SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'V55'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 11 HIS A 218
HIS A 167
HIS A 284
PHE A 310
THR A 121
 FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
FE  A 501 ( 3.3A)
None
V55  A 503 ( 3.3A)
 1.29A 1ydbA-5j55A:
undetectable		 1ydbA-5j55A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDD_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 10 HIS A 218
HIS A 167
HIS A 284
PHE A 310
THR A 121
 FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
FE  A 501 ( 3.3A)
None
V55  A 503 ( 3.3A)
 1.35A 1yddA-5j55A:
undetectable		 1yddA-5j55A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 12 HIS A 218
HIS A 167
HIS A 284
PHE A 310
THR A 121
 FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
FE  A 501 ( 3.3A)
None
V55  A 503 ( 3.3A)
 1.30A 3bl1A-5j55A:
undetectable		 3bl1A-5j55A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 10 HIS A 218
HIS A 167
HIS A 284
PHE A 310
THR A 121
 FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
FE  A 501 ( 3.3A)
None
V55  A 503 ( 3.3A)
 1.31A 3cajA-5j55A:
undetectable		 3cajA-5j55A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 10 HIS A 218
HIS A 167
LEU A 475
THR A 121
PRO A  45
 FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
V55  A 503 ( 3.3A)
V55  A 503 ( 3.3A)
V55  A 503 ( 4.8A)
 1.31A 3cajA-5j55A:
undetectable		 3cajA-5j55A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 10 HIS A 218
HIS A 167
HIS A 284
PHE A 310
THR A 121
 FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
FE  A 501 ( 3.3A)
None
V55  A 503 ( 3.3A)
 1.34A 3dazA-5j55A:
undetectable		 3dazA-5j55A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 10 HIS A 218
HIS A 167
HIS A 284
PHE A 310
THR A 121
 FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
FE  A 501 ( 3.3A)
None
V55  A 503 ( 3.3A)
 1.31A 3dcsA-5j55A:
undetectable		 3dcsA-5j55A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 11 HIS A 218
HIS A 167
HIS A 284
PHE A 310
THR A 121
 FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
FE  A 501 ( 3.3A)
None
V55  A 503 ( 3.3A)
 1.33A 3v2jA-5j55A:
undetectable		 3v2jA-5j55A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2M_A_AZMA303_1
(CARBONIC ANHYDRASE 2)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 10 HIS A 218
HIS A 167
HIS A 284
PHE A 310
THR A 121
 FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
FE  A 501 ( 3.3A)
None
V55  A 503 ( 3.3A)
 1.32A 3v2mA-5j55A:
undetectable		 3v2mA-5j55A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		4 / 5 THR A 118
GLY A  63
VAL A  43
PRO A  45
 None
None
None
V55  A 503 ( 4.8A)
 1.08A 4grkA-5j55A:
undetectable		 4grkA-5j55A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		4 / 5 PHE A 248
PHE A 310
LEU A 475
PRO A  45
 None
None
V55  A 503 ( 3.3A)
V55  A 503 ( 4.8A)
 1.34A 4o8zA-5j55A:
undetectable		 4o8zA-5j55A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		4 / 5 SER A 234
GLU A 135
LYS A 134
ASN A  60
 None
V55  A 503 ( 3.3A)
V55  A 503 (-2.7A)
None
 1.46A 4pclA-5j55A:
undetectable		 4pclA-5j55A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXX_A_CHDA302_0
(CARBONIC ANHYDRASE 2)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 9 HIS A 218
HIS A 167
HIS A 284
PHE A 310
THR A 121
 FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
FE  A 501 ( 3.3A)
None
V55  A 503 ( 3.3A)
 1.29A 4pxxA-5j55A:
undetectable		 4pxxA-5j55A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 140
PRO A 138
ALA A 139
ASP A 136
PHE A  59
 None
None
None
None
V55  A 503 (-3.4A)
 1.22A 5x6yC-5j55A:
undetectable		 5x6yC-5j55A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5j55 CAROTENOID OXYGENASE
(Novosphingobium
aromaticivorans) 		3 / 3 LEU A 475
ASN A 440
LEU A 372
 V55  A 503 ( 3.3A)
None
None
 0.68A 6exiD-5j55A:
undetectable		 6exiD-5j55A:
10.32