SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'V1T'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		7 / 7 TRP A  81
PRO A  82
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
V1T  A1171 (-4.2A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
DMS  A1169 ( 3.8A)
 0.14A 3u5jA-4uydA:
25.8		 3u5jA-4uydA:
92.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		8 / 8 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
V1T  A1171 (-4.2A)
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
DMS  A1169 ( 3.8A)
 0.25A 3u5kA-4uydA:
24.5		 3u5kA-4uydA:
92.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		7 / 7 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 None
V1T  A1171 (-4.2A)
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.28A 3u5kB-4uydA:
24.3		 3u5kB-4uydA:
92.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		8 / 8 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
V1T  A1171 (-4.2A)
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
DMS  A1169 ( 3.8A)
 0.25A 3u5kC-4uydA:
23.7		 3u5kC-4uydA:
92.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		8 / 8 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
V1T  A1171 (-4.2A)
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
DMS  A1169 ( 3.8A)
 0.36A 3u5kD-4uydA:
23.7		 3u5kD-4uydA:
92.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		5 / 5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.38A 4a9jA-4uydA:
20.5		 4a9jA-4uydA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		5 / 5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.32A 4a9jB-4uydA:
20.8		 4a9jB-4uydA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		5 / 5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.37A 4a9jC-4uydA:
20.0		 4a9jC-4uydA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		4 / 6 VAL A  87
LEU A  92
TYR A 139
ASN A 140
 V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
 0.56A 4a9kA-4uydA:
17.1		 4a9kA-4uydA:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		9 / 9 TRP A  81
PRO A  82
GLN A  85
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
V1T  A1171 (-4.2A)
V1T  A1171 (-4.6A)
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
DMS  A1169 ( 3.8A)
 0.35A 4c66A-4uydA:
25.1		 4c66A-4uydA:
92.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		4 / 7 TYR A  97
MET A 132
ASN A 140
ILE A 146
 None
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.51A 4y03A-4uydA:
14.4		 4y03A-4uydA:
27.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		4 / 6 PRO A  82
VAL A  87
TYR A  97
ILE A 146
 V1T  A1171 (-4.2A)
V1T  A1171 (-4.9A)
None
DMS  A1169 ( 4.3A)
 0.77A 5pbeA-4uydA:
15.5		 5pbeA-4uydA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		4 / 6 VAL A  87
TYR A  97
ASN A 140
ILE A 146
 V1T  A1171 (-4.9A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.36A 5pbeA-4uydA:
15.5		 5pbeA-4uydA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		8 / 8 PRO A  82
VAL A  87
LEU A  92
LEU A  94
CYH A 136
TYR A 139
ASN A 140
ILE A 146
 V1T  A1171 (-4.2A)
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 ( 4.4A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.28A 5y1yA-4uydA:
24.2		 5y1yA-4uydA:
100.00