SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'U91'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE A  98
LEU A  68
VAL A 116
ASP A  99
 None
U91  A 403 (-4.8A)
None
None
 1.26A 1dz6A-5mvdA:
undetectable		 1dz6A-5mvdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ARG A  57
ALA A  59
ALA A 104
GLU A 103
 None
U91  A 403 (-3.3A)
None
None
 1.11A 1e7bA-5mvdA:
undetectable		 1e7bA-5mvdA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ARG A  57
ALA A  59
ALA A 104
GLU A 103
 None
U91  A 403 (-3.3A)
None
None
 1.07A 1e7bB-5mvdA:
undetectable		 1e7bB-5mvdA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 336
GLY A 335
GLY A 306
THR A 360
LEU A 359
 None
FMN  A 401 (-3.6A)
FMN  A 401 (-3.6A)
U91  A 403 (-3.9A)
U91  A 403 ( 4.3A)
 0.85A 2egvB-5mvdA:
undetectable		 2egvB-5mvdA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 MET A  43
ALA A  55
ALA A  59
THR A  63
 U91  A 403 (-4.1A)
U91  A 403 (-3.6A)
U91  A 403 (-3.3A)
U91  A 403 ( 4.9A)
 0.85A 2wx2A-5mvdA:
undetectable		 2wx2A-5mvdA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  67
PHE A  37
LEU A  42
TYR A  38
ALA A  55
 None
None
None
None
U91  A 403 (-3.6A)
 1.01A 3vw7A-5mvdA:
undetectable		 3vw7A-5mvdA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 PHE A  98
THR A  63
GLY A 112
VAL A 116
ASP A  99
 None
U91  A 403 ( 4.9A)
None
None
None
 1.20A 4jx1B-5mvdA:
undetectable		 4jx1B-5mvdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 PHE A  98
THR A  63
LEU A  68
VAL A 116
ASP A  99
ILE A  94
 None
U91  A 403 ( 4.9A)
U91  A 403 (-4.8A)
None
None
None
 1.20A 4jx1B-5mvdA:
undetectable		 4jx1B-5mvdA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens) 		11 / 12 MET A  43
ALA A  55
HIS A  56
ALA A  59
PHE A  62
THR A  63
PHE A  98
TYR A 356
LEU A 359
THR A 360
PRO A 364
 U91  A 403 (-4.1A)
U91  A 403 (-3.6A)
U91  A 403 (-4.1A)
U91  A 403 (-3.3A)
None
U91  A 403 ( 4.9A)
None
FMN  A 401 ( 4.2A)
U91  A 403 ( 4.3A)
U91  A 403 (-3.9A)
U91  A 403 ( 4.3A)
 0.15A 5k9dA-5mvdA:
62.3		 5k9dA-5mvdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens) 		11 / 12 MET A  43
ALA A  55
HIS A  56
LEU A  58
ALA A  59
THR A  63
PHE A  98
TYR A 356
LEU A 359
THR A 360
PRO A 364
 U91  A 403 (-4.1A)
U91  A 403 (-3.6A)
U91  A 403 (-4.1A)
None
U91  A 403 (-3.3A)
U91  A 403 ( 4.9A)
None
FMN  A 401 ( 4.2A)
U91  A 403 ( 4.3A)
U91  A 403 (-3.9A)
U91  A 403 ( 4.3A)
 0.38A 5k9dA-5mvdA:
62.3		 5k9dA-5mvdA:
100.00