SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'U2F'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		3 / 3 GLN A 324
TYR A 279
ARG A 208
 None
None
U2F  A 900 (-3.0A)
 0.82A 1gtbA-2iw1A:
undetectable		 1gtbA-2iw1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 6 ASN A 354
ILE A 219
SER A 146
ASN A 378
 U2F  A1457 (-3.8A)
None
KMP  A1456 (-4.1A)
None
 1.20A 1h7xB-2c1zA:
3.9		 1h7xB-2c1zA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE
(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		5 / 11 VAL A 276
TYR A 225
GLY A 215
VAL A 285
PRO A 223
 U2F  A 547 (-4.0A)
None
None
None
None
 1.50A 1i9jH-3h4iA:
undetectable
1i9jL-3h4iA:
undetectable		 1i9jH-3h4iA:
18.31
1i9jL-3h4iA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE
(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		4 / 6 LEU A 185
ALA A 200
ASP A 315
TYR A 318
 None
None
U2F  A 547 (-2.7A)
None
 0.83A 2dpzA-3h4iA:
undetectable		 2dpzA-3h4iA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 5 PHE A 121
THR A 141
LEU A 147
ALA A 120
 KMP  A1456 (-4.5A)
U2F  A1457 (-3.9A)
None
None
 1.36A 2e1qD-2c1zA:
undetectable		 2e1qD-2c1zA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE
(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		4 / 7 HIS A 291
THR A 297
GLY A 292
TYR A 319
 U2F  A 547 (-4.0A)
None
None
None
 1.05A 2f6dA-3h4iA:
undetectable		 2f6dA-3h4iA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		3 / 3 ASN A 145
ASP A 374
ARG A  30
 None
U2F  A1457 (-2.7A)
None
 0.85A 3k13C-2c1zA:
undetectable		 3k13C-2c1zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 10 LEU A 200
VAL A 297
GLY A 284
ILE A 285
LEU A 274
 None
None
U2F  A 900 (-3.6A)
U2F  A 900 (-3.6A)
None
 1.06A 3ogpB-2iw1A:
undetectable		 3ogpB-2iw1A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE
(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		5 / 12 THR A 296
GLY A 229
LEU A 342
VAL A 288
ALA A 287
 U2F  A 547 (-3.6A)
U2F  A 547 (-3.5A)
None
None
None
 1.16A 3t7vA-3h4iA:
undetectable		 3t7vA-3h4iA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		5 / 12 PHE A 316
LEU A 128
TYR A 157
VAL A 161
ALA A 114
 None
None
None
GOL  A 450 (-4.7A)
U2F  A 449 (-4.8A)
 1.44A 4a84A-2am4A:
undetectable		 4a84A-2am4A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 8 GLY A  15
TYR A 308
LEU A 288
TYR A 170
 U2F  A 900 (-3.2A)
None
None
None
 0.82A 4fgzA-2iw1A:
3.0		 4fgzA-2iw1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 8 GLY A  15
TYR A 308
LEU A 288
TYR A 170
 U2F  A 900 (-3.2A)
None
None
None
 0.81A 4fgzB-2iw1A:
3.0		 4fgzB-2iw1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		3 / 3 ASP A 272
LEU A 275
VAL A 234
 None
None
U2F  A 900 (-4.6A)
 0.55A 4jecB-2iw1A:
undetectable		 4jecB-2iw1A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE
(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		5 / 12 VAL A 123
ALA A 181
LEU A 185
GLY A 292
ASP A 315
 None
None
None
None
U2F  A 547 (-2.7A)
 1.31A 4qckA-3h4iA:
undetectable		 4qckA-3h4iA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 6 ILE A  87
PHE A  90
THR A 141
TRP A 140
 None
None
U2F  A1457 (-3.9A)
None
 1.21A 5g08A-2c1zA:
undetectable		 5g08A-2c1zA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE
(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		4 / 6 ARG A 207
GLU A  41
GLU A  15
VAL A  18
 U2F  A 547 (-4.4A)
None
U2F  A 547 ( 4.9A)
None
 1.38A 5h4dA-3h4iA:
4.7		 5h4dA-3h4iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 12 GLY A 203
LEU A 245
ALA A 278
GLY A 210
SER A 214
 U2F  A 900 ( 4.3A)
None
None
None
None
 1.41A 5jglB-2iw1A:
2.0		 5jglB-2iw1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE
(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		5 / 12 SER A 230
GLY A 295
GLY A 293
THR A 297
HIS A 278
 U2F  A 547 (-2.6A)
U2F  A 547 (-3.3A)
U2F  A 547 (-3.4A)
None
U2F  A 547 (-3.5A)
 0.99A 5kocB-3h4iA:
2.0		 5kocB-3h4iA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE
(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		5 / 9 GLY A 283
VAL A 285
ASN A 277
VAL A 276
LEU A 213
 None
None
None
U2F  A 547 (-4.0A)
None
 0.97A 5lw1H-3h4iA:
undetectable		 5lw1H-3h4iA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE
(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		3 / 3 SER A 230
SER A  10
ALA A 294
 U2F  A 547 (-2.6A)
U2F  A 547 (-3.0A)
U2F  A 547 (-3.5A)
 0.69A 6dwnC-3h4iA:
undetectable		 6dwnC-3h4iA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A 214
THR A 315
GLY A 317
ARG A 117
 None
None
MN  A 448 ( 4.8A)
U2F  A 449 (-2.9A)
 1.13A 6gtqB-2am4A:
0.4
6gtqD-2am4A:
undetectable		 6gtqB-2am4A:
21.60
6gtqD-2am4A:
8.97