SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'VBN'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_A_RALA600_1 (ESTROGEN RECEPTOR)	3r5t	FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN (Vibrio cholerae)	5 / 12	THR A 60 ALA A 58 ASP A 126 ILE A 68 LEU A 154	None None VBN A 1 (-3.7A) None None	1.06A	1errA-3r5tA: undetectable	1errA-3r5tA: 22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WMQ_A_HISA2001_0 (HUT OPERON POSITIVE REGULATORY PROTEIN)	3r5t	FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN (Vibrio cholerae)	4 / 6	ILE A 123 GLY A 124 ALA A 125 HIS A 239	VBN A 1 ( 4.8A) VBN A 1 (-3.3A) VBN A 1 (-3.4A) VBN A 1 (-4.1A)	0.90A	1wmqA-3r5tA: undetectable	1wmqA-3r5tA: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WMQ_B_HISB1001_0 (HUT OPERON POSITIVE REGULATORY PROTEIN)	3r5t	FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN (Vibrio cholerae)	4 / 6	ILE A 123 GLY A 124 ALA A 125 HIS A 239	VBN A 1 ( 4.8A) VBN A 1 (-3.3A) VBN A 1 (-3.4A) VBN A 1 (-4.1A)	0.91A	1wmqB-3r5tA: undetectable	1wmqB-3r5tA: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WPU_A_HISA2001_0 (HUT OPERON POSITIVE REGULATORY PROTEIN)	3r5t	FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN (Vibrio cholerae)	4 / 6	ILE A 123 GLY A 124 ALA A 125 HIS A 239	VBN A 1 ( 4.8A) VBN A 1 (-3.3A) VBN A 1 (-3.4A) VBN A 1 (-4.1A)	0.90A	1wpuA-3r5tA: undetectable	1wpuA-3r5tA: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WPU_B_HISB1001_0 (HUT OPERON POSITIVE REGULATORY PROTEIN)	3r5t	FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN (Vibrio cholerae)	4 / 6	ILE A 123 GLY A 124 ALA A 125 HIS A 239	VBN A 1 ( 4.8A) VBN A 1 (-3.3A) VBN A 1 (-3.4A) VBN A 1 (-4.1A)	0.90A	1wpuB-3r5tA: undetectable	1wpuB-3r5tA: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRQ_A_HISA2001_0 (HUT OPERON POSITIVE REGULATORY PROTEIN)	3r5t	FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN (Vibrio cholerae)	4 / 6	ILE A 123 GLY A 124 ALA A 125 HIS A 239	VBN A 1 ( 4.8A) VBN A 1 (-3.3A) VBN A 1 (-3.4A) VBN A 1 (-4.1A)	0.97A	1wrqA-3r5tA: undetectable	1wrqA-3r5tA: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRQ_B_HISB1001_0 (HUT OPERON POSITIVE REGULATORY PROTEIN)	3r5t	FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN (Vibrio cholerae)	4 / 6	ILE A 123 GLY A 124 ALA A 125 HIS A 239	VBN A 1 ( 4.8A) VBN A 1 (-3.3A) VBN A 1 (-3.4A) VBN A 1 (-4.1A)	0.95A	1wrqB-3r5tA: undetectable	1wrqB-3r5tA: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZIA_B_CL9B401_2 (DEOXYCYTIDINE KINASE)	3r5t	FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN (Vibrio cholerae)	4 / 4	ARG A 240 ASP A 241 LEU A 154 ARG A 129	None VBN A 1 ( 4.2A) None None	1.21A	2ziaB-3r5tA: 2.5	2ziaB-3r5tA: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_B_29SB601_1 (ESTROGEN RECEPTOR)	3r5t	FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN (Vibrio cholerae)	5 / 12	THR A 60 ALA A 58 ASP A 126 ILE A 68 LEU A 154	None None VBN A 1 (-3.7A) None None	0.89A	4xi3B-3r5tA: undetectable	4xi3B-3r5tA: 22.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ERR_A_RALA600_1","ESTROGEN RECEPTOR","3r5t","FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN","Vibrio cholerae",5,"THR A  60;ALA A  58;ASP A 126;ILE A  68;LEU A 154","None;None;VBN A   1 (-3.7A);None;None","1.06A","1errA-3r5tA:undetectable",null],["1WMQ_A_HISA2001_0","HUT OPERON POSITIVE REGULATORY PROTEIN","3r5t","FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN","Vibrio cholerae",4,"ILE A 123;GLY A 124;ALA A 125;HIS A 239","VBN A   1 ( 4.8A);VBN A   1 (-3.3A);VBN A   1 (-3.4A);VBN A   1 (-4.1A)","0.90A","1wmqA-3r5tA:undetectable","1errA-3r5tA:22.56"],["1WMQ_B_HISB1001_0","HUT OPERON POSITIVE REGULATORY PROTEIN","3r5t","FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN","Vibrio cholerae",4,"ILE A 123;GLY A 124;ALA A 125;HIS A 239","VBN A   1 ( 4.8A);VBN A   1 (-3.3A);VBN A   1 (-3.4A);VBN A   1 (-4.1A)","0.91A","1wmqB-3r5tA:undetectable","1wmqA-3r5tA:19.28"],["1WPU_A_HISA2001_0","HUT OPERON POSITIVE REGULATORY PROTEIN","3r5t","FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN","Vibrio cholerae",4,"ILE A 123;GLY A 124;ALA A 125;HIS A 239","VBN A   1 ( 4.8A);VBN A   1 (-3.3A);VBN A   1 (-3.4A);VBN A   1 (-4.1A)","0.90A","1wpuA-3r5tA:undetectable","1wmqB-3r5tA:19.28"],["1WPU_B_HISB1001_0","HUT OPERON POSITIVE REGULATORY PROTEIN","3r5t","FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN","Vibrio cholerae",4,"ILE A 123;GLY A 124;ALA A 125;HIS A 239","VBN A   1 ( 4.8A);VBN A   1 (-3.3A);VBN A   1 (-3.4A);VBN A   1 (-4.1A)","0.90A","1wpuB-3r5tA:undetectable","1wpuA-3r5tA:19.28"],["1WRQ_A_HISA2001_0","HUT OPERON POSITIVE REGULATORY PROTEIN","3r5t","FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN","Vibrio cholerae",4,"ILE A 123;GLY A 124;ALA A 125;HIS A 239","VBN A   1 ( 4.8A);VBN A   1 (-3.3A);VBN A   1 (-3.4A);VBN A   1 (-4.1A)","0.97A","1wrqA-3r5tA:undetectable","1wpuB-3r5tA:19.28"],["1WRQ_B_HISB1001_0","HUT OPERON POSITIVE REGULATORY PROTEIN","3r5t","FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN","Vibrio cholerae",4,"ILE A 123;GLY A 124;ALA A 125;HIS A 239","VBN A   1 ( 4.8A);VBN A   1 (-3.3A);VBN A   1 (-3.4A);VBN A   1 (-4.1A)","0.95A","1wrqB-3r5tA:undetectable","1wrqA-3r5tA:19.28"],["2ZIA_B_CL9B401_2","DEOXYCYTIDINE KINASE","3r5t","FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN","Vibrio cholerae",4,"ARG A 240;ASP A 241;LEU A 154;ARG A 129","None;VBN A   1 ( 4.2A);None;None","1.21A","2ziaB-3r5tA:2.5","1wrqB-3r5tA:19.28"],["4XI3_B_29SB601_1","ESTROGEN RECEPTOR","3r5t","FERRIC VIBRIOBACTIN ABC TRANSPORTER, PERIPLASMIC FERRIC VIBRIOBACTIN-BINDING PROTEIN","Vibrio cholerae",5,"THR A  60;ALA A  58;ASP A 126;ILE A  68;LEU A 154","None;None;VBN A   1 (-3.7A);None;None","0.89A","4xi3B-3r5tA:undetectable","2ziaB-3r5tA:19.63"]]