SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'U63'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		12 / 12 ALA A 143
TYR A 145
TYR A 171
ASP A 173
SER A 174
GLN A 175
GLU A 212
ASP A 214
GLU A 217
THR A 246
ARG A 251
ASP A 376
 None
None
None
None
None
U63  A1443 (-4.4A)
None
None
U63  A1443 ( 4.3A)
U63  A1443 (-4.0A)
U63  A1443 (-3.0A)
U63  A1443 ( 4.9A)
 0.34A 1dy4A-4v20A:
65.2		 1dy4A-4v20A:
64.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 5 HIS A 228
TRP A 374
ALA A 379
TRP A 383
 U63  A1443 (-4.2A)
None
U63  A1443 ( 4.9A)
U63  A1443 (-3.6A)
 0.35A 1dy4A-4v20A:
65.2		 1dy4A-4v20A:
64.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 8 ASP A 214
GLY A 260
GLU A 217
ARG A 251
 None
None
U63  A1443 ( 4.3A)
U63  A1443 (-3.0A)
 0.98A 3s3nA-4v20A:
undetectable		 3s3nA-4v20A:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		9 / 9 ASN A 141
ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLU A 212
ASP A 214
GLU A 217
TRP A 374
 None
None
None
None
None
None
None
U63  A1443 ( 4.3A)
None
 0.49A 4ipmA-4v20A:
63.1		 4ipmA-4v20A:
55.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 5 TYR A 171
SER A 372
ASP A 214
ASP A 262
 None
None
None
U63  A1443 ( 3.9A)
 1.06A 4qtuB-4v20A:
undetectable		 4qtuB-4v20A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4v20 CELLOBIOHYDROLASE
(Aspergillus
fumigatus) 		4 / 6 THR A 246
ARG A 251
ASP A 250
GLY A 253
 U63  A1443 (-4.0A)
U63  A1443 (-3.0A)
None
None
 0.81A 5mraA-4v20A:
undetectable
5mraB-4v20A:
undetectable		 5mraA-4v20A:
16.82
5mraB-4v20A:
16.82