SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VGG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 VAL A 313
VAL A 323
ILE A 336
MET A 341
ARG A 385
 None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
None
 0.99A 1iepA-4lggA:
29.4		 1iepA-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.44A 1m17A-4lggA:
29.2		 1m17A-4lggA:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 9 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
VGG  A 601 (-4.5A)
 0.80A 1muoA-4lggA:
7.0		 1muoA-4lggA:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
ILE A 336
MET A 341
ARG A 385
 VGG  A 601 (-3.2A)
VGG  A 601 (-4.2A)
None
None
 0.89A 1opjB-4lggA:
29.5		 1opjB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
LYS A 295
ILE A 336
ARG A 385
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
VGG  A 601 (-4.2A)
None
 1.00A 1opjB-4lggA:
29.5		 1opjB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
LYS A 295
VAL A 313
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
 0.76A 1opjB-4lggA:
29.5		 1opjB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
VAL A 313
ILE A 336
MET A 341
 VGG  A 601 (-3.2A)
None
VGG  A 601 (-4.2A)
None
 0.84A 1opjB-4lggA:
29.5		 1opjB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 9 LEU A 273
VAL A 281
ALA A 293
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.39A 1xbbA-4lggA:
30.2		 1xbbA-4lggA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 11 GLY A 274
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.4A)
VGG  A 601 (-4.5A)
 0.52A 2evaA-4lggA:
26.6		 2evaA-4lggA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
ALA A 293
GLU A 310
MET A 314
VAL A 323
ILE A 336
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.50A 2gqgA-4lggA:
30.8		 2gqgA-4lggA:
46.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
ILE A 336
GLY A 344
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
 0.62A 2gqgA-4lggA:
30.8		 2gqgA-4lggA:
46.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
ILE A 336
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.63A 2gqgB-4lggA:
30.5		 2gqgB-4lggA:
46.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 LEU A 273
LYS A 295
VAL A 313
ILE A 336
ARG A 385
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
None
 1.34A 2hyyA-4lggA:
30.0		 2hyyA-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 LEU A 273
VAL A 313
VAL A 323
ILE A 336
ARG A 385
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 1.08A 2hyyA-4lggA:
30.0		 2hyyA-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
LYS A 295
VAL A 313
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
 0.77A 2hyyB-4lggA:
29.9		 2hyyB-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.65A 2hyyB-4lggA:
29.9		 2hyyB-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 LEU A 273
LYS A 295
VAL A 313
MET A 314
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
 0.84A 2hyyC-4lggA:
30.2		 2hyyC-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 LEU A 273
VAL A 313
MET A 314
ILE A 336
MET A 341
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
None
 0.85A 2hyyC-4lggA:
30.2		 2hyyC-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 VAL A 281
ALA A 293
MET A 314
ILE A 336
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 1.04A 2hyyD-4lggA:
29.9		 2hyyD-4lggA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
GLU A 310
MET A 314
GLY A 344
ASP A 348
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
None
 0.90A 2itoA-4lggA:
29.6		 2itoA-4lggA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
 0.61A 2itoA-4lggA:
29.6		 2itoA-4lggA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
GLY A 344
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.7A)
 0.92A 2ityA-4lggA:
29.7		 2ityA-4lggA:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.65A 2ityA-4lggA:
29.7		 2ityA-4lggA:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
GLY A 344
ASP A 348
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.80A 2itzA-4lggA:
29.4		 2itzA-4lggA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
ILE A 336
TYR A 340
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
 0.70A 2oiqA-4lggA:
16.4		 2oiqA-4lggA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 VAL A 281
ALA A 293
MET A 314
ILE A 336
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.91A 2oiqA-4lggA:
16.4		 2oiqA-4lggA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 5 LEU A 273
VAL A 313
LEU A 317
MET A 341
ARG A 385
 VGG  A 601 (-3.2A)
None
None
None
None
 1.22A 2oiqA-4lggA:
29.6		 2oiqA-4lggA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
ILE A 336
TYR A 340
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
 0.81A 2pl0A-4lggA:
30.8		 2pl0A-4lggA:
67.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 VAL A 281
ALA A 293
MET A 314
VAL A 323
ILE A 336
TYR A 340
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.2A)
 0.86A 2pl0A-4lggA:
30.8		 2pl0A-4lggA:
67.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 GLY A 274
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
ALA A 403
 VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
 0.77A 2wgjA-4lggA:
28.1		 2wgjA-4lggA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 VAL A 281
ALA A 293
TYR A 340
MET A 341
ALA A 403
ASP A 404
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 4.2A)
VGG  A 601 ( 4.7A)
 0.71A 2wgjA-4lggA:
28.1		 2wgjA-4lggA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.38A 2xp2A-4lggA:
30.3		 2xp2A-4lggA:
33.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 ALA A 293
LYS A 295
GLU A 310
MET A 314
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.89A 2y6oA-4lggA:
31.8		 2y6oA-4lggA:
43.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.55A 2y7jA-4lggA:
23.4		 2y7jA-4lggA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 10 VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.40A 2y7jB-4lggA:
23.8		 2y7jB-4lggA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 10 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
 0.45A 2y7jC-4lggA:
10.8		 2y7jC-4lggA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 10 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
 0.32A 2y7jD-4lggA:
23.8		 2y7jD-4lggA:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		11 / 12 LEU A 273
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
ILE A 336
MET A 341
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.56A 2zvaA-4lggA:
33.2		 2zvaA-4lggA:
65.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 10 LEU A 273
ALA A 293
LYS A 295
VAL A 323
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.42A 3aoxA-4lggA:
28.9		 3aoxA-4lggA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 10 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.75A 3cs9A-4lggA:
30.0		 3cs9A-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 10 LEU A 273
VAL A 281
VAL A 323
ILE A 336
VAL A 402
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 0.50A 3cs9A-4lggA:
30.0		 3cs9A-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 ALA A 293
LEU A 322
GLY A 344
HIS A 384
LEU A 393
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.49A 3cs9A-4lggA:
30.0		 3cs9A-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 ( 4.2A)
 0.30A 3cs9B-4lggA:
30.7		 3cs9B-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 ALA A 293
VAL A 313
LEU A 322
GLY A 344
ALA A 403
 VGG  A 601 (-3.5A)
None
None
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
 0.68A 3cs9B-4lggA:
30.7		 3cs9B-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 9 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.82A 3cs9B-4lggA:
30.7		 3cs9B-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 9 LEU A 273
VAL A 281
VAL A 323
ILE A 336
LEU A 393
VAL A 402
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 (-4.5A)
None
 0.79A 3cs9B-4lggA:
30.7		 3cs9B-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 ALA A 293
MET A 314
LEU A 322
HIS A 384
ALA A 403
 VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
None
None
VGG  A 601 ( 4.2A)
 0.68A 3cs9C-4lggA:
30.0		 3cs9C-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 ALA A 293
VAL A 313
MET A 314
LEU A 322
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.6A)
None
VGG  A 601 ( 4.2A)
 0.79A 3cs9C-4lggA:
30.0		 3cs9C-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 9 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.74A 3cs9C-4lggA:
30.0		 3cs9C-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 9 LEU A 273
VAL A 281
VAL A 323
ILE A 336
MET A 341
VAL A 402
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
None
 0.72A 3cs9C-4lggA:
30.0		 3cs9C-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 ( 4.2A)
 0.43A 3cs9D-4lggA:
29.1		 3cs9D-4lggA:
46.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
GLY A 274
GLY A 279
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
None
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.4A)
VGG  A 601 (-4.5A)
 0.78A 3fupA-4lggA:
27.9		 3fupA-4lggA:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 11 LEU A 273
VAL A 281
ALA A 293
VAL A 323
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.90A 3g0eA-4lggA:
26.6		 3g0eA-4lggA:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 10 LEU A 273
VAL A 281
ALA A 293
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.75A 3g0fB-4lggA:
27.6		 3g0fB-4lggA:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.63A 3g5dA-4lggA:
37.6		 3g5dA-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		11 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.68A 3g5dB-4lggA:
37.8		 3g5dB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
MET A 314
VAL A 323
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
 0.76A 3gvuA-4lggA:
30.0		 3gvuA-4lggA:
46.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.87A 3gvuA-4lggA:
30.0		 3gvuA-4lggA:
46.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 5 VAL A 313
ILE A 336
TYR A 340
MET A 341
 None
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
None
 0.96A 3gvuA-4lggA:
30.0		 3gvuA-4lggA:
46.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 4.8A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.62A 3ik3A-4lggA:
29.8		 3ik3A-4lggA:
46.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 7 LEU A 273
LYS A 295
VAL A 313
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
 0.82A 3ik3A-4lggA:
29.9		 3ik3A-4lggA:
46.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 7 LEU A 273
VAL A 313
ILE A 336
MET A 341
 VGG  A 601 (-3.2A)
None
VGG  A 601 (-4.2A)
None
 0.86A 3ik3A-4lggA:
29.9		 3ik3A-4lggA:
46.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 4.8A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.69A 3ik3B-4lggA:
29.6		 3ik3B-4lggA:
46.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 7 LEU A 273
LYS A 295
VAL A 313
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
 0.81A 3ik3B-4lggA:
29.6		 3ik3B-4lggA:
46.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 7 LEU A 273
VAL A 313
ILE A 336
MET A 341
 VGG  A 601 (-3.2A)
None
VGG  A 601 (-4.2A)
None
 0.90A 3ik3B-4lggA:
29.6		 3ik3B-4lggA:
46.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
 0.65A 3k54A-4lggA:
30.8		 3k54A-4lggA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.49A 3k54A-4lggA:
30.8		 3k54A-4lggA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
LYS A 295
VAL A 313
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
 0.73A 3k5vA-4lggA:
29.8		 3k5vA-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
VAL A 313
ILE A 336
MET A 341
 VGG  A 601 (-3.2A)
None
VGG  A 601 (-4.2A)
None
 0.91A 3k5vA-4lggA:
29.8		 3k5vA-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.60A 3k5vA-4lggA:
29.8		 3k5vA-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
LYS A 295
VAL A 313
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
 0.81A 3k5vB-4lggA:
29.8		 3k5vB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.68A 3k5vB-4lggA:
29.8		 3k5vB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.4A)
VGG  A 601 (-4.5A)
 0.58A 3lxnA-4lggA:
26.6		 3lxnA-4lggA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 11 ALA A 293
LYS A 295
VAL A 323
MET A 341
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.75A 3miyA-4lggA:
31.9		 3miyA-4lggA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 9 ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.42A 3miyB-4lggA:
31.8		 3miyB-4lggA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 1.01A 3ms9A-4lggA:
29.4		 3ms9A-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 VAL A 313
VAL A 323
ILE A 336
MET A 341
ARG A 385
 None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
None
 0.99A 3ms9A-4lggA:
29.4		 3ms9A-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 1.04A 3mssA-4lggA:
29.6		 3mssA-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 LYS A 295
VAL A 313
VAL A 323
ILE A 336
ARG A 385
 VGG  A 601 (-3.8A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 1.11A 3mssA-4lggA:
29.6		 3mssA-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 VAL A 313
VAL A 323
ILE A 336
MET A 341
ARG A 385
 None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
None
 0.98A 3mssA-4lggA:
29.6		 3mssA-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 7 LYS A 295
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 (-3.8A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.88A 3mssB-4lggA:
29.7		 3mssB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 7 LYS A 295
VAL A 323
ILE A 336
ARG A 385
 VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 0.97A 3mssB-4lggA:
29.7		 3mssB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 7 VAL A 313
VAL A 323
ILE A 336
MET A 341
 None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 0.88A 3mssB-4lggA:
29.7		 3mssB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 7 VAL A 323
ILE A 336
MET A 341
ARG A 385
 VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
None
 0.80A 3mssB-4lggA:
29.7		 3mssB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 1.05A 3mssC-4lggA:
29.5		 3mssC-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 VAL A 313
VAL A 323
ILE A 336
MET A 341
ARG A 385
 None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
None
 1.03A 3mssC-4lggA:
29.5		 3mssC-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 LEU A 273
ALA A 293
MET A 314
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 1.01A 3mssD-4lggA:
29.7		 3mssD-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 VAL A 281
LYS A 295
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.83A 3mssD-4lggA:
29.7		 3mssD-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 6 VAL A 281
VAL A 313
VAL A 323
ILE A 336
MET A 341
 VGG  A 601 ( 3.5A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 0.93A 3mssD-4lggA:
29.7		 3mssD-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 314
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.89A 3octA-4lggA:
29.2		 3octA-4lggA:
38.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.67A 3octA-4lggA:
29.2		 3octA-4lggA:
38.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 ALA A 293
MET A 314
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.73A 3oezA-4lggA:
36.8		 3oezA-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 VAL A 281
ALA A 293
MET A 314
VAL A 323
TYR A 340
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.80A 3oezA-4lggA:
36.8		 3oezA-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
GLU A 310
VAL A 313
MET A 314
ILE A 336
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
 0.84A 3oezB-4lggA:
37.1		 3oezB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 313
MET A 314
ILE A 336
TYR A 340
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.2A)
 0.79A 3oezB-4lggA:
37.1		 3oezB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 VAL A 281
ALA A 293
VAL A 313
MET A 314
ILE A 336
TYR A 340
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.75A 3oezB-4lggA:
37.1		 3oezB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 ALA A 293
MET A 314
LEU A 322
VAL A 323
GLY A 344
HIS A 384
ALA A 403
 VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 ( 3.2A)
None
VGG  A 601 ( 4.2A)
 0.64A 3oxzA-4lggA:
30.3		 3oxzA-4lggA:
46.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 9 LEU A 273
LYS A 295
VAL A 313
ILE A 336
ARG A 385
VAL A 402
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
None
None
 1.25A 3oxzA-4lggA:
30.3		 3oxzA-4lggA:
46.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 9 LEU A 273
VAL A 313
ILE A 336
MET A 341
ARG A 385
LEU A 393
VAL A 402
 VGG  A 601 (-3.2A)
None
VGG  A 601 (-4.2A)
None
None
VGG  A 601 (-4.5A)
None
 1.08A 3oxzA-4lggA:
30.3		 3oxzA-4lggA:
46.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LYS A 295
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 (-3.8A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.88A 3pyyA-4lggA:
30.1		 3pyyA-4lggA:
45.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.94A 3pyyB-4lggA:
30.4		 3pyyB-4lggA:
45.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 5 LYS A 295
VAL A 313
ILE A 336
ARG A 385
 VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
None
 1.34A 3pyyB-4lggA:
30.4		 3pyyB-4lggA:
45.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 5 VAL A 313
ILE A 336
MET A 341
ARG A 385
 None
VGG  A 601 (-4.2A)
None
None
 1.02A 3pyyB-4lggA:
30.4		 3pyyB-4lggA:
45.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
MET A 314
VAL A 323
TYR A 340
GLY A 344
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
 0.58A 3qlgA-4lggA:
37.7		 3qlgA-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
TYR A 340
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
 0.65A 3qlgA-4lggA:
37.7		 3qlgA-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.54A 3qlgA-4lggA:
37.7		 3qlgA-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
MET A 314
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.65A 3qlgB-4lggA:
37.3		 3qlgB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
VGG  A 601 ( 4.7A)
 0.58A 3qlgB-4lggA:
37.3		 3qlgB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 4 LYS A 295
ILE A 336
MET A 341
LYS A 343
 VGG  A 601 (-3.8A)
VGG  A 601 (-4.2A)
None
None
 0.60A 3qlgB-4lggA:
37.3		 3qlgB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.56A 3sxrA-4lggA:
29.3		 3sxrA-4lggA:
43.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.60A 3sxrB-4lggA:
28.9		 3sxrB-4lggA:
43.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.64A 3ue4A-4lggA:
30.8		 3ue4A-4lggA:
46.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
ILE A 336
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.69A 3ue4B-4lggA:
30.7		 3ue4B-4lggA:
46.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.41A 3zbfA-4lggA:
29.7		 3zbfA-4lggA:
41.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 11 LEU A 273
ALA A 293
LYS A 295
VAL A 323
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.83A 4agdA-4lggA:
27.6		 4agdA-4lggA:
34.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.45A 4anqA-4lggA:
29.9		 4anqA-4lggA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.44A 4ansA-4lggA:
29.8		 4ansA-4lggA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 10 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
None
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.4A)
VGG  A 601 (-4.5A)
 0.52A 4ckjA-4lggA:
30.4		 4ckjA-4lggA:
35.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 VAL A 281
ALA A 293
MET A 314
VAL A 323
TYR A 340
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.89A 4csvA-4lggA:
31.5		 4csvA-4lggA:
62.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.99A 4hjoA-4lggA:
29.0		 4hjoA-4lggA:
32.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
GLY A 344
ASP A 348
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
 0.76A 4i22A-4lggA:
28.1		 4i22A-4lggA:
32.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 10 ALA A 293
VAL A 323
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 (-3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.27A 4ks8A-4lggA:
23.7		 4ks8A-4lggA:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
ILE A 336
TYR A 340
GLY A 344
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.7A)
 0.76A 4mxoA-4lggA:
37.8		 4mxoA-4lggA:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.7A)
 0.58A 4mxoA-4lggA:
37.8		 4mxoA-4lggA:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.69A 4mxoB-4lggA:
38.1		 4mxoB-4lggA:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
GLU A 310
ILE A 336
TYR A 340
GLY A 344
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.7A)
 0.80A 4mxoB-4lggA:
38.1		 4mxoB-4lggA:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
ALA A 293
LYS A 295
GLU A 310
MET A 314
ILE A 336
TYR A 340
GLY A 344
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
 0.89A 4mxxA-4lggA:
37.4		 4mxxA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
ALA A 293
LYS A 295
MET A 314
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.75A 4mxxA-4lggA:
37.4		 4mxxA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
ALA A 293
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.61A 4mxxA-4lggA:
37.4		 4mxxA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.61A 4mxxB-4lggA:
31.3		 4mxxB-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
ILE A 336
TYR A 340
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.7A)
 0.76A 4mxyA-4lggA:
37.6		 4mxyA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.63A 4mxyA-4lggA:
37.6		 4mxyA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
TYR A 340
GLY A 344
ALA A 403
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
VGG  A 601 ( 4.7A)
 0.60A 4mxyB-4lggA:
38.1		 4mxyB-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.32A 4mxyB-4lggA:
38.1		 4mxyB-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
ILE A 336
TYR A 340
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.7A)
 0.76A 4mxzA-4lggA:
37.6		 4mxzA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.63A 4mxzA-4lggA:
37.6		 4mxzA-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
TYR A 340
GLY A 344
ALA A 403
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
VGG  A 601 ( 4.7A)
 0.60A 4mxzB-4lggA:
38.1		 4mxzB-4lggA:
98.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
GLU A 310
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.32A 4mxzB-4lggA:
38.1		 4mxzB-4lggA:
98.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 11 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
ASN A 391
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.5A)
 0.81A 4o0sA-4lggA:
23.9		 4o0sA-4lggA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 11 LEU A 273
VAL A 281
ALA A 293
LYS A 295
ASN A 391
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.69A 4o0sA-4lggA:
23.9		 4o0sA-4lggA:
24.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
LYS A 295
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.83A 4otwA-4lggA:
28.4		 4otwA-4lggA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 5 LEU A 273
VAL A 323
TYR A 340
ARG A 385
 VGG  A 601 (-3.2A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
None
 0.75A 4r7iA-4lggA:
28.5		 4r7iA-4lggA:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.74A 4twpB-4lggA:
30.5		 4twpB-4lggA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 ALA A 293
MET A 314
HIS A 384
LEU A 393
ALA A 403
 VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.58A 4tyjA-4lggA:
29.5		 4tyjA-4lggA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 11 LEU A 273
GLY A 276
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
 VGG  A 601 (-3.2A)
None
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
 0.56A 4u5jA-4lggA:
37.9		 4u5jA-4lggA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 11 LEU A 273
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.43A 4u5jA-4lggA:
37.9		 4u5jA-4lggA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 9 LEU A 273
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.34A 4u5jB-4lggA:
37.3		 4u5jB-4lggA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 9 LEU A 273
VAL A 281
LYS A 295
TYR A 340
ARG A 385
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 (-4.5A)
 0.83A 4v01B-4lggA:
29.2		 4v01B-4lggA:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 11 LEU A 273
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.50A 4wa9A-4lggA:
28.7		 4wa9A-4lggA:
46.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.77A 4wa9B-4lggA:
29.9		 4wa9B-4lggA:
46.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
ALA A 293
MET A 341
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
None
VGG  A 601 (-4.5A)
 0.45A 4wboC-4lggA:
20.0		 4wboC-4lggA:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
 0.61A 4wkqA-4lggA:
29.3		 4wkqA-4lggA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 314
VAL A 323
ILE A 336
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.82A 4xeyA-4lggA:
30.7		 4xeyA-4lggA:
38.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 314
VAL A 323
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.76A 4xeyB-4lggA:
30.3		 4xeyB-4lggA:
38.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.69A 4xeyB-4lggA:
30.3		 4xeyB-4lggA:
38.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		10 / 12 LEU A 273
ALA A 293
GLU A 310
MET A 314
VAL A 323
TYR A 340
MET A 341
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.65A 4xliA-4lggA:
31.0		 4xliA-4lggA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		10 / 12 LEU A 273
ALA A 293
GLU A 310
MET A 314
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.68A 4xliB-4lggA:
30.7		 4xliB-4lggA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
ILE A 336
TYR A 340
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.2A)
 0.66A 4xliB-4lggA:
30.7		 4xliB-4lggA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.39A 5aaaA-4lggA:
29.9		 5aaaA-4lggA:
33.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.70A 5aabA-4lggA:
30.1		 5aabA-4lggA:
33.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.69A 5aacA-4lggA:
30.0		 5aacA-4lggA:
33.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 LEU A 273
GLY A 274
ALA A 293
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.71A 5ajqA-4lggA:
22.9		 5ajqA-4lggA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 LEU A 273
VAL A 281
ALA A 293
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.35A 5h2uA-4lggA:
29.1		 5h2uA-4lggA:
52.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 LEU A 273
ALA A 293
ILE A 336
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.57A 5h2uC-4lggA:
29.2		 5h2uC-4lggA:
52.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 LEU A 273
ALA A 293
LYS A 295
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.61A 5h2uC-4lggA:
29.2		 5h2uC-4lggA:
52.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
ILE A 336
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.45A 5h2uD-4lggA:
29.2		 5h2uD-4lggA:
52.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
TYR A 340
ASP A 348
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
None
 0.91A 5hesB-4lggA:
26.8		 5hesB-4lggA:
28.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 ALA A 293
GLU A 310
ILE A 336
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.69A 5i9xA-4lggA:
30.9		 5i9xA-4lggA:
40.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 ALA A 293
LYS A 295
GLU A 310
MET A 314
TYR A 340
GLY A 344
LEU A 393
 VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.60A 5i9yA-4lggA:
30.8		 5i9yA-4lggA:
40.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 7 GLY A 274
GLY A 276
GLY A 279
VAL A 281
 VGG  A 601 ( 3.8A)
None
None
VGG  A 601 ( 3.5A)
 0.26A 5izjB-4lggA:
20.1		 5izjB-4lggA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 7 GLY A 274
GLY A 276
VAL A 281
LYS A 295
 VGG  A 601 ( 3.8A)
None
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
 0.46A 5izjA-4lggA:
20.4		 5izjA-4lggA:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 10 LEU A 273
VAL A 281
LYS A 295
GLU A 310
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 (-4.2A)
 0.66A 5mo4A-4lggA:
25.5		 5mo4A-4lggA:
37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 VGG  A 601 (-3.5A)
None
VGG  A 601 ( 4.8A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.55A 5mo4A-4lggA:
25.5		 5mo4A-4lggA:
37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 ALA A 293
VAL A 313
LEU A 322
VAL A 323
ALA A 403
 VGG  A 601 (-3.5A)
None
None
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.2A)
 0.76A 5mo4A-4lggA:
25.5		 5mo4A-4lggA:
37.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 10 LEU A 273
VAL A 281
ALA A 293
VAL A 323
TYR A 340
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 (-4.5A)
 0.72A 5n3hA-4lggA:
20.6		 5n3hA-4lggA:
23.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
GLY A 344
LEU A 393
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.51A 5p9iA-4lggA:
29.2		 5p9iA-4lggA:
37.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 5 LEU A 273
TYR A 340
MET A 341
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 4.7A)
 0.34A 5p9iA-4lggA:
29.2		 5p9iA-4lggA:
37.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 ALA A 371
LEU A 451
VAL A 377
ASP A 404
PHE A 405
 None
None
None
VGG  A 601 ( 4.7A)
None
 1.48A 5vlmC-4lggA:
1.2		 5vlmC-4lggA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.2A)
 0.45A 5xv7A-4lggA:
20.7		 5xv7A-4lggA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 LEU A 273
GLY A 274
VAL A 281
GLY A 344
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
 0.71A 5xv7A-4lggA:
20.7		 5xv7A-4lggA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.85A 5yu9A-4lggA:
28.1		 5yu9A-4lggA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 GLY A 274
VAL A 281
ALA A 293
LYS A 295
ASP A 348
LEU A 393
ASP A 404
 VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.85A 5yu9B-4lggA:
28.4		 5yu9B-4lggA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		5 / 12 VAL A 281
ALA A 293
LYS A 295
GLY A 344
ASP A 348
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.2A)
None
 0.66A 5yu9C-4lggA:
27.7		 5yu9C-4lggA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 VAL A 281
ALA A 293
LYS A 295
GLY A 344
ASP A 348
LEU A 393
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
 0.70A 5yu9D-4lggA:
28.1		 5yu9D-4lggA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		6 / 12 VAL A 281
ALA A 293
LYS A 295
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.83A 5yu9D-4lggA:
28.1		 5yu9D-4lggA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 314
TYR A 340
GLY A 344
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
 0.92A 5zv2A-4lggA:
28.5		 5zv2A-4lggA:
13.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
GLU A 310
ILE A 336
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 (-4.2A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.46A 6fnmA-4lggA:
31.5		 6fnmA-4lggA:
42.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
ILE A 336
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.65A 6fnmA-4lggA:
31.5		 6fnmA-4lggA:
42.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 VAL A 281
ALA A 293
MET A 314
VAL A 323
ILE A 336
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 1.01A 6hd4B-4lggA:
29.7		 6hd4B-4lggA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		4 / 6 LEU A 273
VAL A 313
MET A 341
GLY A 344
 VGG  A 601 (-3.2A)
None
None
VGG  A 601 ( 3.2A)
 1.06A 6hd4B-4lggA:
29.7		 6hd4B-4lggA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Gallus
gallus) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
ILE A 336
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.89A 6hd6A-4lggA:
29.7		 6hd6A-4lggA:
11.50