SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UP2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7F_A_BCZA801_0 (NEURAMINIDASE)	2ybq	METHYLTRANSFERASE (Pseudomonas aeruginosa)	5 / 12	GLU A 114 ARG A 111 ARG A 118 GLU A 121 GLU A 117	None UP2 A1268 (-3.8A) None None None	1.41A	1l7fA-2ybqA: undetectable	1l7fA-2ybqA: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7H_A_BCZA801_0 (NEURAMINIDASE)	2ybq	METHYLTRANSFERASE (Pseudomonas aeruginosa)	5 / 12	GLU A 114 ARG A 111 ARG A 118 GLU A 121 GLU A 117	None UP2 A1268 (-3.8A) None None None	1.44A	1l7hA-2ybqA: undetectable	1l7hA-2ybqA: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWR_A_ZMRA513_1 (NEURAMINIDASE)	2ybq	METHYLTRANSFERASE (Pseudomonas aeruginosa)	5 / 12	GLU A 114 ARG A 111 ARG A 118 GLU A 121 GLU A 117	None UP2 A1268 (-3.8A) None None None	1.25A	4mwrA-2ybqA: undetectable	4mwrA-2ybqA: 19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWV_A_BCZA513_0 (NEURAMINIDASE)	2ybq	METHYLTRANSFERASE (Pseudomonas aeruginosa)	5 / 12	GLU A 114 ARG A 111 ARG A 118 GLU A 121 GLU A 117	None UP2 A1268 (-3.8A) None None None	1.39A	4mwvA-2ybqA: undetectable	4mwvA-2ybqA: 19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWX_A_ZMRA513_1 (NEURAMINIDASE)	2ybq	METHYLTRANSFERASE (Pseudomonas aeruginosa)	5 / 12	GLU A 114 ARG A 111 ARG A 118 GLU A 121 GLU A 117	None UP2 A1268 (-3.8A) None None None	1.23A	4mwxA-2ybqA: undetectable	4mwxA-2ybqA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MX0_A_BCZA513_0 (NEURAMINIDASE)	2ybq	METHYLTRANSFERASE (Pseudomonas aeruginosa)	5 / 12	GLU A 114 ARG A 111 ARG A 118 GLU A 121 GLU A 117	None UP2 A1268 (-3.8A) None None None	1.41A	4mx0A-2ybqA: undetectable	4mx0A-2ybqA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N09_C_ADNC401_1 (ADENOSINE KINASE)	2ybq	METHYLTRANSFERASE (Pseudomonas aeruginosa)	5 / 12	ASP A 50 LEU A 41 GLY A 103 LEU A 57 GLY A 112	UP2 A1268 (-3.6A) None SAH A1267 (-4.8A) None None	0.93A	4n09C-2ybqA: undetectable	4n09C-2ybqA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L17_A_ZMRA512_1 (NEURAMINIDASE)	2ybq	METHYLTRANSFERASE (Pseudomonas aeruginosa)	5 / 12	GLU A 114 ARG A 111 ARG A 118 GLU A 121 GLU A 117	None UP2 A1268 (-3.8A) None None None	1.25A	5l17A-2ybqA: undetectable	5l17A-2ybqA: 20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NM4_A_SAMA402_0 (HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9)	2ybq	METHYLTRANSFERASE (Pseudomonas aeruginosa)	4 / 7	ALA A 25 GLY A 103 LEU A 52 GLY A 137	None SAH A1267 (-4.8A) UP2 A1268 ( 4.0A) None	0.81A	6nm4A-2ybqA: undetectable	6nm4A-2ybqA: 18.88

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1L7F_A_BCZA801_0","NEURAMINIDASE","2ybq","METHYLTRANSFERASE","Pseudomonas aeruginosa",5,"GLU A 114;ARG A 111;ARG A 118;GLU A 121;GLU A 117","None;UP2 A1268 (-3.8A);None;None;None","1.41A","1l7fA-2ybqA:undetectable",null],["1L7H_A_BCZA801_0","NEURAMINIDASE","2ybq","METHYLTRANSFERASE","Pseudomonas aeruginosa",5,"GLU A 114;ARG A 111;ARG A 118;GLU A 121;GLU A 117","None;UP2 A1268 (-3.8A);None;None;None","1.44A","1l7hA-2ybqA:undetectable","1l7fA-2ybqA:21.72"],["4MWR_A_ZMRA513_1","NEURAMINIDASE","2ybq","METHYLTRANSFERASE","Pseudomonas aeruginosa",5,"GLU A 114;ARG A 111;ARG A 118;GLU A 121;GLU A 117","None;UP2 A1268 (-3.8A);None;None;None","1.25A","4mwrA-2ybqA:undetectable","1l7hA-2ybqA:21.46"],["4MWV_A_BCZA513_0","NEURAMINIDASE","2ybq","METHYLTRANSFERASE","Pseudomonas aeruginosa",5,"GLU A 114;ARG A 111;ARG A 118;GLU A 121;GLU A 117","None;UP2 A1268 (-3.8A);None;None;None","1.39A","4mwvA-2ybqA:undetectable","4mwrA-2ybqA:19.75"],["4MWX_A_ZMRA513_1","NEURAMINIDASE","2ybq","METHYLTRANSFERASE","Pseudomonas aeruginosa",5,"GLU A 114;ARG A 111;ARG A 118;GLU A 121;GLU A 117","None;UP2 A1268 (-3.8A);None;None;None","1.23A","4mwxA-2ybqA:undetectable","4mwvA-2ybqA:19.75"],["4MX0_A_BCZA513_0","NEURAMINIDASE","2ybq","METHYLTRANSFERASE","Pseudomonas aeruginosa",5,"GLU A 114;ARG A 111;ARG A 118;GLU A 121;GLU A 117","None;UP2 A1268 (-3.8A);None;None;None","1.41A","4mx0A-2ybqA:undetectable","4mwxA-2ybqA:19.50"],["4N09_C_ADNC401_1","ADENOSINE KINASE","2ybq","METHYLTRANSFERASE","Pseudomonas aeruginosa",5,"ASP A  50;LEU A  41;GLY A 103;LEU A  57;GLY A 112","UP2 A1268 (-3.6A);None;SAH A1267 (-4.8A);None;None","0.93A","4n09C-2ybqA:undetectable","4mx0A-2ybqA:19.50"],["5L17_A_ZMRA512_1","NEURAMINIDASE","2ybq","METHYLTRANSFERASE","Pseudomonas aeruginosa",5,"GLU A 114;ARG A 111;ARG A 118;GLU A 121;GLU A 117","None;UP2 A1268 (-3.8A);None;None;None","1.25A","5l17A-2ybqA:undetectable","4n09C-2ybqA:20.28"],["6NM4_A_SAMA402_0","HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9","2ybq","METHYLTRANSFERASE","Pseudomonas aeruginosa",4,"ALA A  25;GLY A 103;LEU A  52;GLY A 137","None;SAH A1267 (-4.8A);UP2 A1268 ( 4.0A);None","0.81A","6nm4A-2ybqA:undetectable","5l17A-2ybqA:20.05"]]