SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'URB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		5 / 7 TYR A 208
VAL A 221
ILE A 234
TYR A 235
GLY A 251
 URB  A 401 ( 3.3A)
None
None
None
None
 1.00A 11gsA-3cxmA:
undetectable		 11gsA-3cxmA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		5 / 10 TYR A 208
VAL A 221
ILE A 234
TYR A 235
GLY A 251
 URB  A 401 ( 3.3A)
None
None
None
None
 1.05A 13gsA-3cxmA:
undetectable		 13gsA-3cxmA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		5 / 8 TYR A 208
VAL A 221
ILE A 234
TYR A 235
GLY A 251
 URB  A 401 ( 3.3A)
None
None
None
None
 1.04A 2gssA-3cxmA:
undetectable		 2gssA-3cxmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		5 / 8 TYR A 208
VAL A 221
ILE A 234
TYR A 235
GLY A 251
 URB  A 401 ( 3.3A)
None
None
None
None
 1.04A 2gssB-3cxmA:
undetectable		 2gssB-3cxmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		5 / 9 TYR A 208
VAL A 221
ILE A 234
TYR A 235
GLY A 251
 URB  A 401 ( 3.3A)
None
None
None
None
 1.11A 3csjB-3cxmA:
undetectable		 3csjB-3cxmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		4 / 7 TYR A 208
VAL A 221
ILE A 234
GLY A 251
 URB  A 401 ( 3.3A)
None
None
None
 0.92A 3gssA-3cxmA:
undetectable		 3gssA-3cxmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		4 / 7 TYR A 208
VAL A 221
ILE A 234
GLY A 251
 URB  A 401 ( 3.3A)
None
None
None
 0.92A 3gssB-3cxmA:
undetectable		 3gssB-3cxmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		4 / 8 TYR A 208
VAL A 221
ILE A 234
GLY A 251
 URB  A 401 ( 3.3A)
None
None
None
 0.95A 3hjoA-3cxmA:
undetectable		 3hjoA-3cxmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		4 / 8 TYR A 208
VAL A 221
ILE A 234
GLY A 251
 URB  A 401 ( 3.3A)
None
None
None
 0.96A 3n9jA-3cxmA:
undetectable		 3n9jA-3cxmA:
23.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		6 / 8 GLY A 204
GLN A 205
TYR A 208
PHE A 219
SER A 230
ASN A 265
 URB  A 401 ( 3.5A)
None
URB  A 401 ( 3.3A)
URB  A 401 ( 4.1A)
BR  A 403 (-3.4A)
URB  A 401 ( 2.9A)
 0.68A 4wryA-3cxmA:
30.8		 4wryA-3cxmA:
39.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		6 / 8 GLY A 204
GLN A 205
TYR A 208
PHE A 219
SER A 230
HIS A 331
 URB  A 401 ( 3.5A)
None
URB  A 401 ( 3.3A)
URB  A 401 ( 4.1A)
BR  A 403 (-3.4A)
URB  A 401 (-4.6A)
 0.86A 4wryA-3cxmA:
30.8		 4wryA-3cxmA:
39.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		6 / 8 GLY A 204
GLN A 205
TYR A 208
PHE A 219
SER A 230
ASN A 265
 URB  A 401 ( 3.5A)
None
URB  A 401 ( 3.3A)
URB  A 401 ( 4.1A)
BR  A 403 (-3.4A)
URB  A 401 ( 2.9A)
 0.71A 4wrzA-3cxmA:
30.3		 4wrzA-3cxmA:
39.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		4 / 8 TYR A 208
PHE A 219
SER A 230
HIS A 331
 URB  A 401 ( 3.3A)
URB  A 401 ( 4.1A)
BR  A 403 (-3.4A)
URB  A 401 (-4.6A)
 0.59A 4wrzA-3cxmA:
30.3		 4wrzA-3cxmA:
39.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		5 / 7 GLY A 204
GLN A 205
TYR A 208
PHE A 219
ASN A 265
 URB  A 401 ( 3.5A)
None
URB  A 401 ( 3.3A)
URB  A 401 ( 4.1A)
URB  A 401 ( 2.9A)
 0.80A 4ws0A-3cxmA:
29.6		 4ws0A-3cxmA:
39.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		6 / 8 GLY A 204
GLN A 205
TYR A 208
PHE A 219
SER A 230
ASN A 265
 URB  A 401 ( 3.5A)
None
URB  A 401 ( 3.3A)
URB  A 401 ( 4.1A)
BR  A 403 (-3.4A)
URB  A 401 ( 2.9A)
 0.99A 4ws1A-3cxmA:
29.7		 4ws1A-3cxmA:
39.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3cxm URACIL-DNA
GLYCOSYLASE
(Leishmania
naiffi) 		4 / 8 TYR A 208
PHE A 219
SER A 230
HIS A 331
 URB  A 401 ( 3.3A)
URB  A 401 ( 4.1A)
BR  A 403 (-3.4A)
URB  A 401 (-4.6A)
 0.63A 4ws1A-3cxmA:
29.7		 4ws1A-3cxmA:
39.92