SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UKA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 HIS A 278
ILE A  64
TYR A   9
ALA A  81
GLU A  13
 UKA  A1200 (-3.9A)
None
None
None
None
 1.41A 1ki7A-3qakA:
undetectable		 1ki7A-3qakA:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 LEU A  85
THR A  88
PHE A 168
GLU A 169
MET A 177
 UKA  A1200 (-4.8A)
UKA  A1200 (-3.6A)
UKA  A1200 (-3.4A)
UKA  A1200 (-2.7A)
UKA  A1200 (-4.8A)
 1.14A 2ydoA-3qakA:
39.0		 2ydoA-3qakA:
64.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		10 / 12 LEU A  85
THR A  88
PHE A 168
MET A 177
TRP A 246
LEU A 249
ASN A 253
ILE A 274
SER A 277
HIS A 278
 UKA  A1200 (-4.8A)
UKA  A1200 (-3.6A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.8A)
None
UKA  A1200 (-4.9A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.9A)
UKA  A1200 (-2.9A)
UKA  A1200 (-3.9A)
 0.31A 2ydoA-3qakA:
39.0		 2ydoA-3qakA:
64.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 7 VAL A  84
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
 None
UKA  A1200 (-3.4A)
UKA  A1200 (-4.8A)
UKA  A1200 (-4.9A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.9A)
 1.00A 3rfmA-3qakA:
31.9		 3rfmA-3qakA:
65.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 8 LEU A  85
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
 UKA  A1200 (-4.8A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.8A)
UKA  A1200 (-4.9A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.9A)
 0.60A 5mzjA-3qakA:
33.4		 5mzjA-3qakA:
69.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 9 ILE A  66
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
 UKA  A1200 (-4.1A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.8A)
UKA  A1200 (-4.9A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.9A)
 0.46A 5mzpA-3qakA:
33.3		 5mzpA-3qakA:
69.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 9 VAL A  84
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
 None
UKA  A1200 (-3.4A)
UKA  A1200 (-4.8A)
UKA  A1200 (-4.9A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.9A)
 0.86A 5mzpA-3qakA:
33.3		 5mzpA-3qakA:
69.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 10 VAL A  84
THR A  88
PHE A 168
GLU A 169
MET A 177
HIS A 278
 None
UKA  A1200 (-3.6A)
UKA  A1200 (-3.4A)
UKA  A1200 (-2.7A)
UKA  A1200 (-4.8A)
UKA  A1200 (-3.9A)
 0.97A 6d9hR-3qakA:
33.3		 6d9hR-3qakA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		8 / 10 VAL A  84
THR A  88
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
HIS A 278
 None
UKA  A1200 (-3.6A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.8A)
UKA  A1200 (-4.9A)
UKA  A1200 (-3.4A)
UKA  A1200 (-4.9A)
UKA  A1200 (-3.9A)
 0.54A 6d9hR-3qakA:
33.3		 6d9hR-3qakA:
11.19