SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'U5P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 5 HIS A 381
HIS A  84
HIS A  89
HIS A 403
ASP A 209
 U5P  A 606 (-3.9A)
ZN  A 601 (-3.5A)
ZN  A 602 (-3.3A)
ZN  A 602 (-3.2A)
None
 1.38A 1e9yB-4xwtA:
2.9		 1e9yB-4xwtA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3qw4 UMP SYNTHASE
(Leishmania
donovani) 		4 / 8 ASN B  51
LEU B  81
ALA B  99
LEU B 103
 U5P  B7485 (-3.3A)
None
None
None
 0.89A 1hwiB-3qw4B:
undetectable		 1hwiB-3qw4B:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3qw4 UMP SYNTHASE
(Leishmania
donovani) 		4 / 8 ASN B  51
LEU B  81
ALA B  99
LEU B 103
 U5P  B7485 (-3.3A)
None
None
None
 0.88A 1hwiD-3qw4B:
undetectable		 1hwiD-3qw4B:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3qw4 UMP SYNTHASE
(Leishmania
donovani) 		4 / 8 ASN B  51
LEU B  81
ALA B  99
LEU B 103
 U5P  B7485 (-3.3A)
None
None
None
 0.88A 1hwiC-3qw4B:
undetectable		 1hwiC-3qw4B:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3opx PROTEIN SSM1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 162
LEU A 120
LEU A 159
THR A 140
LEU A  41
 None
None
None
U5P  A 265 (-3.7A)
None
 1.19A 1jipA-3opxA:
undetectable		 1jipA-3opxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		3 / 3 ARG A 185
ARG A 196
ARG A 215
 U5P  A 250 (-2.6A)
None
U5P  A 250 (-3.8A)
 1.00A 1l7fA-1dbtA:
undetectable		 1l7fA-1dbtA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		3 / 3 ARG A 185
ARG A 196
ARG A 215
 U5P  A 250 (-2.6A)
None
U5P  A 250 (-3.8A)
 0.99A 1l7hA-1dbtA:
undetectable		 1l7hA-1dbtA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 ASP A  68
GLY A 144
THR A 120
ASP A 136
 MG  A 401 (-2.6A)
UTP  A 501 (-3.6A)
None
U5P  A 502 (-4.0A)
 0.78A 1m4iA-2q0fA:
undetectable		 1m4iA-2q0fA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		5 / 5 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 250 (-4.7A)
U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
U5P  A 250 (-4.4A)
 0.62A 1upfA-1i5eA:
27.6		 1upfA-1i5eA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 5 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 600 (-4.5A)
U5P  A 600 (-3.4A)
U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
U5P  A 600 (-4.0A)
 0.54A 1upfA-1o5oA:
27.4		 1upfA-1o5oA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 5 MET A 142
ALA A 144
TYR A 202
ILE A 203
ASP A 209
 U5P  A1250 (-4.5A)
U5P  A1250 (-3.4A)
U5P  A1250 (-4.4A)
U5P  A1250 (-4.1A)
U5P  A1250 (-4.1A)
 0.47A 1upfA-1xttA:
23.7		 1upfA-1xttA:
34.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		4 / 7 ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
U5P  A 250 (-4.4A)
 0.35A 1upfB-1i5eA:
27.7		 1upfB-1i5eA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		4 / 7 MET A 133
ALA A 135
TYR A 193
ILE A 194
 U5P  A 250 (-4.7A)
U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
 0.59A 1upfB-1i5eA:
27.7		 1upfB-1i5eA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 7 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 600 (-4.5A)
U5P  A 600 (-3.4A)
U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
U5P  A 600 (-4.0A)
 0.55A 1upfB-1o5oA:
27.5		 1upfB-1o5oA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 7 MET A 142
ALA A 144
TYR A 202
ILE A 203
ASP A 209
 U5P  A1250 (-4.5A)
U5P  A1250 (-3.4A)
U5P  A1250 (-4.4A)
U5P  A1250 (-4.1A)
U5P  A1250 (-4.1A)
 0.55A 1upfB-1xttA:
24.2		 1upfB-1xttA:
34.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		5 / 5 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 250 (-4.7A)
U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
U5P  A 250 (-4.4A)
 0.58A 1upfC-1i5eA:
27.8		 1upfC-1i5eA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 5 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 600 (-4.5A)
U5P  A 600 (-3.4A)
U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
U5P  A 600 (-4.0A)
 0.50A 1upfC-1o5oA:
27.5		 1upfC-1o5oA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 5 MET A 142
ALA A 144
TYR A 202
ILE A 203
ASP A 209
 U5P  A1250 (-4.5A)
U5P  A1250 (-3.4A)
U5P  A1250 (-4.4A)
U5P  A1250 (-4.1A)
U5P  A1250 (-4.1A)
 0.51A 1upfC-1xttA:
24.0		 1upfC-1xttA:
34.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE
([Bacillus]
caldolyticus) 		4 / 4 MET A 133
ALA A 135
TYR A 193
ILE A 194
 U5P  A 250 (-4.7A)
U5P  A 250 (-3.2A)
U5P  A 250 (-4.5A)
U5P  A 250 (-4.4A)
 0.52A 1upfD-1i5eA:
28.4		 1upfD-1i5eA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 4 MET A 133
ALA A 135
TYR A 193
ILE A 194
 U5P  A 600 (-4.5A)
U5P  A 600 (-3.4A)
U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
 0.47A 1upfD-1o5oA:
27.6		 1upfD-1o5oA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 4 MET A 142
ALA A 144
TYR A 202
ILE A 203
 U5P  A1250 (-4.5A)
U5P  A1250 (-3.4A)
U5P  A1250 (-4.4A)
U5P  A1250 (-4.1A)
 0.54A 1upfD-1xttA:
24.7		 1upfD-1xttA:
34.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3opx PROTEIN SSM1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  86
LEU A  84
ASP A 167
ALA A  97
 None
U5P  A 265 (-4.9A)
None
None
 0.96A 2opxA-3opxA:
2.4		 2opxA-3opxA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 12 HIS A  89
GLY A 174
HIS A 403
HIS A 381
SER A 154
 ZN  A 602 (-3.3A)
None
ZN  A 602 (-3.2A)
U5P  A 606 (-3.9A)
U5P  A 606 (-3.4A)
 1.22A 2pgfA-4xwtA:
undetectable		 2pgfA-4xwtA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 1ucd RIBONUCLEASE MC
(Momordica
charantia) 		3 / 3 VAL A  72
TRP A  81
TRP A  69
 U5P  A 500 (-3.3A)
None
None
 1.06A 2xdcC-1ucdA:
undetectable
2xdcD-1ucdA:
undetectable		 2xdcC-1ucdA:
11.84
2xdcD-1ucdA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1wlj INTERFERON
STIMULATED GENE
20KDA
(Homo
sapiens) 		5 / 12 ARG A  21
ARG A  44
GLY A  24
PRO A  45
VAL A  56
 None
None
None
None
U5P  A 300 ( 4.9A)
 1.30A 2zznA-1wljA:
undetectable		 2zznA-1wljA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 3opx PROTEIN SSM1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  79
TYR A 100
ILE A  86
 U5P  A 265 (-4.7A)
None
None
 0.83A 3eteA-3opxA:
undetectable
3eteB-3opxA:
undetectable		 3eteA-3opxA:
18.92
3eteB-3opxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 LEU A 387
ARG A 215
SER A 190
GLY A 380
 None
None
None
U5P  A 606 (-3.4A)
 0.87A 3hcnA-4xwtA:
4.1		 3hcnA-4xwtA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 LEU A 387
ARG A 215
SER A 190
GLY A 380
 None
None
None
U5P  A 606 (-3.4A)
 0.99A 3hcrB-4xwtA:
3.5		 3hcrB-4xwtA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 3qw4 UMP SYNTHASE
(Leishmania
donovani) 		5 / 10 THR B 179
SER B 137
VAL B 227
GLY B 205
GLY B 202
 None
U5P  B7485 (-2.8A)
U5P  B7485 ( 4.5A)
None
None
 1.22A 3ixlA-3qw4B:
undetectable		 3ixlA-3qw4B:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 ASP A  84
PHE A  52
LEU A  49
PHE A  69
ILE A 137
 None
U5P  A 502 ( 4.4A)
None
None
None
 1.46A 3ko0C-2q0fA:
undetectable
3ko0D-2q0fA:
undetectable
3ko0E-2q0fA:
0.0
3ko0F-2q0fA:
undetectable		 3ko0C-2q0fA:
13.66
3ko0D-2q0fA:
13.66
3ko0E-2q0fA:
13.66
3ko0F-2q0fA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 LEU A  49
PHE A  69
ILE A 137
PHE A  52
ASP A  84
 None
None
None
U5P  A 502 ( 4.4A)
None
 1.50A 3ko0O-2q0fA:
undetectable
3ko0P-2q0fA:
undetectable
3ko0Q-2q0fA:
0.0
3ko0R-2q0fA:
0.0		 3ko0O-2q0fA:
13.66
3ko0P-2q0fA:
13.66
3ko0Q-2q0fA:
13.66
3ko0R-2q0fA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 11 ASP A  84
PHE A  52
LEU A  49
PHE A  69
ILE A 137
 None
U5P  A 502 ( 4.4A)
None
None
None
 1.47A 3ko0Q-2q0fA:
0.0
3ko0R-2q0fA:
0.0
3ko0S-2q0fA:
undetectable
3ko0T-2q0fA:
undetectable		 3ko0Q-2q0fA:
13.66
3ko0R-2q0fA:
13.66
3ko0S-2q0fA:
13.66
3ko0T-2q0fA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2q0f RNA URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 HIS A  61
SER A  65
ASP A  68
ASP A 136
 None
UTP  A 501 (-2.6A)
MG  A 401 (-2.6A)
U5P  A 502 (-4.0A)
 1.01A 3n2oC-2q0fA:
undetectable
3n2oD-2q0fA:
undetectable		 3n2oC-2q0fA:
21.08
3n2oD-2q0fA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A  75
ALA A 139
LEU A  32
THR A  23
ILE A 203
 None
None
None
None
U5P  A1250 (-4.1A)
 1.22A 3prsA-1xttA:
undetectable		 3prsA-1xttA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		5 / 9 LEU A 122
ALA A  89
VAL A 144
GLY A 158
ILE A 117
 U5P  A 250 (-4.2A)
None
None
None
None
 1.21A 3spkA-1dbtA:
undetectable		 3spkA-1dbtA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 ASP A 175
HIS A 381
ILE A  30
HIS A 403
 ZN  A 602 ( 2.5A)
U5P  A 606 (-3.9A)
None
ZN  A 602 (-3.2A)
 1.02A 3t01A-4xwtA:
2.2		 3t01A-4xwtA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 9 ALA A 135
ARG A 104
GLY A 137
ASP A 131
ILE A 179
 U5P  A 600 (-3.4A)
U5P  A 600 (-3.4A)
U5P  A 600 (-3.6A)
U5P  A 600 ( 3.9A)
None
 1.28A 3wdmA-1o5oA:
2.3		 3wdmA-1o5oA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1ucd RIBONUCLEASE MC
(Momordica
charantia) 		3 / 3 VAL A  72
TRP A  81
TRP A  69
 U5P  A 500 (-3.3A)
None
None
 1.17A 3zq8A-1ucdA:
undetectable
3zq8B-1ucdA:
undetectable		 3zq8A-1ucdA:
11.84
3zq8B-1ucdA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 5 HIS A 381
HIS A  84
HIS A  89
HIS A 403
ASP A 209
 U5P  A 606 (-3.9A)
ZN  A 601 (-3.5A)
ZN  A 602 (-3.3A)
ZN  A 602 (-3.2A)
None
 1.35A 4h9mA-4xwtA:
undetectable		 4h9mA-4xwtA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3plr UDP-GLUCOSE
6-DEHYDROGENASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 248
GLY A 250
ILE A 318
ILE A 321
SER A 246
 None
U5P  A 901 (-3.2A)
None
None
U5P  A 901 (-2.8A)
 1.13A 4iv0B-3plrA:
4.8		 4iv0B-3plrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		6 / 12 ASP A 189
VAL A 197
GLY A 214
ILE A 217
PRO A 200
THR A 199
 None
None
U5P  A 250 (-3.4A)
None
None
None
 1.42A 4njuA-1dbtA:
undetectable		 4njuA-1dbtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		6 / 10 ASP A 189
VAL A 197
GLY A 214
ILE A 217
PRO A 200
THR A 199
 None
None
U5P  A 250 (-3.4A)
None
None
None
 1.25A 4njuB-1dbtA:
undetectable		 4njuB-1dbtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		6 / 12 ASP A 189
VAL A 197
GLY A 214
ILE A 217
PRO A 200
THR A 199
 None
None
U5P  A 250 (-3.4A)
None
None
None
 1.43A 4njuC-1dbtA:
undetectable		 4njuC-1dbtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		6 / 10 ASP A 189
VAL A 197
GLY A 214
ILE A 217
PRO A 200
THR A 199
 None
None
U5P  A 250 (-3.4A)
None
None
None
 1.26A 4njuD-1dbtA:
undetectable		 4njuD-1dbtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 HIS A 381
HIS A 403
HIS A  84
HIS A  86
 U5P  A 606 (-3.9A)
ZN  A 602 (-3.2A)
ZN  A 601 (-3.5A)
ZN  A 601 (-3.1A)
 0.95A 4p6sB-4xwtA:
undetectable		 4p6sB-4xwtA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 9 TYR A 193
ILE A 194
GLY A 199
ALA A 135
ARG A 104
 U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
None
U5P  A 600 (-3.4A)
U5P  A 600 (-3.4A)
 0.93A 4yp2B-1o5oA:
undetectable		 4yp2B-1o5oA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 9 TYR A 193
ILE A 194
GLY A 199
ALA A 135
ARG A 104
 U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
None
U5P  A 600 (-3.4A)
U5P  A 600 (-3.4A)
 0.93A 5cf9B-1o5oA:
undetectable		 5cf9B-1o5oA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 211
ARG A 105
ALA A 103
SER A 172
ILE A 203
 None
U5P  A1250 (-3.5A)
None
None
U5P  A1250 (-4.1A)
 1.19A 5ih0A-1xttA:
undetectable		 5ih0A-1xttA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4xwt DR2417
(Deinococcus
radiodurans) 		3 / 3 HIS A 153
ASP A 209
HIS A 381
 ZN  A 601 (-3.4A)
None
U5P  A 606 (-3.9A)
 0.96A 5n1tW-4xwtA:
undetectable		 5n1tW-4xwtA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4xwt DR2417
(Deinococcus
radiodurans) 		6 / 10 HIS A  84
HIS A  86
HIS A  89
HIS A 153
ASP A 175
HIS A 381
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.1A)
ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 602 ( 2.5A)
U5P  A 606 (-3.9A)
 0.29A 5nzwA-4xwtA:
7.9		 5nzwA-4xwtA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 10 HIS A 153
HIS A  84
HIS A 381
ASP A 175
HIS A 403
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.5A)
U5P  A 606 (-3.9A)
ZN  A 602 ( 2.5A)
ZN  A 602 (-3.2A)
 0.95A 5nzwA-4xwtA:
7.9		 5nzwA-4xwtA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 10 HIS A 153
HIS A 381
HIS A  84
THR A  35
HIS A  89
 ZN  A 601 (-3.4A)
U5P  A 606 (-3.9A)
ZN  A 601 (-3.5A)
None
ZN  A 602 (-3.3A)
 1.06A 5nzwA-4xwtA:
7.9		 5nzwA-4xwtA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 1ucd RIBONUCLEASE MC
(Momordica
charantia) 		3 / 3 LYS A  87
HIS A  83
HIS A  88
 U5P  A 500 (-2.7A)
U5P  A 500 (-3.8A)
U5P  A 500 (-3.7A)
 1.42A 5oexA-1ucdA:
0.0		 5oexA-1ucdA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 1ucd RIBONUCLEASE MC
(Momordica
charantia) 		3 / 3 LYS A  87
HIS A  83
HIS A  88
 U5P  A 500 (-2.7A)
U5P  A 500 (-3.8A)
U5P  A 500 (-3.7A)
 1.42A 5oexB-1ucdA:
0.0		 5oexB-1ucdA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 1ucd RIBONUCLEASE MC
(Momordica
charantia) 		3 / 3 LYS A  87
HIS A  83
HIS A  88
 U5P  A 500 (-2.7A)
U5P  A 500 (-3.8A)
U5P  A 500 (-3.7A)
 1.43A 5oexC-1ucdA:
undetectable		 5oexC-1ucdA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 1ucd RIBONUCLEASE MC
(Momordica
charantia) 		3 / 3 LYS A  87
HIS A  83
HIS A  88
 U5P  A 500 (-2.7A)
U5P  A 500 (-3.8A)
U5P  A 500 (-3.7A)
 1.43A 5oexD-1ucdA:
undetectable		 5oexD-1ucdA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3uwq OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Vibrio
cholerae) 		5 / 12 PHE A  46
GLU A  37
VAL A 208
THR A 214
GLY A 210
 None
None
U5P  A 232 (-4.9A)
PEG  A 234 ( 4.5A)
U5P  A 232 (-3.4A)
 1.01A 5tuiB-3uwqA:
undetectable		 5tuiB-3uwqA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 11 HIS A  86
ILE A 155
HIS A  84
HIS A 381
ASP A 179
 ZN  A 601 (-3.1A)
None
ZN  A 601 (-3.5A)
U5P  A 606 (-3.9A)
None
 1.47A 5z0mA-4xwtA:
undetectable
5z0mB-4xwtA:
undetectable		 5z0mA-4xwtA:
9.66
5z0mB-4xwtA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3qw4 UMP SYNTHASE
(Leishmania
donovani) 		5 / 11 VAL B  79
ALA B 105
ASP B  21
THR B 109
ALA B 107
 None
None
U5P  B7485 (-3.4A)
None
None
 1.42A 6dk1C-3qw4B:
undetectable		 6dk1C-3qw4B:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 PHE A  28
GLY A 211
ALA A  81
ILE A 169
LEU A  32
 None
None
U5P  A1250 ( 3.7A)
None
None
 1.04A 6dwnD-1xttA:
undetectable		 6dwnD-1xttA:
14.29