SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VG9'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
ARG A  64
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 3.7A)
 0.78A 1ao8A-2w3wA:
20.4		 1ao8A-2w3wA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
SER A  53
LEU A  61
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.7A)
 0.92A 1ao8A-2w3wA:
20.4		 1ao8A-2w3wA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
 0.77A 1bzfA-2w3wA:
20.3		 1bzfA-2w3wA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.7A)
 0.84A 1bzfA-2w3wA:
20.3		 1bzfA-2w3wA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
PHE A  35
THR A  50
PRO A  55
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.25A 1cd2A-2w3wA:
20.9		 1cd2A-2w3wA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 PHE A  35
LYS A  36
THR A  50
PRO A  55
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.92A 1cd2A-2w3wA:
20.9		 1cd2A-2w3wA:
32.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
ARG A  64
ILE A 102
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
VG9  A1168 ( 4.7A)
 0.61A 1d1gA-2w3wA:
18.7		 1d1gA-2w3wA:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
LEU A  61
ILE A 102
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
VG9  A1168 ( 4.7A)
 0.45A 1d1gA-2w3wA:
18.7		 1d1gA-2w3wA:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  54
ILE A 102
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.2A)
VG9  A1168 ( 4.7A)
 1.42A 1d1gB-2w3wA:
18.7		 1d1gB-2w3wA:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  61
ARG A  64
ILE A 102
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
VG9  A1168 ( 4.7A)
 0.61A 1d1gB-2w3wA:
18.7		 1d1gB-2w3wA:
29.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.58A 1ddrA-2w3wA:
23.0		 1ddrA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
THR A  50
SER A  53
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 3.7A)
None
 0.79A 1ddrA-2w3wA:
23.0		 1ddrA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.47A 1ddrB-2w3wA:
23.3		 1ddrB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.52A 1ddrB-2w3wA:
23.3		 1ddrB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.42A 1ddsA-2w3wA:
23.4		 1ddsA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.58A 1ddsA-2w3wA:
23.4		 1ddsA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.41A 1ddsB-2w3wA:
23.8		 1ddsB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.63A 1ddsB-2w3wA:
23.8		 1ddsB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		10 / 12 ALA A  11
ILE A  24
ASP A  31
LEU A  54
PRO A  55
VAL A  58
LEU A  61
ARG A  64
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.6A)
None
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
 0.53A 1df7A-2w3wA:
28.8		 1df7A-2w3wA:
68.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 TRP A  10
ALA A  11
ASP A  31
LEU A  61
ILE A 102
TYR A 108
 None
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.41A 1dg5A-2w3wA:
28.7		 1dg5A-2w3wA:
68.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		10 / 11 TRP A  10
ALA A  11
ILE A  24
ASP A  31
PHE A  35
SER A  53
LEU A  54
PRO A  55
ILE A 102
TYR A 108
 None
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.2A)
None
 0.63A 1dg5A-2w3wA:
28.7		 1dg5A-2w3wA:
68.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
PHE A  35
THR A  50
PRO A  55
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.31A 1dhfA-2w3wA:
21.5		 1dhfA-2w3wA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.50A 1dhfB-2w3wA:
21.7		 1dhfB-2w3wA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
SER A  53
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.83A 1dhiA-2w3wA:
23.4		 1dhiA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 11 ALA A  11
LEU A  32
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.55A 1dhiB-2w3wA:
23.7		 1dhiB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
SER A  53
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.84A 1dhjA-2w3wA:
23.3		 1dhjA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
LEU A  61
PRO A  62
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.58A 1dhjB-2w3wA:
23.7		 1dhjB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PRO A  62
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
None
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.66A 1dhjB-2w3wA:
23.7		 1dhjB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
SER A  53
PRO A  55
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.74A 1dlsA-2w3wA:
21.9		 1dlsA-2w3wA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
SER A  53
LEU A  61
ARG A  64
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
 0.87A 1draA-2w3wA:
23.2		 1draA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.56A 1draB-2w3wA:
23.7		 1draB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.58A 1drbA-2w3wA:
23.1		 1drbA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
SER A  53
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.87A 1drbA-2w3wA:
23.1		 1drbA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.56A 1drbB-2w3wA:
23.6		 1drbB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.70A 1dreA-2w3wA:
24.2		 1dreA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 1.26A 1dreA-2w3wA:
24.2		 1dreA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
SER A  53
PRO A  55
LEU A  61
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
 0.44A 1drfA-2w3wA:
21.7		 1drfA-2w3wA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.36A 1dyiA-2w3wA:
23.5		 1dyiA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.42A 1dyiA-2w3wA:
23.5		 1dyiA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
 1.14A 1dyiA-2w3wA:
23.5		 1dyiA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.37A 1dyiB-2w3wA:
23.7		 1dyiB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.41A 1dyiB-2w3wA:
23.7		 1dyiB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
PHE A  35
PRO A  55
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.34A 1dyrA-2w3wA:
20.7		 1dyrA-2w3wA:
32.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 0.95A 1hrkA-2w3wA:
undetectable		 1hrkA-2w3wA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 ALA A  11
ASP A  31
PHE A  35
SER A  53
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.39A 1j3jA-2w3wA:
8.3		 1j3jA-2w3wA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 9 ALA A  11
ASP A  31
PHE A  35
SER A  53
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.32A 1j3jB-2w3wA:
20.6		 1j3jB-2w3wA:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.42A 1jolA-2w3wA:
23.5		 1jolA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.43A 1jolA-2w3wA:
23.5		 1jolA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.42A 1jolB-2w3wA:
23.8		 1jolB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
PRO A  62
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
None
None
VG9  A1168 ( 4.7A)
 0.50A 1jolB-2w3wA:
23.8		 1jolB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.37A 1jomA-2w3wA:
22.7		 1jomA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 11 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.53A 1jomA-2w3wA:
22.7		 1jomA-2w3wA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.62A 1qzfA-2w3wA:
12.8		 1qzfA-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.63A 1qzfB-2w3wA:
20.8		 1qzfB-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.63A 1qzfC-2w3wA:
13.4		 1qzfC-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.64A 1qzfD-2w3wA:
12.8		 1qzfD-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.65A 1qzfE-2w3wA:
12.8		 1qzfE-2w3wA:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.35A 1ra2A-2w3wA:
23.6		 1ra2A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
PHE A  35
LYS A  36
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.68A 1ra2A-2w3wA:
23.6		 1ra2A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.51A 1ra3A-2w3wA:
23.5		 1ra3A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.32A 1ra8A-2w3wA:
23.5		 1ra8A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		3 / 3 ASP A  31
LYS A  36
ARG A  64
 VG9  A1168 (-3.0A)
VG9  A1168 ( 4.9A)
VG9  A1168 ( 3.7A)
 0.96A 1ra8A-2w3wA:
23.5		 1ra8A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.35A 1rb2A-2w3wA:
23.6		 1rb2A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.55A 1rb2B-2w3wA:
23.7		 1rb2B-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.41A 1rb2B-2w3wA:
23.7		 1rb2B-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
PHE A  35
LYS A  36
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.74A 1rb2B-2w3wA:
23.7		 1rb2B-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
PHE A  35
LYS A  36
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.61A 1rb2B-2w3wA:
23.7		 1rb2B-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 ALA A  11
ASP A  31
LEU A  32
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.50A 1rb3A-2w3wA:
23.5		 1rb3A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.59A 1rb3B-2w3wA:
23.7		 1rb3B-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.36A 1rd7A-2w3wA:
23.2		 1rd7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.14A 1rd7A-2w3wA:
23.2		 1rd7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.46A 1rd7B-2w3wA:
23.2		 1rd7B-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.44A 1re7A-2w3wA:
23.3		 1re7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 PHE A  35
LYS A  36
THR A  50
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.2A)
None
 0.97A 1re7A-2w3wA:
23.3		 1re7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
PRO A  62
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.46A 1re7B-2w3wA:
23.1		 1re7B-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.67A 1rg7A-2w3wA:
22.0		 1rg7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
THR A  50
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.77A 1rg7A-2w3wA:
22.0		 1rg7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 LYS A  36
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 1.08A 1rg7A-2w3wA:
22.0		 1rg7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ASP A  31
LEU A  32
PHE A  35
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.69A 1rh3A-2w3wA:
24.2		 1rh3A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 1.18A 1rh3A-2w3wA:
24.2		 1rh3A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.37A 1rx2A-2w3wA:
24.9		 1rx2A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.61A 1rx3A-2w3wA:
24.7		 1rx3A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.45A 1rx7A-2w3wA:
22.7		 1rx7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 1.02A 1rx7A-2w3wA:
22.7		 1rx7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
LEU A  61
PRO A  62
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
None
None
VG9  A1168 ( 4.7A)
 0.35A 1rx8A-2w3wA:
24.4		 1rx8A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.60A 1tdrA-2w3wA:
22.9		 1tdrA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 10 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.36A 1tdrB-2w3wA:
23.5		 1tdrB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.55A 1tdrB-2w3wA:
23.5		 1tdrB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
PRO A  55
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.74A 1u70A-2w3wA:
21.2		 1u70A-2w3wA:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
SER A  53
PRO A  55
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.65A 1u72A-2w3wA:
21.8		 1u72A-2w3wA:
32.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
PHE A  35
SER A  53
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.39A 2bl9A-2w3wA:
20.8		 2bl9A-2w3wA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
PHE A  35
SER A  53
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.7A)
 0.83A 2bl9A-2w3wA:
20.8		 2bl9A-2w3wA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 11 ALA A  11
ASP A  31
PHE A  35
SER A  53
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.65A 2blaA-2w3wA:
20.3		 2blaA-2w3wA:
23.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
THR A  50
PRO A  55
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.51A 2cd2A-2w3wA:
21.0		 2cd2A-2w3wA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		10 / 12 ALA A  11
LEU A  32
PHE A  35
LYS A  36
LEU A  61
PRO A  62
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.67A 2d0kA-2w3wA:
23.0		 2d0kA-2w3wA:
35.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.54A 2d0kB-2w3wA:
23.0		 2d0kB-2w3wA:
35.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
LEU A  61
ARG A  64
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
 0.81A 2drcA-2w3wA:
23.3		 2drcA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.54A 2drcB-2w3wA:
23.7		 2drcB-2w3wA:
33.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 1.00A 2hrcA-2w3wA:
undetectable		 2hrcA-2w3wA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 1.11A 2hrcB-2w3wA:
undetectable		 2hrcB-2w3wA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.65A 2oipA-2w3wA:
21.7		 2oipA-2w3wA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.64A 2oipB-2w3wA:
19.9		 2oipB-2w3wA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.58A 2oipC-2w3wA:
21.2		 2oipC-2w3wA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.61A 2oipC-2w3wA:
21.2		 2oipC-2w3wA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.75A 2oipD-2w3wA:
22.0		 2oipD-2w3wA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.80A 2oipE-2w3wA:
20.8		 2oipE-2w3wA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 1.06A 2pnjA-2w3wA:
undetectable		 2pnjA-2w3wA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 0.86A 2po5A-2w3wA:
undetectable		 2po5A-2w3wA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 0.87A 2po7A-2w3wA:
undetectable		 2po7A-2w3wA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 0.87A 2po7B-2w3wA:
undetectable		 2po7B-2w3wA:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
LEU A  32
LEU A  61
PRO A  62
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 3.7A)
None
 0.83A 2qk8A-2w3wA:
23.6		 2qk8A-2w3wA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
PHE A  35
THR A  50
PRO A  55
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.6A)
None
VG9  A1168 ( 4.7A)
 0.50A 2w3aA-2w3wA:
21.7		 2w3aA-2w3wA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 10 ALA A  11
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.17A 2w3aB-2w3wA:
21.8		 2w3aB-2w3wA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
PHE A  35
THR A  50
PRO A  55
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.35A 2w3bA-2w3wA:
21.8		 2w3bA-2w3wA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
PRO A  55
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.39A 2w3bB-2w3wA:
21.9		 2w3bB-2w3wA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
PRO A  55
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.42A 2w3mA-2w3wA:
21.5		 2w3mA-2w3wA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.53A 2w3mB-2w3wA:
21.8		 2w3mB-2w3wA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 VAL A   9
TRP A  10
ALA A  11
ASP A  31
LEU A  32
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
None
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 1.42A 2w3vA-2w3wA:
31.6		 2w3vA-2w3wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		12 / 12 VAL A   9
TRP A  10
ALA A  11
ILE A  24
ASP A  31
LEU A  32
PHE A  35
SER A  53
LEU A  54
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
None
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.50A 2w3vA-2w3wA:
31.6		 2w3vA-2w3wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ALA A  11
ASP A  31
LEU A  32
SER A  53
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.7A)
 0.71A 2w9gA-2w3wA:
22.7		 2w9gA-2w3wA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ALA A  11
ASP A  31
LEU A  32
SER A  53
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.7A)
 0.74A 2w9hA-2w3wA:
22.5		 2w9hA-2w3wA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
ASP A  31
LEU A  32
SER A  53
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.7A)
 0.60A 2w9sA-2w3wA:
22.9		 2w9sA-2w3wA:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
ASP A  31
LEU A  32
SER A  53
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.7A)
 0.60A 2w9sB-2w3wA:
22.8		 2w9sB-2w3wA:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ALA A  11
ASP A  31
SER A  53
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.7A)
 0.63A 2w9sC-2w3wA:
22.9		 2w9sC-2w3wA:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 10 ALA A  11
ASP A  31
LEU A  32
SER A  53
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.7A)
 0.34A 2w9sD-2w3wA:
22.5		 2w9sD-2w3wA:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		4 / 8 ALA A  11
ASP A  31
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.7A)
 0.14A 2w9sE-2w3wA:
22.5		 2w9sE-2w3wA:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 10 ALA A  11
ASP A  31
LEU A  32
SER A  53
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.7A)
 0.34A 2w9sF-2w3wA:
22.4		 2w9sF-2w3wA:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
LEU A  32
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.74A 2zzaA-2w3wA:
24.8		 2zzaA-2w3wA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
LEU A  32
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.72A 2zzaB-2w3wA:
24.8		 2zzaB-2w3wA:
34.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 THR A  50
ILE A  24
ASN A  66
ALA A  11
LEU A  32
 NDP  A1169 (-3.4A)
NDP  A1169 ( 4.4A)
None
VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
 1.17A 3a50A-2w3wA:
undetectable		 3a50A-2w3wA:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 LYS A  36
PRO A  55
LEU A  61
ARG A  64
ILE A 102
TYR A 108
 VG9  A1168 ( 4.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
 1.30A 3cd2A-2w3wA:
20.5		 3cd2A-2w3wA:
32.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ASP A  31
THR A  50
SER A  53
PRO A  55
LEU A  61
PRO A  62
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 3.7A)
None
 0.75A 3cl9A-2w3wA:
20.2		 3cl9A-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ILE A  24
ASP A  31
THR A  50
SER A  53
LEU A  61
PRO A  62
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 3.7A)
None
 0.87A 3cl9A-2w3wA:
20.2		 3cl9A-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 11 VAL A   9
ALA A  11
ASP A  31
LEU A  54
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 1.44A 3clbA-2w3wA:
20.7		 3clbA-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 11 VAL A   9
ALA A  11
ILE A  24
ASP A  31
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.47A 3clbA-2w3wA:
20.7		 3clbA-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ILE A  24
ASP A  31
PHE A  35
THR A  50
SER A  53
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
 0.72A 3clbB-2w3wA:
19.2		 3clbB-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ILE A  24
THR A  50
SER A  53
PRO A  55
TYR A 108
 NDP  A1169 ( 4.4A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
None
 1.11A 3clbB-2w3wA:
19.2		 3clbB-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ILE A  24
ASP A  31
THR A  50
PRO A  55
LEU A  61
ILE A 102
TYR A 108
 NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.72A 3clbC-2w3wA:
20.6		 3clbC-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  54
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 1.49A 3clbC-2w3wA:
20.6		 3clbC-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 VAL A   9
ALA A  11
ILE A  24
ASP A  31
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.46A 3clbC-2w3wA:
20.6		 3clbC-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ILE A  24
ASP A  31
PRO A  55
ILE A 102
TYR A 108
 NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.2A)
None
 0.76A 3clbD-2w3wA:
20.5		 3clbD-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 VAL A   9
ALA A  11
ILE A  24
ASP A  31
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.45A 3clbD-2w3wA:
20.5		 3clbD-2w3wA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
LEU A  32
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.93A 3datA-2w3wA:
23.7		 3datA-2w3wA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
LEU A  32
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 3.7A)
None
 0.57A 3dauA-2w3wA:
24.7		 3dauA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  61
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
None
 0.52A 3dauA-2w3wA:
24.7		 3dauA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.73A 3dfrA-2w3wA:
22.9		 3dfrA-2w3wA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
PRO A  55
LEU A  61
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.7A)
 0.79A 3dfrA-2w3wA:
22.9		 3dfrA-2w3wA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
 0.54A 3drcA-2w3wA:
23.3		 3drcA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
ARG A  64
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
 0.82A 3drcA-2w3wA:
23.3		 3drcA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.53A 3drcB-2w3wA:
23.7		 3drcB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
PRO A  55
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.76A 3eigA-2w3wA:
21.2		 3eigA-2w3wA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
SER A  53
PRO A  55
LEU A  61
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
 0.67A 3eigA-2w3wA:
21.2		 3eigA-2w3wA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
ASP A  31
LEU A  32
SER A  53
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.7A)
 0.76A 3frbX-2w3wA:
22.6		 3frbX-2w3wA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 9 ALA A  11
ASP A  31
LEU A  32
SER A  53
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.7A)
 0.83A 3freX-2w3wA:
22.6		 3freX-2w3wA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ASP A  31
PRO A  55
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.0A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.79A 3hbbA-2w3wA:
20.8		 3hbbA-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 VAL A   9
ALA A  11
ILE A  24
ASP A  31
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.49A 3hbbA-2w3wA:
20.8		 3hbbA-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 9 ALA A  11
ILE A  24
ASP A  31
THR A  50
SER A  53
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
 0.79A 3hbbB-2w3wA:
19.3		 3hbbB-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 9 VAL A   9
ALA A  11
ASP A  31
THR A  50
SER A  53
ILE A 102
TYR A 108
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
 0.64A 3hbbB-2w3wA:
19.3		 3hbbB-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 11 ILE A  24
ASP A  31
PRO A  55
LEU A  61
TYR A 108
 NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
 0.81A 3hbbC-2w3wA:
20.6		 3hbbC-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 11 VAL A   9
ALA A  11
ASP A  31
LEU A  54
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 1.45A 3hbbC-2w3wA:
20.6		 3hbbC-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 11 VAL A   9
ALA A  11
ILE A  24
ASP A  31
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.45A 3hbbC-2w3wA:
20.6		 3hbbC-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ILE A  24
ASP A  31
PRO A  55
ILE A 102
TYR A 108
 NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.2A)
None
 0.74A 3hbbD-2w3wA:
20.7		 3hbbD-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 VAL A   9
ALA A  11
ILE A  24
ASP A  31
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.44A 3hbbD-2w3wA:
20.7		 3hbbD-2w3wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.68A 3hj3A-2w3wA:
22.1		 3hj3A-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.69A 3hj3B-2w3wA:
22.3		 3hj3B-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		10 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.69A 3hj3C-2w3wA:
20.5		 3hj3C-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
ARG A  64
TYR A 108
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 3.7A)
None
 0.71A 3hj3D-2w3wA:
17.7		 3hj3D-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
 0.89A 3hj3D-2w3wA:
17.7		 3hj3D-2w3wA:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
LEU A  32
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.99A 3ia4A-2w3wA:
24.5		 3ia4A-2w3wA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
LEU A  32
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.99A 3ia4B-2w3wA:
24.6		 3ia4B-2w3wA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.86A 3ia4C-2w3wA:
24.5		 3ia4C-2w3wA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
SER A  53
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.87A 3ia4D-2w3wA:
24.6		 3ia4D-2w3wA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 TRP A  10
ALA A  11
LEU A  32
LEU A  61
ARG A  64
THR A 121
 None
VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.81A 3ix9A-2w3wA:
22.9		 3ix9A-2w3wA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
LEU A  32
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.85A 3ix9B-2w3wA:
22.5		 3ix9B-2w3wA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ALA A  11
LEU A  32
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.55A 3jw3A-2w3wA:
23.9		 3jw3A-2w3wA:
32.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.67A 3k2hA-2w3wA:
21.9		 3k2hA-2w3wA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ILE A  24
ASP A  31
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.73A 3k2hB-2w3wA:
21.0		 3k2hB-2w3wA:
15.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.27A 3n0hA-2w3wA:
21.6		 3n0hA-2w3wA:
32.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
THR A  50
PRO A  55
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.7A)
 0.48A 3nrrA-2w3wA:
21.2		 3nrrA-2w3wA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
THR A  50
PRO A  55
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.7A)
 0.52A 3nrrB-2w3wA:
22.1		 3nrrB-2w3wA:
15.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 1.01A 3qfxA-2w3wA:
20.2		 3qfxA-2w3wA:
31.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		11 / 12 VAL A   9
ALA A  11
ILE A  24
ASP A  31
PHE A  35
THR A  50
SER A  53
LEU A  54
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.53A 3qfxA-2w3wA:
20.2		 3qfxA-2w3wA:
31.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 1.34A 3qfxB-2w3wA:
20.1		 3qfxB-2w3wA:
31.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		11 / 12 VAL A   9
ALA A  11
ILE A  24
ASP A  31
PHE A  35
THR A  50
SER A  53
LEU A  54
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.52A 3qfxB-2w3wA:
20.1		 3qfxB-2w3wA:
31.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 10 ALA A  11
ASP A  31
PHE A  35
SER A  53
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.7A)
 0.39A 3qg2A-2w3wA:
20.7		 3qg2A-2w3wA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
ASP A  31
PHE A  35
SER A  53
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
None
VG9  A1168 ( 4.7A)
 0.36A 3qg2B-2w3wA:
20.6		 3qg2B-2w3wA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 ALA A  11
ASP A  31
PHE A  35
SER A  53
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.38A 3qgtA-2w3wA:
20.7		 3qgtA-2w3wA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ALA A  11
ASP A  31
PHE A  35
SER A  53
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.7A)
 0.86A 3qgtA-2w3wA:
20.7		 3qgtA-2w3wA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 ALA A  11
ASP A  31
PHE A  35
SER A  53
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.34A 3qgtB-2w3wA:
20.5		 3qgtB-2w3wA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 ALA A  11
ASP A  31
PHE A  35
SER A  53
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.7A)
 0.87A 3qgtB-2w3wA:
20.5		 3qgtB-2w3wA:
13.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.47A 3ql0A-2w3wA:
24.7		 3ql0A-2w3wA:
33.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.46A 3ql3A-2w3wA:
24.8		 3ql3A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.28A 3s3vA-2w3wA:
21.5		 3s3vA-2w3wA:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 9 ALA A  11
ASP A  31
PHE A  35
SER A  53
ILE A 102
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
VG9  A1168 ( 4.7A)
 0.55A 3tq8A-2w3wA:
24.2		 3tq8A-2w3wA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
LEU A  61
ARG A  64
ILE A 102
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
VG9  A1168 ( 4.7A)
 0.71A 3tq9A-2w3wA:
24.1		 3tq9A-2w3wA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 11 ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
ILE A 102
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
VG9  A1168 ( 4.7A)
 0.55A 3tqbA-2w3wA:
23.6		 3tqbA-2w3wA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 ASP A  31
PHE A  35
THR A  50
SER A  53
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.30A 3um5A-2w3wA:
20.7		 3um5A-2w3wA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 ASP A  31
PHE A  35
THR A  50
SER A  53
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.37A 3um5B-2w3wA:
20.3		 3um5B-2w3wA:
13.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.55A 4cd2A-2w3wA:
19.6		 4cd2A-2w3wA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.30A 4cd2A-2w3wA:
19.6		 4cd2A-2w3wA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.63A 4dfrA-2w3wA:
23.1		 4dfrA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
THR A  50
SER A  53
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 3.7A)
None
 0.89A 4dfrA-2w3wA:
23.1		 4dfrA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.51A 4dfrB-2w3wA:
23.7		 4dfrB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.45A 4dfrB-2w3wA:
23.7		 4dfrB-2w3wA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 VAL A   9
ALA A  11
PHE A  35
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.88A 4eckA-2w3wA:
19.9		 4eckA-2w3wA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
PHE A  35
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.89A 4eckB-2w3wA:
19.4		 4eckB-2w3wA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 VAL A   9
ALA A  11
ASP A  31
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.61A 4eilA-2w3wA:
21.1		 4eilA-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 10 VAL A   9
ALA A  11
ASP A  31
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.66A 4eilB-2w3wA:
21.4		 4eilB-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 VAL A   9
ALA A  11
ASP A  31
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.59A 4eilC-2w3wA:
21.1		 4eilC-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 VAL A   9
ALA A  11
ASP A  31
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.60A 4eilD-2w3wA:
20.6		 4eilD-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 VAL A   9
ALA A  11
ASP A  31
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.58A 4eilE-2w3wA:
21.7		 4eilE-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 9 ALA A  11
ASP A  31
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.67A 4eilF-2w3wA:
20.6		 4eilF-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 VAL A   9
ALA A  11
ASP A  31
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.60A 4eilG-2w3wA:
21.1		 4eilG-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 VAL A   9
ALA A  11
ASP A  31
LEU A  61
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.7A)
 0.33A 4eilG-2w3wA:
21.1		 4eilG-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 9 VAL A   9
ALA A  11
ASP A  31
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.65A 4eilH-2w3wA:
13.8		 4eilH-2w3wA:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.31A 4ej1A-2w3wA:
23.2		 4ej1A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.06A 4ej1A-2w3wA:
23.2		 4ej1A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.38A 4ej1B-2w3wA:
23.1		 4ej1B-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.54A 4fhbA-2w3wA:
23.6		 4fhbA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ARG A  64
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
 1.16A 4fhbA-2w3wA:
23.6		 4fhbA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 ALA A  11
PHE A  35
SER A  53
PRO A  55
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.81A 4g8zX-2w3wA:
21.2		 4g8zX-2w3wA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
PRO A  55
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 0.60A 4gh8A-2w3wA:
25.7		 4gh8A-2w3wA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
PRO A  55
ARG A  64
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 3.7A)
None
 0.61A 4gh8B-2w3wA:
25.4		 4gh8B-2w3wA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.36A 4i13A-2w3wA:
23.1		 4i13A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.05A 4i13A-2w3wA:
23.1		 4i13A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		3 / 3 ASP A  31
ARG A  64
THR A 121
 VG9  A1168 (-3.0A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.65A 4i13A-2w3wA:
23.1		 4i13A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.41A 4i1nA-2w3wA:
23.2		 4i1nA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 11 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.58A 4i1nA-2w3wA:
23.2		 4i1nA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 11 PHE A  35
LYS A  36
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 1.40A 4i1nA-2w3wA:
23.2		 4i1nA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.23A 4kebB-2w3wA:
21.8		 4kebB-2w3wA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
PRO A  55
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.36A 4kfjB-2w3wA:
21.9		 4kfjB-2w3wA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.23A 4kjjA-2w3wA:
24.2		 4kjjA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.94A 4kjjA-2w3wA:
24.2		 4kjjA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		4 / 4 ASP A  31
LEU A  32
ARG A  64
THR A 121
 VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.60A 4kjjA-2w3wA:
24.2		 4kjjA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.19A 4kjkA-2w3wA:
24.9		 4kjkA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.15A 4kjkA-2w3wA:
24.9		 4kjkA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		4 / 4 ASP A  31
LEU A  32
ARG A  64
THR A 121
 VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.59A 4kjkA-2w3wA:
24.9		 4kjkA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
PHE A  35
ARG A  59
LEU A  61
ILE A 102
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
None
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
VG9  A1168 ( 4.7A)
 1.27A 4kjlA-2w3wA:
24.5		 4kjlA-2w3wA:
33.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.22A 4kjlA-2w3wA:
24.5		 4kjlA-2w3wA:
33.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.10A 4kjlA-2w3wA:
24.5		 4kjlA-2w3wA:
33.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 10 TRP A  10
ALA A  11
ASP A  31
LEU A  61
TYR A 108
THR A 121
 None
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 1.07A 4km0A-2w3wA:
26.6		 4km0A-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 10 TRP A  10
ALA A  11
ASP A  31
PHE A  35
THR A  50
LEU A  54
ILE A 102
TYR A 108
THR A 121
 None
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.61A 4km0A-2w3wA:
26.6		 4km0A-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 TRP A  10
ALA A  11
ASP A  31
LEU A  61
TYR A 108
THR A 121
 None
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 1.07A 4km0B-2w3wA:
26.8		 4km0B-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 TRP A  10
ALA A  11
ASP A  31
PHE A  35
THR A  50
LEU A  54
ILE A 102
TYR A 108
THR A 121
 None
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.57A 4km0B-2w3wA:
26.8		 4km0B-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 TRP A  10
ALA A  11
ILE A  24
ASP A  31
PHE A  35
THR A  50
ILE A 102
TYR A 108
THR A 121
 None
VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.63A 4km0B-2w3wA:
26.8		 4km0B-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
None
None
VG9  A1168 ( 4.7A)
 1.05A 4km2A-2w3wA:
26.9		 4km2A-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.43A 4km2A-2w3wA:
26.9		 4km2A-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
THR A  50
VAL A  58
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
None
VG9  A1168 ( 4.2A)
None
 0.68A 4km2A-2w3wA:
26.9		 4km2A-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ILE A  24
ASP A  31
PHE A  35
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.47A 4km2A-2w3wA:
26.9		 4km2A-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ILE A  24
ASP A  31
VAL A  58
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.2A)
None
 0.67A 4km2A-2w3wA:
26.9		 4km2A-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ASP A  31
THR A  50
LEU A  54
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
None
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.70A 4km2A-2w3wA:
26.9		 4km2A-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ASP A  31
THR A  50
LEU A  54
VAL A  58
ILE A 102
TYR A 108
 VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
None
None
VG9  A1168 ( 4.2A)
None
 0.73A 4km2A-2w3wA:
26.9		 4km2A-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  54
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 1.47A 4km2B-2w3wA:
26.4		 4km2B-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ILE A  24
ASP A  31
PHE A  35
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.45A 4km2B-2w3wA:
26.4		 4km2B-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ILE A  24
PHE A  35
VAL A  58
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.9A)
None
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.87A 4km2B-2w3wA:
26.4		 4km2B-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ASP A  31
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.54A 4km2B-2w3wA:
26.4		 4km2B-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
THR A  50
VAL A  58
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
None
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.68A 4km2B-2w3wA:
26.4		 4km2B-2w3wA:
63.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 THR A  50
LEU A  54
VAL A  58
LEU A  61
ILE A 102
TYR A 108
 NDP  A1169 (-3.4A)
None
None
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.50A 4km2B-2w3wA:
26.4		 4km2B-2w3wA:
63.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.69A 4ky8A-2w3wA:
14.8		 4ky8A-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
SER A  53
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.73A 4ky8A-2w3wA:
14.8		 4ky8A-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
SER A  53
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.85A 4ky8B-2w3wA:
15.9		 4ky8B-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.70A 4ky8C-2w3wA:
21.9		 4ky8C-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
SER A  53
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.85A 4ky8C-2w3wA:
21.9		 4ky8C-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.69A 4ky8D-2w3wA:
18.4		 4ky8D-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
SER A  53
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.75A 4ky8D-2w3wA:
18.4		 4ky8D-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.75A 4ky8E-2w3wA:
21.9		 4ky8E-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 VAL A   9
ALA A  11
ASP A  31
SER A  53
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.81A 4ky8E-2w3wA:
21.9		 4ky8E-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 VAL A   9
ALA A  11
ASP A  31
THR A  50
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.60A 4kyaA-2w3wA:
21.0		 4kyaA-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 VAL A   9
ALA A  11
ASP A  31
THR A  50
LEU A  61
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.7A)
 0.37A 4kyaA-2w3wA:
21.0		 4kyaA-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  54
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.7A)
 1.19A 4kyaB-2w3wA:
21.3		 4kyaB-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.68A 4kyaB-2w3wA:
21.3		 4kyaB-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 VAL A   9
ALA A  11
ASP A  31
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.62A 4kyaC-2w3wA:
15.3		 4kyaC-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 10 VAL A   9
ALA A  11
ASP A  31
LEU A  61
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.7A)
 0.37A 4kyaC-2w3wA:
15.3		 4kyaC-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.69A 4kyaD-2w3wA:
13.9		 4kyaD-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 VAL A   9
ALA A  11
ASP A  31
THR A  50
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.60A 4kyaE-2w3wA:
21.0		 4kyaE-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 VAL A   9
ALA A  11
ASP A  31
THR A  50
LEU A  61
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.7A)
 0.38A 4kyaE-2w3wA:
21.0		 4kyaE-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 VAL A   9
ALA A  11
ASP A  31
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.72A 4kyaF-2w3wA:
13.8		 4kyaF-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  61
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.7A)
 0.41A 4kyaF-2w3wA:
13.8		 4kyaF-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 VAL A   9
ALA A  11
ASP A  31
THR A  50
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.61A 4kyaG-2w3wA:
21.0		 4kyaG-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 VAL A   9
ALA A  11
ASP A  31
THR A  50
LEU A  61
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.7A)
 0.37A 4kyaG-2w3wA:
21.0		 4kyaG-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  61
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.68A 4kyaH-2w3wA:
20.5		 4kyaH-2w3wA:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ILE A  24
ASP A  31
PHE A  35
LEU A  54
PRO A  55
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
None
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.33A 4m2xA-2w3wA:
28.2		 4m2xA-2w3wA:
68.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ASP A  23
ILE A  24
PHE A  35
LEU A  54
PRO A  55
LEU A  61
ILE A 102
TYR A 108
 None
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.9A)
None
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.69A 4m2xA-2w3wA:
28.2		 4m2xA-2w3wA:
68.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ILE A  24
ASP A  31
LEU A  54
PRO A  55
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.34A 4m2xC-2w3wA:
10.4		 4m2xC-2w3wA:
68.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ILE A  24
ASP A  31
LEU A  54
PRO A  55
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.35A 4m2xE-2w3wA:
10.5		 4m2xE-2w3wA:
68.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ASP A  23
ILE A  24
LEU A  54
PRO A  55
LEU A  61
ILE A 102
TYR A 108
 None
NDP  A1169 ( 4.4A)
None
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.76A 4m2xE-2w3wA:
10.5		 4m2xE-2w3wA:
68.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ILE A  24
ASP A  31
LEU A  54
PRO A  55
VAL A  58
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
NDP  A1169 ( 4.4A)
VG9  A1168 (-3.0A)
None
VG9  A1168 ( 4.6A)
None
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.38A 4m2xG-2w3wA:
10.2		 4m2xG-2w3wA:
68.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
PHE A  35
THR A  50
PRO A  55
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.6A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.30A 4m6kA-2w3wA:
22.2		 4m6kA-2w3wA:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.33A 4nx6A-2w3wA:
24.9		 4nx6A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.34A 4nx6A-2w3wA:
24.9		 4nx6A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.34A 4nx7A-2w3wA:
25.1		 4nx7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.39A 4nx7A-2w3wA:
25.1		 4nx7A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
PHE A  35
THR A  50
LEU A  61
PRO A  62
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.2A)
None
 0.27A 4p3qA-2w3wA:
24.9		 4p3qA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.45A 4p3qA-2w3wA:
24.9		 4p3qA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.34A 4p3rA-2w3wA:
25.1		 4p3rA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		3 / 3 ASP A  31
ARG A  64
THR A 121
 VG9  A1168 (-3.0A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.66A 4p3rA-2w3wA:
25.1		 4p3rA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 11 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.47A 4p66A-2w3wA:
25.0		 4p66A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 11 ASP A  31
PHE A  35
SER A  53
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.47A 4p68A-2w3wA:
24.7		 4p68A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 PHE A  35
LYS A  36
SER A  53
ARG A  64
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
 1.04A 4p68A-2w3wA:
24.7		 4p68A-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 0.41A 4pssA-2w3wA:
undetectable		 4pssA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.36A 4pstA-2w3wA:
undetectable		 4pstA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
LEU A  32
PHE A  35
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.31A 4psyA-2w3wA:
25.0		 4psyA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
THR A  50
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.48A 4pthA-2w3wA:
24.8		 4pthA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		3 / 3 ASP A  31
LEU A  32
PHE A  35
 VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
 0.26A 4pthA-2w3wA:
24.8		 4pthA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.44A 4ptjA-2w3wA:
24.9		 4ptjA-2w3wA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.68A 4q0dA-2w3wA:
21.8		 4q0dA-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.68A 4q0dB-2w3wA:
21.8		 4q0dB-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
VG9  A1168 ( 4.7A)
 1.28A 4q0dC-2w3wA:
21.8		 4q0dC-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.70A 4q0dC-2w3wA:
21.8		 4q0dC-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.77A 4q0dC-2w3wA:
21.8		 4q0dC-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
VG9  A1168 ( 4.7A)
 1.28A 4q0dD-2w3wA:
21.8		 4q0dD-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.71A 4q0dD-2w3wA:
21.8		 4q0dD-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.77A 4q0dD-2w3wA:
21.8		 4q0dD-2w3wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 VAL A   9
ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.68A 4q0dE-2w3wA:
21.9		 4q0dE-2w3wA:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.64A 4qi9A-2w3wA:
21.8		 4qi9A-2w3wA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.45A 4qi9B-2w3wA:
22.4		 4qi9B-2w3wA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.68A 4qi9B-2w3wA:
22.4		 4qi9B-2w3wA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 11 ALA A  11
ASP A  31
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
None
None
VG9  A1168 ( 4.7A)
 1.17A 4qi9C-2w3wA:
21.8		 4qi9C-2w3wA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 11 ALA A  11
ASP A  31
SER A  53
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.70A 4qi9C-2w3wA:
21.8		 4qi9C-2w3wA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.39A 4qleA-2w3wA:
24.1		 4qleA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.31A 4qleA-2w3wA:
24.1		 4qleA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
 1.04A 4qleA-2w3wA:
24.1		 4qleA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.42A 4qleB-2w3wA:
24.0		 4qleB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 11 ALA A  11
ASP A  31
LEU A  32
SER A  53
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.70A 4qleB-2w3wA:
24.0		 4qleB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 11 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.45A 4qlfA-2w3wA:
21.2		 4qlfA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 11 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.52A 4qlfA-2w3wA:
21.2		 4qlfA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.36A 4qlgA-2w3wA:
24.1		 4qlgA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.49A 4qlgA-2w3wA:
24.1		 4qlgA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.42A 4qlgB-2w3wA:
23.6		 4qlgB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.53A 4qlgB-2w3wA:
23.6		 4qlgB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 1.27A 4qlgB-2w3wA:
23.6		 4qlgB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.38A 4rgcA-2w3wA:
25.0		 4rgcA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.54A 4rgcA-2w3wA:
25.0		 4rgcA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.46A 4x5fA-2w3wA:
23.5		 4x5fA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
PHE A  35
LYS A  36
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.68A 4x5fA-2w3wA:
23.5		 4x5fA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.46A 4x5fB-2w3wA:
23.9		 4x5fB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
PHE A  35
LYS A  36
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.97A 4x5fB-2w3wA:
23.9		 4x5fB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.36A 4x5gA-2w3wA:
23.8		 4x5gA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		9 / 12 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LYS A  36
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.55A 4x5gA-2w3wA:
23.8		 4x5gA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
THR A  50
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.50A 4x5gB-2w3wA:
24.3		 4x5gB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LYS A  36
THR A  50
LEU A  61
ARG A  64
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.95A 4x5gB-2w3wA:
24.3		 4x5gB-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.33A 4x5hA-2w3wA:
23.9		 4x5hA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
PHE A  35
LYS A  36
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.80A 4x5hA-2w3wA:
23.9		 4x5hA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.35A 4x5iA-2w3wA:
23.9		 4x5iA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.69A 4x5iA-2w3wA:
23.9		 4x5iA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.33A 4x5jA-2w3wA:
23.9		 4x5jA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
PHE A  35
LYS A  36
THR A  50
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.77A 4x5jA-2w3wA:
23.9		 4x5jA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.45A 5e8qA-2w3wA:
23.5		 5e8qA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 PHE A  35
LYS A  36
THR A  50
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.2A)
None
 1.05A 5e8qA-2w3wA:
23.5		 5e8qA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		3 / 3 ASP A  31
LEU A  61
ARG A  64
 VG9  A1168 (-3.0A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
 0.70A 5e8qA-2w3wA:
23.5		 5e8qA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
VG9  A1168 ( 4.7A)
 0.47A 5e8qB-2w3wA:
23.8		 5e8qB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
 1.16A 5e8qB-2w3wA:
23.8		 5e8qB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.46A 5eajA-2w3wA:
23.5		 5eajA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.02A 5eajA-2w3wA:
23.5		 5eajA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
PRO A  62
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
None
VG9  A1168 ( 4.7A)
 0.49A 5eajB-2w3wA:
23.8		 5eajB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
None
 1.11A 5eajB-2w3wA:
23.8		 5eajB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
ASP A  31
LEU A  32
SER A  53
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.68A 5hi6A-2w3wA:
24.1		 5hi6A-2w3wA:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  54
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.7A)
 1.46A 5hi6B-2w3wA:
23.9		 5hi6B-2w3wA:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
LEU A  32
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.54A 5hi6B-2w3wA:
23.9		 5hi6B-2w3wA:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
ASP A  31
SER A  53
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
NDP  A1169 ( 3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.89A 5hi6B-2w3wA:
23.9		 5hi6B-2w3wA:
34.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 8 ALA A  11
ASP A  31
LEU A  32
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.39A 5uihA-2w3wA:
23.2		 5uihA-2w3wA:
26.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.48A 5ujxA-2w3wA:
23.5		 5ujxA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.05A 5ujxA-2w3wA:
23.5		 5ujxA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.55A 5ujxB-2w3wA:
23.8		 5ujxB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ARG A  64
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 3.7A)
None
 1.25A 5ujxB-2w3wA:
23.8		 5ujxB-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
ARG A  64
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 3.7A)
None
VG9  A1168 ( 4.7A)
 0.40A 5z6fA-2w3wA:
24.9		 5z6fA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 12 PHE A  35
LYS A  36
THR A  50
ARG A  64
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 3.7A)
None
 1.28A 5z6fA-2w3wA:
24.9		 5z6fA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.40A 5z6jA-2w3wA:
25.3		 5z6jA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.05A 5z6jA-2w3wA:
25.3		 5z6jA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 12 ALA A  11
LEU A  32
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.42A 5z6kA-2w3wA:
25.4		 5z6kA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.02A 5z6kA-2w3wA:
25.4		 5z6kA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		5 / 9 ALA A  11
ASP A  31
LEU A  32
PRO A  62
ARG A  64
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
None
VG9  A1168 ( 3.7A)
 0.60A 5z6lA-2w3wA:
25.5		 5z6lA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		8 / 11 ALA A  11
ASP A  31
LEU A  32
PHE A  35
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 (-3.9A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.83A 5z6mA-2w3wA:
24.9		 5z6mA-2w3wA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 VAL A   9
ALA A  11
ASP A  31
PHE A  35
THR A  50
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
None
VG9  A1168 ( 4.7A)
 0.30A 6aogA-2w3wA:
21.2		 6aogA-2w3wA:
33.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 10 VAL A   9
ALA A  11
ASP A  31
PHE A  35
THR A  50
TYR A 108
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
None
VG9  A1168 ( 4.7A)
 0.31A 6aogB-2w3wA:
20.9		 6aogB-2w3wA:
33.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		7 / 12 ALA A  11
PHE A  35
THR A  50
LEU A  61
ILE A 102
TYR A 108
THR A 121
 VG9  A1168 ( 3.8A)
VG9  A1168 (-3.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
 0.33A 7dfrA-2w3wA:
24.5		 7dfrA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		6 / 12 PHE A  35
LYS A  36
THR A  50
LEU A  61
ILE A 102
TYR A 108
 VG9  A1168 (-3.9A)
VG9  A1168 ( 4.9A)
NDP  A1169 (-3.4A)
VG9  A1168 ( 4.4A)
VG9  A1168 ( 4.2A)
None
 1.04A 7dfrA-2w3wA:
24.5		 7dfrA-2w3wA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2w3w DIHYDROFOLATE
REDUCTASE
(Mycobacterium
avium) 		3 / 3 ASP A  31
LEU A  32
ARG A  64
 VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 3.7A)
 0.50A 7dfrA-2w3wA:
24.5		 7dfrA-2w3wA:
34.50