SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VDN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 8 PHE A 820
HIS A 653
THR A 621
HIS A 617
 VDN  A   1 (-3.6A)
None
None
None
 0.97A 1bzmA-3b2rA:
undetectable		 1bzmA-3b2rA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 5 THR A 723
ASP A 654
HIS A 613
HIS A 684
 None
None
VDN  A   1 (-4.3A)
None
 0.99A 1ei6A-3b2rA:
undetectable		 1ei6A-3b2rA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		8 / 9 TYR A 612
LEU A 725
LEU A 765
VAL A 782
ALA A 783
MET A 816
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.36A 1tbfA-3b2rA:
45.7		 1tbfA-3b2rA:
94.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		9 / 12 TYR A 612
HIS A 613
ALA A 767
ILE A 768
VAL A 782
ALA A 783
MET A 816
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.36A 1udtA-3b2rA:
46.1		 1udtA-3b2rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		9 / 11 TYR A 612
ILE A 778
VAL A 782
ALA A 783
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
None
VDN  A   1 ( 4.2A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.74A 1uduA-3b2rA:
43.4		 1uduA-3b2rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		11 / 12 TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
ALA A 783
PHE A 786
MET A 816
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.4A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
None
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.60A 1uduB-3b2rA:
43.4		 1uduB-3b2rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		8 / 10 TYR A 612
HIS A 613
ALA A 783
PHE A 786
MET A 816
GLN A 817
GLY A 819
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 4.0A)
None
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 ( 4.1A)
VDN  A   1 (-3.6A)
 0.42A 1uhoA-3b2rA:
46.0		 1uhoA-3b2rA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 613
HIS A 657
LEU A 765
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.96A 1xlxA-3b2rA:
30.9		 1xlxA-3b2rA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 613
HIS A 657
PHE A 786
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.84A 1xlxB-3b2rA:
30.8		 1xlxB-3b2rA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
None
VDN  A   1 (-3.6A)
 0.77A 1xmuA-3b2rA:
31.0		 1xmuA-3b2rA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
None
 0.73A 1xmuB-3b2rA:
31.0		 1xmuB-3b2rA:
28.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.4A)
 1.00A 1xomA-3b2rA:
31.5		 1xomA-3b2rA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		7 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.65A 1xomA-3b2rA:
31.5		 1xomA-3b2rA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 613
LEU A 765
PHE A 786
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 4.7A)
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.68A 1xomB-3b2rA:
31.6		 1xomB-3b2rA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.6A)
 0.67A 1xoqA-3b2rA:
31.6		 1xoqA-3b2rA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.6A)
 0.68A 1xoqB-3b2rA:
31.7		 1xoqB-3b2rA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.4A)
 0.94A 1xosA-3b2rA:
31.1		 1xosA-3b2rA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		8 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
GLN A 817
PHE A 820
ILE A 824
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
None
 0.65A 1xosA-3b2rA:
31.1		 1xosA-3b2rA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 TYR A 612
HIS A 613
LEU A 765
GLN A 817
PHE A 820
ILE A 824
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
None
 0.58A 1xotA-3b2rA:
31.0		 1xotA-3b2rA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
LEU A 765
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.59A 1xotB-3b2rA:
31.1		 1xotB-3b2rA:
28.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		11 / 12 TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.4A)
None
VDN  A   1 ( 4.7A)
None
VDN  A   1 ( 4.2A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.53A 1xozA-3b2rA:
45.7		 1xozA-3b2rA:
94.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		9 / 10 TYR A 612
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ALA A 783
MET A 816
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.28A 1xp0A-3b2rA:
45.9		 1xp0A-3b2rA:
94.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		9 / 11 TYR A 612
HIS A 613
ALA A 767
ILE A 768
VAL A 782
PHE A 786
ILE A 813
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.7A)
None
VDN  A   1 ( 4.2A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.47A 2h42A-3b2rA:
46.2		 2h42A-3b2rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		10 / 12 TYR A 612
HIS A 613
ALA A 767
ILE A 768
VAL A 782
ALA A 783
ILE A 813
MET A 816
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
VDN  A   1 ( 4.2A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.36A 2h42B-3b2rA:
46.2		 2h42B-3b2rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		11 / 12 TYR A 612
LEU A 725
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ALA A 783
PHE A 786
ILE A 813
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
None
VDN  A   1 ( 4.2A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.41A 2h42C-3b2rA:
46.6		 2h42C-3b2rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		8 / 12 TYR A 612
HIS A 613
LEU A 725
LEU A 765
GLU A 785
PHE A 786
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
None
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.81A 2weyA-3b2rA:
36.5		 2weyA-3b2rA:
38.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 8 LEU A 725
PHE A 786
GLN A 817
PHE A 820
 None
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.52A 2weyB-3b2rA:
36.2		 2weyB-3b2rA:
38.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ASP A 764
LEU A 765
GLN A 775
 None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.4A)
 0.68A 3g4lA-3b2rA:
31.3		 3g4lA-3b2rA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ASP A 764
LEU A 765
GLN A 817
 None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
 0.50A 3g4lA-3b2rA:
31.3		 3g4lA-3b2rA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.6A)
 0.61A 3g4lB-3b2rA:
31.6		 3g4lB-3b2rA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.4A)
 1.02A 3g4lD-3b2rA:
31.9		 3g4lD-3b2rA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 817
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
 0.55A 3g4lD-3b2rA:
31.9		 3g4lD-3b2rA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 TYR A 612
PHE A 786
GLN A 817
PHE A 820
ILE A 824
 VDN  A   1 (-4.8A)
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
None
 0.40A 3iakA-3b2rA:
30.8		 3iakA-3b2rA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 9 TYR A 612
HIS A 613
LEU A 725
VAL A 782
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.42A 3jwqA-3b2rA:
45.0		 3jwqA-3b2rA:
93.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		7 / 11 TYR A 612
HIS A 613
LEU A 725
ALA A 767
VAL A 782
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 3.8A)
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.40A 3jwqB-3b2rA:
44.9
3jwqC-3b2rA:
44.9		 3jwqB-3b2rA:
93.33
3jwqC-3b2rA:
93.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 TYR A 612
HIS A 613
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.46A 3jwqC-3b2rA:
44.9		 3jwqC-3b2rA:
93.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		7 / 11 TYR A 612
HIS A 613
LEU A 725
ALA A 767
PHE A 786
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 3.8A)
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.52A 3jwqA-3b2rA:
45.0
3jwqD-3b2rA:
44.6		 3jwqA-3b2rA:
93.33
3jwqD-3b2rA:
93.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 TYR A 612
PHE A 786
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.53A 3tvxB-3b2rA:
31.6		 3tvxB-3b2rA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 8 GLU A 785
GLY A 659
VAL A 610
HIS A 613
HIS A 684
 None
None
None
VDN  A   1 (-4.3A)
None
 1.30A 5f8yA-3b2rA:
undetectable		 5f8yA-3b2rA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 8 GLU A 785
GLY A 659
VAL A 610
HIS A 613
HIS A 684
 None
None
None
VDN  A   1 (-4.3A)
None
 1.34A 5f8yB-3b2rA:
undetectable		 5f8yB-3b2rA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 ASP A 654
HIS A 613
HIS A 617
HIS A 684
 None
VDN  A   1 (-4.3A)
None
None
 0.80A 5ncdA-3b2rA:
undetectable
5ncdD-3b2rA:
undetectable		 5ncdA-3b2rA:
21.92
5ncdD-3b2rA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 ASP A 654
HIS A 613
HIS A 617
HIS A 684
 None
VDN  A   1 (-4.3A)
None
None
 0.81A 5ncdB-3b2rA:
undetectable
5ncdC-3b2rA:
undetectable		 5ncdB-3b2rA:
21.92
5ncdC-3b2rA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 8 ASP A 654
HIS A 613
HIS A 617
HIS A 684
 None
VDN  A   1 (-4.3A)
None
None
 0.90A 5nekB-3b2rA:
undetectable		 5nekB-3b2rA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 8 ASP A 654
HIS A 613
HIS A 617
HIS A 684
 None
VDN  A   1 (-4.3A)
None
None
 0.85A 5nekD-3b2rA:
undetectable		 5nekD-3b2rA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 ASP A 654
HIS A 613
HIS A 617
HIS A 684
 None
VDN  A   1 (-4.3A)
None
None
 0.87A 5nelA-3b2rA:
undetectable
5nelD-3b2rA:
undetectable		 5nelA-3b2rA:
21.92
5nelD-3b2rA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 HIS A 684
ASP A 654
HIS A 613
 None
None
VDN  A   1 (-4.3A)
 0.79A 5oexB-3b2rA:
undetectable		 5oexB-3b2rA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 HIS A 684
ASP A 654
HIS A 613
 None
None
VDN  A   1 (-4.3A)
 0.76A 5oexD-3b2rA:
undetectable		 5oexD-3b2rA:
19.40