SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'URA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		4 / 7 TYR A  66
VAL A  79
TYR A  93
GLY A 109
 URA  A 230 (-3.2A)
None
None
None
 0.92A 11gsA-1flzA:
undetectable		 11gsA-1flzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 ARG A 137
THR A 140
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.28A 1jdvA-3kvyA:
24.8
1jdvD-3kvyA:
24.8		 1jdvA-3kvyA:
24.68
1jdvD-3kvyA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 ARG A 137
THR A 140
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.29A 1jdvB-3kvyA:
24.8
1jdvC-3kvyA:
25.4		 1jdvB-3kvyA:
24.68
1jdvC-3kvyA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 ARG A 137
THR A 140
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.29A 1jdvA-3kvyA:
24.8
1jdvD-3kvyA:
24.8		 1jdvA-3kvyA:
24.68
1jdvD-3kvyA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.08A 1jdvE-3bjeA:
28.4
1jdvF-3bjeA:
28.9		 1jdvE-3bjeA:
23.68
1jdvF-3bjeA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.42A 1jdvE-3bjeA:
28.4
1jdvF-3bjeA:
28.9		 1jdvE-3bjeA:
23.68
1jdvF-3bjeA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 12 ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.33A 1jdvE-3kvyA:
24.7
1jdvF-3kvyA:
25.4		 1jdvE-3kvyA:
24.68
1jdvF-3kvyA:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 12 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.31A 1jdvE-3qpbA:
31.7
1jdvF-3qpbA:
31.3		 1jdvE-3qpbA:
31.29
1jdvF-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3qe7 URACIL PERMEASE
(Escherichia
coli) 		5 / 12 LEU A 147
GLY A 142
LEU A  38
LEU A 331
PHE A  73
 None
None
None
None
URA  A 430 (-3.4A)
 0.83A 1mx1D-3qe7A:
undetectable		 1mx1D-3qe7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.45A 1odiA-3bjeA:
21.3		 1odiA-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.33A 1odiA-3bjeA:
21.3		 1odiA-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.36A 1odiA-3kvyA:
16.1		 1odiA-3kvyA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.49A 1odiA-3qpbA:
26.3		 1odiA-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1odiA-3qpbA:
26.3		 1odiA-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.49A 1odiB-3bjeA:
30.2		 1odiB-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.29A 1odiB-3bjeA:
30.2		 1odiB-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 1odiB-3kvyA:
25.2		 1odiB-3kvyA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.45A 1odiB-3qpbA:
33.9		 1odiB-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.35A 1odiB-3qpbA:
33.9		 1odiB-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.45A 1odiC-3bjeA:
30.2		 1odiC-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.24A 1odiC-3bjeA:
30.2		 1odiC-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.38A 1odiC-3kvyA:
25.2		 1odiC-3kvyA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.46A 1odiC-3qpbA:
33.8		 1odiC-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.37A 1odiC-3qpbA:
33.8		 1odiC-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.48A 1odiD-3bjeA:
30.3		 1odiD-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.25A 1odiD-3bjeA:
30.3		 1odiD-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.33A 1odiD-3kvyA:
25.1		 1odiD-3kvyA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.47A 1odiD-3qpbA:
33.8		 1odiD-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1odiD-3qpbA:
33.8		 1odiD-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.44A 1odiE-3bjeA:
30.3		 1odiE-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.27A 1odiE-3bjeA:
30.3		 1odiE-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.32A 1odiE-3kvyA:
25.1		 1odiE-3kvyA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.48A 1odiE-3qpbA:
33.8		 1odiE-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.35A 1odiE-3qpbA:
33.8		 1odiE-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.45A 1odiF-3bjeA:
30.1		 1odiF-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.26A 1odiF-3bjeA:
30.1		 1odiF-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.35A 1odiF-3kvyA:
25.0		 1odiF-3kvyA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.50A 1odiF-3qpbA:
33.5		 1odiF-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1odiF-3qpbA:
33.5		 1odiF-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 9 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.02A 1pk7A-3bjeA:
28.6		 1pk7A-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 9 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.31A 1pk7A-3kvyA:
25.3		 1pk7A-3kvyA:
26.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 9 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.29A 1pk7A-3qpbA:
31.9		 1pk7A-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 8 ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.06A 1pk7B-3bjeA:
28.6		 1pk7B-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.26A 1pk7B-3kvyA:
25.5		 1pk7B-3kvyA:
26.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 8 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.28A 1pk7B-3qpbA:
32.1		 1pk7B-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.42A 1pk7C-3bjeA:
29.0		 1pk7C-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.19A 1pk7C-3bjeA:
29.0		 1pk7C-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.29A 1pk7C-3kvyA:
13.1		 1pk7C-3kvyA:
26.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.36A 1pk7C-3qpbA:
32.1		 1pk7C-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.35A 1pk9A-3bjeA:
28.7		 1pk9A-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.10A 1pk9A-3bjeA:
28.7		 1pk9A-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.31A 1pk9A-3kvyA:
25.3		 1pk9A-3kvyA:
26.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 1pk9A-3qpbA:
31.8		 1pk9A-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.31A 1pk9B-3bjeA:
28.6		 1pk9B-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.03A 1pk9B-3bjeA:
28.6		 1pk9B-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 9 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.30A 1pk9B-3kvyA:
25.4		 1pk9B-3kvyA:
26.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 9 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 1pk9B-3qpbA:
32.0		 1pk9B-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.40A 1pk9C-3bjeA:
28.0		 1pk9C-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.21A 1pk9C-3kvyA:
24.8		 1pk9C-3kvyA:
26.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.32A 1pk9C-3qpbA:
32.3		 1pk9C-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.35A 1pw7A-3bjeA:
28.8		 1pw7A-3bjeA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.06A 1pw7A-3bjeA:
28.8		 1pw7A-3bjeA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.29A 1pw7A-3kvyA:
25.4		 1pw7A-3kvyA:
26.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1pw7A-3qpbA:
31.8		 1pw7A-3qpbA:
31.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 10 ARG A  90
GLY A  95
GLU A 195
MET A 196
GLU A 197
ILE A 220
 SO4  A 301 ( 3.0A)
URI  A 303 ( 3.4A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
URI  A 303 (-2.7A)
URA  A 304 (-4.3A)
 1.47A 1pw7A-5lhvA:
31.9		 1pw7A-5lhvA:
31.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.36A 1pw7B-3bjeA:
29.2		 1pw7B-3bjeA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 9 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.32A 1pw7B-3kvyA:
25.4		 1pw7B-3kvyA:
26.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 9 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.36A 1pw7B-3qpbA:
32.2		 1pw7B-3qpbA:
31.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 MET A  87
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 0.78A 1pw7C-3bjeA:
29.1		 1pw7C-3bjeA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.06A 1pxxC-5gnwC:
undetectable		 1pxxC-5gnwC:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.22A 1rxcB-3bjeA:
31.0		 1rxcB-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.26A 1rxcB-3kvyA:
27.1		 1rxcB-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.23A 1rxcB-5lhvA:
24.3		 1rxcB-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.33A 1rxcC-3bjeA:
5.7		 1rxcC-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 7 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.41A 1rxcC-3kvyA:
25.9		 1rxcC-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.29A 1rxcC-5lhvA:
42.9		 1rxcC-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.18A 1rxcD-3bjeA:
30.7		 1rxcD-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 7 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.29A 1rxcD-3kvyA:
26.9		 1rxcD-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.26A 1rxcD-5lhvA:
43.7		 1rxcD-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.22A 1rxcE-3bjeA:
30.9		 1rxcE-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.30A 1rxcE-3kvyA:
27.2		 1rxcE-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.17A 1rxcE-5lhvA:
43.7		 1rxcE-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.22A 1rxcF-3bjeA:
31.1		 1rxcF-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 7 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.26A 1rxcF-3kvyA:
27.3		 1rxcF-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.22A 1rxcF-5lhvA:
43.8		 1rxcF-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 1rxcI-3bjeA:
30.9		 1rxcI-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.26A 1rxcI-3kvyA:
27.3		 1rxcI-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.26A 1rxcI-5lhvA:
44.0		 1rxcI-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.27A 1rxcK-3bjeA:
29.7		 1rxcK-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.30A 1rxcK-3kvyA:
25.6		 1rxcK-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.22A 1rxcK-5lhvA:
42.1		 1rxcK-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.21A 1rxcL-3bjeA:
30.9		 1rxcL-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 7 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.23A 1rxcL-3kvyA:
27.2		 1rxcL-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.19A 1rxcL-5lhvA:
43.8		 1rxcL-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 ALA C 134
PHE C  80
GLN C  78
LEU C  69
ARG C  42
 None
None
None
URA  C 301 (-3.9A)
None
 1.35A 1u70A-5gnwC:
undetectable		 1u70A-5gnwC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.34A 1vhwA-3bjeA:
29.5
1vhwD-3bjeA:
29.5		 1vhwA-3bjeA:
24.44
1vhwD-3bjeA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.37A 1vhwA-3kvyA:
25.4
1vhwD-3kvyA:
25.5		 1vhwA-3kvyA:
26.75
1vhwD-3kvyA:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 1vhwA-3qpbA:
32.8
1vhwD-3qpbA:
32.8		 1vhwA-3qpbA:
30.54
1vhwD-3qpbA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 MET A  87
ARG A 137
GLY A 142
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.32A 1vhwB-3bjeA:
29.8
1vhwF-3bjeA:
29.3		 1vhwB-3bjeA:
24.44
1vhwF-3bjeA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 9 MET A 109
ARG A 137
GLY A 142
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.35A 1vhwB-3kvyA:
25.3
1vhwF-3kvyA:
24.9		 1vhwB-3kvyA:
26.75
1vhwF-3kvyA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.33A 1vhwC-3bjeA:
29.6
1vhwE-3bjeA:
29.4		 1vhwC-3bjeA:
24.44
1vhwE-3bjeA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.37A 1vhwC-3kvyA:
25.5
1vhwE-3kvyA:
25.3		 1vhwC-3kvyA:
26.75
1vhwE-3kvyA:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.42A 1vhwC-3qpbA:
32.8
1vhwE-3qpbA:
32.6		 1vhwC-3qpbA:
30.54
1vhwE-3qpbA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 11 ARG A  90
GLY A  95
GLU A 195
MET A 196
GLU A 197
ILE A 220
 SO4  A 301 ( 3.0A)
URI  A 303 ( 3.4A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
URI  A 303 (-2.7A)
URA  A 304 (-4.3A)
 1.46A 1vhwC-5lhvA:
32.4
1vhwE-5lhvA:
32.2		 1vhwC-5lhvA:
26.81
1vhwE-5lhvA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.33A 1vhwA-3bjeA:
29.5
1vhwD-3bjeA:
29.5		 1vhwA-3bjeA:
24.44
1vhwD-3bjeA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.37A 1vhwA-3kvyA:
25.4
1vhwD-3kvyA:
25.5		 1vhwA-3kvyA:
26.75
1vhwD-3kvyA:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.42A 1vhwA-3qpbA:
32.8
1vhwD-3qpbA:
32.8		 1vhwA-3qpbA:
30.54
1vhwD-3qpbA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 11 ARG A  90
GLY A  95
GLU A 195
MET A 196
GLU A 197
ILE A 220
 SO4  A 301 ( 3.0A)
URI  A 303 ( 3.4A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
URI  A 303 (-2.7A)
URA  A 304 (-4.3A)
 1.47A 1vhwA-5lhvA:
32.3
1vhwD-5lhvA:
32.4		 1vhwA-5lhvA:
26.81
1vhwD-5lhvA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.34A 1vhwC-3bjeA:
29.6
1vhwE-3bjeA:
29.4		 1vhwC-3bjeA:
24.44
1vhwE-3bjeA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.38A 1vhwC-3kvyA:
25.5
1vhwE-3kvyA:
25.3		 1vhwC-3kvyA:
26.75
1vhwE-3kvyA:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 1vhwC-3qpbA:
32.8
1vhwE-3qpbA:
32.6		 1vhwC-3qpbA:
30.54
1vhwE-3qpbA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.36A 1vhwB-3bjeA:
29.8
1vhwF-3bjeA:
29.3		 1vhwB-3bjeA:
24.44
1vhwF-3bjeA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.38A 1vhwB-3kvyA:
25.3
1vhwF-3kvyA:
24.9		 1vhwB-3kvyA:
26.75
1vhwF-3kvyA:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.44A 1vhwB-3qpbA:
32.8
1vhwF-3qpbA:
33.4		 1vhwB-3qpbA:
30.54
1vhwF-3qpbA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 10 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.02A 1z35A-3bjeA:
16.6		 1z35A-3bjeA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 10 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.47A 1z35A-3bjeA:
16.6		 1z35A-3bjeA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		8 / 10 MET A 109
ARG A 137
THR A 140
GLY A 142
THR A 209
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
None
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.59A 1z35A-3kvyA:
23.9		 1z35A-3kvyA:
26.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 10 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.51A 1z35A-3qpbA:
32.7		 1z35A-3qpbA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 9 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.03A 1z37A-3bjeA:
29.0		 1z37A-3bjeA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 9 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.45A 1z37A-3bjeA:
29.0		 1z37A-3bjeA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 9 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.49A 1z37A-3kvyA:
23.8		 1z37A-3kvyA:
26.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 9 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 1z37A-3qpbA:
32.8		 1z37A-3qpbA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.43A 2ac7A-3bjeA:
27.6
2ac7B-3bjeA:
27.7		 2ac7A-3bjeA:
26.00
2ac7B-3bjeA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.35A 2ac7A-3kvyA:
23.5
2ac7B-3kvyA:
23.6		 2ac7A-3kvyA:
25.24
2ac7B-3kvyA:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.30A 2ac7A-3qpbA:
30.7
2ac7B-3qpbA:
30.7		 2ac7A-3qpbA:
31.10
2ac7B-3qpbA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.43A 2ac7A-3bjeA:
27.6
2ac7B-3bjeA:
27.7		 2ac7A-3bjeA:
26.00
2ac7B-3bjeA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 2ac7A-3kvyA:
23.5
2ac7B-3kvyA:
23.6		 2ac7A-3kvyA:
25.24
2ac7B-3kvyA:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.31A 2ac7A-3qpbA:
30.7
2ac7B-3qpbA:
30.7		 2ac7A-3qpbA:
31.10
2ac7B-3qpbA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 3qe7 URACIL PERMEASE
(Escherichia
coli) 		5 / 12 LEU A 134
GLY A 133
VAL A 344
ALA A  31
LEU A  34
 BNG  A 431 ( 4.7A)
BNG  A 431 (-3.2A)
None
URA  A 430 ( 3.8A)
None
 0.76A 2oz7A-3qe7A:
undetectable		 2oz7A-3qe7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		4 / 7 TRP A 153
GLY A  94
ILE A 222
PHE A 156
 None
URA  A1282 (-3.6A)
None
None
 1.04A 2qmzA-1oe5A:
undetectable
2qmzB-1oe5A:
undetectable		 2qmzA-1oe5A:
21.80
2qmzB-1oe5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3qe7 URACIL PERMEASE
(Escherichia
coli) 		5 / 12 PHE A  73
PRO A  43
ALA A  44
ALA A 140
ALA A 144
 URA  A 430 (-3.4A)
None
None
None
None
 1.00A 2x2nA-3qe7A:
undetectable		 2x2nA-3qe7A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3qe7 URACIL PERMEASE
(Escherichia
coli) 		5 / 12 PHE A  73
PRO A  43
ALA A  44
ALA A 140
ALA A 144
 URA  A 430 (-3.4A)
None
None
None
None
 0.96A 2x2nB-3qe7A:
undetectable		 2x2nB-3qe7A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 10 THR A 140
GLY A 142
PHE A 242
GLN A 246
ARG A 248
GLU A 284
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-4.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
 0.29A 3kvrA-3bjeA:
23.9		 3kvrA-3bjeA:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		10 / 10 THR A 140
GLY A 142
PHE A 212
GLN A 216
ARG A 218
GLU A 247
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-4.5A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
None
None
None
 0.18A 3kvrA-3kvyA:
49.5		 3kvrA-3kvyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 THR A  97
GLY A  99
PHE A 165
GLU A 196
MET A 197
 R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.5A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
 0.42A 3kvrA-3qpbA:
24.6		 3kvrA-3qpbA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 10 PHE A 161
GLN A 165
ARG A 167
GLU A 195
MET A 196
ILE A 220
 URI  A 303 (-4.3A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
URA  A 304 (-4.3A)
 1.18A 3kvrA-5lhvA:
26.1		 3kvrA-5lhvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		7 / 10 THR A  93
GLY A  95
PHE A 161
GLN A 165
ARG A 167
GLU A 195
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URI  A 303 (-4.3A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
 0.33A 3kvrA-5lhvA:
26.1		 3kvrA-5lhvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 10 THR A 140
GLY A 142
PHE A 242
GLN A 246
ARG A 248
GLU A 284
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-4.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
 0.21A 3kvrB-3bjeA:
23.9		 3kvrB-3bjeA:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		10 / 10 THR A 140
GLY A 142
PHE A 212
GLN A 216
ARG A 218
GLU A 247
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-4.5A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
None
None
None
 0.26A 3kvrB-3kvyA:
8.3		 3kvrB-3kvyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 THR A  97
GLY A  99
PHE A 165
GLU A 196
MET A 197
 R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.5A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
 0.46A 3kvrB-3qpbA:
24.5		 3kvrB-3qpbA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		7 / 10 THR A  93
GLY A  95
PHE A 161
GLN A 165
ARG A 167
GLU A 195
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URI  A 303 (-4.3A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
 0.30A 3kvrB-5lhvA:
26.0		 3kvrB-5lhvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 10 THR A  93
PHE A 161
GLN A 165
ARG A 167
MET A 196
ILE A 220
 SO4  A 301 ( 2.9A)
URI  A 303 (-4.3A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
URA  A 304 (-4.3A)
 1.35A 3kvrB-5lhvA:
26.0		 3kvrB-5lhvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.20A 3kvvA-3bjeA:
30.5		 3kvvA-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.25A 3kvvA-3kvyA:
26.0		 3kvvA-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 6 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.18A 3kvvA-5lhvA:
44.2		 3kvvA-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.21A 3kvvB-3bjeA:
30.4		 3kvvB-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.26A 3kvvB-3kvyA:
25.8		 3kvvB-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 6 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.16A 3kvvB-5lhvA:
43.8		 3kvvB-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.21A 3kvvC-3bjeA:
30.0		 3kvvC-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.27A 3kvvC-3kvyA:
25.4		 3kvvC-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 6 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.17A 3kvvC-5lhvA:
43.3		 3kvvC-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.28A 3kvvD-3bjeA:
29.9		 3kvvD-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.32A 3kvvD-3kvyA:
25.2		 3kvvD-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 6 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.19A 3kvvD-5lhvA:
43.5		 3kvvD-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.24A 3kvvE-3bjeA:
30.9		 3kvvE-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.28A 3kvvE-3kvyA:
26.3		 3kvvE-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 6 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.11A 3kvvE-5lhvA:
44.5		 3kvvE-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.25A 3kvvF-3bjeA:
13.6		 3kvvF-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.29A 3kvvF-3kvyA:
25.1		 3kvvF-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 6 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.18A 3kvvF-5lhvA:
42.8		 3kvvF-5lhvA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  99
GLY A 100
VAL A  95
VAL A 139
LEU A 143
 URA  A1255 (-3.2A)
None
None
None
None
 1.03A 3m6wA-3qpbA:
undetectable		 3m6wA-3qpbA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 THR A 140
GLY A 142
GLN A 246
ARG A 248
GLU A 284
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
 0.31A 3nbqA-3bjeA:
23.3		 3nbqA-3bjeA:
26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		9 / 9 THR A 140
GLY A 142
GLN A 216
ARG A 218
GLU A 247
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
None
None
None
 0.15A 3nbqA-3kvyA:
46.7		 3nbqA-3kvyA:
75.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 9 GLN A 165
ARG A 167
GLU A 195
MET A 196
ILE A 220
 URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
URA  A 304 (-4.3A)
 1.06A 3nbqA-5lhvA:
26.0		 3nbqA-5lhvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 9 THR A  93
GLY A  95
GLN A 165
ARG A 167
GLU A 195
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
 0.32A 3nbqA-5lhvA:
26.0		 3nbqA-5lhvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.26A 3nbqB-3bjeA:
23.4		 3nbqB-3bjeA:
26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		8 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
None
None
 0.21A 3nbqB-3kvyA:
46.4		 3nbqB-3kvyA:
75.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
 0.33A 3nbqB-5lhvA:
26.0		 3nbqB-5lhvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.24A 3nbqC-3bjeA:
23.4		 3nbqC-3bjeA:
26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		8 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
None
None
 0.16A 3nbqC-3kvyA:
46.5		 3nbqC-3kvyA:
75.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
 0.28A 3nbqC-5lhvA:
25.9		 3nbqC-5lhvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
ARG A 311
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
None
 0.37A 3nbqD-3bjeA:
23.5		 3nbqD-3bjeA:
26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		9 / 9 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
LEU A 271
LEU A 272
ARG A 274
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
None
None
None
 0.23A 3nbqD-3kvyA:
46.5		 3nbqD-3kvyA:
75.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 9 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ARG A 222
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.50A 3nbqD-5lhvA:
26.1		 3nbqD-5lhvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 9 MET A 109
ARG A 137
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.46A 3u40A-3kvyA:
24.3
3u40F-3kvyA:
23.3		 3u40A-3kvyA:
27.36
3u40F-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 MET A 109
ARG A 137
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.44A 3u40B-3kvyA:
24.4
3u40C-3kvyA:
24.0		 3u40B-3kvyA:
27.36
3u40C-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.46A 3u40B-3bjeA:
28.6
3u40C-3bjeA:
15.2		 3u40B-3bjeA:
23.61
3u40C-3bjeA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 12 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 3u40B-3kvyA:
24.5
3u40C-3kvyA:
24.0		 3u40B-3kvyA:
27.36
3u40C-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.44A 3u40B-3qpbA:
31.0
3u40C-3qpbA:
30.9		 3u40B-3qpbA:
29.79
3u40C-3qpbA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.43A 3u40D-3bjeA:
29.1
3u40E-3bjeA:
27.9		 3u40D-3bjeA:
23.61
3u40E-3bjeA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.33A 3u40D-3kvyA:
24.6
3u40E-3kvyA:
23.7		 3u40D-3kvyA:
27.36
3u40E-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.39A 3u40D-3qpbA:
31.2
3u40E-3qpbA:
31.3		 3u40D-3qpbA:
29.79
3u40E-3qpbA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.51A 3u40D-3bjeA:
29.1
3u40E-3bjeA:
27.9		 3u40D-3bjeA:
23.61
3u40E-3bjeA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 12 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.37A 3u40D-3kvyA:
24.6
3u40E-3kvyA:
23.7		 3u40D-3kvyA:
27.36
3u40E-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.47A 3u40D-3qpbA:
31.2
3u40E-3qpbA:
31.3		 3u40D-3qpbA:
29.79
3u40E-3qpbA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 MET A 109
ARG A 137
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.39A 3u40A-3kvyA:
24.3
3u40F-3kvyA:
23.3		 3u40A-3kvyA:
27.36
3u40F-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.43A 3uawA-3bjeA:
17.2		 3uawA-3bjeA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.27A 3uawA-3bjeA:
17.2		 3uawA-3bjeA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.36A 3uawA-3kvyA:
24.4		 3uawA-3kvyA:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 3uawA-3qpbA:
31.5		 3uawA-3qpbA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 10 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.42A 3uayA-3bjeA:
29.5		 3uayA-3bjeA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 10 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 3uayA-3kvyA:
24.9		 3uayA-3kvyA:
25.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 10 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.32A 3uayA-3qpbA:
31.2		 3uayA-3qpbA:
31.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 10 ARG A  90
GLY A  95
GLU A 195
MET A 196
GLU A 197
ILE A 220
 SO4  A 301 ( 3.0A)
URI  A 303 ( 3.4A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
URI  A 303 (-2.7A)
URA  A 304 (-4.3A)
 1.50A 3uayA-5lhvA:
13.0		 3uayA-5lhvA:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.14A 4coxA-5gnwC:
undetectable		 4coxA-5gnwC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.14A 4coxB-5gnwC:
undetectable		 4coxB-5gnwC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.14A 4coxD-5gnwC:
0.4		 4coxD-5gnwC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.34A 4d9hA-3bjeA:
28.2		 4d9hA-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.06A 4d9hA-3bjeA:
28.2		 4d9hA-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.32A 4d9hA-3kvyA:
25.0		 4d9hA-3kvyA:
25.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.37A 4d9hA-3qpbA:
30.4		 4d9hA-3qpbA:
34.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 MET A  87
GLY A 142
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.09A 4da6A-3bjeA:
27.8		 4da6A-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 10 MET A  87
ARG A 137
GLY A 142
ALA A 239
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
None
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 0.96A 4da7A-3bjeA:
28.1		 4da7A-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.35A 4da7A-3kvyA:
25.0		 4da7A-3kvyA:
25.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.37A 4da7A-3qpbA:
30.3		 4da7A-3qpbA:
34.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.30A 4danA-3bjeA:
27.8		 4danA-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
URA  A 501 (-3.2A)
 1.09A 4danA-3bjeA:
27.8		 4danA-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.30A 4danA-3kvyA:
24.6		 4danA-3kvyA:
25.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.38A 4danA-3qpbA:
29.9		 4danA-3qpbA:
34.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.32A 4danA-3bjeA:
27.8
4danB-3bjeA:
28.0		 4danA-3bjeA:
27.25
4danB-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.15A 4danA-3bjeA:
27.8
4danB-3bjeA:
28.0		 4danA-3bjeA:
27.25
4danB-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 12 ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.32A 4danA-3kvyA:
24.6
4danB-3kvyA:
24.5		 4danA-3kvyA:
25.08
4danB-3kvyA:
25.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 4danA-3qpbA:
29.9
4danB-3qpbA:
30.2		 4danA-3qpbA:
34.58
4danB-3qpbA:
34.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4e1vA-3bjeA:
17.2		 4e1vA-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.28A 4e1vA-3kvyA:
25.9		 4e1vA-3kvyA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.20A 4e1vA-5lhvA:
42.1		 4e1vA-5lhvA:
75.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.25A 4e1vB-3bjeA:
29.6		 4e1vB-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 7 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.33A 4e1vB-3kvyA:
25.7		 4e1vB-3kvyA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.18A 4e1vB-5lhvA:
20.0		 4e1vB-5lhvA:
75.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4e1vC-3bjeA:
29.6		 4e1vC-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.29A 4e1vC-3kvyA:
25.4		 4e1vC-3kvyA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.18A 4e1vC-5lhvA:
20.2		 4e1vC-5lhvA:
75.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4e1vD-3bjeA:
29.9		 4e1vD-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.30A 4e1vD-3kvyA:
25.7		 4e1vD-3kvyA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.17A 4e1vD-5lhvA:
42.2		 4e1vD-5lhvA:
75.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4e1vE-3bjeA:
30.0		 4e1vE-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.30A 4e1vE-3kvyA:
26.2		 4e1vE-3kvyA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.18A 4e1vE-5lhvA:
42.2		 4e1vE-5lhvA:
75.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.26A 4e1vF-3bjeA:
29.6		 4e1vF-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.29A 4e1vF-3kvyA:
25.7		 4e1vF-3kvyA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 6 GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.23A 4e1vF-5lhvA:
41.8		 4e1vF-5lhvA:
75.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.38A 4e1vG-3bjeA:
28.8		 4e1vG-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.49A 4e1vG-3kvyA:
25.4		 4e1vG-3kvyA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.40A 4e1vG-5lhvA:
19.1		 4e1vG-5lhvA:
75.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4e1vH-3bjeA:
29.7		 4e1vH-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.30A 4e1vH-3kvyA:
25.7		 4e1vH-3kvyA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		6 / 8 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ILE A 219
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.17A 4e1vH-5lhvA:
19.6		 4e1vH-5lhvA:
75.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3qe7 URACIL PERMEASE
(Escherichia
coli) 		4 / 8 LEU A 236
PRO A 284
SER A  72
GLY A 271
 None
None
URA  A 430 (-4.4A)
None
 1.01A 4klrB-3qe7A:
undetectable		 4klrB-3qe7A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3qe7 URACIL PERMEASE
(Escherichia
coli) 		5 / 9 ALA A 140
ILE A 329
GLY A  30
ALA A  31
VAL A  37
 None
None
None
URA  A 430 ( 3.8A)
None
 1.04A 4r1zA-3qe7A:
undetectable		 4r1zA-3qe7A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 7 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.20A 4txnA-3bjeA:
23.2		 4txnA-3bjeA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 7 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
 0.33A 4txnA-3kvyA:
41.6		 4txnA-3kvyA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 THR A  93
GLN A 165
ARG A 167
MET A 196
ILE A 220
 SO4  A 301 ( 2.9A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
URA  A 304 (-4.3A)
 1.39A 4txnA-5lhvA:
25.0		 4txnA-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
 0.36A 4txnA-5lhvA:
25.0		 4txnA-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 7 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4txnB-3bjeA:
23.1		 4txnB-3bjeA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 7 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
 0.36A 4txnB-3kvyA:
41.8		 4txnB-3kvyA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 THR A  93
GLN A 165
ARG A 167
MET A 196
ILE A 220
 SO4  A 301 ( 2.9A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
URA  A 304 (-4.3A)
 1.37A 4txnB-5lhvA:
25.0		 4txnB-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
 0.39A 4txnB-5lhvA:
25.0		 4txnB-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 7 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.20A 4txnC-3bjeA:
23.0		 4txnC-3bjeA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 7 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
 0.32A 4txnC-3kvyA:
41.8		 4txnC-3kvyA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 THR A  93
GLN A 165
ARG A 167
MET A 196
ILE A 220
 SO4  A 301 ( 2.9A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
URA  A 304 (-4.3A)
 1.40A 4txnC-5lhvA:
25.0		 4txnC-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
 0.36A 4txnC-5lhvA:
25.0		 4txnC-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 7 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.20A 4txnD-3bjeA:
22.9		 4txnD-3bjeA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 7 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
 0.36A 4txnD-3kvyA:
41.7		 4txnD-3kvyA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 THR A  93
GLN A 165
ARG A 167
MET A 196
ILE A 220
 SO4  A 301 ( 2.9A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
URA  A 304 (-4.3A)
 1.38A 4txnD-5lhvA:
24.9		 4txnD-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 5lhv URIDINE
PHOSPHORYLASE
(Vibrio
cholerae) 		5 / 7 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
 0.38A 4txnD-5lhvA:
24.9		 4txnD-5lhvA:
25.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		4 / 8 GLY A  62
GLN A  63
PHE A  77
ASN A 123
 URA  A 230 ( 4.1A)
None
URA  A 230 (-3.6A)
URA  A 230 (-2.9A)
 0.94A 4wryA-1flzA:
30.8		 4wryA-1flzA:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		6 / 8 GLY A  62
TYR A  66
PHE A  77
SER A  88
ASN A 123
HIS A 187
 URA  A 230 ( 4.1A)
URA  A 230 (-3.2A)
URA  A 230 (-3.6A)
URA  A 230 ( 4.9A)
URA  A 230 (-2.9A)
URA  A 230 (-4.1A)
 0.38A 4wryA-1flzA:
30.8		 4wryA-1flzA:
36.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 8 GLY A  94
PHE A 109
SER A 148
ASN A 174
HIS A 250
 URA  A1282 (-3.6A)
URA  A1282 (-3.6A)
URA  A1282 ( 4.4A)
URA  A1282 (-3.0A)
URA  A1282 (-4.1A)
 0.39A 4wryA-1oe5A:
10.4		 4wryA-1oe5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		4 / 8 GLY C  55
GLN C  56
ASN C  94
HIS C 168
 URA  C 301 ( 3.9A)
None
URA  C 301 (-2.9A)
URA  C 301 (-3.6A)
 0.54A 4wryA-5gnwC:
8.5		 4wryA-5gnwC:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		4 / 8 GLY A  62
GLN A  63
PHE A  77
ASN A 123
 URA  A 230 ( 4.1A)
None
URA  A 230 (-3.6A)
URA  A 230 (-2.9A)
 0.92A 4wrzA-1flzA:
30.7		 4wrzA-1flzA:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		4 / 8 GLY A  62
PHE A  77
SER A 189
ASN A 123
 URA  A 230 ( 4.1A)
URA  A 230 (-3.6A)
None
URA  A 230 (-2.9A)
 0.89A 4wrzA-1flzA:
30.7		 4wrzA-1flzA:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		6 / 8 GLY A  62
TYR A  66
PHE A  77
SER A  88
ASN A 123
HIS A 187
 URA  A 230 ( 4.1A)
URA  A 230 (-3.2A)
URA  A 230 (-3.6A)
URA  A 230 ( 4.9A)
URA  A 230 (-2.9A)
URA  A 230 (-4.1A)
 0.38A 4wrzA-1flzA:
30.7		 4wrzA-1flzA:
36.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 8 GLY A  94
PHE A 109
SER A 148
ASN A 174
HIS A 250
 URA  A1282 (-3.6A)
URA  A1282 (-3.6A)
URA  A1282 ( 4.4A)
URA  A1282 (-3.0A)
URA  A1282 (-4.1A)
 0.44A 4wrzA-1oe5A:
10.1		 4wrzA-1oe5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		4 / 8 GLY C  55
GLN C  56
ASN C  94
HIS C 168
 URA  C 301 ( 3.9A)
None
URA  C 301 (-2.9A)
URA  C 301 (-3.6A)
 0.52A 4wrzA-5gnwC:
8.4		 4wrzA-5gnwC:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		5 / 7 GLY A  62
TYR A  66
PHE A  77
ASN A 123
HIS A 187
 URA  A 230 ( 4.1A)
URA  A 230 (-3.2A)
URA  A 230 (-3.6A)
URA  A 230 (-2.9A)
URA  A 230 (-4.1A)
 0.29A 4ws0A-1flzA:
30.3		 4ws0A-1flzA:
36.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		4 / 7 GLY A  94
PHE A 109
ASN A 174
HIS A 250
 URA  A1282 (-3.6A)
URA  A1282 (-3.6A)
URA  A1282 (-3.0A)
URA  A1282 (-4.1A)
 0.42A 4ws0A-1oe5A:
9.8		 4ws0A-1oe5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		4 / 7 GLY C  55
GLN C  56
ASN C  94
HIS C 168
 URA  C 301 ( 3.9A)
None
URA  C 301 (-2.9A)
URA  C 301 (-3.6A)
 0.59A 4ws0A-5gnwC:
8.0		 4ws0A-5gnwC:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		6 / 8 GLY A  62
TYR A  66
PHE A  77
SER A  88
ASN A 123
HIS A 187
 URA  A 230 ( 4.1A)
URA  A 230 (-3.2A)
URA  A 230 (-3.6A)
URA  A 230 ( 4.9A)
URA  A 230 (-2.9A)
URA  A 230 (-4.1A)
 0.32A 4ws1A-1flzA:
30.3		 4ws1A-1flzA:
36.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 8 GLY A  94
PHE A 109
SER A 148
ASN A 174
HIS A 250
 URA  A1282 (-3.6A)
URA  A1282 (-3.6A)
URA  A1282 ( 4.4A)
URA  A1282 (-3.0A)
URA  A1282 (-4.1A)
 0.45A 4ws1A-1oe5A:
9.7		 4ws1A-1oe5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		4 / 8 GLY C  55
GLN C  56
ASN C  94
HIS C 168
 URA  C 301 ( 3.9A)
None
URA  C 301 (-2.9A)
URA  C 301 (-3.6A)
 0.56A 4ws1A-5gnwC:
7.9		 4ws1A-5gnwC:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 10 LEU A  65
ALA A  97
LEU A 101
ARG A 202
LEU A  84
 None
None
URA  A 232 ( 4.4A)
None
None
 1.50A 5hyrA-1kskA:
undetectable		 5hyrA-1kskA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 MET A  87
ARG A 137
GLY A 142
ALA A 239
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
None
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.30A 5i3cA-3bjeA:
28.9		 5i3cA-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 9 MET A 109
ARG A 137
GLY A 142
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 5i3cA-3kvyA:
25.1		 5i3cA-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
GLY A 142
ALA A 239
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
None
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.37A 5i3cB-3bjeA:
29.0		 5i3cB-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 MET A 109
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 5i3cB-3kvyA:
14.4		 5i3cB-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
GLY A 142
ALA A 239
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
None
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.10A 5i3cC-3bjeA:
29.3		 5i3cC-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 11 MET A 109
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 5i3cC-3kvyA:
25.3		 5i3cC-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.04A 5iktA-5gnwC:
undetectable		 5iktA-5gnwC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 12 ILE A 222
LEU A 270
PHE A  92
ASN A 174
GLY A 223
 None
None
None
URA  A1282 (-3.0A)
None
 1.26A 5il1A-1oe5A:
undetectable		 5il1A-1oe5A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 12 ILE A 222
LEU A 270
PHE A  92
ASN A 174
GLY A 223
 None
None
None
URA  A1282 (-3.0A)
None
 1.26A 5k7uA-1oe5A:
undetectable		 5k7uA-1oe5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 12 ASN A 174
GLY A  94
LEU A 119
GLY A 149
SER A 148
 URA  A1282 (-3.0A)
URA  A1282 (-3.6A)
None
None
URA  A1282 ( 4.4A)
 1.16A 5vooB-1oe5A:
undetectable		 5vooB-1oe5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 12 ASN A 174
GLY A  94
LEU A 119
GLY A 149
SER A 148
 URA  A1282 (-3.0A)
URA  A1282 (-3.6A)
None
None
URA  A1282 ( 4.4A)
 1.10A 5vooD-1oe5A:
undetectable		 5vooD-1oe5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 12 ASN A 174
GLY A  94
LEU A 119
GLY A 149
SER A 148
 URA  A1282 (-3.0A)
URA  A1282 (-3.6A)
None
None
URA  A1282 ( 4.4A)
 1.04A 5vooF-1oe5A:
undetectable		 5vooF-1oe5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 5 THR A 140
THR A 209
GLN A 216
ASP A 159
 SO4  A 311 ( 3.1A)
None
URA  A 312 (-3.3A)
None
 1.38A 6ectA-3kvyA:
undetectable		 6ectA-3kvyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3qe7 URACIL PERMEASE
(Escherichia
coli) 		5 / 12 HIS A  24
PRO A 216
VAL A 294
GLU A 290
GLY A 289
 None
None
None
URA  A 430 (-2.6A)
BNG  A 431 ( 3.0A)
 1.40A 6gngA-3qe7A:
undetectable		 6gngA-3qe7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		3 / 3 ASP A  64
SER A 189
SER A  88
 None
None
URA  A 230 ( 4.9A)
 0.69A 6mxtA-1flzA:
0.0		 6mxtA-1flzA:
18.37