SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VGH'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1M17_A_AQ4A999_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951ALA A1978LYS A1980LEU A2028MET A2029GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.8A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.35A | 1m17A-3zbfA:27.6 | 1m17A-3zbfA:34.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MUO_A_ADNA1_1 (AURORA-RELATEDKINASE 1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 9 | LEU A1951GLY A1952VAL A1959ALA A1978LEU A2010LEU A2086 | VGH A3000 ( 4.4A)NoneNoneVGH A3000 (-3.4A)VGH A3000 (-4.8A)VGH A3000 (-4.3A) | 1.06A | 1muoA-3zbfA:18.8 | 1muoA-3zbfA:26.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OPJ_B_STIB4_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 4 / 6 | LEU A1951LYS A1980ILE A2024MET A2029 | VGH A3000 ( 4.4A)VGH A3000 ( 4.7A)NoneNone | 0.87A | 1opjB-3zbfA:24.6 | 1opjB-3zbfA:38.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | ALA A1978LYS A1980LEU A2010LEU A2070HIS A2077GLY A2101 | VGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)NoneNoneVGH A3000 (-3.5A) | 0.80A | 1uwhB-3zbfA:19.0 | 1uwhB-3zbfA:30.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | VAL A1959ALA A1978LEU A2010LEU A2070HIS A2077GLY A2101 | NoneVGH A3000 (-3.4A)VGH A3000 (-4.8A)NoneNoneVGH A3000 (-3.5A) | 0.82A | 1uwjA-3zbfA:10.4 | 1uwjA-3zbfA:30.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | VAL A1959ALA A1978LEU A2010LEU A2070HIS A2077GLY A2101 | NoneVGH A3000 (-3.4A)VGH A3000 (-4.8A)NoneNoneVGH A3000 (-3.5A) | 0.82A | 1uwjB-3zbfA:10.4 | 1uwjB-3zbfA:30.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XBB_A_STIA1_1 (TYROSINE-PROTEINKINASE SYK) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 5 / 9 | LEU A1951VAL A1959ALA A1978GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.31A | 1xbbA-3zbfA:28.9 | 1xbbA-3zbfA:33.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XKK_A_FMMA91_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | GLY A2032LEU A2035ARG A2039LEU A2086ASP A2102PHE A2103 | VGH A3000 (-3.5A)NoneNoneVGH A3000 (-4.3A)NoneNone | 0.90A | 1xkkA-3zbfA:24.5 | 1xkkA-3zbfA:38.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2GQG_A_1N1A501_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951ALA A1978LYS A1980MET A2001ILE A2024GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.63A | 2gqgA-3zbfA:28.9 | 2gqgA-3zbfA:39.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITO_A_IREA2020_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | LEU A1951ALA A1978LYS A1980MET A2001GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.74A | 2itoA-3zbfA:26.1 | 2itoA-3zbfA:33.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITY_A_IREA2020_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 9 / 12 | LEU A1951GLY A1952VAL A1959ALA A1978LYS A1980GLU A1997MET A2001GLY A2032ASP A2102 | VGH A3000 ( 4.4A)NoneNoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneNoneVGH A3000 (-3.5A)None | 0.81A | 2ityA-3zbfA:28.6 | 2ityA-3zbfA:33.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITY_A_IREA2020_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 9 / 12 | LEU A1951GLY A1952VAL A1959ALA A1978LYS A1980MET A2001GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneNoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.69A | 2ityA-3zbfA:28.6 | 2ityA-3zbfA:33.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITZ_A_IREA2021_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980MET A2001GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.75A | 2itzA-3zbfA:28.6 | 2itzA-3zbfA:33.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITZ_A_IREA2021_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951VAL A1959LYS A1980GLU A1997MET A2001GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 ( 4.7A)NoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.94A | 2itzA-3zbfA:28.6 | 2itzA-3zbfA:33.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2WGJ_A_VGHA2346_1 (HEPATOCYTE GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | VAL A1959ALA A1978LEU A2010LEU A2026MET A2029GLY A2032ASP A2102 | NoneVGH A3000 (-3.4A)VGH A3000 (-4.8A)VGH A3000 ( 4.2A)NoneVGH A3000 (-3.5A)None | 0.47A | 2wgjA-3zbfA:30.4 | 2wgjA-3zbfA:37.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2XP2_A_VGHA9000_1 (TYROSINE-PROTEINKINASE RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 9 / 9 | LEU A1951VAL A1959ALA A1978LEU A2026MET A2029GLY A2032LEU A2086GLY A2101ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.2A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)VGH A3000 (-3.5A)None | 0.35A | 2xp2A-3zbfA:34.7 | 2xp2A-3zbfA:48.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7J_A_B49A1294_1 (PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | ALA A1978LEU A2028MET A2029GLY A2032LEU A2086ASP A2102 | VGH A3000 (-3.4A)VGH A3000 ( 4.8A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.65A | 2y7jA-3zbfA:25.6 | 2y7jA-3zbfA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7J_A_B49A1294_1 (PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | VAL A1959ALA A1978LEU A2028MET A2029GLY A2032LEU A2086 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.8A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.45A | 2y7jA-3zbfA:25.6 | 2y7jA-3zbfA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7J_B_B49B1294_1 (PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 10 | ALA A1978LEU A2028MET A2029GLY A2032LEU A2086ASP A2102 | VGH A3000 (-3.4A)VGH A3000 ( 4.8A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.64A | 2y7jB-3zbfA:21.0 | 2y7jB-3zbfA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7J_B_B49B1294_1 (PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 10 | VAL A1959ALA A1978LEU A2028MET A2029GLY A2032LEU A2086 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.8A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.38A | 2y7jB-3zbfA:21.0 | 2y7jB-3zbfA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7J_C_B49C1294_1 (PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 10 | VAL A1959ALA A1978LEU A2028MET A2029GLY A2032LEU A2086 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.8A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.42A | 2y7jC-3zbfA:21.2 | 2y7jC-3zbfA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7J_D_B49D1294_1 (PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 10 | VAL A1959ALA A1978LEU A2028MET A2029GLY A2032LEU A2086 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.8A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.35A | 2y7jD-3zbfA:25.9 | 2y7jD-3zbfA:24.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ZVA_A_1N1A513_1 (TYROSINE-PROTEINKINASE LYN) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951ALA A1978LYS A1980MET A2001ILE A2024MET A2029GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneNoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.50A | 2zvaA-3zbfA:26.3 | 2zvaA-3zbfA:38.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3AOX_A_EMHA901_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 10 | ALA A1978LEU A2026LEU A2028MET A2029GLY A2031LEU A2086 | VGH A3000 (-3.4A)VGH A3000 ( 4.2A)VGH A3000 ( 4.8A)NoneNoneVGH A3000 (-4.3A) | 0.90A | 3aoxA-3zbfA:33.8 | 3aoxA-3zbfA:45.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3AOX_A_EMHA901_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 10 | LEU A1951ALA A1978LEU A2026LEU A2028MET A2029GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.2A)VGH A3000 ( 4.8A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.44A | 3aoxA-3zbfA:33.8 | 3aoxA-3zbfA:45.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3AOX_A_EMHA901_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 10 | LEU A1951ALA A1978LYS A1980LEU A2026LEU A2028GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.2A)VGH A3000 ( 4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.54A | 3aoxA-3zbfA:33.8 | 3aoxA-3zbfA:45.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_B_NILB600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 5 / 9 | LEU A1951VAL A1959ILE A2024PHE A2075LEU A2086 | VGH A3000 ( 4.4A)NoneNoneNoneVGH A3000 (-4.3A) | 0.81A | 3cs9B-3zbfA:26.0 | 3cs9B-3zbfA:39.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_B_NILB600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 5 / 9 | LEU A1951VAL A1959LYS A1980ILE A2024PHE A2075 | VGH A3000 ( 4.4A)NoneVGH A3000 ( 4.7A)NoneNone | 0.93A | 3cs9B-3zbfA:26.0 | 3cs9B-3zbfA:39.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3K54_A_1N1A1_1 (TYROSINE-PROTEINKINASE BTK) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951ALA A1978LYS A1980MET A2001ILE A2024GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.64A | 3k54A-3zbfA:26.9 | 3k54A-3zbfA:36.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MIY_B_B49B2_1 (TYROSINE-PROTEINKINASE ITK/TSK) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 5 / 9 | ALA A1978LYS A1980MET A2029GLY A2032LEU A2086 | VGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.55A | 3miyB-3zbfA:32.8 | 3miyB-3zbfA:37.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OXZ_A_0LIA1_2 (TYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 5 / 9 | LEU A1951LYS A1980ILE A2024MET A2029LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 ( 4.7A)NoneNoneVGH A3000 (-4.3A) | 0.79A | 3oxzA-3zbfA:31.1 | 3oxzA-3zbfA:40.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3SXR_A_1N1A1_1 (CYTOPLASMICTYROSINE-PROTEINKINASE BMX) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951VAL A1959ALA A1978MET A2001ILE A2024GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)NoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.80A | 3sxrA-3zbfA:25.2 | 3sxrA-3zbfA:39.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3UE4_A_DB8A601_1 (TYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951ALA A1978LYS A1980GLU A1997ILE A2024MET A2029GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneNoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.62A | 3ue4A-3zbfA:33.4 | 3ue4A-3zbfA:37.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3UE4_B_DB8B601_1 (TYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951VAL A1959ALA A1978GLU A1997ILE A2024GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)NoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.78A | 3ue4B-3zbfA:26.5 | 3ue4B-3zbfA:37.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3UE4_B_DB8B601_1 (TYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951VAL A1959ALA A1978GLU A1997MET A2001GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)NoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.83A | 3ue4B-3zbfA:26.5 | 3ue4B-3zbfA:37.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3UG2_A_IREA1_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980LEU A2028MET A2029GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.8A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.54A | 3ug2A-3zbfA:27.3 | 3ug2A-3zbfA:34.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V5W_A_8PRA701_2 (G-PROTEIN COUPLEDRECEPTOR KINASE 2) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 3 / 3 | LEU A2026MET A2029ASP A2033 | VGH A3000 ( 4.2A)NoneVGH A3000 (-4.5A) | 0.60A | 3v5wA-3zbfA:7.5 | 3v5wA-3zbfA:18.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ANQ_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 9 | LEU A1951VAL A1959ALA A1978LEU A2026MET A2029GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.2A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.34A | 4anqA-3zbfA:34.5 | 4anqA-3zbfA:49.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ANS_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 9 | LEU A1951VAL A1959ALA A1978MET A2029GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.33A | 4ansA-3zbfA:34.4 | 4ansA-3zbfA:49.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4CSV_A_STIA1265_2 (SRC-ABL TYROSINEKINASE ANCESTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 4 / 4 | LYS A1980ILE A2024MET A2029PHE A2075 | VGH A3000 ( 4.7A)NoneNoneNone | 0.80A | 4csvA-3zbfA:25.9 | 4csvA-3zbfA:41.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4HJO_A_AQ4A1001_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | LEU A1951VAL A1959ALA A1978MET A2029GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.51A | 4hjoA-3zbfA:29.7 | 4hjoA-3zbfA:35.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IAA_A_RTZA401_1 (SERINE/THREONINE-PROTEIN KINASE PIM-1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 11 | VAL A1959ALA A1978LYS A1980LEU A2026ASP A2033LEU A2086 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.2A)VGH A3000 (-4.5A)VGH A3000 (-4.3A) | 0.85A | 4iaaA-3zbfA:17.5 | 4iaaA-3zbfA:25.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IAA_A_RTZA401_1 (SERINE/THREONINE-PROTEIN KINASE PIM-1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 5 / 11 | VAL A1959ALA A1978LYS A1980LEU A2026ASP A2102 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.2A)None | 0.62A | 4iaaA-3zbfA:17.5 | 4iaaA-3zbfA:25.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MKC_A_4MKA1503_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951GLY A1957VAL A1959ALA A1978LYS A1980LEU A2026LEU A2028 | VGH A3000 ( 4.4A)NoneNoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.2A)VGH A3000 ( 4.8A) | 1.22A | 4mkcA-3zbfA:34.0 | 4mkcA-3zbfA:45.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MKC_A_4MKA1503_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 10 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980LEU A2026LEU A2028GLY A2032ASP A2033LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.2A)VGH A3000 ( 4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.5A)VGH A3000 (-4.3A)None | 0.55A | 4mkcA-3zbfA:34.0 | 4mkcA-3zbfA:45.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXO_A_DB8A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980MET A2001ILE A2024GLY A2032ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneNoneVGH A3000 (-3.5A)None | 0.64A | 4mxoA-3zbfA:26.4 | 4mxoA-3zbfA:40.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXO_B_DB8B601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980ILE A2024GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.55A | 4mxoB-3zbfA:26.4 | 4mxoB-3zbfA:40.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXX_A_DB8A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951ALA A1978LYS A1980GLU A1997MET A2001ILE A2024GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneNoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.90A | 4mxxA-3zbfA:26.1 | 4mxxA-3zbfA:40.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXY_A_DB8A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980ILE A2024GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.57A | 4mxyA-3zbfA:32.8 | 4mxyA-3zbfA:40.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXY_B_DB8B601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.52A | 4mxyB-3zbfA:28.2 | 4mxyB-3zbfA:40.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXZ_A_DB8A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980ILE A2024GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.57A | 4mxzA-3zbfA:32.8 | 4mxzA-3zbfA:40.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXZ_B_DB8B601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.52A | 4mxzB-3zbfA:28.2 | 4mxzB-3zbfA:40.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O0U_A_ADNA501_1 (AURORA KINASE A) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 4 / 6 | VAL A1959ALA A1978LEU A2010LEU A2086 | NoneVGH A3000 (-3.4A)VGH A3000 (-4.8A)VGH A3000 (-4.3A) | 0.43A | 4o0uA-3zbfA:18.9 | 4o0uA-3zbfA:27.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 5 / 12 | ALA A1978LYS A1980LEU A2010GLY A2101PHE A2103 | VGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)VGH A3000 (-3.5A)None | 0.97A | 4rzvA-3zbfA:10.5 | 4rzvA-3zbfA:30.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 5 / 12 | ALA A1978LYS A1980LEU A2010ILE A2024GLY A2101 | VGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)NoneVGH A3000 (-3.5A) | 0.74A | 4rzvA-3zbfA:10.5 | 4rzvA-3zbfA:30.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4TWP_A_AXIA601_1 (TYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | VAL A1959ALA A1978LYS A1980MET A2029GLY A2032ASN A2084LEU A2086ASP A2102 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)NoneVGH A3000 (-4.3A)None | 0.78A | 4twpA-3zbfA:27.0 | 4twpA-3zbfA:39.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4TWP_B_AXIB601_1 (TYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980MET A2029GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.87A | 4twpB-3zbfA:33.7 | 4twpB-3zbfA:39.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4TWP_B_AXIB601_1 (TYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | VAL A1959ALA A1978LYS A1980MET A2029GLY A2032ASN A2084LEU A2086ASP A2102 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)NoneVGH A3000 (-4.3A)None | 0.80A | 4twpB-3zbfA:33.7 | 4twpB-3zbfA:39.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4U5J_A_RXTA601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 11 | LEU A1951VAL A1959ALA A1978MET A2029GLY A2032ASN A2084LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)NoneVGH A3000 (-3.5A)NoneVGH A3000 (-4.3A)None | 0.65A | 4u5jA-3zbfA:26.2 | 4u5jA-3zbfA:40.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4U5J_B_RXTB601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 9 | LEU A1951VAL A1959ALA A1978MET A2029GLY A2032LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)None | 0.61A | 4u5jB-3zbfA:26.2 | 4u5jB-3zbfA:40.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WA9_A_AXIA9000_1 (TYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 11 | LEU A1951ALA A1978MET A2029GLY A2032ASN A2084LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)NoneVGH A3000 (-3.5A)NoneVGH A3000 (-4.3A) | 0.46A | 4wa9A-3zbfA:29.3 | 4wa9A-3zbfA:40.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WA9_B_AXIB9000_1 (TYROSINE-PROTEINKINASE ABL1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | VAL A1959ALA A1978LYS A1980MET A2029GLY A2032ASN A2084LEU A2086 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)NoneVGH A3000 (-4.3A) | 0.99A | 4wa9B-3zbfA:26.6 | 4wa9B-3zbfA:40.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4WBO_C_ANWC601_0 (RHODOPSIN KINASE) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 4 / 6 | LEU A1951ALA A1978MET A2029LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)NoneVGH A3000 (-4.3A) | 0.60A | 4wboC-3zbfA:22.6 | 4wboC-3zbfA:19.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WKQ_A_IREA1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951ALA A1978LYS A1980MET A2001LEU A2028GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneVGH A3000 ( 4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.63A | 4wkqA-3zbfA:32.7 | 4wkqA-3zbfA:34.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XLI_B_1N1B600_1 (NON-SPECIFICPROTEIN-TYROSINEKINASE) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951ALA A1978LYS A1980MET A2001ILE A2024GLY A2032LEU A2086 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.63A | 4xliB-3zbfA:28.8 | 4xliB-3zbfA:39.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XOY_A_DX4A401_0 (MITOGEN-ACTIVATEDPROTEIN KINASE 1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 4 / 6 | ALA A1978LEU A2028MET A2029LEU A2086 | VGH A3000 (-3.4A)VGH A3000 ( 4.8A)NoneVGH A3000 (-4.3A) | 0.22A | 4xoyA-3zbfA:12.8 | 4xoyA-3zbfA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XP3_A_DX4A401_0 (MITOGEN-ACTIVATEDPROTEIN KINASE 1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 4 / 6 | ALA A1978LEU A2028MET A2029LEU A2086 | VGH A3000 (-3.4A)VGH A3000 ( 4.8A)NoneVGH A3000 (-4.3A) | 0.29A | 4xp3A-3zbfA:23.4 | 4xp3A-3zbfA:27.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | ALA A1978LYS A1980LEU A2010GLY A2101ASP A2102PHE A2103 | VGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)VGH A3000 (-3.5A)NoneNone | 0.85A | 4xv2A-3zbfA:22.3 | 4xv2A-3zbfA:31.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | VAL A1959ALA A1978LYS A1980LEU A2010GLY A2101PHE A2103 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)VGH A3000 (-3.5A)None | 0.85A | 4xv2A-3zbfA:22.3 | 4xv2A-3zbfA:31.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | ALA A1978LYS A1980LEU A2010GLY A2101ASP A2102PHE A2103 | VGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)VGH A3000 (-3.5A)NoneNone | 0.80A | 4xv2B-3zbfA:28.3 | 4xv2B-3zbfA:31.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5AAA_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 9 / 9 | LEU A1951VAL A1959ALA A1978LEU A2026MET A2029GLY A2032LEU A2086GLY A2101ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.2A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)VGH A3000 (-3.5A)None | 0.34A | 5aaaA-3zbfA:34.5 | 5aaaA-3zbfA:47.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5AAB_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 10 / 10 | LEU A1951VAL A1959ALA A1978LYS A1980LEU A2026MET A2029GLY A2032LEU A2086GLY A2101ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.2A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)VGH A3000 (-3.5A)None | 0.51A | 5aabA-3zbfA:34.4 | 5aabA-3zbfA:47.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5AAC_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 10 | LEU A1951ALA A1978LYS A1980LEU A2026MET A2029GLY A2032LEU A2086GLY A2101 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.2A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)VGH A3000 (-3.5A) | 0.62A | 5aacA-3zbfA:34.7 | 5aacA-3zbfA:48.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5AAC_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 9 / 10 | LEU A1951VAL A1959ALA A1978LEU A2026MET A2029GLY A2032LEU A2086GLY A2101ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.2A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)VGH A3000 (-3.5A)None | 0.41A | 5aacA-3zbfA:34.7 | 5aacA-3zbfA:48.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 5 / 12 | ALA A1978LYS A1980LEU A2010GLY A2101PHE A2103 | VGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)VGH A3000 (-3.5A)None | 0.78A | 5cswA-3zbfA:22.5 | 5cswA-3zbfA:30.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 5 / 12 | VAL A1959ALA A1978LYS A1980LEU A2010GLY A2101 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)VGH A3000 (-3.5A) | 0.73A | 5cswA-3zbfA:22.5 | 5cswA-3zbfA:30.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | VAL A1959ALA A1978LYS A1980LEU A2010GLY A2101PHE A2103 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)VGH A3000 (-3.5A)None | 0.92A | 5cswB-3zbfA:22.4 | 5cswB-3zbfA:30.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5E72_A_SAMA400_1 (N2,N2-DIMETHYLGUANOSINETRNAMETHYLTRANSFERASE) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 4 / 4 | ASP A2079GLY A2104ASP A2102ASP A2033 | NoneNoneNoneVGH A3000 (-4.5A) | 1.06A | 5e72A-3zbfA:undetectable | 5e72A-3zbfA:21.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_A_1N1A501_1 (PROTEIN-TYROSINEKINASE 6) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | ALA A1978LEU A2010LEU A2028GLY A2031LEU A2086GLY A2101 | VGH A3000 (-3.4A)VGH A3000 (-4.8A)VGH A3000 ( 4.8A)NoneVGH A3000 (-4.3A)VGH A3000 (-3.5A) | 0.82A | 5h2uA-3zbfA:28.9 | 5h2uA-3zbfA:36.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_A_1N1A501_1 (PROTEIN-TYROSINEKINASE 6) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | LEU A1951VAL A1959ALA A1978LEU A2010LEU A2028GLY A2032LEU A2086GLY A2101 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 (-4.8A)VGH A3000 ( 4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.3A)VGH A3000 (-3.5A) | 0.63A | 5h2uA-3zbfA:28.9 | 5h2uA-3zbfA:36.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_B_1N1B501_1 (PROTEIN-TYROSINEKINASE 6) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | ALA A1978LEU A2010ILE A2024LEU A2028GLY A2031LEU A2086GLY A2101 | VGH A3000 (-3.4A)VGH A3000 (-4.8A)NoneVGH A3000 ( 4.8A)NoneVGH A3000 (-4.3A)VGH A3000 (-3.5A) | 1.03A | 5h2uB-3zbfA:25.2 | 5h2uB-3zbfA:36.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_B_1N1B501_1 (PROTEIN-TYROSINEKINASE 6) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | LEU A1951LEU A2010GLY A2032LEU A2086GLY A2101ASP A2102 | VGH A3000 ( 4.4A)VGH A3000 (-4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.3A)VGH A3000 (-3.5A)None | 0.75A | 5h2uB-3zbfA:25.2 | 5h2uB-3zbfA:36.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_B_1N1B501_1 (PROTEIN-TYROSINEKINASE 6) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 9 / 12 | LEU A1951VAL A1959ALA A1978LEU A2010ILE A2024LEU A2028GLY A2032LEU A2086GLY A2101 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 (-4.8A)NoneVGH A3000 ( 4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.3A)VGH A3000 (-3.5A) | 0.66A | 5h2uB-3zbfA:25.2 | 5h2uB-3zbfA:36.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_C_1N1C501_1 (PROTEIN-TYROSINEKINASE 6) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951ALA A1978LEU A2010ILE A2024GLY A2032LEU A2086GLY A2101 | VGH A3000 ( 4.4A)VGH A3000 (-3.4A)VGH A3000 (-4.8A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A)VGH A3000 (-3.5A) | 0.65A | 5h2uC-3zbfA:29.1 | 5h2uC-3zbfA:36.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_D_1N1D504_1 (PROTEIN-TYROSINEKINASE 6) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 9 / 12 | LEU A1951VAL A1959ALA A1978LEU A2010ILE A2024LEU A2028GLY A2032LEU A2086GLY A2101 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 (-4.8A)NoneVGH A3000 ( 4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.3A)VGH A3000 (-3.5A) | 0.64A | 5h2uD-3zbfA:25.2 | 5h2uD-3zbfA:36.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HI2_A_BAXA801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | ALA A1978LYS A1980LEU A2010LEU A2070HIS A2077GLY A2101 | VGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)NoneNoneVGH A3000 (-3.5A) | 0.78A | 5hi2A-3zbfA:19.6 | 5hi2A-3zbfA:31.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | VAL A1959ALA A1978LYS A1980LEU A2010ILE A2024GLY A2101 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)NoneVGH A3000 (-3.5A) | 0.73A | 5hieA-3zbfA:10.7 | 5hieA-3zbfA:32.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | VAL A1959ALA A1978LYS A1980LEU A2010ILE A2024GLY A2101 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)NoneVGH A3000 (-3.5A) | 0.74A | 5hieB-3zbfA:10.7 | 5hieB-3zbfA:32.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_D_P06D801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 6 / 12 | VAL A1959ALA A1978LYS A1980LEU A2010ILE A2024GLY A2101 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 (-4.8A)NoneVGH A3000 (-3.5A) | 0.75A | 5hieD-3zbfA:26.4 | 5hieD-3zbfA:32.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y7Z_A_IREA401_0 (CYCLIN-G-ASSOCIATEDKINASE) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980LEU A2028GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.89A | 5y7zA-3zbfA:23.7 | 5y7zA-3zbfA:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y7Z_A_IREA401_0 (CYCLIN-G-ASSOCIATEDKINASE) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951VAL A1959ALA A1978LYS A1980LEU A2028GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)VGH A3000 ( 4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.89A | 5y7zA-3zbfA:23.7 | 5y7zA-3zbfA:28.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y7Z_A_IREA401_0 (CYCLIN-G-ASSOCIATEDKINASE) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951VAL A1959LYS A1980GLU A1997LEU A2028GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 ( 4.7A)NoneVGH A3000 ( 4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.3A) | 1.01A | 5y7zA-3zbfA:23.7 | 5y7zA-3zbfA:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y7Z_A_IREA401_0 (CYCLIN-G-ASSOCIATEDKINASE) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 7 / 12 | LEU A1951VAL A1959LYS A1980GLU A1997LEU A2028GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 ( 4.7A)NoneVGH A3000 ( 4.8A)VGH A3000 (-3.5A)VGH A3000 (-4.3A) | 1.01A | 5y7zA-3zbfA:23.7 | 5y7zA-3zbfA:28.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ZV2_A_LEVA801_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 3 / 3 | LYS A1980LEU A2086ASP A2102 | VGH A3000 ( 4.7A)VGH A3000 (-4.3A)None | 0.89A | 5zv2A-3zbfA:31.7 | 5zv2A-3zbfA:16.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6FNM_A_1N1A1001_1 (-) |
3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homosapiens) | 8 / 12 | VAL A1959ALA A1978LYS A1980MET A2001ILE A2024MET A2029GLY A2032LEU A2086 | NoneVGH A3000 (-3.4A)VGH A3000 ( 4.7A)NoneNoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.90A | 6fnmA-3zbfA:28.3 | 6fnmA-3zbfA:35.89 |