SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UCA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  69
PHE A  70
ARG A 132
MET A 134
 None
None
UCA  A 301 (-4.1A)
None
 1.06A 2eikA-4w97A:
undetectable
2eikJ-4w97A:
undetectable		 2eikA-4w97A:
17.49
2eikJ-4w97A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  69
PHE A  70
ARG A 132
MET A 134
 None
None
UCA  A 301 (-4.1A)
None
 1.07A 2zxwN-4w97A:
undetectable
2zxwW-4w97A:
undetectable		 2zxwN-4w97A:
17.49
2zxwW-4w97A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 159
ASP A 153
ARG A 132
 UCA  A 301 (-3.5A)
None
UCA  A 301 (-4.1A)
 0.98A 4mx0A-4w97A:
undetectable		 4mx0A-4w97A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  66
VAL A  58
VAL A   4
TYR A 108
 None
None
None
UCA  A 301 (-3.6A)
 1.12A 4r7iA-4w97A:
undetectable		 4r7iA-4w97A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 158
TYR A  73
GLN A 131
 None
None
UCA  A 301 (-3.9A)
 1.08A 5jsdA-4w97A:
undetectable
5jsdB-4w97A:
undetectable		 5jsdA-4w97A:
15.40
5jsdB-4w97A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 158
TYR A  73
GLN A 131
 None
None
UCA  A 301 (-3.9A)
 1.08A 5jsdB-4w97A:
undetectable
5jsdC-4w97A:
undetectable		 5jsdB-4w97A:
15.40
5jsdC-4w97A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 109
ILE A 124
GLN A 118
ASP A  67
 UCA  A 301 (-3.5A)
None
None
None
 1.04A 5vlmH-4w97A:
6.7		 5vlmH-4w97A:
25.84