SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UPG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AVN_A_HSMA264_1
(CARBONIC ANHYDRASE
II)		 1ll2 GLYCOGENIN-1
(Oryctolagus
cuniculus) 		4 / 4 ASN A 188
HIS A 212
ASN A 133
GLN A 164
 None
MN  A 333 ( 3.4A)
UPG  A 334 (-3.4A)
UPG  A 334 (-2.9A)
 1.18A 1avnA-1ll2A:
0.0		 1avnA-1ll2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 ARG A  25
ASP A 142
ASP A 143
TYR A 179
 None
MG  A 325 ( 2.6A)
UPG  A 326 (-3.5A)
UPG  A 326 (-4.6A)
 1.11A 1ceaB-2pa4A:
undetectable		 1ceaB-2pa4A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 ARG A  25
ASP A 142
ASP A 143
TYR A 179
 None
MG  A 325 ( 2.6A)
UPG  A 326 (-3.5A)
UPG  A 326 (-4.6A)
 0.88A 1cebA-2pa4A:
undetectable		 1cebA-2pa4A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 5 ARG A 312
ALA A 249
ASP A 241
GLY A 247
 IOD  A 405 (-3.7A)
UPG  A 401 (-3.2A)
None
None
 0.94A 1e7bA-4lisA:
undetectable		 1e7bA-4lisA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 5 ARG A 312
ALA A 249
ASP A 241
GLY A 247
 IOD  A 405 (-3.7A)
UPG  A 401 (-3.2A)
None
None
 0.94A 1e7cA-4lisA:
undetectable		 1e7cA-4lisA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 6 LEU A 169
HIS A  92
LEU A  59
LEU A  62
 None
UPG  A1415 (-4.6A)
None
None
 0.94A 1errA-2xa2A:
undetectable		 1errA-2xa2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 7 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.88A 1gtfL-2icyA:
undetectable
1gtfM-2icyA:
undetectable		 1gtfL-2icyA:
12.69
1gtfM-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.87A 1gtfN-2icyA:
undetectable
1gtfO-2icyA:
undetectable		 1gtfN-2icyA:
12.69
1gtfO-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 1z45 GAL10 BIFUNCTIONAL
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 10 THR A 160
PRO A 159
GLY A 158
LEU A 318
ARG A 144
 None
None
None
UPG  A 704 (-3.9A)
None
 1.27A 1h4oA-1z45A:
undetectable
1h4oB-1z45A:
undetectable		 1h4oA-1z45A:
13.03
1h4oB-1z45A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 1z45 GAL10 BIFUNCTIONAL
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 8 THR A 160
PRO A 159
GLY A 158
LEU A 318
ARG A 144
 None
None
None
UPG  A 704 (-3.9A)
None
 1.27A 1h4oG-1z45A:
undetectable		 1h4oG-1z45A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 12 LEU A 143
GLY A  84
GLY A  83
THR A 139
LEU A 107
 None
UPG  A 484 (-3.3A)
UPG  A 484 (-3.0A)
None
None
 1.07A 1liiA-3gueA:
undetectable		 1liiA-3gueA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.27A 1mj2A-3gueA:
undetectable		 1mj2A-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.25A 1mj2A-5nzgA:
undetectable		 1mj2A-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.31A 1mj2C-3gueA:
undetectable		 1mj2C-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.29A 1mj2C-5nzgA:
undetectable		 1mj2C-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.33A 1mjoA-3gueA:
undetectable		 1mjoA-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.31A 1mjoA-5nzgA:
undetectable		 1mjoA-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.31A 1mjoB-3gueA:
undetectable		 1mjoB-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.28A 1mjoB-5nzgA:
undetectable		 1mjoB-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 9 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.31A 1mjoC-3gueA:
undetectable		 1mjoC-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.30A 1mjoC-5nzgA:
undetectable		 1mjoC-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 327
ASP A 231
ASN A 228
 UPG  A 402 (-2.7A)
None
None
 0.76A 1nbhA-1qrrA:
7.3		 1nbhA-1qrrA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 327
ASP A 231
ASN A 228
 UPG  A 402 (-2.7A)
None
None
 0.76A 1nbhD-1qrrA:
7.0		 1nbhD-1qrrA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 12 HIS A 155
ILE A 156
LEU A 169
VAL A 114
ILE A  78
 None
UPG  A1415 (-4.3A)
None
None
None
 1.01A 1zq9A-2xa2A:
4.0		 1zq9A-2xa2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 GLU A 445
GLY A 449
ASN A 224
ALA A 452
ALA A 456
 None
UPG  A1525 ( 3.7A)
None
None
None
 1.20A 2br4B-2wzgA:
undetectable		 2br4B-2wzgA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_A_SAMA1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ASN B 200
VAL B 229
GLY B 204
SER B 207
HIS B 205
 None
None
None
UPG  B 403 ( 4.7A)
None
 1.21A 2cl5A-4xsrB:
4.2		 2cl5A-4xsrB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		5 / 9 GLN A 236
GLU A 334
ILE A 350
ALA A 326
VAL A 347
 None
UPG  A1415 (-3.0A)
None
None
None
 1.28A 2drdA-2xa2A:
undetectable		 2drdA-2xa2A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 PHE A 239
ALA A 452
SER A 448
ALA A 456
GLY A 451
 None
None
UPG  A1525 ( 4.9A)
None
None
 1.23A 2igtC-2wzgA:
undetectable		 2igtC-2wzgA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLN B  99
ALA B 101
GLY B  13
LEU B  17
ASP B   7
 None
None
UPG  B 403 ( 4.0A)
UPG  B 403 (-4.6A)
None
 1.14A 2nv4A-4xsrB:
undetectable		 2nv4A-4xsrB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 5 PRO A 141
ILE A  46
GLY A  45
LYS A  35
 UPG  A 326 (-4.2A)
None
None
UPG  A 326 (-3.0A)
 0.95A 2qeuA-2pa4A:
undetectable
2qeuC-2pa4A:
undetectable		 2qeuA-2pa4A:
19.94
2qeuC-2pa4A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 MET A 315
THR A 334
LEU A 297
ILE A 304
PRO A 189
 None
None
None
None
UPG  A 901 (-4.1A)
 1.12A 2qxsB-2icyA:
undetectable		 2qxsB-2icyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 SER A 210
ALA A 214
THR A 242
ILE A 245
 None
UPG  A 326 (-3.9A)
UPG  A 326 (-4.3A)
None
 0.87A 3bpxA-2pa4A:
undetectable
3bpxB-2pa4A:
undetectable		 3bpxA-2pa4A:
19.18
3bpxB-2pa4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A 138
 None
UPG  A 326 (-3.2A)
None
None
None
 1.38A 3fi0D-2pa4A:
undetectable		 3fi0D-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A  16
 None
UPG  A 326 (-3.2A)
None
None
None
 1.24A 3fi0F-2pa4A:
undetectable		 3fi0F-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A 138
 None
UPG  A 326 (-3.2A)
None
None
None
 1.36A 3fi0F-2pa4A:
undetectable		 3fi0F-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A  16
 None
UPG  A 326 (-3.2A)
None
None
None
 1.23A 3fi0J-2pa4A:
undetectable		 3fi0J-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A 138
 None
UPG  A 326 (-3.2A)
None
None
None
 1.40A 3fi0J-2pa4A:
undetectable		 3fi0J-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A  16
 None
UPG  A 326 (-3.2A)
None
None
None
 1.18A 3fi0R-2pa4A:
undetectable		 3fi0R-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 123
GLN A 112
ILE A 224
VAL A 136
VAL A 138
 None
UPG  A 326 (-3.2A)
None
None
None
 1.35A 3fi0R-2pa4A:
undetectable		 3fi0R-2pa4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 ALA A 121
LEU A 228
VAL A 138
ILE A 245
LEU A 166
 UPG  A 326 (-3.5A)
None
None
None
None
 1.25A 3jw3B-2pa4A:
undetectable		 3jw3B-2pa4A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 10 ALA A 121
LEU A 228
VAL A 138
ILE A 245
LEU A 166
 UPG  A 326 (-3.5A)
None
None
None
None
 1.13A 3jw5B-2pa4A:
undetectable		 3jw5B-2pa4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		5 / 12 GLU A 288
GLY A  44
GLU A 279
ALA A 350
GLY A 256
 None
None
UPG  A 484 (-2.7A)
UPG  A 484 ( 4.2A)
UPG  A 484 (-3.5A)
 1.33A 3jzjA-3gueA:
1.5		 3jzjA-3gueA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 GLU A 302
ASN A 301
GLY A 260
VAL A 318
ARG A 263
 None
None
None
None
UPG  A 402 (-3.7A)
 1.28A 3k13A-1qrrA:
3.4		 3k13A-1qrrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 10 TYR A 237
GLY A 255
VAL A 234
ASN A 223
GLY A 226
 None
UPG  A1001 (-3.2A)
None
None
None
 1.31A 3km6A-3vtfA:
undetectable		 3km6A-3vtfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 TYR A 237
GLY A 255
VAL A 234
ASN A 223
GLY A 226
 None
UPG  A1001 (-3.2A)
None
None
None
 1.33A 3kmoA-3vtfA:
undetectable		 3kmoA-3vtfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
VAL A 455
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 1.06A 3mteA-3srzA:
undetectable		 3mteA-3srzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 0.93A 3mteB-3srzA:
undetectable		 3mteB-3srzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 0.92A 3p2kA-3srzA:
undetectable		 3p2kA-3srzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
VAL A 455
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 1.11A 3p2kB-3srzA:
undetectable		 3p2kB-3srzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 0.96A 3p2kC-3srzA:
undetectable		 3p2kC-3srzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 0.90A 3p2kD-3srzA:
undetectable		 3p2kD-3srzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Burkholderia
vietnamiensis) 		5 / 10 PRO A  10
HIS A 113
GLY A 112
GLY A  58
ALA A  12
 UPG  A 301 (-4.3A)
None
None
None
UPG  A 301 (-3.2A)
 1.13A 3pp7B-5i1fA:
4.6		 3pp7B-5i1fA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 PRO A 210
GLN A 214
GLU A 199
ARG A 300
 None
None
None
UPG  A 401 (-2.8A)
 1.28A 3s3oA-1ek6A:
1.0		 3s3oA-1ek6A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 6 LEU A 218
VAL A 207
MET A 204
VAL A 220
 None
None
None
UPG  A 342 (-3.7A)
 1.09A 3soaA-3enkA:
undetectable		 3soaA-3enkA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 ASP A 285
ALA A 265
ILE A 372
ARG A 272
ASP A 269
 UPG  A 556 (-2.8A)
UPG  A 556 (-3.7A)
None
UPG  A 556 (-2.9A)
UPG  A 556 (-2.9A)
 1.35A 3w37A-3srzA:
undetectable		 3w37A-3srzA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 ASP A 285
ALA A 265
ILE A 372
ARG A 272
ASP A 269
 UPG  A 556 (-2.8A)
UPG  A 556 (-3.7A)
None
UPG  A 556 (-2.9A)
UPG  A 556 (-2.9A)
 1.35A 3welA-3srzA:
undetectable		 3welA-3srzA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 LEU A 196
LEU A 170
ILE A 247
MET A 148
 None
None
UPG  A1525 (-4.6A)
None
 0.94A 4do3B-2wzgA:
undetectable		 4do3B-2wzgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 1ll2 GLYCOGENIN-1
(Oryctolagus
cuniculus) 		4 / 5 SER A 134
GLY A 135
THR A  83
ASP A 102
 UPG  A 334 (-3.2A)
UPG  A 334 ( 4.1A)
None
MN  A 333 ( 3.1A)
 1.04A 4eohA-1ll2A:
undetectable		 4eohA-1ll2A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1ll2 GLYCOGENIN-1
(Oryctolagus
cuniculus) 		5 / 8 GLY A  18
ALA A 103
ASP A 104
ASP A 102
THR A  39
 None
UPG  A 334 (-3.3A)
MN  A 333 ( 2.1A)
MN  A 333 ( 3.1A)
None
 1.28A 4eyrB-1ll2A:
undetectable		 4eyrB-1ll2A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 VAL A 121
VAL A 122
GLU A 155
GLY A 175
ALA A 181
 None
None
UPG  A1001 (-3.7A)
None
None
 1.14A 4fwdA-3vtfA:
undetectable		 4fwdA-3vtfA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 ARG B 208
GLY B  13
ASN B  97
MET B 274
 UPG  B 403 (-3.6A)
UPG  B 403 ( 4.0A)
None
None
 1.31A 4g0vB-4xsrB:
undetectable		 4g0vB-4xsrB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 ALA B 150
ASN B 151
LEU B 120
GLU B 288
 None
UPG  B 403 (-3.9A)
None
UPG  B 403 (-3.5A)
 0.87A 4g24A-4xsrB:
undetectable		 4g24A-4xsrB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1ll2 GLYCOGENIN-1
(Oryctolagus
cuniculus) 		4 / 4 LEU A  92
LEU A   9
GLN A   4
GLU A 119
 None
UPG  A 334 (-4.2A)
None
None
 1.21A 4i41A-1ll2A:
0.0		 4i41A-1ll2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 8 ASN A 455
ALA A 452
PRO A 450
LEU A 316
 None
None
UPG  A1525 (-4.9A)
None
 0.84A 4jjkA-2wzgA:
4.0		 4jjkA-2wzgA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 ASN A 207
GLU A 199
TYR A 211
ARG A 220
 UPG  A 401 (-3.1A)
None
UPG  A 401 ( 4.7A)
None
 1.18A 4mi4B-1ek6A:
undetectable
4mi4C-1ek6A:
undetectable		 4mi4B-1ek6A:
19.65
4mi4C-1ek6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 ASN A 295
GLY A 337
ALA A 338
ALA A 273
ILE A 317
 UPG  A 901 (-3.0A)
None
None
None
None
 0.94A 4nkxB-2icyA:
undetectable		 4nkxB-2icyA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 ASN A 295
GLY A 337
ALA A 338
ALA A 273
ILE A 317
 UPG  A 901 (-3.0A)
None
None
None
None
 0.91A 4nkxC-2icyA:
undetectable		 4nkxC-2icyA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 ASN A 295
GLY A 337
ALA A 338
ALA A 273
ILE A 317
 UPG  A 901 (-3.0A)
None
None
None
None
 0.91A 4nkxD-2icyA:
undetectable		 4nkxD-2icyA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 ILE A 240
ILE A 194
LEU A  81
GLY A 357
ASN A 306
 None
None
UPG  A 601 (-3.6A)
None
UPG  A 601 (-3.7A)
 1.01A 4o1eB-5nzgA:
undetectable		 4o1eB-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		3 / 3 THR A 232
ASN A 187
PHE A 186
 None
UPG  A 401 (-3.3A)
None
 0.84A 4pd9A-1ek6A:
0.0		 4pd9A-1ek6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		3 / 3 THR A 227
ASN A 182
PHE A 181
 None
UPG  A 342 (-3.3A)
None
 0.82A 4pd9A-3enkA:
undetectable		 4pd9A-3enkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 9 PHE A 343
ASN A 295
GLY A 337
THR A 334
VAL A 195
 None
UPG  A 901 (-3.0A)
None
None
None
 1.21A 4r20B-2icyA:
undetectable		 4r20B-2icyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 4 VAL A 131
ALA A 148
ASN A 150
GLN A 154
 None
None
UPG  A 342 ( 4.3A)
None
 1.32A 4zgfA-3enkA:
undetectable		 4zgfA-3enkA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5eevL-2icyA:
undetectable
5eevV-2icyA:
undetectable		 5eevL-2icyA:
12.69
5eevV-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5eewL-2icyA:
undetectable
5eewV-2icyA:
undetectable		 5eewL-2icyA:
12.69
5eewV-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5eezL-2icyA:
undetectable
5eezV-2icyA:
undetectable		 5eezL-2icyA:
12.69
5eezV-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5ef1L-2icyA:
undetectable
5ef1V-2icyA:
undetectable		 5ef1L-2icyA:
12.69
5ef1V-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.85A 5ef2L-2icyA:
undetectable
5ef2V-2icyA:
undetectable		 5ef2L-2icyA:
12.69
5ef2V-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 8 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.86A 5ef3L-2icyA:
undetectable
5ef3V-2icyA:
undetectable		 5ef3L-2icyA:
12.69
5ef3V-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Burkholderia
vietnamiensis) 		5 / 12 LEU A 136
LEU A 111
ILE A 235
ALA A 128
LEU A 210
 None
UPG  A 301 (-3.6A)
None
None
None
 1.31A 5ienA-5i1fA:
undetectable		 5ienA-5i1fA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 GLY A  21
GLN A 112
LYS A  69
 UPG  A 326 (-3.4A)
UPG  A 326 (-3.2A)
UPG  A 326 ( 4.3A)
 0.76A 5imsB-2pa4A:
undetectable		 5imsB-2pa4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ASN B 200
VAL B 229
GLY B 204
SER B 207
HIS B 205
 None
None
None
UPG  B 403 ( 4.7A)
None
 1.25A 5lsaA-4xsrB:
4.4		 5lsaA-4xsrB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 LEU A 507
GLN A 509
ARG A 272
ASN A 383
ILE A 374
 None
None
UPG  A 556 (-2.9A)
UPG  A 556 (-3.7A)
None
 1.39A 5uhbC-3srzA:
1.4		 5uhbC-3srzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 GLY A 159
TRP A 170
GLN A 149
TYR A 276
 UPG  A 352 (-3.8A)
UPG  A 352 ( 4.9A)
None
None
 1.27A 5vlmG-1guqA:
undetectable		 5vlmG-1guqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Burkholderia
vietnamiensis) 		5 / 10 VAL A 160
GLY A 203
GLY A 172
ILE A 235
ALA A 246
 None
None
UPG  A 301 (-3.3A)
None
None
 0.86A 5vm8B-5i1fA:
undetectable		 5vm8B-5i1fA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		7 / 10 GLY B  14
HIS B 121
ASN B 174
LYS B 213
GLU B 288
PRO B 289
GLY B 291
 UPG  B 403 (-3.2A)
UPG  B 403 (-3.9A)
UPG  B 403 (-3.2A)
UPG  B 403 (-2.7A)
UPG  B 403 (-3.5A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.70A 5vncC-4xsrB:
25.4		 5vncC-4xsrB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1ll2 GLYCOGENIN-1
(Oryctolagus
cuniculus) 		3 / 3 ASP A 125
ASN A 133
ASP A 102
 UPG  A 334 (-4.1A)
UPG  A 334 (-3.4A)
MN  A 333 ( 3.1A)
 0.82A 5vopA-1ll2A:
undetectable		 5vopA-1ll2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1ll2 GLYCOGENIN-1
(Oryctolagus
cuniculus) 		3 / 3 ASP A 125
ASN A 133
ASP A 102
 UPG  A 334 (-4.1A)
UPG  A 334 (-3.4A)
MN  A 333 ( 3.1A)
 0.82A 5vopB-1ll2A:
undetectable		 5vopB-1ll2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		4 / 5 HIS A 273
TRP A 279
GLY A 269
ASN A 300
 None
None
UPG  A1415 (-2.9A)
None
 1.39A 5x7pB-2xa2A:
3.0		 5x7pB-2xa2A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		3 / 3 ALA A 133
VAL A  94
TYR A 157
 UPG  A 401 ( 3.7A)
None
UPG  A 401 ( 4.4A)
 0.70A 5zmqH-1ek6A:
0.0		 5zmqH-1ek6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1z45 GAL10 BIFUNCTIONAL
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 136
VAL A  97
TYR A 163
 UPG  A 704 (-3.6A)
None
NAD  A 703 ( 4.6A)
 0.62A 5zmqH-1z45A:
undetectable		 5zmqH-1z45A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Burkholderia
vietnamiensis) 		4 / 5 PRO A 126
VAL A   4
GLY A 206
VAL A 157
 CL  A 305 (-3.9A)
None
UPG  A 301 ( 4.3A)
None
 0.97A 6ak3B-5i1fA:
undetectable		 6ak3B-5i1fA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2xa2 TREHALOSE-SYNTHASE
TRET
(Pyrococcus
horikoshii) 		3 / 3 PHE A 240
ASP A 241
LYS A 244
 None
None
UPG  A1415 (-3.3A)
 0.88A 6awtD-2xa2A:
undetectable		 6awtD-2xa2A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 3enk UDP-GLUCOSE
4-EPIMERASE
(Burkholderia
pseudomallei) 		4 / 8 GLY A 153
GLN A 154
THR A 155
SER A 128
 None
None
None
UPG  A 342 (-2.7A)
 1.00A 6eqpA-3enkA:
3.2		 6eqpA-3enkA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2
(Trypanosoma
brucei) 		4 / 6 GLN A 282
GLU A 348
HIS A 190
ALA A 350
 None
GOL  A 490 (-3.6A)
UPG  A 484 (-3.7A)
UPG  A 484 ( 4.2A)
 1.34A 6f6jC-3gueA:
undetectable
6f6jD-3gueA:
undetectable		 6f6jC-3gueA:
22.22
6f6jD-3gueA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 GLN A 287
GLU A 353
HIS A 191
ALA A 355
 None
None
UPG  A 601 (-3.8A)
UPG  A 601 ( 4.2A)
 1.42A 6f6jC-5nzgA:
undetectable
6f6jD-5nzgA:
undetectable		 6f6jC-5nzgA:
undetectable
6f6jD-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLN B   8
ASN B 174
ARG B 208
PRO B 289
GLY B 291
 None
UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.98A 6gneA-4xsrB:
27.5		 6gneA-4xsrB:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLY B  13
GLY B  14
ASN B 174
ARG B 208
PRO B 289
 UPG  B 403 ( 4.0A)
UPG  B 403 (-3.2A)
UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.4A)
 0.73A 6gneA-4xsrB:
27.5		 6gneA-4xsrB:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLY B  14
ASN B 174
ARG B 208
PRO B 289
GLY B 291
 UPG  B 403 (-3.2A)
UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.79A 6gneA-4xsrB:
27.5		 6gneA-4xsrB:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		6 / 12 GLU B  16
GLN B   8
ASN B 174
ARG B 208
PRO B 289
GLY B 291
 None
None
UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 1.12A 6gneB-4xsrB:
27.4		 6gneB-4xsrB:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		7 / 12 GLU B  16
GLY B  13
GLY B  14
ASN B 174
ARG B 208
PRO B 289
GLY B 291
 None
UPG  B 403 ( 4.0A)
UPG  B 403 (-3.2A)
UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.88A 6gneB-4xsrB:
27.4		 6gneB-4xsrB:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ASN B 174
ARG B 208
GLU B 288
PRO B 289
GLY B 291
 UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.5A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.86A 6gnfA-4xsrB:
12.8		 6gnfA-4xsrB:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ASN B 174
ARG B 208
GLU B 288
PRO B 289
GLY B 291
 UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.5A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.89A 6gnfC-4xsrB:
25.6		 6gnfC-4xsrB:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		7 / 12 GLU B  16
GLY B  14
HIS B 121
ARG B 208
GLU B 288
PRO B 289
GLY B 291
 None
UPG  B 403 (-3.2A)
UPG  B 403 (-3.9A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.5A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.80A 6gngA-4xsrB:
11.1		 6gngA-4xsrB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 5 GLY A  84
LEU A  85
SER A 132
GLN A 162
 UPG  A 601 (-3.2A)
None
None
UPG  A 601 (-3.3A)
 1.21A 6ji6A-5nzgA:
undetectable		 6ji6A-5nzgA:
undetectable