SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'UAG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 228
ILE A 178
THR A 196
MET A 219
 None
None
UAG  A1498 (-4.7A)
None
 1.16A 1kglA-2wtzA:
undetectable		 1kglA-2wtzA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 11 LEU A  86
ILE A  63
LEU A  36
PHE A  37
ARG A  48
 None
None
None
UAG  A1498 ( 4.7A)
None
 1.37A 2bxmA-1e8cA:
0.0		 2bxmA-1e8cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 252
ALA A 227
LEU A 228
ALA A 225
THR A 196
 None
None
None
UAG  A1498 ( 4.8A)
UAG  A1498 (-4.7A)
 1.10A 2jjpA-2wtzA:
undetectable		 2jjpA-2wtzA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 5 HIS A 214
GLN A 190
GLY A 187
SER A 185
 None
UAG  A1498 (-2.8A)
None
KCX  A 224 ( 4.0A)
 1.17A 4fu8A-1e8cA:
undetectable		 4fu8A-1e8cA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 6 THR A 157
GLU A 182
THR A 158
HIS A 214
 UAG  A1498 (-3.9A)
None
UAG  A1498 (-4.3A)
None
 0.98A 4pgfA-1e8cA:
2.4		 4pgfA-1e8cA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE
(Mycobacterium
tuberculosis) 		4 / 6 THR A 195
GLU A 220
THR A 196
HIS A 252
 UAG  A1498 (-3.1A)
None
UAG  A1498 (-4.7A)
None
 1.01A 4pgfA-2wtzA:
3.1		 4pgfA-2wtzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 7 GLU A 468
THR A 142
THR A 157
HIS A 359
 API  A1499 (-3.1A)
None
UAG  A1498 (-3.9A)
API  A1499 (-3.7A)
 0.91A 4qwpB-1e8cA:
undetectable		 4qwpB-1e8cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 228
ILE A 178
THR A 196
MET A 219
 None
None
UAG  A1498 (-4.7A)
None
 1.20A 5ljeA-2wtzA:
undetectable		 5ljeA-2wtzA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 235
PHE A 236
LEU A 265
SER A 222
 None
None
KCX  A 262 ( 4.4A)
UAG  A1498 (-2.6A)
 1.16A 5uxcA-2wtzA:
undetectable		 5uxcA-2wtzA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 180
THR A 158
ARG A 377
 UAG  A1498 ( 4.6A)
None
None
 1.01A 5wm2A-2wtzA:
2.2		 5wm2A-2wtzA:
27.20