SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UQ8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1G5Y_C_9CRC502_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3q34	YCEI-LIKE FAMILY PROTEIN (Pseudomonas savastanoi)	5 / 10	PHE A 86 ARG A 125 LEU A 124 PHE A 34 ILE A 155	None None UQ8 A 1 ( 4.7A) UQ8 A 1 (-3.8A) UQ8 A 1 ( 4.8A)	1.26A	1g5yC-3q34A: undetectable	1g5yC-3q34A: 22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	3q34	YCEI-LIKE FAMILY PROTEIN (Pseudomonas savastanoi)	5 / 12	VAL A 182 LEU A 188 ALA A 186 LEU A 32 ALA A 133	None None UQ8 A 1 ( 4.4A) UQ8 A 1 (-4.3A) UQ8 A 1 ( 3.9A)	0.99A	1sa1A-3q34A: undetectable 1sa1B-3q34A: undetectable	1sa1A-3q34A: 16.89 1sa1B-3q34A: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	3q34	YCEI-LIKE FAMILY PROTEIN (Pseudomonas savastanoi)	5 / 12	VAL A 182 LEU A 188 ALA A 186 LEU A 32 ALA A 133	None None UQ8 A 1 ( 4.4A) UQ8 A 1 (-4.3A) UQ8 A 1 ( 3.9A)	1.01A	1sa1C-3q34A: undetectable 1sa1D-3q34A: undetectable	1sa1C-3q34A: 16.89 1sa1D-3q34A: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_B_SAMB201_0 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	3e8t	TAKEOUT-LIKE PROTEIN 1 (Epiphyas postvittana)	5 / 12	ALA A 91 GLY A 65 LEU A 116 LEU A 118 LEU A 58	UQ8 A 221 ( 4.7A) None None UQ8 A 221 (-4.9A) None	0.98A	2nyuB-3e8tA: undetectable	2nyuB-3e8tA: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3V_A_TOPA1169_1 (DIHYDROFOLATE REDUCTASE)	3q34	YCEI-LIKE FAMILY PROTEIN (Pseudomonas savastanoi)	5 / 12	ILE A 96 LEU A 32 LEU A 124 ILE A 155 THR A 149	UQ8 A 1 (-3.6A) UQ8 A 1 (-4.3A) UQ8 A 1 ( 4.7A) UQ8 A 1 ( 4.8A) None	1.08A	2w3vA-3q34A: undetectable	2w3vA-3q34A: 23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DFR_A_MTXA164_1 (DIHYDROFOLATE REDUCTASE)	3q34	YCEI-LIKE FAMILY PROTEIN (Pseudomonas savastanoi)	5 / 12	LEU A 124 LEU A 120 LEU A 153 LEU A 32 ALA A 94	UQ8 A 1 ( 4.7A) UQ8 A 1 (-4.4A) None UQ8 A 1 (-4.3A) UQ8 A 1 ( 4.4A)	1.14A	3dfrA-3q34A: undetectable	3dfrA-3q34A: 23.30

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1G5Y_C_9CRC502_1","RETINOIC ACID RECEPTOR RXR-ALPHA","3q34","YCEI-LIKE FAMILY PROTEIN","Pseudomonas savastanoi",5,"PHE A  86;ARG A 125;LEU A 124;PHE A  34;ILE A 155","None;None;UQ8 A   1 ( 4.7A);UQ8 A   1 (-3.8A);UQ8 A   1 ( 4.8A)","1.26A","1g5yC-3q34A:undetectable",null],["1SA1_B_PODB700_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","3q34","YCEI-LIKE FAMILY PROTEIN","Pseudomonas savastanoi",5,"VAL A 182;LEU A 188;ALA A 186;LEU A  32;ALA A 133","None;None;UQ8 A   1 ( 4.4A);UQ8 A   1 (-4.3A);UQ8 A   1 ( 3.9A)","0.99A","1sa1A-3q34A:undetectable;1sa1B-3q34A:undetectable","1g5yC-3q34A:22.64"],["1SA1_D_PODD701_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","3q34","YCEI-LIKE FAMILY PROTEIN","Pseudomonas savastanoi",5,"VAL A 182;LEU A 188;ALA A 186;LEU A  32;ALA A 133","None;None;UQ8 A   1 ( 4.4A);UQ8 A   1 (-4.3A);UQ8 A   1 ( 3.9A)","1.01A","1sa1C-3q34A:undetectable;1sa1D-3q34A:undetectable","1sa1A-3q34A:16.89;1sa1B-3q34A:18.16"],["2NYU_B_SAMB201_0","PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2","3e8t","TAKEOUT-LIKE PROTEIN 1","Epiphyas postvittana",5,"ALA A  91;GLY A  65;LEU A 116;LEU A 118;LEU A  58","UQ8 A 221 ( 4.7A);None;None;UQ8 A 221 (-4.9A);None","0.98A","2nyuB-3e8tA:undetectable","1sa1C-3q34A:16.89;1sa1D-3q34A:18.16"],["2W3V_A_TOPA1169_1","DIHYDROFOLATE REDUCTASE","3q34","YCEI-LIKE FAMILY PROTEIN","Pseudomonas savastanoi",5,"ILE A  96;LEU A  32;LEU A 124;ILE A 155;THR A 149","UQ8 A   1 (-3.6A);UQ8 A   1 (-4.3A);UQ8 A   1 ( 4.7A);UQ8 A   1 ( 4.8A);None","1.08A","2w3vA-3q34A:undetectable","2nyuB-3e8tA:21.85"],["3DFR_A_MTXA164_1","DIHYDROFOLATE REDUCTASE","3q34","YCEI-LIKE FAMILY PROTEIN","Pseudomonas savastanoi",5,"LEU A 124;LEU A 120;LEU A 153;LEU A  32;ALA A  94","UQ8 A   1 ( 4.7A);UQ8 A   1 (-4.4A);None;UQ8 A   1 (-4.3A);UQ8 A   1 ( 4.4A)","1.14A","3dfrA-3q34A:undetectable","2w3vA-3q34A:23.68"]]