SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VGH'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
ALA A1978
LYS A1980
LEU A2028
MET A2029
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.35A 1m17A-3zbfA:
27.6
1m17A-3zbfA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 9 LEU A1951
GLY A1952
VAL A1959
ALA A1978
LEU A2010
LEU A2086
VGH  A3000 ( 4.4A)
None
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
VGH  A3000 (-4.3A)
1.06A 1muoA-3zbfA:
18.8
1muoA-3zbfA:
26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
4 / 6 LEU A1951
LYS A1980
ILE A2024
MET A2029
VGH  A3000 ( 4.4A)
VGH  A3000 ( 4.7A)
None
None
0.87A 1opjB-3zbfA:
24.6
1opjB-3zbfA:
38.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 ALA A1978
LYS A1980
LEU A2010
LEU A2070
HIS A2077
GLY A2101
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
None
None
VGH  A3000 (-3.5A)
0.80A 1uwhB-3zbfA:
19.0
1uwhB-3zbfA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 VAL A1959
ALA A1978
LEU A2010
LEU A2070
HIS A2077
GLY A2101
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
None
VGH  A3000 (-3.5A)
0.82A 1uwjA-3zbfA:
10.4
1uwjA-3zbfA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 VAL A1959
ALA A1978
LEU A2010
LEU A2070
HIS A2077
GLY A2101
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
None
VGH  A3000 (-3.5A)
0.82A 1uwjB-3zbfA:
10.4
1uwjB-3zbfA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
5 / 9 LEU A1951
VAL A1959
ALA A1978
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.31A 1xbbA-3zbfA:
28.9
1xbbA-3zbfA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 GLY A2032
LEU A2035
ARG A2039
LEU A2086
ASP A2102
PHE A2103
VGH  A3000 (-3.5A)
None
None
VGH  A3000 (-4.3A)
None
None
0.90A 1xkkA-3zbfA:
24.5
1xkkA-3zbfA:
38.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
ALA A1978
LYS A1980
MET A2001
ILE A2024
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.63A 2gqgA-3zbfA:
28.9
2gqgA-3zbfA:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 LEU A1951
ALA A1978
LYS A1980
MET A2001
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.74A 2itoA-3zbfA:
26.1
2itoA-3zbfA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
9 / 12 LEU A1951
GLY A1952
VAL A1959
ALA A1978
LYS A1980
GLU A1997
MET A2001
GLY A2032
ASP A2102
VGH  A3000 ( 4.4A)
None
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-3.5A)
None
0.81A 2ityA-3zbfA:
28.6
2ityA-3zbfA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
9 / 12 LEU A1951
GLY A1952
VAL A1959
ALA A1978
LYS A1980
MET A2001
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.69A 2ityA-3zbfA:
28.6
2ityA-3zbfA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
MET A2001
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.75A 2itzA-3zbfA:
28.6
2itzA-3zbfA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
VAL A1959
LYS A1980
GLU A1997
MET A2001
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.94A 2itzA-3zbfA:
28.6
2itzA-3zbfA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 VAL A1959
ALA A1978
LEU A2010
LEU A2026
MET A2029
GLY A2032
ASP A2102
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
None
0.47A 2wgjA-3zbfA:
30.4
2wgjA-3zbfA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
9 / 9 LEU A1951
VAL A1959
ALA A1978
LEU A2026
MET A2029
GLY A2032
LEU A2086
GLY A2101
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
None
0.35A 2xp2A-3zbfA:
34.7
2xp2A-3zbfA:
48.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 ALA A1978
LEU A2028
MET A2029
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.65A 2y7jA-3zbfA:
25.6
2y7jA-3zbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 VAL A1959
ALA A1978
LEU A2028
MET A2029
GLY A2032
LEU A2086
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.45A 2y7jA-3zbfA:
25.6
2y7jA-3zbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 10 ALA A1978
LEU A2028
MET A2029
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.64A 2y7jB-3zbfA:
21.0
2y7jB-3zbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 10 VAL A1959
ALA A1978
LEU A2028
MET A2029
GLY A2032
LEU A2086
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.38A 2y7jB-3zbfA:
21.0
2y7jB-3zbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 10 VAL A1959
ALA A1978
LEU A2028
MET A2029
GLY A2032
LEU A2086
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.42A 2y7jC-3zbfA:
21.2
2y7jC-3zbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 10 VAL A1959
ALA A1978
LEU A2028
MET A2029
GLY A2032
LEU A2086
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.35A 2y7jD-3zbfA:
25.9
2y7jD-3zbfA:
24.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
ALA A1978
LYS A1980
MET A2001
ILE A2024
MET A2029
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.50A 2zvaA-3zbfA:
26.3
2zvaA-3zbfA:
38.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 10 ALA A1978
LEU A2026
LEU A2028
MET A2029
GLY A2031
LEU A2086
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.2A)
VGH  A3000 ( 4.8A)
None
None
VGH  A3000 (-4.3A)
0.90A 3aoxA-3zbfA:
33.8
3aoxA-3zbfA:
45.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 10 LEU A1951
ALA A1978
LEU A2026
LEU A2028
MET A2029
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.2A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.44A 3aoxA-3zbfA:
33.8
3aoxA-3zbfA:
45.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 10 LEU A1951
ALA A1978
LYS A1980
LEU A2026
LEU A2028
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.2A)
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.54A 3aoxA-3zbfA:
33.8
3aoxA-3zbfA:
45.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
5 / 9 LEU A1951
VAL A1959
ILE A2024
PHE A2075
LEU A2086
VGH  A3000 ( 4.4A)
None
None
None
VGH  A3000 (-4.3A)
0.81A 3cs9B-3zbfA:
26.0
3cs9B-3zbfA:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
5 / 9 LEU A1951
VAL A1959
LYS A1980
ILE A2024
PHE A2075
VGH  A3000 ( 4.4A)
None
VGH  A3000 ( 4.7A)
None
None
0.93A 3cs9B-3zbfA:
26.0
3cs9B-3zbfA:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
ALA A1978
LYS A1980
MET A2001
ILE A2024
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.64A 3k54A-3zbfA:
26.9
3k54A-3zbfA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
5 / 9 ALA A1978
LYS A1980
MET A2029
GLY A2032
LEU A2086
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.55A 3miyB-3zbfA:
32.8
3miyB-3zbfA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
5 / 9 LEU A1951
LYS A1980
ILE A2024
MET A2029
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-4.3A)
0.79A 3oxzA-3zbfA:
31.1
3oxzA-3zbfA:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
VAL A1959
ALA A1978
MET A2001
ILE A2024
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.80A 3sxrA-3zbfA:
25.2
3sxrA-3zbfA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
ALA A1978
LYS A1980
GLU A1997
ILE A2024
MET A2029
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.62A 3ue4A-3zbfA:
33.4
3ue4A-3zbfA:
37.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
VAL A1959
ALA A1978
GLU A1997
ILE A2024
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.78A 3ue4B-3zbfA:
26.5
3ue4B-3zbfA:
37.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
VAL A1959
ALA A1978
GLU A1997
MET A2001
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.83A 3ue4B-3zbfA:
26.5
3ue4B-3zbfA:
37.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
LEU A2028
MET A2029
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.54A 3ug2A-3zbfA:
27.3
3ug2A-3zbfA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
3 / 3 LEU A2026
MET A2029
ASP A2033
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-4.5A)
0.60A 3v5wA-3zbfA:
7.5
3v5wA-3zbfA:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 9 LEU A1951
VAL A1959
ALA A1978
LEU A2026
MET A2029
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.34A 4anqA-3zbfA:
34.5
4anqA-3zbfA:
49.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 9 LEU A1951
VAL A1959
ALA A1978
MET A2029
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.33A 4ansA-3zbfA:
34.4
4ansA-3zbfA:
49.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_2
(SRC-ABL TYROSINE
KINASE ANCESTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
4 / 4 LYS A1980
ILE A2024
MET A2029
PHE A2075
VGH  A3000 ( 4.7A)
None
None
None
0.80A 4csvA-3zbfA:
25.9
4csvA-3zbfA:
41.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 LEU A1951
VAL A1959
ALA A1978
MET A2029
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.51A 4hjoA-3zbfA:
29.7
4hjoA-3zbfA:
35.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 11 VAL A1959
ALA A1978
LYS A1980
LEU A2026
ASP A2033
LEU A2086
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.2A)
VGH  A3000 (-4.5A)
VGH  A3000 (-4.3A)
0.85A 4iaaA-3zbfA:
17.5
4iaaA-3zbfA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
5 / 11 VAL A1959
ALA A1978
LYS A1980
LEU A2026
ASP A2102
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.2A)
None
0.62A 4iaaA-3zbfA:
17.5
4iaaA-3zbfA:
25.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
GLY A1957
VAL A1959
ALA A1978
LYS A1980
LEU A2026
LEU A2028
VGH  A3000 ( 4.4A)
None
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.2A)
VGH  A3000 ( 4.8A)
1.22A 4mkcA-3zbfA:
34.0
4mkcA-3zbfA:
45.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
10 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
LEU A2026
LEU A2028
GLY A2032
ASP A2033
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.2A)
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.5A)
VGH  A3000 (-4.3A)
None
0.55A 4mkcA-3zbfA:
34.0
4mkcA-3zbfA:
45.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
MET A2001
ILE A2024
GLY A2032
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-3.5A)
None
0.64A 4mxoA-3zbfA:
26.4
4mxoA-3zbfA:
40.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
ILE A2024
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.55A 4mxoB-3zbfA:
26.4
4mxoB-3zbfA:
40.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
ALA A1978
LYS A1980
GLU A1997
MET A2001
ILE A2024
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.90A 4mxxA-3zbfA:
26.1
4mxxA-3zbfA:
40.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
ILE A2024
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.57A 4mxyA-3zbfA:
32.8
4mxyA-3zbfA:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.52A 4mxyB-3zbfA:
28.2
4mxyB-3zbfA:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
ILE A2024
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.57A 4mxzA-3zbfA:
32.8
4mxzA-3zbfA:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.52A 4mxzB-3zbfA:
28.2
4mxzB-3zbfA:
40.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
4 / 6 VAL A1959
ALA A1978
LEU A2010
LEU A2086
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
VGH  A3000 (-4.3A)
0.43A 4o0uA-3zbfA:
18.9
4o0uA-3zbfA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
5 / 12 ALA A1978
LYS A1980
LEU A2010
GLY A2101
PHE A2103
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
0.97A 4rzvA-3zbfA:
10.5
4rzvA-3zbfA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
5 / 12 ALA A1978
LYS A1980
LEU A2010
ILE A2024
GLY A2101
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
None
VGH  A3000 (-3.5A)
0.74A 4rzvA-3zbfA:
10.5
4rzvA-3zbfA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 VAL A1959
ALA A1978
LYS A1980
MET A2029
GLY A2032
ASN A2084
LEU A2086
ASP A2102
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
None
VGH  A3000 (-4.3A)
None
0.78A 4twpA-3zbfA:
27.0
4twpA-3zbfA:
39.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
MET A2029
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.87A 4twpB-3zbfA:
33.7
4twpB-3zbfA:
39.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 VAL A1959
ALA A1978
LYS A1980
MET A2029
GLY A2032
ASN A2084
LEU A2086
ASP A2102
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
None
VGH  A3000 (-4.3A)
None
0.80A 4twpB-3zbfA:
33.7
4twpB-3zbfA:
39.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 11 LEU A1951
VAL A1959
ALA A1978
MET A2029
GLY A2032
ASN A2084
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
None
VGH  A3000 (-3.5A)
None
VGH  A3000 (-4.3A)
None
0.65A 4u5jA-3zbfA:
26.2
4u5jA-3zbfA:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 9 LEU A1951
VAL A1959
ALA A1978
MET A2029
GLY A2032
LEU A2086
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
0.61A 4u5jB-3zbfA:
26.2
4u5jB-3zbfA:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 11 LEU A1951
ALA A1978
MET A2029
GLY A2032
ASN A2084
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
None
VGH  A3000 (-3.5A)
None
VGH  A3000 (-4.3A)
0.46A 4wa9A-3zbfA:
29.3
4wa9A-3zbfA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 VAL A1959
ALA A1978
LYS A1980
MET A2029
GLY A2032
ASN A2084
LEU A2086
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
None
VGH  A3000 (-4.3A)
0.99A 4wa9B-3zbfA:
26.6
4wa9B-3zbfA:
40.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
4 / 6 LEU A1951
ALA A1978
MET A2029
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
None
VGH  A3000 (-4.3A)
0.60A 4wboC-3zbfA:
22.6
4wboC-3zbfA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
ALA A1978
LYS A1980
MET A2001
LEU A2028
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.63A 4wkqA-3zbfA:
32.7
4wkqA-3zbfA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
ALA A1978
LYS A1980
MET A2001
ILE A2024
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.63A 4xliB-3zbfA:
28.8
4xliB-3zbfA:
39.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
4 / 6 ALA A1978
LEU A2028
MET A2029
LEU A2086
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-4.3A)
0.22A 4xoyA-3zbfA:
12.8
4xoyA-3zbfA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
4 / 6 ALA A1978
LEU A2028
MET A2029
LEU A2086
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-4.3A)
0.29A 4xp3A-3zbfA:
23.4
4xp3A-3zbfA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 ALA A1978
LYS A1980
LEU A2010
GLY A2101
ASP A2102
PHE A2103
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
None
0.85A 4xv2A-3zbfA:
22.3
4xv2A-3zbfA:
31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 VAL A1959
ALA A1978
LYS A1980
LEU A2010
GLY A2101
PHE A2103
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
0.85A 4xv2A-3zbfA:
22.3
4xv2A-3zbfA:
31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 ALA A1978
LYS A1980
LEU A2010
GLY A2101
ASP A2102
PHE A2103
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
None
0.80A 4xv2B-3zbfA:
28.3
4xv2B-3zbfA:
31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
9 / 9 LEU A1951
VAL A1959
ALA A1978
LEU A2026
MET A2029
GLY A2032
LEU A2086
GLY A2101
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
None
0.34A 5aaaA-3zbfA:
34.5
5aaaA-3zbfA:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
10 / 10 LEU A1951
VAL A1959
ALA A1978
LYS A1980
LEU A2026
MET A2029
GLY A2032
LEU A2086
GLY A2101
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
None
0.51A 5aabA-3zbfA:
34.4
5aabA-3zbfA:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 10 LEU A1951
ALA A1978
LYS A1980
LEU A2026
MET A2029
GLY A2032
LEU A2086
GLY A2101
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
0.62A 5aacA-3zbfA:
34.7
5aacA-3zbfA:
48.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
9 / 10 LEU A1951
VAL A1959
ALA A1978
LEU A2026
MET A2029
GLY A2032
LEU A2086
GLY A2101
ASP A2102
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
None
0.41A 5aacA-3zbfA:
34.7
5aacA-3zbfA:
48.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
5 / 12 ALA A1978
LYS A1980
LEU A2010
GLY A2101
PHE A2103
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
0.78A 5cswA-3zbfA:
22.5
5cswA-3zbfA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
5 / 12 VAL A1959
ALA A1978
LYS A1980
LEU A2010
GLY A2101
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
0.73A 5cswA-3zbfA:
22.5
5cswA-3zbfA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 VAL A1959
ALA A1978
LYS A1980
LEU A2010
GLY A2101
PHE A2103
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
0.92A 5cswB-3zbfA:
22.4
5cswB-3zbfA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
4 / 4 ASP A2079
GLY A2104
ASP A2102
ASP A2033
None
None
None
VGH  A3000 (-4.5A)
1.06A 5e72A-3zbfA:
undetectable
5e72A-3zbfA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 ALA A1978
LEU A2010
LEU A2028
GLY A2031
LEU A2086
GLY A2101
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
0.82A 5h2uA-3zbfA:
28.9
5h2uA-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 LEU A1951
VAL A1959
ALA A1978
LEU A2010
LEU A2028
GLY A2032
LEU A2086
GLY A2101
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
0.63A 5h2uA-3zbfA:
28.9
5h2uA-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 ALA A1978
LEU A2010
ILE A2024
LEU A2028
GLY A2031
LEU A2086
GLY A2101
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
1.03A 5h2uB-3zbfA:
25.2
5h2uB-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 LEU A1951
LEU A2010
GLY A2032
LEU A2086
GLY A2101
ASP A2102
VGH  A3000 ( 4.4A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
None
0.75A 5h2uB-3zbfA:
25.2
5h2uB-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
9 / 12 LEU A1951
VAL A1959
ALA A1978
LEU A2010
ILE A2024
LEU A2028
GLY A2032
LEU A2086
GLY A2101
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
0.66A 5h2uB-3zbfA:
25.2
5h2uB-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
ALA A1978
LEU A2010
ILE A2024
GLY A2032
LEU A2086
GLY A2101
VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
0.65A 5h2uC-3zbfA:
29.1
5h2uC-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
9 / 12 LEU A1951
VAL A1959
ALA A1978
LEU A2010
ILE A2024
LEU A2028
GLY A2032
LEU A2086
GLY A2101
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
None
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
0.64A 5h2uD-3zbfA:
25.2
5h2uD-3zbfA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 ALA A1978
LYS A1980
LEU A2010
LEU A2070
HIS A2077
GLY A2101
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
None
None
VGH  A3000 (-3.5A)
0.78A 5hi2A-3zbfA:
19.6
5hi2A-3zbfA:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 VAL A1959
ALA A1978
LYS A1980
LEU A2010
ILE A2024
GLY A2101
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
None
VGH  A3000 (-3.5A)
0.73A 5hieA-3zbfA:
10.7
5hieA-3zbfA:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 VAL A1959
ALA A1978
LYS A1980
LEU A2010
ILE A2024
GLY A2101
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
None
VGH  A3000 (-3.5A)
0.74A 5hieB-3zbfA:
10.7
5hieB-3zbfA:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
6 / 12 VAL A1959
ALA A1978
LYS A1980
LEU A2010
ILE A2024
GLY A2101
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
None
VGH  A3000 (-3.5A)
0.75A 5hieD-3zbfA:
26.4
5hieD-3zbfA:
32.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
LEU A2028
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.89A 5y7zA-3zbfA:
23.7
5y7zA-3zbfA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
VAL A1959
ALA A1978
LYS A1980
LEU A2028
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.89A 5y7zA-3zbfA:
23.7
5y7zA-3zbfA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
VAL A1959
LYS A1980
GLU A1997
LEU A2028
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
None
VGH  A3000 ( 4.7A)
None
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
1.01A 5y7zA-3zbfA:
23.7
5y7zA-3zbfA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
7 / 12 LEU A1951
VAL A1959
LYS A1980
GLU A1997
LEU A2028
GLY A2032
LEU A2086
VGH  A3000 ( 4.4A)
None
VGH  A3000 ( 4.7A)
None
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
1.01A 5y7zA-3zbfA:
23.7
5y7zA-3zbfA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
3 / 3 LYS A1980
LEU A2086
ASP A2102
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.3A)
None
0.89A 5zv2A-3zbfA:
31.7
5zv2A-3zbfA:
16.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo
sapiens)
8 / 12 VAL A1959
ALA A1978
LYS A1980
MET A2001
ILE A2024
MET A2029
GLY A2032
LEU A2086
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
0.90A 6fnmA-3zbfA:
28.3
6fnmA-3zbfA:
35.89