SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VKC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4ccw CARBOXYL ESTERASE NP
(Bacillus
subtilis) 		5 / 10 ASP A  88
TRP A  71
GLY A 133
GLY A 132
SER A 130
 None
None
None
None
VKC  A1294 ( 3.8A)
 1.20A 1w76B-4ccwA:
12.4		 1w76B-4ccwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4ccw CARBOXYL ESTERASE NP
(Bacillus
subtilis) 		5 / 9 GLY A  63
ALA A  64
SER A 130
LEU A 131
HIS A 274
 None
VKC  A1294 (-3.4A)
VKC  A1294 ( 3.8A)
None
VKC  A1294 ( 4.9A)
 0.65A 1y7iA-4ccwA:
17.9		 1y7iA-4ccwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4ccw CARBOXYL ESTERASE NP
(Bacillus
subtilis) 		5 / 10 ALA A  64
SER A 130
LEU A 131
PHE A 182
HIS A 274
 VKC  A1294 (-3.4A)
VKC  A1294 ( 3.8A)
None
VKC  A1294 (-4.5A)
VKC  A1294 ( 4.9A)
 1.07A 1y7iB-4ccwA:
17.8		 1y7iB-4ccwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4ccw CARBOXYL ESTERASE NP
(Bacillus
subtilis) 		5 / 12 PHE A 162
PHE A  66
PHE A 201
ALA A 170
PHE A 182
 None
VKC  A1294 ( 4.1A)
None
VKC  A1294 (-3.5A)
VKC  A1294 (-4.5A)
 1.49A 3apxA-4ccwA:
undetectable		 3apxA-4ccwA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4ccw CARBOXYL ESTERASE NP
(Bacillus
subtilis) 		4 / 7 HIS A 274
LEU A 129
GLY A 242
ALA A 272
 VKC  A1294 ( 4.9A)
None
None
None
 0.95A 3tehB-4ccwA:
undetectable		 3tehB-4ccwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 4ccw CARBOXYL ESTERASE NP
(Bacillus
subtilis) 		5 / 11 VAL A 275
SER A 130
PHE A 182
ALA A  64
PHE A 201
 None
VKC  A1294 ( 3.8A)
VKC  A1294 (-4.5A)
VKC  A1294 (-3.4A)
None
 1.30A 4evrA-4ccwA:
3.2		 4evrA-4ccwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4ccw CARBOXYL ESTERASE NP
(Bacillus
subtilis) 		4 / 8 ASP A  92
TYR A 108
ASN A 213
SER A 130
 None
None
None
VKC  A1294 ( 3.8A)
 0.82A 5l1fA-4ccwA:
undetectable
5l1fB-4ccwA:
undetectable		 5l1fA-4ccwA:
17.65
5l1fB-4ccwA:
17.65