SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UPL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.83A 1rx2A-1lshA:
undetectable		 1rx2A-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 7 ARG A 806
GLY A 814
ILE A 815
PRO A 284
 None
None
UPL  A2014 ( 4.6A)
None
 0.70A 2fxdB-1lshA:
undetectable		 2fxdB-1lshA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 10 ALA A 123
GLY A 814
ILE A 815
VAL A  69
LEU A  97
 None
None
UPL  A2014 ( 4.6A)
None
None
 0.99A 3ogpA-1lshA:
undetectable		 3ogpA-1lshA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 11 ILE A 126
MET A 291
LEU A  46
ILE A 815
THR A 120
 UPL  A2014 ( 4.7A)
None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
UPL  A2014 ( 3.9A)
 1.07A 4p66A-1lshA:
undetectable		 4p66A-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 11 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.82A 4p66A-1lshA:
undetectable		 4p66A-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.93A 4pstA-1lshA:
undetectable		 4pstA-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.97A 4pthA-1lshA:
undetectable		 4pthA-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 5 TYR A  28
GLN A 254
SER A 252
ASP A 878
 UPL  A2014 (-4.6A)
None
None
UPL  A2014 (-4.2A)
 1.00A 4qtuB-1lshA:
undetectable		 4qtuB-1lshA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 9 ILE A 813
GLY A  48
GLN A 236
LEU A  46
LEU A  86
 UPL  A2014 ( 4.9A)
UPL  A2014 (-3.7A)
None
UPL  A2014 ( 4.2A)
None
 1.20A 5fhzB-1lshA:
undetectable		 5fhzB-1lshA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 10 ILE A 813
GLY A  48
GLN A 236
LEU A  46
LEU A  86
 UPL  A2014 ( 4.9A)
UPL  A2014 (-3.7A)
None
UPL  A2014 ( 4.2A)
None
 1.10A 5fhzC-1lshA:
undetectable		 5fhzC-1lshA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 PRO A 653
THR A 508
ILE A 647
GLN A 578
SER A 544
 UPL  A2032 ( 4.6A)
None
None
None
None
 1.26A 5hgcA-1lshA:
0.0		 5hgcA-1lshA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 11 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 1.07A 5z6mA-1lshA:
undetectable		 5z6mA-1lshA:
8.86