SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UMA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WG8_A_SAMA3142_0 (PREDICTED S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	5 / 12	GLY A 17 GLY A 14 GLY A 42 ASP A 94 SER A 19	None UMA A 963 ( 3.7A) None UMA A 963 ( 4.9A) None	1.08A	1wg8A-1uagA: 3.1	1wg8A-1uagA: 24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WG8_B_SAMB3141_0 (PREDICTED S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	5 / 12	GLY A 17 GLY A 14 GLY A 42 ASP A 94 SER A 19	None UMA A 963 ( 3.7A) None UMA A 963 ( 4.9A) None	1.01A	1wg8B-1uagA: 3.3	1wg8B-1uagA: 24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOJ_C_FRDC305_1 (POL POLYPROTEIN PEPTIDE INHIBITOR)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	4 / 5	LEU A 67 GLY A 12 PRO A 31 VAL A 8	None UMA A 963 ( 4.1A) None None	0.83A	2aojA-1uagA: undetectable	2aojA-1uagA: 12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_B_RALB600_1 (ESTROGEN RECEPTOR)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	5 / 12	ALA A 102 LEU A 147 ARG A 27 GLY A 137 LEU A 156	None None None UMA A 963 (-4.3A) None	1.01A	2jfaB-1uagA: undetectable	2jfaB-1uagA: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UUD_A_ESTA600_1 (ESTROGEN RECEPTOR)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	5 / 11	ALA A 102 LEU A 147 ARG A 27 GLY A 137 LEU A 156	None None None UMA A 963 (-4.3A) None	1.26A	3uudA-1uagA: undetectable	3uudA-1uagA: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VNS_A_DVAA602_0 (NRPS ADENYLATION PROTEIN CYTC1)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	4 / 7	ASP A 94 PHE A 98 GLY A 136 THR A 16	UMA A 963 ( 4.9A) None None UMA A 963 (-3.6A)	1.04A	3vnsA-1uagA: 4.3	3vnsA-1uagA: 23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B17_A_SAMA1358_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	5 / 12	PRO A 72 GLY A 73 ASP A 35 MET A 34 VAL A 33	UMA A 963 (-3.8A) UMA A 963 (-3.1A) UMA A 963 (-3.4A) None None	1.04A	4b17A-1uagA: 2.1	4b17A-1uagA: 20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_C_MXMC606_2 (PROSTAGLANDIN G/H SYNTHASE 2)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	3 / 3	LEU A 416 ARG A 37 MET A 34	None UMA A 963 (-3.0A) None	0.94A	4m11C-1uagA: undetectable	4m11C-1uagA: 20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PBH_A_BEZA401_0 (TRAP DICARBOXYLATE TRANSPORTER, DCTP SUBUNIT, PUTATIVE)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	5 / 12	ILE A 74 THR A 36 LEU A 81 ASP A 59 LEU A 62	UMA A 963 ( 4.4A) UMA A 963 (-3.3A) None None None	1.46A	4pbhA-1uagA: undetectable	4pbhA-1uagA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XE5_A_OBNA1104_2 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	4 / 6	ILE A 68 VAL A 33 THR A 16 ARG A 100	None None UMA A 963 (-3.6A) None	1.17A	4xe5A-1uagA: undetectable	4xe5A-1uagA: 18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_B_29SB601_1 (ESTROGEN RECEPTOR)	1uag	UDP-N-ACETYLMURAMOYL -L-ALANINE/:D-GLUTAM ATE LIGASE (Escherichia coli)	5 / 12	ALA A 102 LEU A 147 ARG A 27 GLY A 137 LEU A 156	None None None UMA A 963 (-4.3A) None	0.99A	4xi3B-1uagA: undetectable	4xi3B-1uagA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UL4_A_SAMA803_0 (OXSB PROTEIN)	2jfn	GLUTAMATE RACEMASE (Escherichia coli)	5 / 12	ALA A 134 GLY A 137 GLY A 61 ILE A 68 LEU A 100	None None GLU A1287 (-3.5A) None UMA A1286 (-4.4A)	1.02A	5ul4A-2jfnA: 2.7	5ul4A-2jfnA: 17.80

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1WG8_A_SAMA3142_0","PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",5,"GLY A  17;GLY A  14;GLY A  42;ASP A  94;SER A  19","None;UMA A 963 ( 3.7A);None;UMA A 963 ( 4.9A);None","1.08A","1wg8A-1uagA:3.1",null],["1WG8_B_SAMB3141_0","PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",5,"GLY A  17;GLY A  14;GLY A  42;ASP A  94;SER A  19","None;UMA A 963 ( 3.7A);None;UMA A 963 ( 4.9A);None","1.01A","1wg8B-1uagA:3.3","1wg8A-1uagA:24.73"],["2AOJ_C_FRDC305_1","POL POLYPROTEIN;PEPTIDE INHIBITOR","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",4,"LEU A  67;GLY A  12;PRO A  31;VAL A   8","None;UMA A 963 ( 4.1A);None;None","0.83A","2aojA-1uagA:undetectable","1wg8B-1uagA:24.73"],["2JFA_B_RALB600_1","ESTROGEN RECEPTOR","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",5,"ALA A 102;LEU A 147;ARG A  27;GLY A 137;LEU A 156","None;None;None;UMA A 963 (-4.3A);None","1.01A","2jfaB-1uagA:undetectable","2aojA-1uagA:12.80"],["3UUD_A_ESTA600_1","ESTROGEN RECEPTOR","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",5,"ALA A 102;LEU A 147;ARG A  27;GLY A 137;LEU A 156","None;None;None;UMA A 963 (-4.3A);None","1.26A","3uudA-1uagA:undetectable","2jfaB-1uagA:21.45"],["3VNS_A_DVAA602_0","NRPS ADENYLATION PROTEIN CYTC1","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",4,"ASP A  94;PHE A  98;GLY A 136;THR A  16","UMA A 963 ( 4.9A);None;None;UMA A 963 (-3.6A)","1.04A","3vnsA-1uagA:4.3","3uudA-1uagA:22.10"],["4B17_A_SAMA1358_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",5,"PRO A  72;GLY A  73;ASP A  35;MET A  34;VAL A  33","UMA A 963 (-3.8A);UMA A 963 (-3.1A);UMA A 963 (-3.4A);None;None","1.04A","4b17A-1uagA:2.1","3vnsA-1uagA:23.94"],["4M11_C_MXMC606_2","PROSTAGLANDIN G\/H SYNTHASE 2","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",3,"LEU A 416;ARG A  37;MET A  34","None;UMA A 963 (-3.0A);None","0.94A","4m11C-1uagA:undetectable","4b17A-1uagA:20.57"],["4PBH_A_BEZA401_0","TRAP DICARBOXYLATE TRANSPORTER, DCTP SUBUNIT, PUTATIVE","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",5,"ILE A  74;THR A  36;LEU A  81;ASP A  59;LEU A  62","UMA A 963 ( 4.4A);UMA A 963 (-3.3A);None;None;None","1.46A","4pbhA-1uagA:undetectable","4m11C-1uagA:20.69"],["4XE5_A_OBNA1104_2","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",4,"ILE A  68;VAL A  33;THR A  16;ARG A 100","None;None;UMA A 963 (-3.6A);None","1.17A","4xe5A-1uagA:undetectable","4pbhA-1uagA:21.34"],["4XI3_B_29SB601_1","ESTROGEN RECEPTOR","1uag","UDP-N-ACETYLMURAMOYL-L-ALANINE\/:D-GLUTAMATE LIGASE","Escherichia coli",5,"ALA A 102;LEU A 147;ARG A  27;GLY A 137;LEU A 156","None;None;None;UMA A 963 (-4.3A);None","0.99A","4xi3B-1uagA:undetectable","4xe5A-1uagA:18.39"],["5UL4_A_SAMA803_0","OXSB PROTEIN","2jfn","GLUTAMATE RACEMASE","Escherichia coli",5,"ALA A 134;GLY A 137;GLY A  61;ILE A  68;LEU A 100","None;None;GLU A1287 (-3.5A);None;UMA A1286 (-4.4A)","1.02A","5ul4A-2jfnA:2.7","4xi3B-1uagA:21.68"]]