SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'URE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 11 ARG A1610
SER A1609
GLY A1635
ASN A1330
PHE A1349
 URE  A1902 ( 4.9A)
BTI  A1901 ( 3.5A)
URE  A1902 (-3.0A)
BTI  A1901 (-3.8A)
BTI  A1901 (-4.6A)
 1.42A 1ho5A-3va7A:
undetectable		 1ho5A-3va7A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 10 ARG A1610
SER A1609
GLY A1635
ASN A1330
PHE A1349
 URE  A1902 ( 4.9A)
BTI  A1901 ( 3.5A)
URE  A1902 (-3.0A)
BTI  A1901 (-3.8A)
BTI  A1901 (-4.6A)
 1.44A 1ho5B-3va7A:
undetectable		 1ho5B-3va7A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE
(Oryza
sativa) 		4 / 7 PHE A  77
ALA A 146
ILE A 121
PRO A 118
 URE  A 904 (-4.6A)
None
None
None
 0.99A 1oniA-3umvA:
undetectable
1oniB-3umvA:
undetectable		 1oniA-3umvA:
16.89
1oniB-3umvA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE
(Oryza
sativa) 		4 / 6 PHE A  77
ALA A 146
ILE A 121
PRO A 118
 URE  A 904 (-4.6A)
None
None
None
 1.11A 1oniH-3umvA:
undetectable
1oniI-3umvA:
0.0		 1oniH-3umvA:
16.89
1oniI-3umvA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE
(Oryza
sativa) 		4 / 7 ILE A 121
PRO A 118
PHE A  77
ALA A 146
 None
None
URE  A 904 (-4.6A)
None
 0.94A 1oniG-3umvA:
undetectable
1oniI-3umvA:
undetectable		 1oniG-3umvA:
16.89
1oniI-3umvA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 6fej ALL4940 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 7 PHE A  43
ILE A  19
ILE A  24
THR A 123
 None
URE  A 201 (-3.6A)
None
None
 0.76A 1sbrB-6fejA:
undetectable		 1sbrB-6fejA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 5 LEU A 152
ASP A 150
GLY A 135
ALA A 126
 URE  A 578 (-4.7A)
None
None
None
 0.82A 2aohB-2i1jA:
undetectable		 2aohB-2i1jA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 11 GLY A1621
GLY A1313
GLN A1638
THR A1604
CYH A1626
 None
None
None
None
URE  A1902 (-3.6A)
 1.50A 2dr2A-3va7A:
3.3		 2dr2A-3va7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 ILE A  91
TYR A 213
PHE A  89
THR A  83
GLU A  87
 None
None
None
URE  A1299 ( 4.8A)
URE  A1299 (-2.6A)
 1.46A 2dttE-2xlaA:
0.0
2dttF-2xlaA:
0.0		 2dttE-2xlaA:
20.17
2dttF-2xlaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2xla SLL1785 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLU A 124
GLN A 249
PHE A 238
ILE A 247
 CU  A1298 (-2.6A)
None
URE  A1299 (-4.7A)
None
 1.03A 2qmzA-2xlaA:
undetectable
2qmzB-2xlaA:
undetectable		 2qmzA-2xlaA:
21.21
2qmzB-2xlaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 11 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
None
None
URE  A1902 (-4.3A)
None
 0.99A 2y7kA-3va7A:
undetectable		 2y7kA-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 11 THR A1643
ILE A1627
GLY A1616
TYR A1628
PRO A1590
 None
None
None
URE  A1902 (-4.3A)
None
 1.42A 2y7kA-3va7A:
undetectable		 2y7kA-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 10 THR A1643
ILE A1627
GLY A1616
TYR A1628
PRO A1590
 None
None
None
URE  A1902 (-4.3A)
None
 1.36A 2y7kB-3va7A:
undetectable		 2y7kB-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 12 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
None
None
URE  A1902 (-4.3A)
None
 1.02A 2y7kC-3va7A:
undetectable		 2y7kC-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 12 THR A1643
ILE A1627
GLY A1616
TYR A1628
PRO A1590
 None
None
None
URE  A1902 (-4.3A)
None
 1.26A 2y7kC-3va7A:
undetectable		 2y7kC-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 12 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
None
None
URE  A1902 (-4.3A)
None
 1.09A 2y7kD-3va7A:
undetectable		 2y7kD-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 10 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
None
None
URE  A1902 (-4.3A)
None
 1.04A 2y7pA-3va7A:
undetectable		 2y7pA-3va7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 9 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
None
None
URE  A1902 (-4.3A)
None
 1.13A 2y7wA-3va7A:
2.0		 2y7wA-3va7A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		4 / 7 PHE A1349
GLY A1635
TRP A1549
ARG A1544
 BTI  A1901 (-4.6A)
URE  A1902 (-3.0A)
None
None
 1.26A 3aruA-3va7A:
undetectable		 3aruA-3va7A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE
(Oryza
sativa) 		4 / 6 ARG A 214
GLU A 215
PHE A 112
PRO A 110
 None
None
URE  A 905 (-4.8A)
None
 1.42A 3gclA-3umvA:
undetectable		 3gclA-3umvA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 6fej ALL4940 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 VAL A  95
VAL A  93
TYR A  27
GLY A  81
GLY A  18
 None
None
URE  A 202 (-4.7A)
None
None
 1.14A 3ls4H-6fejA:
undetectable		 3ls4H-6fejA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE
(Oryza
sativa) 		3 / 3 GLU A 215
PHE A 112
GLN A 216
 None
URE  A 905 (-4.8A)
None
 0.91A 3r55A-3umvA:
undetectable		 3r55A-3umvA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 12 ASP A1584
ASP A1321
GLY A1636
SER A1609
ARG A1296
 URE  A1902 (-4.0A)
None
URE  A1902 (-3.7A)
BTI  A1901 ( 3.5A)
GOL  A1907 (-3.4A)
 1.04A 4djfB-3va7A:
undetectable		 4djfB-3va7A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		3 / 3 ARG B 228
HIS B 203
TYR B 139
 None
URE  B 946 (-4.7A)
None
 0.91A 4fu8A-1ep5B:
4.0		 4fu8A-1ep5B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		3 / 3 ARG B 228
HIS B 204
TYR B 139
 None
URE  B 946 (-4.3A)
None
 1.07A 4fu8A-1ep5B:
4.0		 4fu8A-1ep5B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		3 / 3 ARG B 228
HIS B 203
TYR B 139
 None
URE  B 946 (-4.7A)
None
 0.98A 4fu9A-1ep5B:
9.2		 4fu9A-1ep5B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		3 / 3 ARG B 228
HIS B 204
TYR B 139
 None
URE  B 946 (-4.3A)
None
 0.97A 4fu9A-1ep5B:
9.2		 4fu9A-1ep5B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 6 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
URE  A 577 (-4.2A)
URE  A 577 (-3.4A)
None
 1.09A 4yv5B-2i1jA:
undetectable		 4yv5B-2i1jA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2i1j MOESIN
(Spodoptera
frugiperda) 		4 / 6 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
URE  A 577 (-4.2A)
URE  A 577 (-3.4A)
None
 1.10A 4yv5A-2i1jA:
undetectable		 4yv5A-2i1jA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE
(Oryza
sativa) 		5 / 12 LEU A 225
ILE A 226
CYH A 230
PHE A  81
PHE A 114
 URE  A 903 (-4.5A)
None
None
None
URE  A 905 (-4.0A)
 1.11A 6a7pA-3umvA:
undetectable		 6a7pA-3umvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE
(Oryza
sativa) 		4 / 4 GLU A 232
VAL A 229
LEU A 225
THR A 115
 EDO  A 708 ( 4.4A)
None
URE  A 903 (-4.5A)
None
 1.42A 6dynA-3umvA:
undetectable		 6dynA-3umvA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE
(Oryza
sativa) 		4 / 5 GLU A 232
VAL A 229
LEU A 225
THR A 115
 EDO  A 708 ( 4.4A)
None
URE  A 903 (-4.5A)
None
 1.41A 6dyoA-3umvA:
undetectable		 6dyoA-3umvA:
11.04