SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VIB'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ME7_A_MOAA600_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE)	5edl	PUTATIVE HMP/THIAMINE PERMEASE PROTEIN YKOE (Bacillus subtilis)	4 / 8	SER A 127 ILE A  91 GLY A  92 GLY A 120	None VIB  A 201 ( 4.2A) VIB  A 201 ( 4.6A) None	0.73A	1me7A-5edlA: undetectable	1me7A-5edlA: 17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NG8_A_DVAA8_0 (GRAMICIDIN A)	4nmy	ABC-TYPE TRANSPORT SYSTEM, EXTRACELLULAR SOLUTE-BINDING PROTEIN (Clostridioides difficile)	4 / 4	GLY A 112 VAL A 140 TRP A 114 GLY A 115	None None VIB  A 401 (-3.7A) None	1.11A	1ng8A-4nmyA: undetectable	1ng8A-4nmyA: 3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NG8_B_DVAB8_0 (GRAMICIDIN A)	4nmy	ABC-TYPE TRANSPORT SYSTEM, EXTRACELLULAR SOLUTE-BINDING PROTEIN (Clostridioides difficile)	4 / 4	GLY A 112 VAL A 140 TRP A 114 GLY A 115	None None VIB  A 401 (-3.7A) None	1.10A	1ng8B-4nmyA: undetectable	1ng8B-4nmyA: 3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YVP_A_ACTA2001_0 (60-KDA SS-A/RO RIBONUCLEOPROTEIN)	3myu	HIGH AFFINITY TRANSPORT SYSTEM PROTEIN P37 (Mycoplasma genitalium)	4 / 5	TYR A 176 SER A 216 SER A 218 ASN A  95	VIB  A 500 (-3.8A) None None VIB  A 500 ( 4.8A)	1.07A	1yvpA-3myuA: undetectable	1yvpA-3myuA: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NV4_A_ACTA148_0 (UPF0066 PROTEIN AF_0241)	4nmy	ABC-TYPE TRANSPORT SYSTEM, EXTRACELLULAR SOLUTE-BINDING PROTEIN (Clostridioides difficile)	3 / 3	VAL A 122 GLU A  64 GLU A 119	None VIB  A 401 (-2.9A) None	0.80A	2nv4A-4nmyA: undetectable	2nv4A-4nmyA: 16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y00_B_Y00B601_2 (BETA-1 ADRENERGIC RECEPTOR)	4nmy	ABC-TYPE TRANSPORT SYSTEM, EXTRACELLULAR SOLUTE-BINDING PROTEIN (Clostridioides difficile)	3 / 3	VAL A  84 ASN A  15 TRP A  12	None VIB  A 401 (-3.3A) VIB  A 401 (-3.6A)	1.10A	2y00B-4nmyA: undetectable	2y00B-4nmyA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	4kys	THIAMINE PYRIDINYLASE I (Clostridium botulinum)	5 / 12	ASP A 302 GLY A 301 PHE A  55 LEU A 380 ALA A 125	VIB  A 501 (-2.9A) None None None None	1.12A	3d91A-4kysA: undetectable	3d91A-4kysA: 20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QEO_A_LLTA261_1 (DEOXYCYTIDINE KINASE)	4nmy	ABC-TYPE TRANSPORT SYSTEM, EXTRACELLULAR SOLUTE-BINDING PROTEIN (Clostridioides difficile)	5 / 10	VAL A 180 LEU A 187 TYR A 274 PHE A 123 GLU A  64	None None None None VIB  A 401 (-2.9A)	1.37A	3qeoA-4nmyA: 0.0	3qeoA-4nmyA: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UBE_A_2FAA401_1 (ADENOSINE KINASE)	1ig0	THIAMIN PYROPHOSPHOKINASE (Saccharomyces cerevisiae)	5 / 12	SER A 202 GLY A 190 GLY A 191 PHE A 127 GLN A 198	None None None None VIB  A 702 ( 4.5A)	1.30A	4ubeA-1ig0A: undetectable	4ubeA-1ig0A: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGW_A_CTYA404_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	3myu	HIGH AFFINITY TRANSPORT SYSTEM PROTEIN P37 (Mycoplasma genitalium)	5 / 12	ILE A 343 GLY A 344 ILE A 111 PHE A 328 TYR A 348	VIB  A 500 (-4.8A) VIB  A 500 (-3.6A) None None None	1.22A	5igwA-3myuA: undetectable	5igwA-3myuA: 23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M5K_B_ADNB502_2 (ADENOSYLHOMOCYSTEINA SE)	4nmy	ABC-TYPE TRANSPORT SYSTEM, EXTRACELLULAR SOLUTE-BINDING PROTEIN (Clostridioides difficile)	4 / 4	GLN A  63 THR A 191 LEU A 183 LEU A 187	None VIB  A 401 (-3.0A) None None	1.31A	5m5kB-4nmyA: undetectable	5m5kB-4nmyA: 23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_A_CVIA301_1 (REGULATORY PROTEIN TETR)	4nmy	ABC-TYPE TRANSPORT SYSTEM, EXTRACELLULAR SOLUTE-BINDING PROTEIN (Clostridioides difficile)	4 / 8	TRP A 114 GLN A  65 TRP A 158 VAL A 122	VIB  A 401 (-3.7A) None VIB  A 401 (-4.0A) None	1.06A	5vlmA-4nmyA: undetectable	5vlmA-4nmyA: 19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_F_CVIF301_1 (REGULATORY PROTEIN TETR)	4nmy	ABC-TYPE TRANSPORT SYSTEM, EXTRACELLULAR SOLUTE-BINDING PROTEIN (Clostridioides difficile)	4 / 8	TRP A 114 GLN A  65 TRP A 158 VAL A 122	VIB  A 401 (-3.7A) None VIB  A 401 (-4.0A) None	0.97A	5vlmF-4nmyA: undetectable	5vlmF-4nmyA: 19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA902_1 (MRNA CAPPING ENZYME P5)	4kys	THIAMINE PYRIDINYLASE I (Clostridium botulinum)	3 / 3	TYR A  46 ASP A  78 ASP A  94	VIB  A 501 (-4.4A) None VIB  A 501 (-3.4A)	0.82A	5x6yA-4kysA: undetectable	5x6yA-4kysA: 20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7F_A_SAMA301_0 (PUTATIVE O-METHYLTRANSFERASE RV1220C)	5edl	PUTATIVE HMP/THIAMINE PERMEASE PROTEIN YKOE (Bacillus subtilis)	5 / 12	GLY A 120 GLY A  96 GLY A  98 VAL A 102 ILE A  91	None None MPG  A 203 ( 4.1A) None VIB  A 201 ( 4.2A)	0.95A	5x7fA-5edlA: undetectable	5x7fA-5edlA: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZW4_A_SAMA302_0 (PUTATIVE O-METHYLTRANSFERASE YRRM)	5edl	PUTATIVE HMP/THIAMINE PERMEASE PROTEIN YKOE (Bacillus subtilis)	5 / 12	ILE A  91 ALA A  57 ALA A  99 ALA A 119 PHE A 103	VIB  A 201 ( 4.2A) None None None None	0.89A	5zw4A-5edlA: undetectable	5zw4A-5edlA: 25.51