SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'U10'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		4 / 5 THR L 226
HIS M 266
HIS L 230
HIS L 190
 U10  L 272 (-4.2A)
FE  M 302 (-3.3A)
FE  M 302 (-3.4A)
FE  M 302 ( 3.3A)
 1.24A 1ei6A-1pssL:
undetectable		 1ei6A-1pssL:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		4 / 5 LEU A  33
ALA A  35
LEU A  77
MET A 111
 None
None
None
U10  A 501 ( 4.6A)
 1.15A 2oaxA-4nv2A:
undetectable		 2oaxA-4nv2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		4 / 7 GLY M  56
ILE M  50
ARG M 132
LEU M  60
 None
U10  L 272 ( 4.8A)
None
None
 0.96A 2xrhA-1pssM:
undetectable		 2xrhA-1pssM:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 11 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.29A 2y7kA-1pssM:
undetectable		 2y7kA-1pssM:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 10 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.25A 2y7kB-1pssM:
undetectable		 2y7kB-1pssM:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 12 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.21A 2y7kC-1pssM:
undetectable		 2y7kC-1pssM:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 12 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.18A 2y7kD-1pssM:
undetectable		 2y7kD-1pssM:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 10 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.33A 2y7pA-1pssM:
undetectable		 2y7pA-1pssM:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 9 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.09A 2y7wA-1pssM:
undetectable		 2y7wA-1pssM:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 10 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.08A 2y7wB-1pssM:
undetectable		 2y7wB-1pssM:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 7 THR M 222
ILE M 223
GLY M 220
HIS M 266
ILE M 265
 U10  M 303 (-3.5A)
None
None
FE  M 302 (-3.3A)
U10  M 303 (-4.3A)
 1.09A 2y7wC-1pssM:
undetectable		 2y7wC-1pssM:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1pss PHOTOSYNTHETIC
REACTION CENTER
PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		5 / 12 LEU M 224
GLY L 225
GLN M  11
ARG M  13
ILE L 224
 None
U10  L 272 (-4.3A)
None
None
U10  L 272 (-4.4A)
 1.22A 4djeA-1pssM:
undetectable		 4djeA-1pssM:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 12 HIS L 230
ARG L 217
ASN M  44
ILE L 224
ARG L 231
 FE  M 302 (-3.4A)
None
None
U10  L 272 (-4.4A)
None
 1.40A 4kmuH-1pssL:
0.8		 4kmuH-1pssL:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		4 / 8 LEU L 189
ILE M 270
VAL M 276
THR M 277
 U10  L 272 ( 4.1A)
None
None
BPH  M   5 (-3.3A)
 0.96A 4ma7A-1pssL:
undetectable		 4ma7A-1pssL:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		5 / 11 GLY A  76
LEU A  77
LEU A 143
ALA A  27
SER A  31
 U10  A 501 (-3.6A)
None
None
None
None
 1.12A 4wnuA-4nv2A:
undetectable		 4wnuA-4nv2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		5 / 11 LEU A 107
GLY A  76
LEU A  77
ALA A  27
SER A  31
 None
U10  A 501 (-3.6A)
None
None
None
 1.21A 4wnuC-4nv2A:
undetectable		 4wnuC-4nv2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		4 / 8 PHE L 215
GLU L 212
HIS M 266
THR L 182
 None
U10  L 272 (-3.8A)
FE  M 302 (-3.3A)
BCL  M   1 (-3.8A)
 1.38A 5hqaA-1pssL:
undetectable		 5hqaA-1pssL:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		4 / 8 GLU L 106
VAL L  36
GLY L  19
LEU L  21
 None
U10  M 303 (-3.9A)
None
None
 1.02A 5sxqB-1pssL:
0.4		 5sxqB-1pssL:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		4 / 8 GLU L 106
VAL L  36
GLY L  19
LEU L  21
 None
U10  M 303 (-3.9A)
None
None
 1.03A 5syjA-1pssL:
0.7		 5syjA-1pssL:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 12 LEU L 193
HIS L 230
ASN M  44
ILE L 224
ARG L 231
 U10  L 272 (-3.8A)
FE  M 302 (-3.4A)
None
U10  L 272 (-4.4A)
None
 1.31A 5uhbC-1pssL:
undetectable		 5uhbC-1pssL:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 12 LEU L 193
HIS L 230
ASN M  44
ILE L 224
ARG L 231
 U10  L 272 (-3.8A)
FE  M 302 (-3.4A)
None
U10  L 272 (-4.4A)
None
 1.23A 5uhcC-1pssL:
1.5		 5uhcC-1pssL:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 12 LEU L 193
HIS L 230
ASN M  44
ILE L 224
ARG L 231
 U10  L 272 (-3.8A)
FE  M 302 (-3.4A)
None
U10  L 272 (-4.4A)
None
 1.25A 5uhdC-1pssL:
0.0		 5uhdC-1pssL:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		5 / 12 LEU L 193
HIS L 230
ASN M  44
ILE L 224
ARG L 231
 U10  L 272 (-3.8A)
FE  M 302 (-3.4A)
None
U10  L 272 (-4.4A)
None
 1.17A 5uhgC-1pssL:
undetectable		 5uhgC-1pssL:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1pss PHOTOSYNTHETIC
REACTION CENTER
PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		5 / 12 LEU L 232
ILE L 224
LEU M  39
GLY M  40
PHE M  42
 None
U10  L 272 (-4.4A)
None
None
None
 1.08A 6qxsB-1pssL:
0.0		 6qxsB-1pssL:
21.86