SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VDY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 5ieo CDL2.3A
(synthetic
construct) 		5 / 10 ILE A  37
GLU A 106
PHE A  68
ILE A 100
LEU A  58
 VDY  A 206 ( 3.9A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.1A)
VDY  A 206 (-2.9A)
VDY  A 206 ( 4.7A)
 1.18A 2w3aB-5ieoA:
undetectable		 2w3aB-5ieoA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_A_VDYA201_1
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		5 / 12 LEU A  12
PHE A  15
LEU A  54
GLU A 106
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 ( 3.9A)
VDY  A 206 (-2.4A)
VDY  A 206 ( 3.1A)
 1.29A 5ienA-5ieoA:
22.8		 5ienA-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_A_VDYA201_1
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		8 / 12 LEU A  12
PHE A  15
MET A  42
MET A  61
ILE A 100
GLU A 106
THR A 121
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.1A)
VDY  A 206 (-2.9A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.4A)
VDY  A 206 ( 3.1A)
 0.85A 5ienA-5ieoA:
22.8		 5ienA-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_A_VDYA201_1
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		9 / 12 LEU A  12
PHE A  15
MET A  42
TRP A  55
LEU A  58
MET A  61
GLU A 106
THR A 121
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 4.4A)
VDY  A 206 ( 4.7A)
VDY  A 206 ( 3.1A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.4A)
VDY  A 206 ( 3.1A)
 0.38A 5ienA-5ieoA:
22.8		 5ienA-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_A_VDYA201_2
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		6 / 12 ILE A  37
PRO A  39
LEU A  54
VAL A  63
LEU A  88
TYR A 104
 VDY  A 206 ( 3.9A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.9A)
None
VDY  A 206 (-4.6A)
VDY  A 206 ( 2.8A)
 0.67A 5ienA-5ieoA:
22.8		 5ienA-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_A_VDYA201_2
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		8 / 12 TYR A  31
ILE A  37
PRO A  39
LEU A  54
VAL A  63
GLY A  90
TYR A 104
LEU A 118
 None
VDY  A 206 ( 3.9A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.9A)
None
None
VDY  A 206 ( 2.8A)
VDY  A 206 ( 4.4A)
 0.26A 5ienA-5ieoA:
22.8		 5ienA-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_A_VDYA201_2
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		5 / 12 TYR A  31
VAL A  63
GLY A  90
PRO A  91
LEU A 118
 None
None
None
None
VDY  A 206 ( 4.4A)
 0.92A 5ienA-5ieoA:
22.8		 5ienA-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_B_VDYB201_1
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		7 / 10 ILE A  37
PRO A  39
MET A  42
LEU A  54
VAL A  63
LEU A  88
LEU A 118
 VDY  A 206 ( 3.9A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.9A)
None
VDY  A 206 (-4.6A)
VDY  A 206 ( 4.4A)
 0.68A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_B_VDYB201_1
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		7 / 10 TYR A  31
ILE A  37
PRO A  39
MET A  42
LEU A  54
VAL A  63
LEU A 118
 None
VDY  A 206 ( 3.9A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.9A)
None
VDY  A 206 ( 4.4A)
 0.25A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_B_VDYB201_1
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		5 / 10 TYR A  31
LEU A  54
VAL A  63
PRO A  91
LEU A 118
 None
VDY  A 206 ( 3.9A)
None
None
VDY  A 206 ( 4.4A)
 0.90A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_B_VDYB201_2
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		7 / 12 LEU A  12
PHE A  15
ILE A 100
TYR A 104
GLU A 106
THR A 121
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 (-2.9A)
VDY  A 206 ( 2.8A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.4A)
VDY  A 206 ( 3.1A)
 0.71A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_B_VDYB201_2
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		7 / 12 LEU A  12
PHE A  15
LEU A  54
ILE A 100
TYR A 104
GLU A 106
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 ( 3.9A)
VDY  A 206 (-2.9A)
VDY  A 206 ( 2.8A)
VDY  A 206 (-2.4A)
VDY  A 206 ( 3.1A)
 1.34A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEN_B_VDYB201_2
(CDL2.2)		 5ieo CDL2.3A
(synthetic
construct) 		9 / 12 LEU A  12
PHE A  15
TRP A  55
LEU A  58
MET A  61
TYR A 104
GLU A 106
THR A 121
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
VDY  A 206 ( 4.4A)
VDY  A 206 ( 4.7A)
VDY  A 206 ( 3.1A)
VDY  A 206 ( 2.8A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.4A)
VDY  A 206 ( 3.1A)
 0.42A 5ienB-5ieoA:
22.7		 5ienB-5ieoA:
91.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEP_A_VDYA201_1
(CDL2.3B)		 5ieo CDL2.3A
(synthetic
construct) 		11 / 12 LEU A  12
PHE A  15
TYR A  31
LEU A  54
TRP A  55
LEU A  58
PHE A  68
PHE A  86
GLU A 106
THR A 121
ALA A 123
 VDY  A 206 ( 4.3A)
VDY  A 206 (-3.5A)
None
VDY  A 206 ( 3.9A)
VDY  A 206 ( 4.4A)
VDY  A 206 ( 4.7A)
VDY  A 206 (-3.1A)
VDY  A 206 ( 3.0A)
VDY  A 206 (-2.4A)
VDY  A 206 (-3.4A)
VDY  A 206 ( 3.1A)
 0.12A 5iepA-5ieoA:
24.9		 5iepA-5ieoA:
94.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEP_A_VDYA201_2
(CDL2.3B)		 5ieo CDL2.3A
(synthetic
construct) 		9 / 9 ILE A  37
PRO A  39
MET A  42
MET A  61
VAL A  63
LEU A  88
ILE A 100
TYR A 104
LEU A 118
 VDY  A 206 ( 3.9A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.5A)
VDY  A 206 ( 3.1A)
None
VDY  A 206 (-4.6A)
VDY  A 206 (-2.9A)
VDY  A 206 ( 2.8A)
VDY  A 206 ( 4.4A)
 0.38A 5iepA-5ieoA:
24.9		 5iepA-5ieoA:
94.16