SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UFP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 LYS A  50
ILE A  81
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.80A 1axwA-2tddA:
35.8		 1axwA-2tddA:
51.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 LYS A  50
LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.71A 1axwA-2tddA:
35.8		 1axwA-2tddA:
51.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 11 LYS A  50
ILE A  81
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.71A 1axwB-2tddA:
35.7		 1axwB-2tddA:
51.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 11 LYS A  50
ILE A  81
TRP A  82
ASP A 221
GLY A 225
PHE A 228
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.83A 1axwB-2tddA:
35.7		 1axwB-2tddA:
51.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 LEU A 195
ASP A 221
LEU A 224
GLY A 225
TYR A 261
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.59A 1b02A-2tddA:
31.0		 1b02A-2tddA:
33.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.73A 1hvyA-2tddA:
35.1		 1hvyA-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ILE A  81
ASP A 221
GLY A 225
TYR A 261
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.77A 1hvyA-2tddA:
35.1		 1hvyA-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.09A 1hvyA-2tddA:
35.1		 1hvyA-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.71A 1hvyB-2tddA:
35.0		 1hvyB-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ILE A  81
ASP A 221
GLY A 225
TYR A 261
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.80A 1hvyB-2tddA:
35.0		 1hvyB-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.03A 1hvyB-2tddA:
35.0		 1hvyB-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.78A 1hvyC-2tddA:
35.1		 1hvyC-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 GLU A  60
ILE A  81
ASP A 221
GLY A 225
TYR A 261
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.70A 1hvyC-2tddA:
35.1		 1hvyC-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.07A 1hvyC-2tddA:
35.1		 1hvyC-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.70A 1hvyD-2tddA:
34.9		 1hvyD-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ASP A 221
LEU A 224
GLY A 225
TYR A 261
 None
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.67A 1hvyD-2tddA:
34.9		 1hvyD-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
ILE A  81
LEU A 195
ASP A 221
GLY A 225
TYR A 261
 None
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.81A 1hvyD-2tddA:
34.9		 1hvyD-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 ILE A  81
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.13A 1hvyD-2tddA:
34.9		 1hvyD-2tddA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 9 GLU A  60
ILE A  81
TRP A  82
ASP A 221
GLY A 225
TYR A 261
 None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.73A 1i00A-2tddA:
32.8		 1i00A-2tddA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 9 ILE A  81
TRP A  82
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.17A 1i00A-2tddA:
32.8		 1i00A-2tddA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 9 TRP A  82
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.08A 1i00A-2tddA:
32.8		 1i00A-2tddA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 9 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.93A 1i00B-2tddA:
33.1		 1i00B-2tddA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 9 ILE A  81
ASP A 221
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 1.18A 1i00B-2tddA:
33.1		 1i00B-2tddA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 9 ILE A  79
TRP A  80
ASP A 169
GLY A 173
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.80A 1i00B-4fogA:
22.0		 1i00B-4fogA:
49.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.53A 1ju6A-2tddA:
34.5		 1ju6A-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 9 LYS A  50
ASP A 221
LEU A 224
GLY A 225
TYR A 261
 THF  A 568 ( 4.7A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.66A 1ju6B-2tddA:
34.5		 1ju6B-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.53A 1ju6C-2tddA:
34.5		 1ju6C-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 LYS A  50
ASP A 221
LEU A 224
GLY A 225
TYR A 261
 THF  A 568 ( 4.7A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.66A 1ju6D-2tddA:
34.5		 1ju6D-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 LYS A  50
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.62A 1jujA-2tddA:
34.7		 1jujA-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 LYS A  50
ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 1jujA-2tddA:
34.7		 1jujA-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 LYS A  50
ILE A  81
TRP A  82
ASP A 221
PHE A 228
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.99A 1jujA-2tddA:
34.7		 1jujA-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 LYS A  50
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.62A 1jujB-2tddA:
34.7		 1jujB-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 LYS A  50
ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 1jujB-2tddA:
34.7		 1jujB-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 LYS A  50
ILE A  81
TRP A  82
ASP A 221
PHE A 228
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.99A 1jujB-2tddA:
34.7		 1jujB-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 LYS A  50
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.62A 1jujC-2tddA:
34.6		 1jujC-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 LYS A  50
ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 1jujC-2tddA:
34.6		 1jujC-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 LYS A  50
ILE A  81
TRP A  82
ASP A 221
PHE A 228
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.99A 1jujC-2tddA:
34.6		 1jujC-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 LYS A  50
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.62A 1jujD-2tddA:
34.6		 1jujD-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 LYS A  50
ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 1jujD-2tddA:
34.6		 1jujD-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 LYS A  50
ILE A  81
TRP A  82
ASP A 221
PHE A 228
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.99A 1jujD-2tddA:
34.6		 1jujD-2tddA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ASP A 221
LEU A 224
GLY A 225
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.72A 1rtsB-2tddA:
34.6		 1rtsB-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.57A 1rtsB-2tddA:
34.6		 1rtsB-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 1rtsB-2tddA:
34.6		 1rtsB-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A 195
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.79A 1tlsA-2tddA:
35.5		 1tlsA-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A  81
LEU A 195
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.92A 1tlsB-2tddA:
35.6		 1tlsB-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A 195
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.79A 1tlsB-2tddA:
35.6		 1tlsB-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A  81
LEU A 195
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 1tsnA-2tddA:
35.5		 1tsnA-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A  81
TRP A  82
LEU A 195
GLY A 225
PHE A 228
 THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.94A 1tsnA-2tddA:
35.5		 1tsnA-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A 195
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.75A 1tsnA-2tddA:
35.5		 1tsnA-2tddA:
51.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 5 ALA A 220
PHE A 255
ASN A 229
ILE A 230
 None
None
UFP  A 529 (-3.7A)
None
 1.00A 1yc2D-2tddA:
undetectable		 1yc2D-2tddA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.76A 2kceA-2tddA:
35.8		 2kceA-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.86A 2kceB-2tddA:
35.7		 2kceB-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ASP A 221
LEU A 224
GLY A 225
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.85A 2tsrA-2tddA:
33.8		 2tsrA-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.64A 2tsrA-2tddA:
33.8		 2tsrA-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 2tsrA-2tddA:
33.8		 2tsrA-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 8 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.81A 2tsrB-2tddA:
34.1		 2tsrB-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 8 ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.07A 2tsrB-2tddA:
34.1		 2tsrB-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.84A 2tsrC-2tddA:
33.5		 2tsrC-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 GLU A  60
ILE A  81
ASP A 221
GLY A 225
TYR A 261
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.73A 2tsrC-2tddA:
33.5		 2tsrC-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.11A 2tsrC-2tddA:
33.5		 2tsrC-2tddA:
43.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 GLN A 165
ALA A 168
LEU A  45
VAL A  50
ILE A 178
 UFP  A 301 (-4.1A)
UFP  A 301 ( 4.9A)
None
None
None
 1.17A 3claA-4fogA:
undetectable		 3claA-4fogA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A  81
GLY A 225
TYR A 233
LEU A 195
 THF  A 568 ( 4.8A)
UFP  A 529 ( 4.0A)
None
THF  A 568 (-4.6A)
 0.78A 3elzA-2tddA:
undetectable		 3elzA-2tddA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLN A 217
THR A 254
VAL A  13
LEU A 260
ILE A  31
 UFP  A 529 ( 4.7A)
None
None
None
None
 1.39A 3em0B-2tddA:
undetectable		 3em0B-2tddA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		3 / 3 SER A 219
GLN A 217
PHE A 255
 UFP  A 529 (-3.4A)
UFP  A 529 ( 4.7A)
None
 0.71A 3g4lC-2tddA:
undetectable		 3g4lC-2tddA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ILE A  81
LEU A 195
ASP A 221
PHE A 228
 None
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.82A 3k2hA-2tddA:
34.2		 3k2hA-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.80A 3k2hA-2tddA:
34.2		 3k2hA-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.72A 3k2hA-2tddA:
34.2		 3k2hA-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
ILE A  81
TRP A  82
LEU A 195
ASP A 221
PHE A 228
 None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.93A 3k2hB-2tddA:
34.6		 3k2hB-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.80A 3k2hB-2tddA:
34.6		 3k2hB-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.69A 3k2hB-2tddA:
34.6		 3k2hB-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.69A 3nrrA-2tddA:
35.0		 3nrrA-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.64A 3nrrA-2tddA:
35.0		 3nrrA-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ILE A  81
ASP A 221
GLY A 225
PHE A 228
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.82A 3nrrA-2tddA:
35.0		 3nrrA-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.73A 3nrrB-2tddA:
35.0		 3nrrB-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.63A 3nrrB-2tddA:
35.0		 3nrrB-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ILE A  81
ASP A 221
GLY A 225
PHE A 228
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.81A 3nrrB-2tddA:
35.0		 3nrrB-2tddA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  59
ILE A 238
MET A 188
PHE A 150
HIS A 147
 None
None
None
None
UFP  A 301 (-4.0A)
 1.20A 3qt0A-4fogA:
undetectable		 3qt0A-4fogA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ALA A 258
HIS A 259
LEU A 260
GLY A  17
HIS A  18
 None
UFP  A 529 (-4.1A)
None
None
None
 1.32A 3tm4A-2tddA:
undetectable		 3tm4A-2tddA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ALA A 258
HIS A 259
LEU A 260
GLY A  17
HIS A  18
 None
UFP  A 529 (-4.1A)
None
None
None
 1.29A 3tm4B-2tddA:
undetectable		 3tm4B-2tddA:
24.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 LEU A  56
HIS A 199
LEU A 224
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 None
None
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 0.79A 3uwlB-2tddA:
43.0		 3uwlB-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A  56
ILE A  81
HIS A 199
GLY A 225
PHE A 228
ASN A 229
 None
THF  A 568 ( 4.8A)
None
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.82A 3uwlB-2tddA:
43.0		 3uwlB-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 LEU A  56
ILE A  81
TRP A  82
LEU A 195
GLY A 225
PHE A 228
ASN A 229
 None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.90A 3uwlB-2tddA:
43.0		 3uwlB-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 LEU A  56
LEU A 195
LEU A 224
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 None
THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 0.89A 3uwlB-2tddA:
43.0		 3uwlB-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A  79
TRP A  80
LEU A 143
HIS A 147
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
UFP  A 301 (-4.0A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.55A 3uwlB-4fogA:
40.1		 3uwlB-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 LEU A  56
LEU A 195
HIS A 199
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 (-4.6A)
None
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.99A 3uwlD-2tddA:
42.9		 3uwlD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 LEU A  56
LEU A 195
LEU A 224
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 None
THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 0.86A 3uwlD-2tddA:
42.9		 3uwlD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 LEU A  56
TRP A  82
LEU A 195
LEU A 224
GLY A 225
PHE A 228
ASN A 229
 None
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.87A 3uwlD-2tddA:
42.9		 3uwlD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 TRP A  80
TRP A  83
LEU A 143
HIS A 147
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
UFP  A 301 (-4.0A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.58A 3uwlD-4fogA:
38.2		 3uwlD-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.83A 4eb4A-2tddA:
34.5		 4eb4A-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 ILE A  81
ASP A 221
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 1.17A 4eb4A-2tddA:
34.5		 4eb4A-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.92A 4eb4A-4fogA:
37.5		 4eb4A-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
TRP A  80
ASP A 169
GLY A 173
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.61A 4eb4A-4fogA:
37.5		 4eb4A-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 4eb4B-2tddA:
34.6		 4eb4B-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 ILE A  81
ASP A 221
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 1.14A 4eb4B-2tddA:
34.6		 4eb4B-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.89A 4eb4B-4fogA:
37.7		 4eb4B-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
TRP A  80
ASP A 169
GLY A 173
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.59A 4eb4B-4fogA:
37.7		 4eb4B-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 9 ILE A  81
ASP A 221
GLY A 225
ASN A 229
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 0.59A 4eb4C-2tddA:
33.5		 4eb4C-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 9 ILE A  81
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 1.27A 4eb4C-2tddA:
33.5		 4eb4C-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  79
ASP A 169
GLY A 173
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.59A 4eb4C-4fogA:
36.4		 4eb4C-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  79
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 1.07A 4eb4C-4fogA:
36.4		 4eb4C-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 ASP A 221
LEU A 224
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 0.99A 4eb4D-2tddA:
34.3		 4eb4D-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 ILE A  81
ASP A 221
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 1.19A 4eb4D-2tddA:
34.3		 4eb4D-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.99A 4eb4D-4fogA:
37.8		 4eb4D-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
TRP A  80
ASP A 169
GLY A 173
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.67A 4eb4D-4fogA:
37.8		 4eb4D-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 11 LYS A  50
ILE A  81
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.70A 4fogA-2tddA:
35.3		 4fogA-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 11 LYS A  50
ILE A  81
TRP A  82
LEU A 195
ASP A 221
GLY A 225
PHE A 228
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.75A 4fogA-2tddA:
35.3		 4fogA-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 11 ILE A  81
TRP A  82
LEU A 195
ASP A 221
GLY A 225
PHE A 228
 THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.86A 4fogC-2tddA:
35.8		 4fogC-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 11 ILE A  81
TRP A  82
TRP A  85
LEU A 195
GLY A 225
PHE A 228
 THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-3.1A)
THF  A 568 (-4.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 1.05A 4fogC-2tddA:
35.8		 4fogC-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.65A 4fogC-2tddA:
35.8		 4fogC-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		8 / 11 LYS A  50
ILE A  81
LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 4fogD-2tddA:
35.7		 4fogD-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		8 / 11 LYS A  50
ILE A  81
TRP A  82
LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.91A 4fogD-2tddA:
35.7		 4fogD-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 GLU A  60
ILE A  81
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 4foxA-2tddA:
35.6		 4foxA-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.81A 4foxA-2tddA:
35.6		 4foxA-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.74A 4foxB-2tddA:
35.7		 4foxB-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 GLU A  60
ILE A  81
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.76A 4foxB-2tddA:
35.7		 4foxB-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
ILE A  81
TRP A  82
LEU A 195
ASP A 221
PHE A 228
 None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.75A 4foxB-2tddA:
35.7		 4foxB-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.69A 4foxC-2tddA:
35.4		 4foxC-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 11 GLU A  60
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.78A 4foxC-2tddA:
35.4		 4foxC-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 GLU A  60
TRP A  82
LEU A 195
ASP A 221
PHE A 228
 None
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.81A 4foxC-2tddA:
35.4		 4foxC-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 None
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.72A 4foxD-2tddA:
35.7		 4foxD-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.86A 4foxD-2tddA:
35.7		 4foxD-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ILE A  81
TRP A  82
ASP A 221
PHE A 228
 None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.90A 4foxD-2tddA:
35.7		 4foxD-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LYS A  50
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.68A 4foxE-2tddA:
35.6		 4foxE-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 LYS A  50
GLU A  60
ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.7A)
None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.76A 4foxE-2tddA:
35.6		 4foxE-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LYS A  50
GLU A  60
ILE A  81
TRP A  82
ASP A 221
PHE A 228
 THF  A 568 ( 4.7A)
None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.78A 4foxE-2tddA:
35.6		 4foxE-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 11 GLU A  60
ILE A  81
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.88A 4foxF-2tddA:
35.5		 4foxF-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 11 GLU A  60
ILE A  81
TRP A  82
LEU A 195
ASP A 221
PHE A 228
 None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.87A 4foxF-2tddA:
35.5		 4foxF-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 GLU A  60
ILE A  81
LEU A 195
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 4foxG-2tddA:
35.2		 4foxG-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
ILE A  81
TRP A  82
LEU A 195
ASP A 221
PHE A 228
 None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.80A 4foxG-2tddA:
35.2		 4foxG-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.81A 4foxG-2tddA:
35.2		 4foxG-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 GLU A  60
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 None
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.68A 4foxH-2tddA:
35.1		 4foxH-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 GLU A  60
ILE A  81
ASP A 221
GLY A 225
PHE A 228
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.89A 4foxH-2tddA:
35.1		 4foxH-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 GLU A  60
ILE A  81
TRP A  82
ASP A 221
PHE A 228
 None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-4.8A)
 0.95A 4foxH-2tddA:
35.1		 4foxH-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 None
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.67A 4fqsA-2tddA:
35.7		 4fqsA-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ILE A  81
ASP A 221
GLY A 225
PHE A 228
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.84A 4fqsA-2tddA:
35.7		 4fqsA-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 None
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.67A 4fqsB-2tddA:
35.7		 4fqsB-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ILE A  81
ASP A 221
GLY A 225
PHE A 228
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.85A 4fqsB-2tddA:
35.7		 4fqsB-2tddA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 7 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.98A 4iqqA-2tddA:
32.8		 4iqqA-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 7 ILE A  81
ASP A 221
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.22A 4iqqA-2tddA:
32.8		 4iqqA-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.67A 4iqqB-2tddA:
32.5		 4iqqB-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.85A 4iqqB-2tddA:
32.5		 4iqqB-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.60A 4iqqC-2tddA:
32.5		 4iqqC-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 4iqqC-2tddA:
32.5		 4iqqC-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 8 ASP A 221
LEU A 224
GLY A 225
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.89A 4iqqD-2tddA:
32.5		 4iqqD-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 8 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.69A 4iqqD-2tddA:
32.5		 4iqqD-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 8 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.81A 4iqqD-2tddA:
32.5		 4iqqD-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 LEU A 195
ASP A 221
LEU A 224
GLY A 225
TYR A 261
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.72A 5fctA-2tddA:
34.6		 5fctA-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LYS A  50
VAL A  52
ILE A  81
TRP A  82
LEU A 195
CYH A 198
 THF  A 568 ( 4.7A)
None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-3.0A)
 0.98A 5fctB-2tddA:
34.7		 5fctB-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LYS A  50
VAL A  52
LEU A 195
CYH A 198
LEU A 224
TYR A 261
 THF  A 568 ( 4.7A)
None
THF  A 568 (-4.6A)
UFP  A 529 (-3.0A)
THF  A 568 (-3.6A)
UFP  A 529 (-4.7A)
 0.99A 5fctB-2tddA:
34.7		 5fctB-2tddA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 12 LYS A  48
VAL A  50
ILE A  79
TRP A  80
LEU A 143
CYH A 146
TYR A 209
 C2F  A 302 ( 3.9A)
None
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
UFP  A 301 (-2.9A)
C2F  A 302 ( 4.6A)
 0.45A 5fctB-4fogA:
38.2		 5fctB-4fogA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.62A 5h3aA-2tddA:
33.1		 5h3aA-2tddA:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.62A 5h3aB-2tddA:
33.5		 5h3aB-2tddA:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.83A 5h3aB-2tddA:
33.5		 5h3aB-2tddA:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.55A 5j7wC-2tddA:
42.7		 5j7wC-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A  56
GLU A  60
ILE A  81
LEU A 195
GLY A 225
PHE A 228
 None
None
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.80A 5j7wC-2tddA:
42.7		 5j7wC-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A  56
GLU A  60
LEU A 195
ASP A 221
GLY A 225
PHE A 228
 None
None
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.72A 5j7wC-2tddA:
42.7		 5j7wC-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.67A 5j7wC-2tddA:
42.7		 5j7wC-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 12 GLU A  60
ILE A  81
TRP A  82
LEU A 195
ASP A 221
GLY A 225
PHE A 228
 None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.91A 5j7wD-2tddA:
42.7		 5j7wD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 GLU A  60
LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
 None
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.76A 5j7wD-2tddA:
42.7		 5j7wD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.77A 5j7wD-2tddA:
42.7		 5j7wD-2tddA:
73.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 5 TYR A 202
SER A 183
ALA A 184
GLN A 217
 None
None
None
UFP  A 529 ( 4.7A)
 1.22A 5n0tA-2tddA:
undetectable		 5n0tA-2tddA:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.70A 5nooA-2tddA:
32.6		 5nooA-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.89A 5nooA-2tddA:
32.6		 5nooA-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.64A 5nooB-2tddA:
32.7		 5nooB-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.89A 5nooB-2tddA:
32.7		 5nooB-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 6 ASP A 221
LEU A 224
GLY A 225
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.97A 5nooC-2tddA:
32.2		 5nooC-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 6 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.90A 5nooC-2tddA:
32.2		 5nooC-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 8 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.67A 5nooD-2tddA:
32.8		 5nooD-2tddA:
41.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		3 / 3 HIS A 259
SER A  30
LYS A  20
 UFP  A 529 (-4.1A)
None
None
 0.95A 5os7A-2tddA:
undetectable		 5os7A-2tddA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.89A 5x5qB-2tddA:
35.1		 5x5qB-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ASP A 221
LEU A 224
GLY A 225
TYR A 261
 None
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.83A 5x5qB-2tddA:
35.1		 5x5qB-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 GLU A  60
ILE A  81
ASP A 221
GLY A 225
TYR A 261
 None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.74A 5x5qB-2tddA:
35.1		 5x5qB-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ASP A 221
LEU A 224
GLY A 225
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.85A 5x5qC-2tddA:
33.7		 5x5qC-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.64A 5x5qC-2tddA:
33.7		 5x5qC-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 7 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.83A 5x5qC-2tddA:
33.7		 5x5qC-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 8 ASP A 221
LEU A 224
GLY A 225
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.85A 5x5qD-2tddA:
33.9		 5x5qD-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 8 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.66A 5x5qD-2tddA:
33.9		 5x5qD-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 8 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 5x5qD-2tddA:
33.9		 5x5qD-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 6 ASP A 221
LEU A 224
GLY A 225
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.83A 5x5qE-2tddA:
33.7		 5x5qE-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 6 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.65A 5x5qE-2tddA:
33.7		 5x5qE-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 8 ASP A 221
LEU A 224
GLY A 225
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.84A 5x5qF-2tddA:
33.3		 5x5qF-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 8 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.67A 5x5qF-2tddA:
33.3		 5x5qF-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		4 / 8 LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.83A 5x5qF-2tddA:
33.3		 5x5qF-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 ILE A  81
ASP A 221
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 1.20A 5x66A-2tddA:
35.1
5x66B-2tddA:
35.3		 5x66A-2tddA:
45.09
5x66B-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 ILE A  81
ASP A 221
LEU A 224
GLY A 225
ASN A 229
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 0.49A 5x66A-2tddA:
35.1
5x66B-2tddA:
35.3		 5x66A-2tddA:
45.09
5x66B-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.96A 5x66A-4fogA:
37.7
5x66B-4fogA:
37.9		 5x66A-4fogA:
50.52
5x66B-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		7 / 9 ILE A  81
ASP A 221
LEU A 224
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 1.13A 5x66C-2tddA:
35.2		 5x66C-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 9 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.93A 5x66C-4fogA:
37.9		 5x66C-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 10 ILE A  81
ASP A 221
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 1.17A 5x66D-2tddA:
35.2		 5x66D-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.92A 5x66D-4fogA:
38.1		 5x66D-4fogA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 ILE A  81
ASP A 221
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 1.15A 5x66F-2tddA:
35.2		 5x66F-2tddA:
45.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LYS A  50
ILE A  81
ASP A 221
LEU A 224
GLY A 225
TYR A 261
 THF  A 568 ( 4.7A)
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.74A 5x66F-2tddA:
35.2		 5x66F-2tddA:
45.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		3 / 3 HIS A 259
SER A  30
LYS A  20
 UFP  A 529 (-4.1A)
None
None
 0.95A 6gmdB-2tddA:
undetectable		 6gmdB-2tddA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		8 / 12 PRO A  53
LEU A  56
ILE A  81
TRP A  82
LEU A 195
GLY A 225
PHE A 228
ASN A 229
 THF  A 568 (-4.4A)
None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.80A 6qxsB-2tddA:
43.0		 6qxsB-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		8 / 12 PRO A  53
LEU A  56
LEU A 195
LEU A 224
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 THF  A 568 (-4.4A)
None
THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 0.87A 6qxsB-2tddA:
43.0		 6qxsB-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		8 / 12 PRO A  53
LEU A  56
TRP A  82
LEU A 195
LEU A 224
GLY A 225
PHE A 228
ASN A 229
 THF  A 568 (-4.4A)
None
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.83A 6qxsB-2tddA:
43.0		 6qxsB-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A  79
TRP A  80
TRP A  83
LEU A 143
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.50A 6qxsB-4fogA:
38.1		 6qxsB-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 PRO A  53
ASP A 221
LEU A 224
GLY A 225
ASN A 229
 THF  A 568 (-4.4A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.53A 6qxsD-2tddA:
43.0		 6qxsD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 PRO A  53
LEU A  56
ILE A  81
ASP A 221
GLY A 225
ASN A 229
 THF  A 568 (-4.4A)
None
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.63A 6qxsD-2tddA:
43.0		 6qxsD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 PRO A  53
LEU A  56
ILE A  81
LEU A 195
ASP A 221
GLY A 225
 THF  A 568 (-4.4A)
None
THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
 0.82A 6qxsD-2tddA:
43.0		 6qxsD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 PRO A  53
LEU A  56
ILE A  81
TRP A  82
GLY A 225
ASN A 229
 THF  A 568 (-4.4A)
None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.62A 6qxsD-2tddA:
43.0		 6qxsD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 PRO A  53
LEU A  56
ILE A  81
TRP A  82
LEU A 195
GLY A 225
 THF  A 568 (-4.4A)
None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 ( 4.0A)
 0.90A 6qxsD-2tddA:
43.0		 6qxsD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 PRO A  53
LEU A 195
ASP A 221
LEU A 224
GLY A 225
 THF  A 568 (-4.4A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
 0.88A 6qxsD-2tddA:
43.0		 6qxsD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A  79
TRP A  80
TRP A  83
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.51A 6qxsD-4fogA:
38.0		 6qxsD-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A  56
HIS A 199
LEU A 224
PHE A 228
TYR A 261
 None
None
THF  A 568 (-3.6A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.82A 6qyaB-2tddA:
42.6		 6qyaB-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A  56
LEU A 195
LEU A 224
GLY A 225
PHE A 228
 None
THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.73A 6qyaB-2tddA:
42.6		 6qyaB-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A  56
LEU A 224
GLY A 225
PHE A 228
TYR A 261
 None
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.55A 6qyaB-2tddA:
42.6		 6qyaB-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A  79
TRP A  80
TRP A  83
LEU A 143
HIS A 147
GLY A 173
PHE A 176
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-3.9A)
C2F  A 302 (-4.8A)
UFP  A 301 (-4.0A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
C2F  A 302 ( 4.6A)
 0.50A 6qyaB-4fogA:
37.5		 6qyaB-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A  56
HIS A 199
LEU A 224
PHE A 228
TYR A 261
 None
None
THF  A 568 (-3.6A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
 0.83A 6qyaD-2tddA:
42.6		 6qyaD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A  56
ILE A  81
TRP A  82
PHE A 228
ASN A 229
 None
THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.61A 6qyaD-2tddA:
42.6		 6qyaD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A  56
LEU A 195
LEU A 224
GLY A 225
PHE A 228
 None
THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
 0.73A 6qyaD-2tddA:
42.6		 6qyaD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A  56
LEU A 224
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 None
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 0.57A 6qyaD-2tddA:
42.6		 6qyaD-2tddA:
73.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A  79
TRP A  80
LEU A 143
HIS A 147
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
UFP  A 301 (-4.0A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.48A 6qyaD-4fogA:
37.6		 6qyaD-4fogA:
52.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 ASP A 221
LEU A 224
GLY A 225
PHE A 228
ASN A 229
TYR A 261
 UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
UFP  A 529 (-4.7A)
 0.51A 6r2eA-2tddA:
34.4		 6r2eA-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 ILE A  81
LEU A 195
ASP A 221
GLY A 225
PHE A 228
ASN A 229
 THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.84A 6r2eA-2tddA:
34.4		 6r2eA-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A  81
TRP A  82
LEU A 195
PHE A 228
ASN A 229
 THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.81A 6r2eA-2tddA:
34.4		 6r2eA-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
ASN A 229
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.68A 6r2eA-2tddA:
34.4		 6r2eA-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
C2F  A 302 ( 4.6A)
 0.69A 6r2eA-4fogA:
37.8		 6r2eA-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 ILE A  81
TRP A  82
LEU A 195
ASP A 221
ASN A 229
 THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 (-3.7A)
 0.86A 6r2eB-2tddA:
34.1		 6r2eB-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 LEU A 195
ASP A 221
LEU A 224
GLY A 225
ASN A 229
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.64A 6r2eB-2tddA:
34.1		 6r2eB-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.63A 6r2eB-4fogA:
37.7		 6r2eB-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 ILE A  81
LEU A 195
ASP A 221
GLY A 225
ASN A 229
 THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.88A 6r2eC-2tddA:
34.5		 6r2eC-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 LEU A 195
ASP A 221
LEU A 224
GLY A 225
ASN A 229
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.76A 6r2eC-2tddA:
34.5		 6r2eC-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.67A 6r2eC-4fogA:
37.8		 6r2eC-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 10 LEU A 195
ASP A 221
LEU A 224
GLY A 225
ASN A 229
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.66A 6r2eD-2tddA:
34.1		 6r2eD-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.60A 6r2eD-4fogA:
37.8		 6r2eD-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 ILE A  81
TRP A  82
TYR A 146
LEU A 195
PHE A 228
ASN A 229
 THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
None
THF  A 568 (-4.6A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.85A 6r2eE-2tddA:
34.3		 6r2eE-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 12 ILE A  81
TYR A 146
LEU A 195
GLY A 225
PHE A 228
ASN A 229
 THF  A 568 ( 4.8A)
None
THF  A 568 (-4.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.90A 6r2eE-2tddA:
34.3		 6r2eE-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A 195
LEU A 224
GLY A 225
PHE A 228
ASN A 229
 THF  A 568 (-4.6A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.63A 6r2eE-2tddA:
34.3		 6r2eE-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A  79
TRP A  80
TYR A  94
LEU A 143
GLY A 173
PHE A 176
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
None
C2F  A 302 (-4.8A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
 0.51A 6r2eE-4fogA:
37.8		 6r2eE-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 ILE A  81
LEU A 195
ASP A 221
GLY A 225
ASN A 229
 THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.89A 6r2eF-2tddA:
34.2		 6r2eF-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 LEU A 195
ASP A 221
LEU A 224
GLY A 225
ASN A 229
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.70A 6r2eF-2tddA:
34.2		 6r2eF-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 11 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.64A 6r2eF-4fogA:
37.8		 6r2eF-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 11 ILE A  81
LEU A 195
ASP A 221
GLY A 225
PHE A 228
ASN A 229
 THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.82A 6r2eG-2tddA:
34.4		 6r2eG-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 11 ILE A  81
TRP A  82
LEU A 195
PHE A 228
ASN A 229
 THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
THF  A 568 (-4.6A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.82A 6r2eG-2tddA:
34.4		 6r2eG-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		6 / 11 LEU A 195
ASP A 221
LEU A 224
GLY A 225
PHE A 228
ASN A 229
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-3.7A)
 0.64A 6r2eG-2tddA:
34.4		 6r2eG-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 11 ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 (-3.7A)
UFP  A 301 (-2.8A)
 0.59A 6r2eG-4fogA:
37.8		 6r2eG-4fogA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A  81
LEU A 195
ASP A 221
GLY A 225
ASN A 229
 THF  A 568 ( 4.8A)
THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.97A 6r2eH-2tddA:
34.3		 6r2eH-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 ILE A  81
TRP A  82
TYR A 146
LEU A 195
ASN A 229
 THF  A 568 ( 4.8A)
THF  A 568 ( 4.6A)
None
THF  A 568 (-4.6A)
UFP  A 529 (-3.7A)
 0.79A 6r2eH-2tddA:
34.3		 6r2eH-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2tdd THYMIDYLATE SYNTHASE
(Lactobacillus
casei) 		5 / 12 LEU A 195
ASP A 221
LEU A 224
GLY A 225
ASN A 229
 THF  A 568 (-4.6A)
UFP  A 529 (-4.7A)
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-3.7A)
 0.76A 6r2eH-2tddA:
34.3		 6r2eH-2tddA:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4fog THYMIDYLATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A  79
TRP A  80
TYR A  94
LEU A 143
ASP A 169
GLY A 173
ASN A 177
 C2F  A 302 (-3.3A)
C2F  A 302 ( 3.8A)
None
C2F  A 302 (-4.8A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
UFP  A 301 (-2.8A)
 0.75A 6r2eH-4fogA:
37.8		 6r2eH-4fogA:
44.92