SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UNK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 9 GLY A 176
HIS A 175
HIS A 135
THR A 256
ALA A 160
 UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
MN  A 402 (-3.3A)
UNK  A 408 ( 3.5A)
MN  A 401 ( 4.8A)
 1.43A 1gtnQ-4dz4A:
undetectable
1gtnR-4dz4A:
undetectable		 1gtnQ-4dz4A:
11.56
1gtnR-4dz4A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 255
ALA A 160
GLY A 176
HIS A 175
HIS A 135
 None
MN  A 401 ( 4.8A)
UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
MN  A 402 (-3.3A)
 0.97A 1gtnL-4dz4A:
undetectable
1gtnV-4dz4A:
undetectable		 1gtnL-4dz4A:
11.56
1gtnV-4dz4A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3b84 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 5 LEU A  16
VAL A  43
CYH A  46
CYH A  47
 None
UNK  A 900 ( 4.8A)
UNK  A 900 ( 1.7A)
UNK  A 901 ( 2.0A)
 1.10A 1mz9D-3b84A:
undetectable		 1mz9D-3b84A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 176
HIS A 175
HIS A 135
GLY A 255
ALA A 160
 UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
MN  A 402 (-3.3A)
None
MN  A 401 ( 4.8A)
 0.99A 1utdO-4dz4A:
undetectable
1utdP-4dz4A:
undetectable		 1utdO-4dz4A:
11.56
1utdP-4dz4A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		4 / 5 HIS A 175
ASP A 163
HIS A 161
ASP A 159
 UNK  A 407 ( 3.8A)
MN  A 402 (-2.5A)
MN  A 401 (-3.4A)
MN  A 402 ( 2.5A)
 1.24A 3c0zA-4dz4A:
11.3		 3c0zA-4dz4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		4 / 5 HIS A 175
ASP A 242
HIS A 161
ASP A 244
 UNK  A 407 ( 3.8A)
MN  A 401 ( 2.8A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
 1.23A 3c0zA-4dz4A:
11.3		 3c0zA-4dz4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 9 HIS A 161
ASP A 163
HIS A 175
GLY A 176
THR A 256
 MN  A 401 (-3.4A)
MN  A 402 (-2.5A)
UNK  A 407 ( 3.8A)
UNK  A 409 ( 3.4A)
UNK  A 408 ( 3.5A)
 0.23A 3gn0A-4dz4A:
30.1		 3gn0A-4dz4A:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 9 HIS A 161
ASP A 163
HIS A 175
GLY A 176
THR A 256
 MN  A 401 (-3.4A)
MN  A 402 (-2.5A)
UNK  A 407 ( 3.8A)
UNK  A 409 ( 3.4A)
UNK  A 408 ( 3.5A)
 0.25A 3gn0B-4dz4A:
30.3		 3gn0B-4dz4A:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 10 HIS A 175
ASP A 242
HIS A 161
ASP A 244
PRO A 248
 UNK  A 407 ( 3.8A)
MN  A 401 ( 2.8A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
 1.43A 4bz6A-4dz4A:
11.8		 4bz6A-4dz4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 175
ASP A 242
HIS A 161
ASP A 244
PRO A 248
 UNK  A 407 ( 3.8A)
MN  A 401 ( 2.8A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
 1.42A 4bz6A-4dz4A:
11.8
4bz6B-4dz4A:
11.4		 4bz6A-4dz4A:
21.69
4bz6B-4dz4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 10 HIS A 175
ASP A 242
HIS A 161
ASP A 244
PRO A 248
 UNK  A 407 ( 3.8A)
MN  A 401 ( 2.8A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
 1.43A 4bz6D-4dz4A:
11.3		 4bz6D-4dz4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 157
GLY A 176
ASP A 159
HIS A 161
ASP A 244
 None
UNK  A 409 ( 3.4A)
MN  A 402 ( 2.5A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
 1.11A 4qa0A-4dz4A:
12.0		 4qa0A-4dz4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 157
GLY A 176
ASP A 159
HIS A 161
ASP A 244
 None
UNK  A 409 ( 3.4A)
MN  A 402 ( 2.5A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
 1.11A 4qa2A-4dz4A:
11.8		 4qa2A-4dz4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 157
GLY A 176
ASP A 159
HIS A 161
ASP A 244
 None
UNK  A 409 ( 3.4A)
MN  A 402 ( 2.5A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
 1.12A 4qa2B-4dz4A:
11.7		 4qa2B-4dz4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 ASP A 292
HIS A 175
ASP A 163
HIS A 161
ASP A 159
 None
UNK  A 407 ( 3.8A)
MN  A 402 (-2.5A)
MN  A 401 (-3.4A)
MN  A 402 ( 2.5A)
 1.20A 5ef8A-4dz4A:
11.7		 5ef8A-4dz4A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 ASP A 292
HIS A 175
ASP A 163
HIS A 161
ASP A 159
 None
UNK  A 407 ( 3.8A)
MN  A 402 (-2.5A)
MN  A 401 (-3.4A)
MN  A 402 ( 2.5A)
 1.19A 5ef8B-4dz4A:
11.7		 5ef8B-4dz4A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 161
ASP A 244
THR A 254
GLY A 176
HIS A 175
 MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
 1.32A 5m66A-4dz4A:
undetectable		 5m66A-4dz4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 161
ASP A 244
THR A 254
GLY A 176
HIS A 175
 MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
 1.28A 6f3nB-4dz4A:
2.2		 6f3nB-4dz4A:
22.06