SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UTP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 ASP A  68
GLY A 144
THR A 120
ASP A 136
 MG  A 401 (-2.6A)
UTP  A 501 (-3.6A)
None
U5P  A 502 (-4.0A)
 0.78A 1m4iA-2q0fA:
undetectable		 1m4iA-2q0fA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 12 PHE A 313
SER A 475
PHE A 479
VAL A 300
ALA A 309
 None
None
UTP  A 701 (-4.5A)
None
None
 1.33A 1q23A-5idoA:
undetectable
1q23B-5idoA:
undetectable		 1q23A-5idoA:
17.58
1q23B-5idoA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 7 LEU A 396
THR A 435
VAL A 551
ASP A 543
 None
EDO  A1004 (-3.7A)
UTP  A1001 ( 4.4A)
None
 0.96A 2qblA-5wu3A:
undetectable		 2qblA-5wu3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		5 / 9 ILE A  51
GLY A  68
TYR A  50
GLY A  43
ARG A  49
 None
UTP  A1227 (-3.2A)
None
UTP  A1227 (-3.6A)
None
 1.36A 2y7wA-2j4lA:
undetectable		 2y7wA-2j4lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		5 / 9 ILE A  51
GLY A  68
TYR A  50
GLY A  44
ARG A  49
 None
UTP  A1227 (-3.2A)
None
None
None
 1.20A 2y7wA-2j4lA:
undetectable		 2y7wA-2j4lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 HIS A  61
SER A  65
ASP A  68
ASP A 136
 None
UTP  A 501 (-2.6A)
MG  A 401 (-2.6A)
U5P  A 502 (-4.0A)
 1.01A 3n2oC-2q0fA:
undetectable
3n2oD-2q0fA:
undetectable		 3n2oC-2q0fA:
21.08
3n2oD-2q0fA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 9 TYR A 524
LYS A 505
ILE A 502
LEU A 487
VAL A 300
 UTP  A 701 (-4.2A)
UTP  A 701 (-3.0A)
None
None
None
 1.47A 3oxzA-5idoA:
undetectable		 3oxzA-5idoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 12 ASN A 178
GLY A 183
GLY A 184
SER A 185
THR A 175
 UTP  A 501 ( 4.9A)
None
None
None
None
 1.00A 3uboA-2q0fA:
undetectable		 3uboA-2q0fA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 5 TYR A 656
SER A 484
ASP A 654
ILE A 652
 None
UTP  A 701 (-3.1A)
None
None
 1.19A 3uj7B-5idoA:
undetectable		 3uj7B-5idoA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 ILE A 295
ASP A 312
ILE A 311
GLY A 307
 None
UTP  A 701 ( 4.7A)
None
None
 0.61A 4acaC-5idoA:
undetectable		 4acaC-5idoA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 ILE A 295
ASP A 312
ILE A 311
GLY A 307
 None
UTP  A 701 ( 4.7A)
None
None
 0.60A 4acbC-5idoA:
undetectable		 4acbC-5idoA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5u03 CTP SYNTHASE 1
(Homo
sapiens) 		5 / 12 THR A   7
GLY A 149
GLY A 148
LEU A 147
LEU A 207
 None
UTP  A 602 (-4.1A)
UTP  A 602 (-3.5A)
None
None
 0.98A 5c0oF-5u03A:
undetectable		 5c0oF-5u03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 7 PRO A 149
TYR A 145
SER A   8
ASN A 140
 None
None
UTP  A1227 (-3.6A)
None
 1.12A 5l1fC-2j4lA:
3.0		 5l1fC-2j4lA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 8 ALA A 127
VAL A 126
THR A 119
GLY A  38
 None
None
UTP  A1227 (-2.8A)
None
 0.86A 5v0vA-2j4lA:
2.2		 5v0vA-2j4lA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 THR A 435
ASN A 392
PHE A 395
PRO A 544
 EDO  A1004 (-3.7A)
UTP  A1001 (-2.6A)
None
None
 1.18A 5v4vA-5wu3A:
undetectable		 5v4vA-5wu3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 THR A 435
ASN A 392
PHE A 395
PRO A 544
 EDO  A1004 (-3.7A)
UTP  A1001 (-2.6A)
None
None
 1.19A 5v4vB-5wu3A:
undetectable		 5v4vB-5wu3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5a9a POLYHEDRIN
(Simulium
ubiquitum
cypovirus) 		3 / 3 HIS A  95
HIS A  96
ARG A  78
 UTP  A1245 (-4.7A)
UTP  A1245 (-4.0A)
UTP  A1245 (-3.0A)
 1.14A 6b58A-5a9aA:
undetectable		 6b58A-5a9aA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 10 VAL A  67
GLY A  53
SER A 148
ALA A 149
VAL A  70
 None
UTP  A 501 (-3.6A)
UTP  A 501 (-3.3A)
None
None
 1.49A 6hu9L-2q0fA:
undetectable
6hu9P-2q0fA:
undetectable
6hu9T-2q0fA:
undetectable		 6hu9L-2q0fA:
22.00
6hu9P-2q0fA:
20.42
6hu9T-2q0fA:
10.48