SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VIN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		4 / 6 ILE A 150
ILE A 203
ILE A 264
ASP A 294
 VIN  A6331 (-4.0A)
None
None
VIN  A6331 (-4.0A)
 0.70A 1uwhA-3dtcA:
27.5		 1uwhA-3dtcA:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		4 / 6 ILE A 150
VAL A 158
ILE A 203
ILE A 264
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
None
None
 0.66A 1uwhA-3dtcA:
27.5		 1uwhA-3dtcA:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 6 ILE A 150
VAL A 158
ILE A 203
ILE A 264
ASP A 294
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
None
None
VIN  A6331 (-4.0A)
 0.80A 1uwhB-3dtcA:
27.2		 1uwhB-3dtcA:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 7 ILE A 150
LYS A 171
ILE A 203
ILE A 264
ASP A 294
 VIN  A6331 (-4.0A)
None
None
None
VIN  A6331 (-4.0A)
 1.07A 1uwjA-3dtcA:
12.8		 1uwjA-3dtcA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		7 / 9 VAL A 158
ALA A 169
MET A 220
ALA A 223
GLY A 226
PRO A 227
LEU A 275
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 (-3.8A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-4.5A)
 0.42A 1xbbA-3dtcA:
26.9		 1xbbA-3dtcA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 12 ALA A 169
GLY A 226
LEU A 275
THR A 293
PHE A 295
 VIN  A6331 (-3.4A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
None
 0.48A 1xkkA-3dtcA:
28.7		 1xkkA-3dtcA:
30.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 11 GLY A 151
VAL A 158
ALA A 169
MET A 220
ALA A 223
LEU A 275
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 (-3.8A)
VIN  A6331 (-4.5A)
 0.51A 2evaA-3dtcA:
27.5		 2evaA-3dtcA:
39.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 9 VAL A 158
ILE A 150
LEU A 277
ARG A 224
GLY A 225
 VIN  A6331 (-4.7A)
VIN  A6331 (-4.0A)
None
None
None
 1.45A 2xf3B-3dtcA:
undetectable		 2xf3B-3dtcA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 9 VAL A 158
ILE A 150
LEU A 277
ARG A 224
GLY A 225
 VIN  A6331 (-4.7A)
VIN  A6331 (-4.0A)
None
None
None
 1.46A 2xfsB-3dtcA:
undetectable		 2xfsB-3dtcA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 9 VAL A 158
ILE A 150
LEU A 277
ARG A 224
GLY A 225
 VIN  A6331 (-4.7A)
VIN  A6331 (-4.0A)
None
None
None
 1.46A 2xh9B-3dtcA:
undetectable		 2xh9B-3dtcA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 12 ILE A 150
VAL A 158
ALA A 169
ILE A 204
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.46A 2y7jA-3dtcA:
23.3		 2y7jA-3dtcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 10 ILE A 150
VAL A 158
ALA A 169
ILE A 204
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.39A 2y7jB-3dtcA:
23.7		 2y7jB-3dtcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 10 ILE A 150
VAL A 158
ALA A 169
ILE A 204
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.42A 2y7jC-3dtcA:
23.3		 2y7jC-3dtcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 10 ILE A 150
VAL A 158
ALA A 169
ILE A 204
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.36A 2y7jD-3dtcA:
23.6		 2y7jD-3dtcA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		7 / 12 VAL A 158
ALA A 169
LEU A 206
GLY A 226
LEU A 275
THR A 293
PHE A 295
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
None
 0.59A 3bbtB-3dtcA:
21.4		 3bbtB-3dtcA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		7 / 12 VAL A 158
ALA A 169
LEU A 218
GLY A 226
LEU A 275
THR A 293
PHE A 295
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
None
 0.39A 3bbtD-3dtcA:
29.4		 3bbtD-3dtcA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 9 ILE A 150
ALA A 169
PHE A 222
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.43A 3miyB-3dtcA:
29.0		 3miyB-3dtcA:
35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 12 GLY A 151
VAL A 158
ALA A 169
LYS A 171
ILE A 204
GLY A 226
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
 0.93A 3ohtB-3dtcA:
5.1		 3ohtB-3dtcA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 12 MET A 220
ASP A 268
LYS A 270
ASN A 273
GLY A 296
GLY A 311
 VIN  A6331 (-3.7A)
SO4  A8001 ( 4.8A)
SO4  A8001 (-3.0A)
VIN  A6331 ( 4.8A)
None
None
 0.97A 4an2A-3dtcA:
25.9		 4an2A-3dtcA:
28.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 11 GLY A 151
VAL A 158
ALA A 169
ALA A 223
GLY A 226
LEU A 275
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.8A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.40A 4ckiA-3dtcA:
26.9		 4ckiA-3dtcA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 10 GLY A 151
GLY A 153
VAL A 158
ALA A 169
ALA A 223
LEU A 275
 VIN  A6331 (-3.5A)
SO4  A8001 ( 4.3A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.8A)
VIN  A6331 (-4.5A)
 0.51A 4ckjA-3dtcA:
26.8		 4ckjA-3dtcA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		9 / 12 GLY A 151
VAL A 158
ALA A 169
LEU A 218
MET A 220
GLY A 226
LEU A 275
THR A 293
ASP A 294
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-3.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
VIN  A6331 (-4.0A)
 0.73A 4i22A-3dtcA:
21.5		 4i22A-3dtcA:
30.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		8 / 12 PHE A 155
VAL A 158
ALA A 169
ILE A 204
ASP A 268
ASN A 273
LEU A 275
ASP A 294
 VIN  A6331 ( 2.9A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
SO4  A8001 ( 4.8A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-4.5A)
VIN  A6331 (-4.0A)
 0.86A 4i41A-3dtcA:
22.0		 4i41A-3dtcA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		8 / 12 PHE A 155
VAL A 158
ALA A 169
ILE A 204
ASP A 268
LYS A 270
ASN A 273
LEU A 275
 VIN  A6331 ( 2.9A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
SO4  A8001 ( 4.8A)
SO4  A8001 (-3.0A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-4.5A)
 0.87A 4i41A-3dtcA:
22.0		 4i41A-3dtcA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 10 ILE A 150
ALA A 169
MET A 220
PHE A 222
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.21A 4ks8A-3dtcA:
24.9		 4ks8A-3dtcA:
29.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		4 / 7 VAL A 158
ALA A 169
MET A 220
LEU A 275
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 (-4.5A)
 0.40A 4l9iA-3dtcA:
7.6		 4l9iA-3dtcA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 8 GLY A 153
VAL A 158
ALA A 169
LYS A 171
MET A 220
 SO4  A8001 ( 4.3A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-3.7A)
 1.05A 4l9iB-3dtcA:
19.7		 4l9iB-3dtcA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 8 GLY A 153
VAL A 158
ALA A 169
MET A 220
LEU A 275
 SO4  A8001 ( 4.3A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 (-4.5A)
 0.63A 4l9iB-3dtcA:
19.7		 4l9iB-3dtcA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 12 ILE A 150
GLY A 151
VAL A 158
ALA A 169
MET A 220
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 (-4.5A)
 0.35A 4qmzA-3dtcA:
25.3		 4qmzA-3dtcA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 12 ILE A 150
GLY A 151
VAL A 158
MET A 220
GLY A 225
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.7A)
None
VIN  A6331 (-4.5A)
 0.98A 4qmzA-3dtcA:
25.3		 4qmzA-3dtcA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		8 / 12 VAL A 158
ALA A 169
LYS A 171
PHE A 222
GLY A 226
ASN A 273
LEU A 275
ASP A 294
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 ( 4.8A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-4.5A)
VIN  A6331 (-4.0A)
 0.78A 4twpA-3dtcA:
27.3		 4twpA-3dtcA:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		8 / 12 VAL A 158
ALA A 169
LYS A 171
PHE A 222
GLY A 226
ASN A 273
LEU A 275
ASP A 294
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 ( 4.8A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-4.5A)
VIN  A6331 (-4.0A)
 0.70A 4twpB-3dtcA:
27.3		 4twpB-3dtcA:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		4 / 6 VAL A 158
ILE A 203
ARG A 267
ILE A 292
 VIN  A6331 (-4.7A)
None
None
None
 0.53A 4tyjA-3dtcA:
18.0		 4tyjA-3dtcA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		4 / 6 VAL A 158
LYS A 171
ILE A 203
ILE A 292
 VIN  A6331 (-4.7A)
None
None
None
 0.65A 4tyjA-3dtcA:
18.0		 4tyjA-3dtcA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 7 VAL A 158
ILE A 204
ALA A 223
ARG A 267
ILE A 292
 VIN  A6331 (-4.7A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.8A)
None
None
 0.77A 4uxqA-3dtcA:
26.4		 4uxqA-3dtcA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		4 / 7 VAL A 158
LYS A 171
ALA A 223
ILE A 203
 VIN  A6331 (-4.7A)
None
VIN  A6331 (-3.8A)
None
 0.82A 4uxqA-3dtcA:
26.4		 4uxqA-3dtcA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 7 VAL A 158
LYS A 171
ILE A 204
ALA A 223
ILE A 292
 VIN  A6331 (-4.7A)
None
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.8A)
None
 0.83A 4uxqA-3dtcA:
26.4		 4uxqA-3dtcA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		4 / 8 ILE A 204
ARG A 267
LEU A 275
ILE A 292
 VIN  A6331 ( 4.9A)
None
VIN  A6331 (-4.5A)
None
 0.75A 4v04A-3dtcA:
26.6		 4v04A-3dtcA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 10 VAL A 158
LYS A 171
ILE A 204
ARG A 267
LEU A 275
ILE A 292
 VIN  A6331 (-4.7A)
None
VIN  A6331 ( 4.9A)
None
VIN  A6331 (-4.5A)
None
 1.00A 4v04B-3dtcA:
26.6		 4v04B-3dtcA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 12 ALA A 169
ALA A 223
LEU A 256
HIS A 266
ASP A 294
 VIN  A6331 (-3.4A)
VIN  A6331 (-3.8A)
None
None
VIN  A6331 (-4.0A)
 0.85A 4v04B-3dtcA:
26.6		 4v04B-3dtcA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		7 / 12 VAL A 158
ALA A 169
LYS A 171
PHE A 222
GLY A 226
ASN A 273
LEU A 275
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 ( 4.8A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-4.5A)
 0.72A 4wa9B-3dtcA:
27.3		 4wa9B-3dtcA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 12 MET A 220
VAL A 168
ILE A 276
ILE A 274
ASN A 273
 VIN  A6331 (-3.7A)
None
None
None
VIN  A6331 ( 4.8A)
 1.47A 4xueA-3dtcA:
undetectable		 4xueA-3dtcA:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 12 VAL A 158
ALA A 169
ILE A 204
ALA A 223
PHE A 295
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.8A)
None
 0.50A 5hesA-3dtcA:
14.8		 5hesA-3dtcA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 12 ILE A 150
ALA A 169
LYS A 171
ILE A 204
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.4A)
None
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.69A 5i9xA-3dtcA:
20.9		 5i9xA-3dtcA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 9 GLY A 151
VAL A 158
ALA A 169
ILE A 204
MET A 220
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.7A)
 0.58A 5lw1B-3dtcA:
20.4		 5lw1B-3dtcA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 9 ILE A 150
GLY A 151
VAL A 158
ALA A 169
ILE A 204
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-4.5A)
 1.34A 5lw1B-3dtcA:
20.4		 5lw1B-3dtcA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 10 GLY A 151
VAL A 158
ALA A 169
ILE A 204
MET A 220
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.7A)
 0.64A 5lw1E-3dtcA:
20.1		 5lw1E-3dtcA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 12 GLU A 148
ILE A 150
GLY A 151
ALA A 169
GLY A 226
ASP A 294
 None
VIN  A6331 (-4.0A)
VIN  A6331 (-3.5A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.0A)
 1.02A 5vc3A-3dtcA:
16.8		 5vc3A-3dtcA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 12 GLY A 151
VAL A 158
ALA A 169
LEU A 218
LEU A 275
THR A 293
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
 0.62A 5yu9A-3dtcA:
27.7		 5yu9A-3dtcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		6 / 12 GLY A 151
VAL A 158
ALA A 169
LEU A 218
LEU A 275
THR A 293
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
 0.65A 5yu9B-3dtcA:
21.5		 5yu9B-3dtcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 12 VAL A 158
ALA A 169
LEU A 218
GLY A 226
THR A 293
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-3.4A)
VIN  A6331 (-3.6A)
 0.48A 5yu9C-3dtcA:
19.7		 5yu9C-3dtcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens) 		5 / 12 VAL A 158
ALA A 169
GLY A 226
LEU A 275
THR A 293
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
 0.47A 5yu9D-3dtcA:
19.6		 5yu9D-3dtcA:
14.45