SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TZP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 1g67 THIAMIN PHOSPHATE
SYNTHASE
(Bacillus
subtilis) 		6 / 9 LEU A 170
GLY A 149
VAL A 197
ILE A 189
GLY A 187
ILE A 171
 None
ICP  A2001 (-3.6A)
None
None
TZP  A2005 ( 3.9A)
None
 1.49A 1hpvA-1g67A:
undetectable		 1hpvA-1g67A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1g67 THIAMIN PHOSPHATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 PHE A 224
ALA A 210
TYR A 154
GLY A 187
ILE A 189
 None
None
None
TZP  A2005 ( 3.9A)
None
 1.19A 1kglA-1g67A:
undetectable		 1kglA-1g67A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1g67 THIAMIN PHOSPHATE
SYNTHASE
(Bacillus
subtilis) 		4 / 5 GLY A 187
ILE A 186
VAL A 197
SER A 206
 TZP  A2005 ( 3.9A)
ICP  A2001 ( 3.7A)
None
ICP  A2001 ( 4.1A)
 1.23A 1rs7A-1g67A:
0.0		 1rs7A-1g67A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1g67 THIAMIN PHOSPHATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 GLN A  57
GLU A  60
ILE A 208
ASN A  36
TYR A  29
 ICP  A2001 (-3.3A)
None
TZP  A2005 (-3.6A)
None
ICP  A2001 (-4.2A)
 1.25A 4s0vA-1g67A:
2.6		 4s0vA-1g67A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1g67 THIAMIN PHOSPHATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 ASP A 192
VAL A 205
ILE A 189
GLY A 188
VAL A 165
 None
None
None
TZP  A2005 (-3.5A)
None
 1.06A 4y8wA-1g67A:
0.0		 4y8wA-1g67A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1g67 THIAMIN PHOSPHATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 ASP A 192
VAL A 205
ILE A 189
GLY A 188
VAL A 165
 None
None
None
TZP  A2005 (-3.5A)
None
 1.09A 4y8wB-1g67A:
undetectable		 4y8wB-1g67A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g67 THIAMIN PHOSPHATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 ILE A 189
TYR A 154
GLY A 188
VAL A 165
ILE A 198
 None
None
TZP  A2005 (-3.5A)
None
None
 1.06A 5n0xA-1g67A:
undetectable		 5n0xA-1g67A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1g67 THIAMIN PHOSPHATE
SYNTHASE
(Bacillus
subtilis) 		6 / 12 LEU A 170
GLY A 149
VAL A 197
GLY A 187
SER A 169
ILE A 171
 None
ICP  A2001 (-3.6A)
None
TZP  A2005 ( 3.9A)
None
None
 1.45A 5t2zB-1g67A:
undetectable		 5t2zB-1g67A:
19.16