SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UGA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.73A 1dmaA-1z7eA:
undetectable		 1dmaA-1z7eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 6 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.79A 1dmaB-1z7eA:
undetectable		 1dmaB-1z7eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1dlj UDP-GLUCOSE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 216
PRO A 262
GLY A 257
GLY A 255
TYR A  85
 None
None
UGA  A 404 (-3.2A)
None
None
 1.09A 2igtB-1dljA:
4.9		 2igtB-1dljA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 5 PRO A 459
ILE A 462
PRO A 402
TYR A 398
 None
None
None
UGA  A1101 (-4.5A)
 1.21A 3d9lA-1z7eA:
undetectable
3d9lY-1z7eA:
undetectable		 3d9lA-1z7eA:
12.76
3d9lY-1z7eA:
1.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		3 / 3 LYS A 331
THR A 334
ILE A  46
 UGA  A 501 (-2.7A)
None
None
 0.91A 4e0fB-2y0eA:
undetectable		 4e0fB-2y0eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.87A 4hyfA-1z7eA:
undetectable		 4hyfA-1z7eA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 8 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.90A 4hyfB-1z7eA:
undetectable		 4hyfB-1z7eA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 8 GLY A 612
TYR A 398
TYR A 613
GLU A 434
 None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
 0.86A 4hyfC-1z7eA:
undetectable		 4hyfC-1z7eA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1dlj UDP-GLUCOSE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 255
GLY A 257
ILE A 331
ILE A 294
SER A 253
 None
UGA  A 404 (-3.2A)
None
None
UGA  A 404 (-2.7A)
 1.12A 4iv0B-1dljA:
5.4		 4iv0B-1dljA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1dlj UDP-GLUCOSE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 255
GLY A 257
ILE A 331
ILE A 294
SER A 253
 None
UGA  A 404 (-3.2A)
None
None
UGA  A 404 (-2.7A)
 1.12A 4mwzA-1dljA:
5.4		 4mwzA-1dljA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 5 ARG A 489
ASP A 471
GLU A 434
VAL A 405
 None
None
UGA  A1101 (-4.0A)
None
 1.45A 4nkvB-1z7eA:
undetectable		 4nkvB-1z7eA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 6 SER A 269
LYS A 331
PHE A 330
TRP A 407
 None
UGA  A 501 (-2.7A)
UGA  A 501 (-4.7A)
None
 1.14A 5dlvA-2y0eA:
0.0		 5dlvA-2y0eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		4 / 7 SER A 269
LYS A 331
PHE A 330
TRP A 407
 None
UGA  A 501 (-2.7A)
UGA  A 501 (-4.7A)
None
 1.12A 5dlvB-2y0eA:
undetectable		 5dlvB-2y0eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2y0e UDP-GLUCOSE
DEHYDROGENASE
(Burkholderia
cepacia) 		3 / 3 PHE A 330
ASP A 335
LEU A 373
 UGA  A 501 (-4.7A)
None
None
 0.79A 5uhbC-2y0eA:
undetectable		 5uhbC-2y0eA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		4 / 7 ALA A 393
ILE A 512
LEU A 498
ILE A 528
 ATP  A1001 ( 3.6A)
None
None
UGA  A1101 (-3.5A)
 0.88A 6b5vA-1z7eA:
undetectable
6b5vB-1z7eA:
undetectable		 6b5vA-1z7eA:
7.16
6b5vB-1z7eA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1z7e PROTEIN ARNA
(Escherichia
coli) 		5 / 11 ILE A 525
TYR A 608
GLY A 507
SER A 509
ALA A 511
 None
UGA  A1101 ( 4.6A)
None
None
UGA  A1101 (-3.3A)
 1.18A 6ieyA-1z7eA:
3.7
6ieyB-1z7eA:
3.5		 6ieyA-1z7eA:
18.61
6ieyB-1z7eA:
18.61