SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VIV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
LEU A 137
ILE A 154
ILE A 171
ILE A 179
LEU A 183
VAL A 191
ILE A 194
ILE A 210
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
None
None
VIV  A 301 ( 4.0A)
None
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.23A 1oipA-1r5lA:
43.4		 1oipA-1r5lA:
93.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		12 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
LEU A 137
ILE A 154
ILE A 171
ILE A 179
LEU A 183
VAL A 191
ILE A 194
ILE A 210
 None
None
None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.8A)
None
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
None
VIV  A 302 ( 4.9A)
VIV  A 302 ( 4.6A)
None
 0.19A 1oipA-5mueA:
39.1		 1oipA-5mueA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 5 SER A 136
SER A 140
PHE A 158
VAL A 182
PHE A 187
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
VIV  A 301 (-3.9A)
 0.28A 1oipA-1r5lA:
43.4		 1oipA-1r5lA:
93.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		5 / 5 SER A 136
SER A 140
PHE A 158
VAL A 182
PHE A 187
 VIV  A 302 (-3.5A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.4A)
VIV  A 302 (-4.0A)
 0.22A 1oipA-5mueA:
39.1		 1oipA-5mueA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 TRP A 122
VAL A 132
PHE A 133
ILE A 154
PHE A 158
TRP A 163
ILE A 171
ILE A 179
VAL A 182
VAL A 191
ILE A 194
ILE A 210
 None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 3.9A)
None
VIV  A 301 (-3.9A)
None
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.02A 1r5lA-1r5lA:
45.9		 1r5lA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 12 VAL A 135
PHE A 133
PHE A 158
VAL A 182
ILE A 194
 None
VIV  A 301 ( 3.9A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
VIV  A 301 ( 4.5A)
 1.34A 1r5lA-1r5lA:
45.9		 1r5lA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		12 / 12 TRP A 122
VAL A 132
PHE A 133
ILE A 154
PHE A 158
TRP A 163
ILE A 171
ILE A 179
VAL A 182
VAL A 191
ILE A 194
ILE A 210
 None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.1A)
None
VIV  A 302 (-3.9A)
None
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.9A)
VIV  A 302 ( 4.6A)
None
 0.24A 1r5lA-5mueA:
39.2		 1r5lA-5mueA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 135
PHE A 133
PHE A 158
VAL A 182
ILE A 194
 None
VIV  A 302 ( 4.1A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.6A)
 1.34A 1r5lA-5mueA:
39.2		 1r5lA-5mueA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R5L_A_VIVA301_1
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 4 SER A 136
SER A 140
LEU A 183
PHE A 187
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
None
VIV  A 301 (-3.9A)
 0.03A 1r5lA-1r5lA:
45.9		 1r5lA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R5L_A_VIVA301_1
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 4 SER A 136
SER A 140
LEU A 183
PHE A 187
 VIV  A 302 (-3.5A)
VIV  A 302 (-3.2A)
None
VIV  A 302 (-4.0A)
 0.14A 1r5lA-5mueA:
39.2		 1r5lA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 12 ILE A 218
ALA A 176
ILE A 179
THR A 215
GLU A 220
 None
None
VIV  A 301 ( 4.0A)
None
None
 1.29A 1vq1A-1r5lA:
undetectable		 1vq1A-1r5lA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 7 ILE A 179
LEU A 183
SER A 140
VAL A 103
 VIV  A 301 ( 4.0A)
None
VIV  A 301 (-3.1A)
None
 0.98A 3r9vA-1r5lA:
undetectable
3r9vB-1r5lA:
undetectable		 3r9vA-1r5lA:
21.78
3r9vB-1r5lA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		11 / 11 TRP A 122
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.68A 3w67A-1r5lA:
37.7		 3w67A-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		11 / 11 TRP A 122
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
 0.61A 3w67A-5mueA:
34.0		 3w67A-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		11 / 12 ILE A 119
TRP A 122
SER A 136
LEU A 137
PHE A 158
TRP A 163
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
 None
None
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.9A)
None
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
 0.67A 3w67B-1r5lA:
37.7		 3w67B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		6 / 12 ILE A 119
TRP A 122
SER A 136
LEU A 137
VAL A 191
PHE A 158
 None
None
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-4.7A)
VIV  A 301 (-3.9A)
 1.49A 3w67B-1r5lA:
37.7		 3w67B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		11 / 12 ILE A 119
TRP A 122
SER A 136
LEU A 137
PHE A 158
TRP A 163
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
 None
None
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.9A)
None
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
 0.66A 3w67B-5mueA:
33.9		 3w67B-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 119
TRP A 122
SER A 136
LEU A 137
VAL A 191
PHE A 158
 None
None
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 ( 4.9A)
VIV  A 302 (-3.9A)
 1.47A 3w67B-5mueA:
33.9		 3w67B-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
LEU A 137
SER A 140
ALA A 156
PHE A 158
ILE A 179
LEU A 183
PHE A 187
VAL A 191
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 ( 4.4A)
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.0A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.54A 3w67C-1r5lA:
37.3		 3w67C-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		12 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
LEU A 137
SER A 140
ALA A 156
PHE A 158
ILE A 179
LEU A 183
PHE A 187
VAL A 191
 None
None
None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.2A)
VIV  A 302 ( 4.4A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.0A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
 0.56A 3w67C-5mueA:
33.6		 3w67C-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		9 / 12 VAL A 132
SER A 136
LEU A 137
SER A 140
PHE A 158
VAL A 182
PHE A 187
ILE A 194
LEU A 196
 VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.5A)
None
 0.55A 3w67D-1r5lA:
37.0		 3w67D-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		11 / 12 VAL A 132
SER A 136
SER A 140
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
ILE A 194
LEU A 196
 VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.5A)
None
 0.51A 3w67D-1r5lA:
37.0		 3w67D-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		10 / 12 VAL A 132
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 171
VAL A 182
PHE A 187
ILE A 194
LEU A 196
 VIV  A 302 (-4.4A)
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.4A)
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.6A)
None
 0.45A 3w67D-5mueA:
33.4		 3w67D-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		11 / 12 VAL A 132
SER A 136
SER A 140
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
ILE A 194
LEU A 196
 VIV  A 302 (-4.4A)
VIV  A 302 (-3.5A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.6A)
None
 0.49A 3w67D-5mueA:
33.4		 3w67D-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 TYR A 100
TRP A 122
VAL A 132
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.44A 3w68A-1r5lA:
38.7		 3w68A-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		12 / 12 TYR A 100
TRP A 122
VAL A 132
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 302 (-4.4A)
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
 0.38A 3w68A-5mueA:
34.9		 3w68A-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		9 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
SER A 136
LEU A 137
PHE A 158
PHE A 187
VAL A 191
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.9A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.45A 3w68B-1r5lA:
37.9		 3w68B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		9 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
SER A 136
LEU A 137
VAL A 191
PHE A 158
PHE A 187
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-4.7A)
VIV  A 301 (-3.9A)
VIV  A 301 (-3.9A)
 1.40A 3w68B-1r5lA:
37.9		 3w68B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		10 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
SER A 136
PHE A 158
ILE A 179
LEU A 183
PHE A 187
VAL A 191
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.0A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.38A 3w68B-1r5lA:
37.9		 3w68B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		10 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
SER A 136
LEU A 137
PHE A 158
ILE A 179
PHE A 187
VAL A 191
 None
None
None
VIV  A 302 (-4.4A)
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
 0.43A 3w68B-5mueA:
34.0		 3w68B-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		9 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
SER A 136
LEU A 137
VAL A 191
PHE A 158
PHE A 187
 None
None
None
VIV  A 302 (-4.4A)
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 ( 4.9A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.0A)
 1.40A 3w68B-5mueA:
34.0		 3w68B-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		10 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
SER A 136
PHE A 158
ILE A 179
LEU A 183
PHE A 187
VAL A 191
 None
None
None
VIV  A 302 (-4.4A)
VIV  A 302 (-3.5A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.0A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
 0.43A 3w68B-5mueA:
34.0		 3w68B-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		10 / 12 ILE A 119
TRP A 122
VAL A 132
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.29A 3w68C-1r5lA:
37.3		 3w68C-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 12 ILE A 119
TRP A 122
VAL A 132
VAL A 191
PHE A 158
 None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-4.7A)
VIV  A 301 (-3.9A)
 1.16A 3w68C-1r5lA:
37.3		 3w68C-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		8 / 12 ILE A 119
VAL A 132
LEU A 137
PHE A 158
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.52A 3w68C-1r5lA:
37.3		 3w68C-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		11 / 12 ILE A 119
TRP A 122
VAL A 132
LEU A 137
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.9A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
 0.47A 3w68C-5mueA:
33.6		 3w68C-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		11 / 12 TYR A 100
TRP A 122
VAL A 132
LEU A 137
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.50A 3w68D-1r5lA:
36.8		 3w68D-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		11 / 12 TYR A 100
TRP A 122
VAL A 132
LEU A 137
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.9A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
 0.45A 3w68D-5mueA:
33.2		 3w68D-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 ILE A 119
VAL A 132
ILE A 154
PHE A 158
TRP A 163
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
ILE A 194
PHE A 203
 None
VIV  A 301 ( 4.7A)
None
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.20A 5mueA-1r5lA:
39.2		 5mueA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		6 / 12 VAL A 135
PHE A 158
VAL A 182
LEU A 183
VAL A 191
ILE A 194
 None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
 1.21A 5mueA-1r5lA:
39.2		 5mueA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 ILE A 119
VAL A 132
LEU A 137
ILE A 154
TRP A 163
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
ILE A 194
PHE A 203
 None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
None
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.42A 5mugA-1r5lA:
37.0		 5mugA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		12 / 12 ILE A 119
VAL A 132
LEU A 137
ILE A 154
TRP A 163
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
ILE A 194
PHE A 203
 None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.8A)
None
None
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
VIV  A 302 ( 4.6A)
None
 0.31A 5mugA-5mueA:
39.4		 5mugA-5mueA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 SER A 136
SER A 140
PHE A 158
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
 0.15A 5mugA-1r5lA:
37.0		 5mugA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		3 / 3 SER A 136
SER A 140
PHE A 158
 VIV  A 302 (-3.5A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
 0.10A 5mugA-5mueA:
39.4		 5mugA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 12 PHE A 237
PHE A 158
ALA A 176
ALA A 180
THR A 184
 None
VIV  A 301 (-3.9A)
None
None
None
 1.24A 5tl8A-1r5lA:
undetectable		 5tl8A-1r5lA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 237
PHE A 158
ALA A 176
ALA A 180
THR A 184
 None
VIV  A 302 (-3.9A)
None
None
None
 1.25A 5tl8A-5mueA:
undetectable		 5tl8A-5mueA:
17.91