SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UVW'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_E_ACTE502_0 (RNA POLYMERASE 3D-POL)	1xco	PHOSPHATE ACETYLTRANSFERASE (Bacillus subtilis)	3 / 3	ARG A 89 LYS A 90 LYS A 92	UVW A 402 (-2.7A) None UVW A 402 (-2.6A)	1.14A	4k50E-1xcoA: undetectable	4k50E-1xcoA: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_I_ACTI506_0 (RNA POLYMERASE 3D-POL)	1xco	PHOSPHATE ACETYLTRANSFERASE (Bacillus subtilis)	3 / 3	ARG A 89 LYS A 90 LYS A 92	UVW A 402 (-2.7A) None UVW A 402 (-2.6A)	1.14A	4k50I-1xcoA: undetectable	4k50I-1xcoA: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z90_E_4LEE401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	1xco	PHOSPHATE ACETYLTRANSFERASE (Bacillus subtilis)	4 / 7	LEU A 137 THR A 132 THR A 129 THR A 149	None None UVW A 418 (-4.1A) None	0.92A	4z90A-1xcoA: undetectable 4z90B-1xcoA: undetectable 4z90C-1xcoA: undetectable 4z90D-1xcoA: undetectable 4z90E-1xcoA: undetectable	4z90A-1xcoA: 21.20 4z90B-1xcoA: 21.20 4z90C-1xcoA: 21.20 4z90D-1xcoA: 21.20 4z90E-1xcoA: 21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z91_F_4LEF401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	1xco	PHOSPHATE ACETYLTRANSFERASE (Bacillus subtilis)	4 / 7	THR A 129 THR A 149 LEU A 137 THR A 132	UVW A 418 (-4.1A) None None None	0.89A	4z91F-1xcoA: undetectable 4z91G-1xcoA: undetectable 4z91H-1xcoA: undetectable 4z91I-1xcoA: undetectable 4z91J-1xcoA: undetectable	4z91F-1xcoA: 21.20 4z91G-1xcoA: 21.20 4z91H-1xcoA: 21.20 4z91I-1xcoA: 21.20 4z91J-1xcoA: 21.20

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4K50_E_ACTE502_0","RNA POLYMERASE 3D-POL","1xco","PHOSPHATE ACETYLTRANSFERASE","Bacillus subtilis",3,"ARG A  89;LYS A  90;LYS A  92","UVW A 402 (-2.7A);None;UVW A 402 (-2.6A)","1.14A","4k50E-1xcoA:undetectable",null],["4K50_I_ACTI506_0","RNA POLYMERASE 3D-POL","1xco","PHOSPHATE ACETYLTRANSFERASE","Bacillus subtilis",3,"ARG A  89;LYS A  90;LYS A  92","UVW A 402 (-2.7A);None;UVW A 402 (-2.6A)","1.14A","4k50I-1xcoA:undetectable","4k50E-1xcoA:21.46"],["4Z90_E_4LEE401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","1xco","PHOSPHATE ACETYLTRANSFERASE","Bacillus subtilis",4,"LEU A 137;THR A 132;THR A 129;THR A 149","None;None;UVW A 418 (-4.1A);None","0.92A","4z90A-1xcoA:undetectable;4z90B-1xcoA:undetectable;4z90C-1xcoA:undetectable;4z90D-1xcoA:undetectable;4z90E-1xcoA:undetectable","4k50I-1xcoA:21.46"],["4Z91_F_4LEF401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","1xco","PHOSPHATE ACETYLTRANSFERASE","Bacillus subtilis",4,"THR A 129;THR A 149;LEU A 137;THR A 132","UVW A 418 (-4.1A);None;None;None","0.89A","4z91F-1xcoA:undetectable;4z91G-1xcoA:undetectable;4z91H-1xcoA:undetectable;4z91I-1xcoA:undetectable;4z91J-1xcoA:undetectable","4z90A-1xcoA:21.20;4z90B-1xcoA:21.20;4z90C-1xcoA:21.20;4z90D-1xcoA:21.20;4z90E-1xcoA:21.20"]]