SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TZD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		4 / 7 THR A 379
GLY A 427
THR A 523
ILE A 452
 TZD  A 605 ( 4.7A)
TZD  A 605 (-3.2A)
None
None
 0.99A 1gtnJ-5dgtA:
undetectable
1gtnK-5dgtA:
undetectable		 1gtnJ-5dgtA:
11.31
1gtnK-5dgtA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 12 TYR A 458
ILE A 435
GLY A 427
ALA A 460
GLY A 404
 TZD  A 605 (-3.0A)
None
TZD  A 605 (-3.2A)
TZD  A 605 (-3.3A)
None
 1.20A 1kiaB-5dgtA:
2.9		 1kiaB-5dgtA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 11 THR A 377
ALA A 431
ALA A 460
GLY A 459
THR A 457
 TZD  A 605 (-2.8A)
None
TZD  A 605 (-3.3A)
TZD  A 605 (-3.4A)
None
 1.09A 3mg0V-5dgtA:
undetectable
3mg0W-5dgtA:
undetectable		 3mg0V-5dgtA:
19.61
3mg0W-5dgtA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 9 ALA A 431
ILE A 426
PHE A 405
GLY A 402
GLY A 429
 None
None
None
TZD  A 605 ( 3.8A)
TZD  A 605 (-3.4A)
 1.35A 6awoA-5dgtA:
undetectable		 6awoA-5dgtA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 9 ALA A 431
ILE A 426
PHE A 405
GLY A 402
GLY A 429
 None
None
None
TZD  A 605 ( 3.8A)
TZD  A 605 (-3.4A)
 1.35A 6awqA-5dgtA:
undetectable		 6awqA-5dgtA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 11 THR A 377
ALA A 431
ALA A 460
GLY A 459
THR A 457
 TZD  A 605 (-2.8A)
None
TZD  A 605 (-3.3A)
TZD  A 605 (-3.4A)
None
 1.08A 6hwdV-5dgtA:
undetectable		 6hwdV-5dgtA:
12.27