SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'URF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DF7_A_MTXA501_1 (DIHYDROFOLATE REDUCTASE)	1upf	URACIL PHOSPHORIBOSYLTRANSF ERASE (Toxoplasma gondii)	5 / 12	ILE D 29 ALA D 197 ILE D 229 GLN D 200 ILE D 25	None None URF D 999 (-4.0A) None None	0.99A	1df7A-1upfD: undetectable	1df7A-1upfD: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SGU_B_MK1B2632_1 (POL POLYPROTEIN)	1upf	URACIL PHOSPHORIBOSYLTRANSF ERASE (Toxoplasma gondii)	5 / 8	ALA D 218 ILE D 229 GLY D 232 ILE D 52 PRO D 165	None URF D 999 (-4.0A) None None None	1.12A	1sguA-1upfD: undetectable	1sguA-1upfD: 19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2X_G_TMQG202_1 (DIHYDROFOLATE REDUCTASE)	1upf	URACIL PHOSPHORIBOSYLTRANSF ERASE (Toxoplasma gondii)	5 / 12	ILE D 29 ALA D 197 ILE D 229 GLN D 200 ILE D 25	None None URF D 999 (-4.0A) None None	1.10A	4m2xG-1upfD: undetectable	4m2xG-1upfD: 20.60