SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VCA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5hj1 PULLULANASE C
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ILE A 239
ALA A 233
LEU A 241
LEU A 186
ILE A 199
 None
VCA  A 301 ( 4.0A)
None
VCA  A 301 ( 4.7A)
None
 1.08A 1bsxA-5hj1A:
undetectable		 1bsxA-5hj1A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5hj1 PULLULANASE C
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ILE A 239
ALA A 233
LEU A 241
LEU A 186
ILE A 199
 None
VCA  A 301 ( 4.0A)
None
VCA  A 301 ( 4.7A)
None
 1.08A 1bsxB-5hj1A:
undetectable		 1bsxB-5hj1A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5hj1 PULLULANASE C
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 ILE A 199
ARG A 242
THR A 263
LEU A 262
 None
None
None
VCA  A 301 ( 4.6A)
 1.03A 3wg7N-5hj1A:
undetectable
3wg7W-5hj1A:
undetectable		 3wg7N-5hj1A:
11.21
3wg7W-5hj1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 5hj1 PULLULANASE C
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 LEU A 197
LEU A 227
ILE A 260
LEU A 186
LEU A 241
 None
None
None
VCA  A 301 ( 4.7A)
None
 1.09A 5og9B-5hj1A:
undetectable		 5og9B-5hj1A:
15.06