SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UHB'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1DMA_A_NCAA700_0 (EXOTOXIN A) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 4 / 7 | HIS A 415GLY A 416TYR A 449TYR A 460 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 (-3.4A) | 0.31A | 1dmaA-5dsyA:5.8 | 1dmaA-5dsyA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1DMA_A_NCAA700_0 (EXOTOXIN A) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 4 / 7 | HIS A 415GLY A 416TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.52A | 1dmaA-5dsyA:5.8 | 1dmaA-5dsyA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1DMA_B_NCAB700_0 (EXOTOXIN A) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 6 / 6 | HIS A 415GLY A 416TYR A 449ALA A 451TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 ( 4.1A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.52A | 1dmaB-5dsyA:5.1 | 1dmaB-5dsyA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ERR_A_RALA600_2 (ESTROGEN RECEPTOR) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 4 / 6 | LEU A 412HIS A 415LEU A 391LEU A 359 | NoneUHB A1001 (-3.7A)NoneNone | 0.88A | 1errA-5dsyA:undetectable | 1errA-5dsyA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XAT_A_CLMA301_0 (XENOBIOTICACETYLTRANSFERASE) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 3 / 3 | GLY A 416TYR A 460SER A 457 | UHB A1001 (-3.9A)UHB A1001 (-3.4A)UHB A1001 (-2.5A) | 0.75A | 2xatA-5dsyA:undetectable | 2xatA-5dsyA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U9H_A_NCAA1163_0 (TANKYRASE-2) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 6 / 8 | HIS A 415GLY A 416TYR A 449ALA A 451SER A 457TYR A 460 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 ( 4.1A)UHB A1001 (-2.5A)UHB A1001 (-3.4A) | 0.42A | 3u9hA-5dsyA:18.6 | 3u9hA-5dsyA:29.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U9H_A_NCAA1163_0 (TANKYRASE-2) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 6 / 8 | HIS A 415GLY A 416TYR A 449LYS A 456SER A 457TYR A 460 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 ( 4.6A)UHB A1001 (-2.5A)UHB A1001 (-3.4A) | 0.96A | 3u9hA-5dsyA:18.6 | 3u9hA-5dsyA:29.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U9H_A_NCAA1163_0 (TANKYRASE-2) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 6 / 8 | HIS A 415GLY A 416TYR A 449SER A 457TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 (-2.5A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.81A | 3u9hA-5dsyA:18.6 | 3u9hA-5dsyA:29.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U9H_B_NCAB1164_0 (TANKYRASE-2) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 7 / 8 | HIS A 415GLY A 416TYR A 449ALA A 451SER A 457TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 ( 4.1A)UHB A1001 (-2.5A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.81A | 3u9hB-5dsyA:18.6 | 3u9hB-5dsyA:29.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U9H_B_NCAB1164_0 (TANKYRASE-2) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 6 / 8 | HIS A 415GLY A 416TYR A 449LYS A 456SER A 457TYR A 460 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 ( 4.6A)UHB A1001 (-2.5A)UHB A1001 (-3.4A) | 1.00A | 3u9hB-5dsyA:18.6 | 3u9hB-5dsyA:29.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AE1_A_NCAA1536_0 (DIPHTHERIA TOXIN) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 5 / 6 | HIS A 415GLY A 416TYR A 449TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.69A | 4ae1A-5dsyA:5.4 | 4ae1A-5dsyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AE1_B_NCAB1536_0 (DIPHTHERIA TOXIN) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 5 / 5 | HIS A 415GLY A 416TYR A 449TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.75A | 4ae1B-5dsyA:5.7 | 4ae1B-5dsyA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4BJC_A_RPBA2162_1 (TANKYRASE-2) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 7 / 8 | HIS A 415GLY A 416TYR A 449ALA A 451LYS A 456SER A 457GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 ( 4.1A)UHB A1001 ( 4.6A)UHB A1001 (-2.5A)UHB A1001 (-3.5A) | 1.29A | 4bjcA-5dsyA:18.4 | 4bjcA-5dsyA:29.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4BJC_A_RPBA2162_1 (TANKYRASE-2) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 7 / 8 | HIS A 415GLY A 416TYR A 449ALA A 451SER A 457TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 ( 4.1A)UHB A1001 (-2.5A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.78A | 4bjcA-5dsyA:18.4 | 4bjcA-5dsyA:29.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4HYF_A_NCAA1201_0 (TANKYRASE-2) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 7 / 7 | HIS A 415GLY A 416TYR A 449ALA A 451SER A 457TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 ( 4.1A)UHB A1001 (-2.5A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.61A | 4hyfA-5dsyA:19.5 | 4hyfA-5dsyA:29.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4HYF_B_NCAB1201_0 (TANKYRASE-2) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 8 / 8 | HIS A 415GLY A 416TYR A 449ALA A 451LYS A 456SER A 457TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 ( 4.1A)UHB A1001 ( 4.6A)UHB A1001 (-2.5A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.93A | 4hyfB-5dsyA:19.7 | 4hyfB-5dsyA:29.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4HYF_C_NCAC1201_0 (TANKYRASE-2) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 8 / 8 | HIS A 415GLY A 416TYR A 449ALA A 451LYS A 456SER A 457TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 (-3.8A)UHB A1001 ( 4.1A)UHB A1001 ( 4.6A)UHB A1001 (-2.5A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.57A | 4hyfC-5dsyA:19.6 | 4hyfC-5dsyA:29.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4J26_A_ESTA600_1 (ESTROGEN RECEPTORBETA) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 5 / 12 | LEU A 471MET A 556LEU A 356GLY A 429LEU A 430 | NoneNoneNoneNoneUHB A1001 ( 4.7A) | 1.29A | 4j26A-5dsyA:undetectable | 4j26A-5dsyA:23.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RV6_A_RPBA1103_1 (POLY [ADP-RIBOSE]POLYMERASE 1) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 9 / 11 | HIS A 415GLY A 416TYR A 442TYR A 449ALA A 451LYS A 456SER A 457TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 ( 4.7A)UHB A1001 (-3.8A)UHB A1001 ( 4.1A)UHB A1001 ( 4.6A)UHB A1001 (-2.5A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.57A | 4rv6A-5dsyA:35.2 | 4rv6A-5dsyA:40.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RV6_B_RPBB1103_1 (POLY [ADP-RIBOSE]POLYMERASE 1) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 9 / 11 | HIS A 415GLY A 416TYR A 442TYR A 449ALA A 451LYS A 456SER A 457TYR A 460GLU A 545 | UHB A1001 (-3.7A)UHB A1001 (-3.9A)UHB A1001 ( 4.7A)UHB A1001 (-3.8A)UHB A1001 ( 4.1A)UHB A1001 ( 4.6A)UHB A1001 (-2.5A)UHB A1001 (-3.4A)UHB A1001 (-3.5A) | 0.57A | 4rv6B-5dsyA:36.1 | 4rv6B-5dsyA:40.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HA9_B_TP0B406_1 (POLY [ADP-RIBOSE]POLYMERASE 1) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 7 / 9 | HIS A 415SER A 417ASN A 421ILE A 425TYR A 449SER A 457TYR A 460 | UHB A1001 (-3.7A)UHB A1001 (-2.5A)UHB A1001 (-3.7A)UHB A1001 (-4.6A)UHB A1001 (-3.8A)UHB A1001 (-2.5A)UHB A1001 (-3.4A) | 0.53A | 5ha9B-5dsyA:32.8 | 5ha9B-5dsyA:40.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y2T_A_8LXA501_0 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) |
5dsy | POLY [ADP-RIBOSE]POLYMERASE 2 (Homosapiens) | 5 / 12 | PHE A 444GLY A 445TYR A 460ILE A 432LEU A 541 | NoneNoneUHB A1001 (-3.4A)NoneNone | 1.01A | 5y2tA-5dsyA:undetectable | 5y2tA-5dsyA:undetectable |