TYR A 122
PHE A 130
TYR A 136
ALA A 303
ALA A 307
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
 0.98A 3l4dC-4uymA:
36.4		 3l4dC-4uymA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.92A 3l4dC-5hs1A:
39.4		 3l4dC-5hs1A:
28.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 126
TYR A 140
THR A 318
LEU A 380
MET A 509
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.08A 3l4dC-5hs1A:
39.4		 3l4dC-5hs1A:
28.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		6 / 12 TYR A 122
PHE A 130
TYR A 136
PHE A 229
ALA A 307
ILE A 373
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
VOR  A 590 ( 4.0A)
HEM  A 580 (-4.1A)
 0.82A 3ld6A-4uymA:
48.4		 3ld6A-4uymA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A 126
PHE A 134
TYR A 140
GLY A 310
THR A 318
MET A 509
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 ( 4.2A)
 0.59A 3ld6A-5hs1A:
45.6		 3ld6A-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A 126
PHE A 134
TYR A 140
PHE A 236
GLY A 310
THR A 318
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
 0.74A 3ld6A-5hs1A:
45.6		 3ld6A-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 TYR A 122
PHE A 130
TYR A 136
ALA A 307
ILE A 373
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.0A)
HEM  A 580 (-4.1A)
 0.71A 3ld6B-4uymA:
48.1		 3ld6B-4uymA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 TYR A 122
PHE A 130
TYR A 136
PHE A 229
ALA A 307
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
VOR  A 590 ( 4.0A)
 0.70A 3ld6B-4uymA:
48.1		 3ld6B-4uymA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 134
TYR A 140
GLY A 310
THR A 318
MET A 509
 VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 ( 4.2A)
 0.59A 3ld6B-5hs1A:
45.4		 3ld6B-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A 126
PHE A 134
TYR A 140
PHE A 236
GLY A 310
THR A 318
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
 0.75A 3ld6B-5hs1A:
45.4		 3ld6B-5hs1A:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 9 TYR A 126
ILE A 139
TYR A 140
THR A 318
LEU A 380
MET A 509
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 0.88A 4wmzA-5hs1A:
63.3		 4wmzA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		8 / 9 TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.41A 4wmzA-5hs1A:
63.3		 4wmzA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A  73
GLY A 315
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.77A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
TYR A 126
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
None
 0.50A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 TYR A 126
ILE A 139
THR A 318
LEU A 380
THR A 507
MET A 509
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
VOR  A 602 ( 4.2A)
 1.38A 4zdyA-5hs1A:
63.6		 4zdyA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 7 PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
 VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.39A 4zdzA-5hs1A:
63.5		 4zdzA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		9 / 9 TYR A 126
THR A 130
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
LEU A 383
 VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
HEM  A 601 (-4.0A)
 0.44A 4ze0A-5hs1A:
63.6		 4ze0A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 GLY A  69
LEU A 125
PHE A 130
PHE A 229
HIS A 374
 None
None
VOR  A 590 (-4.6A)
None
None
 1.17A 4ze1A-4uymA:
52.3		 4ze1A-4uymA:
50.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 TYR A  68
GLY A  69
LEU A 125
PHE A 130
HIS A 374
 None
None
None
VOR  A 590 (-4.6A)
None
 0.98A 4ze1A-4uymA:
52.3		 4ze1A-4uymA:
50.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  73
MET A  74
GLY A 315
LEU A 380
HIS A 381
 None
None
HEM  A 601 (-3.5A)
VOR  A 602 (-4.0A)
None
 0.62A 4ze1A-5hs1A:
63.7		 4ze1A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 TYR A  72
GLY A  73
MET A  74
LEU A 129
PHE A 134
PHE A 236
GLY A 314
LEU A 380
HIS A 381
PHE A 384
THR A 507
 None
None
None
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
VOR  A 602 (-4.0A)
None
None
None
 0.58A 4ze1A-5hs1A:
63.7		 4ze1A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 5 VAL A  70
TYR A 126
ILE A 139
PRO A 238
THR A 318
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
None
HEM  A 601 (-3.4A)
 0.50A 4ze1A-5hs1A:
undetectable		 4ze1A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 5 VAL A  71
TYR A 126
ILE A 139
PRO A 238
THR A 318
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
None
HEM  A 601 (-3.4A)
 1.32A 4ze1A-5hs1A:
undetectable		 4ze1A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		6 / 12 GLY A  69
TYR A 122
LEU A 125
PHE A 130
PHE A 229
HIS A 374
 None
VOR  A 590 (-3.8A)
None
VOR  A 590 (-4.6A)
None
None
 1.16A 4ze2A-4uymA:
52.3		 4ze2A-4uymA:
50.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A  73
GLY A 315
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.78A 4ze2A-5hs1A:
63.4		 4ze2A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
HIS A 381
THR A 507
 None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.60A 4ze2A-5hs1A:
63.4		 4ze2A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		7 / 7 TYR A 126
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.45A 4ze3A-5hs1A:
63.3		 4ze3A-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 GLY A  69
PHE A 130
TYR A 136
PHE A 229
HIS A 374
 None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
 0.97A 5eqbA-4uymA:
52.5		 5eqbA-4uymA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  73
GLY A 315
LEU A 380
HIS A 381
THR A 507
 None
HEM  A 601 (-3.5A)
VOR  A 602 (-4.0A)
None
None
 0.47A 5eqbA-5hs1A:
63.2		 5eqbA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 310
GLY A 314
LEU A 380
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-4.3A)
VOR  A 602 (-3.0A)
VOR  A 602 (-4.0A)
None
None
None
 0.55A 5eqbA-5hs1A:
63.2		 5eqbA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 4 TYR A  72
TYR A 126
PRO A 238
THR A 318
 None
VOR  A 602 ( 3.8A)
None
HEM  A 601 (-3.4A)
 0.36A 5eqbA-5hs1A:
63.2		 5eqbA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 TYR A  68
PHE A 130
TYR A 136
PHE A 229
HIS A 374
 None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
 0.98A 5esgA-4uymA:
52.5		 5esgA-4uymA:
50.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 139
TYR A 140
VAL A 242
THR A 318
LEU A 380
MET A 509
 VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
None
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.42A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  72
GLY A 315
THR A 318
LEU A 380
HIS A 381
 None
HEM  A 601 (-3.5A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.91A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		10 / 12 TYR A  72
PHE A 134
ILE A 139
TYR A 140
PHE A 236
VAL A 242
GLY A 314
THR A 318
LEU A 380
HIS A 381
 None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
None
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.48A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  96
TYR A 126
PRO A 238
ILE A 239
 None
VOR  A 602 ( 3.8A)
None
None
 0.36A 5esgA-5hs1A:
63.7		 5esgA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  69
LEU A  96
ILE A 139
TYR A 140
LEU A 383
 None
None
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
HEM  A 601 (-4.0A)
 1.10A 5eshA-5hs1A:
63.7		 5eshA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 ALA A  69
LEU A  96
TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
LEU A 380
PHE A 384
 None
None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.59A 5eshA-5hs1A:
63.7		 5eshA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
TYR A 140
THR A 318
LEU A 380
MET A 509
 VOR  A 602 ( 3.8A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
VOR  A 602 ( 4.2A)
 1.02A 5eshA-5hs1A:
63.7		 5eshA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		6 / 12 GLY A  69
TYR A 122
LEU A 125
PHE A 130
TYR A 136
PHE A 229
 None
VOR  A 590 (-3.8A)
None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
 1.19A 5eskA-4uymA:
51.9		 5eskA-4uymA:
45.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
TYR A 126
LEU A 129
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
 0.47A 5eskA-5hs1A:
63.2		 5eskA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 129
TYR A 126
PHE A 236
GLY A 314
THR A 318
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
 1.19A 5eskA-5hs1A:
63.2		 5eskA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ALA A  69
PRO A 238
LEU A 380
HIS A 381
 None
None
VOR  A 602 (-4.0A)
None
 0.58A 5eskA-5hs1A:
63.2		 5eskA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		6 / 12 GLY A  69
TYR A 122
PHE A 130
TYR A 136
PHE A 229
HIS A 374
 None
VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
 1.07A 5eslA-4uymA:
51.4		 5eslA-4uymA:
50.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
None
 0.49A 5eslA-5hs1A:
63.1		 5eslA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 5 ALA A  69
TYR A  72
PRO A 238
GLY A 310
LEU A 380
 None
None
None
VOR  A 602 (-4.3A)
VOR  A 602 (-4.0A)
 0.48A 5eslA-5hs1A:
63.1		 5eslA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		7 / 7 TYR A 126
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.44A 5esmA-5hs1A:
63.8		 5esmA-5hs1A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 ALA A  69
TYR A  72
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
GLY A 314
LEU A 380
HIS A 381
PHE A 384
 None
None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
VOR  A 602 (-4.0A)
None
None
 0.67A 5fsaA-5hs1A:
55.8		 5fsaA-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 ALA A  69
TYR A  72
TYR A 126
LEU A 129
PHE A 134
ILE A 139
PHE A 236
PHE A 241
GLY A 314
HIS A 381
PHE A 384
 None
None
VOR  A 602 ( 3.8A)
None
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
None
VOR  A 602 (-3.0A)
None
None
 0.63A 5fsaA-5hs1A:
55.8		 5fsaA-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 125
PHE A 130
TYR A 136
PHE A 229
HIS A 374
 None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
 1.20A 5fsaB-4uymA:
51.5		 5fsaB-4uymA:
50.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		6 / 12 TYR A  68
GLY A  69
LEU A 125
PHE A 130
TYR A 136
HIS A 374
 None
None
None
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
 1.01A 5fsaB-4uymA:
51.5		 5fsaB-4uymA:
50.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		9 / 12 TYR A  72
GLY A  73
LEU A 129
PHE A 134
TYR A 140
GLY A 314
THR A 318
HIS A 381
PHE A 384
 None
None
None
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
 0.62A 5fsaB-5hs1A:
54.7		 5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		9 / 12 TYR A  72
LEU A 129
PHE A 134
TYR A 140
PHE A 236
GLY A 314
THR A 318
HIS A 381
PHE A 384
 None
None
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
 0.64A 5fsaB-5hs1A:
54.7		 5fsaB-5hs1A:
59.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 ALA A  69
TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
GLY A 314
THR A 318
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
None
None
None
 0.66A 5jlcA-5hs1A:
57.8		 5jlcA-5hs1A:
84.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 113
PRO A 410
PHE A 463
MET A 509
LEU A 407
 HEM  A 601 (-4.7A)
None
HEM  A 601 (-4.4A)
VOR  A 602 ( 4.2A)
None
 1.28A 5ljbA-5hs1A:
undetectable		 5ljbA-5hs1A:
12.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 134
TYR A 140
THR A 318
LEU A 380
THR A 507
 VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
 0.86A 5tl8A-5hs1A:
43.0		 5tl8A-5hs1A:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 TYR A 122
PHE A 130
TYR A 136
PHE A 229
HIS A 374
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
 1.06A 5v5zA-4uymA:
50.2		 5v5zA-4uymA:
45.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 134
TYR A 126
PHE A 236
GLY A 314
THR A 318
 VOR  A 602 (-4.7A)
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
 1.13A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
ILE A 139
TYR A 140
PHE A 241
LEU A 383
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
None
HEM  A 601 (-4.0A)
 1.25A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
PHE A 241
GLY A 314
THR A 318
LEU A 380
HIS A 381
PHE A 384
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
None
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.53A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		6 / 10 TYR A 122
PHE A 130
TYR A 136
ALA A 303
ALA A 307
CYH A 463
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
HEM  A 580 (-2.3A)
 0.80A 6ay4A-4uymA:
43.8		 6ay4A-4uymA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 10 TYR A 126
PHE A 134
TYR A 140
PHE A 236
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 1.37A 6ay4A-5hs1A:
42.8		 6ay4A-5hs1A:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 10 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
CYH A 470
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
HEM  A 601 (-2.4A)
 0.71A 6ay4A-5hs1A:
42.8		 6ay4A-5hs1A:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		6 / 9 TYR A 122
PHE A 130
TYR A 136
ALA A 303
ALA A 307
CYH A 463
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
HEM  A 580 (-2.3A)
 0.81A 6ay6A-4uymA:
43.9		 6ay6A-4uymA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		6 / 9 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
CYH A 470
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
HEM  A 601 (-2.4A)
 0.49A 6ay6A-5hs1A:
42.6		 6ay6A-5hs1A:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 PHE A 130
TYR A 136
ALA A 303
ALA A 307
LEU A 503
 VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
VOR  A 590 (-3.5A)
 0.93A 6aybA-4uymA:
39.1		 6aybA-4uymA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 TYR A 122
PHE A 130
TYR A 136
ALA A 303
ALA A 307
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
 0.71A 6aybA-4uymA:
39.1		 6aybA-4uymA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.54A 6aybA-5hs1A:
42.8		 6aybA-5hs1A:
32.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 TYR A 122
PHE A 130
TYR A 136
ALA A 303
ALA A 307
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
 0.69A 6aycA-4uymA:
44.1		 6aycA-4uymA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  69
TYR A 126
PHE A 134
TYR A 140
LEU A 380
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.0A)
 1.08A 6aycA-5hs1A:
43.1		 6aycA-5hs1A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 126
PHE A 134
TYR A 140
THR A 318
LEU A 380
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
HEM  A 601 (-4.3A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
 0.51A 6aycA-5hs1A:
43.1		 6aycA-5hs1A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uym 14-ALPHA STEROL
DEMETHYLASE
(Aspergillus
fumigatus) 		5 / 12 GLY A  69
TYR A 122
PHE A 130
PHE A 229
HIS A 374
 None
VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
None
None
 1.11A 6e8qA-4uymA:
51.9		 6e8qA-4uymA:
10.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE
(Saccharomyces
cerevisiae) 		11 / 12 GLY A  73
TYR A 126
PHE A 134
ILE A 139
PHE A 236
GLY A 314
THR A 318
LEU A 380
HIS A 381
PHE A 384
THR A 507
 None
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
None
 0.55A 6e8qA-5hs1A:
63.5		 6e8qA-5hs1A:
100.00