SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UP6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ALA A 198
ASP A 197
GLY A 156
ALA A  18
ILE A  16
 None
None
None
UP6  A5001 (-3.7A)
None
 0.99A 3ekwA-1losA:
undetectable		 3ekwA-1losA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 2guu ODCASE
(Plasmodium
vivax) 		4 / 4 ALA A 299
VAL A 297
GLY A 273
THR A 226
 UP6  A5203 ( 3.9A)
None
UP6  A5203 ( 4.9A)
UP6  A5203 (-3.0A)
 1.08A 4ubeA-2guuA:
2.6		 4ubeA-2guuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 LEU A  21
ALA A  18
VAL A  34
ILE A  38
 None
UP6  A5001 (-3.7A)
None
None
 0.89A 4xe3A-1losA:
undetectable		 4xe3A-1losA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 HIS A 128
TYR A 206
ILE A 205
ALA A 203
VAL A 201
 None
None
None
UP6  A5001 (-3.3A)
UP6  A5001 ( 4.5A)
 1.10A 5n0sA-1losA:
undetectable		 5n0sA-1losA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 HIS A 128
TYR A 206
ILE A 205
ALA A 203
VAL A 201
 None
None
None
UP6  A5001 (-3.3A)
UP6  A5001 ( 4.5A)
 1.11A 5n0sB-1losA:
undetectable		 5n0sB-1losA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 HIS A 128
TYR A 206
ILE A 205
ALA A 203
VAL A 201
 None
None
None
UP6  A5001 (-3.3A)
UP6  A5001 ( 4.5A)
 1.08A 5n0xA-1losA:
undetectable		 5n0xA-1losA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A  87
ALA A  69
LYS A  42
 None
None
UP6  A5001 (-2.8A)
 0.66A 6fgcA-1losA:
undetectable		 6fgcA-1losA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A  87
ALA A  69
LYS A  42
 None
None
UP6  A5001 (-2.8A)
 0.62A 6fgdA-1losA:
undetectable		 6fgdA-1losA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 MET A  19
ALA A 208
LEU A 207
ALA A 203
 None
None
None
UP6  A5001 (-3.3A)
 1.10A 6fosB-1losA:
undetectable		 6fosB-1losA:
16.96