SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UD2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 118
HIS A  97
ALA A 100
GLY A 102
 None
None
NAD  A 342 (-2.9A)
UD2  A 343 ( 3.9A)
 1.11A 1l7xA-1sb8A:
2.4		 1l7xA-1sb8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 6 ASN A 118
HIS A  97
ALA A 100
GLY A 102
 None
None
NAD  A 343 (-3.3A)
UD2  A 344 ( 3.9A)
 1.14A 1l7xA-3rucA:
2.5		 1l7xA-3rucA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 118
HIS A  97
ALA A 100
GLY A 102
 None
None
NAD  A 342 (-2.9A)
UD2  A 343 ( 3.9A)
 1.12A 1l7xB-1sb8A:
0.7		 1l7xB-1sb8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A 237
ASP A 239
GLY A 336
GLY A 335
LEU A 227
 None
UD2  A 683 (-3.4A)
UD2  A 683 (-3.5A)
UD2  A 683 ( 4.8A)
None
 0.83A 1liiA-2z87A:
undetectable		 1liiA-2z87A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 235
ILE A 239
PRO A 212
ALA A 209
 None
None
None
UD2  A 343 (-3.6A)
 0.76A 1n49A-1sb8A:
undetectable		 1n49A-1sb8A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 335
ALA A 236
PHE A 333
LEU A 369
PHE A 351
 UD2  A 683 ( 4.8A)
None
None
None
None
 1.27A 1nw3A-2z87A:
undetectable		 1nw3A-2z87A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 TYR A 417
GLY A 359
GLY A 360
GLU A 361
LEU A 219
 None
UD2  A 683 ( 4.3A)
None
UD2  A 683 (-3.6A)
UD2  A 683 (-3.7A)
 1.05A 1qzzA-2z87A:
3.0		 1qzzA-2z87A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		5 / 12 THR A 269
GLN A 273
ILE A 226
VAL A 224
ALA A 277
 None
None
UD2  A 343 (-4.7A)
None
None
 0.98A 2g72B-1sb8A:
5.5		 2g72B-1sb8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		3 / 3 THR A 232
SER A 233
ARG A 234
 UD2  A 343 (-4.1A)
None
UD2  A 343 (-3.7A)
 0.80A 3phnA-1sb8A:
undetectable		 3phnA-1sb8A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3ruc WBGU
(Plesiomonas
shigelloides) 		3 / 3 THR A 232
SER A 233
ARG A 234
 UD2  A 344 (-3.6A)
None
UD2  A 344 (-3.6A)
 0.77A 3phnA-3rucA:
undetectable		 3phnA-3rucA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A 340
PHE A 351
ILE A 237
GLY A 335
 None
None
None
UD2  A 683 ( 4.8A)
 0.99A 4ejjC-2z87A:
undetectable		 4ejjC-2z87A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 239
VAL A 338
PHE A 351
LEU A 227
 UD2  A 683 (-3.4A)
None
None
None
 1.09A 4f8hB-2z87A:
undetectable
4f8hC-2z87A:
undetectable		 4f8hB-2z87A:
20.52
4f8hC-2z87A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A 219
PHE A 333
GLU A 361
PHE A 340
LEU A 227
 UD2  A 683 (-3.7A)
None
UD2  A 683 (-3.6A)
None
None
 1.39A 4la0A-2z87A:
undetectable		 4la0A-2z87A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 1sb8 WBPP
(Pseudomonas
aeruginosa) 		4 / 6 SER A 306
LEU A 307
ASP A 235
LEU A 152
 UD2  A 343 (-3.4A)
None
None
None
 0.72A 4wozA-1sb8A:
2.8
4wozB-1sb8A:
2.8		 4wozA-1sb8A:
22.52
4wozB-1sb8A:
22.52