SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TYU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2fr5 CYTIDINE DEAMINASE
(Mus
musculus) 		5 / 12 ALA A  70
GLY A  39
VAL A  38
VAL A 115
ILE A  85
 None
None
TYU  A1001 (-4.1A)
None
None
 0.82A 2o4lB-2fr5A:
undetectable		 2o4lB-2fr5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2fr5 CYTIDINE DEAMINASE
(Mus
musculus) 		5 / 12 ARG A 103
GLY A  39
VAL A  38
VAL A 115
ILE A  85
 None
None
TYU  A1001 (-4.1A)
None
None
 0.88A 2o4lB-2fr5A:
undetectable		 2o4lB-2fr5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2fr5 CYTIDINE DEAMINASE
(Mus
musculus) 		4 / 7 VAL A  38
ALA A  66
PRO A 120
THR A 118
 TYU  A1001 (-4.1A)
TYU  A1001 (-3.9A)
None
None
 1.00A 2q6oA-2fr5A:
undetectable		 2q6oA-2fr5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 2fr5 CYTIDINE DEAMINASE
(Mus
musculus) 		5 / 12 ARG A 103
GLY A  39
VAL A  38
VAL A 115
ILE A  85
 None
None
TYU  A1001 (-4.1A)
None
None
 0.79A 3cyxB-2fr5A:
undetectable		 3cyxB-2fr5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2fr5 CYTIDINE DEAMINASE
(Mus
musculus) 		5 / 9 ALA A  70
GLY A  39
VAL A  38
VAL A 115
ILE A  85
 None
None
TYU  A1001 (-4.1A)
None
None
 0.92A 3oxvA-2fr5A:
undetectable		 3oxvA-2fr5A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 2fr5 CYTIDINE DEAMINASE
(Mus
musculus) 		5 / 10 ALA A  70
GLY A  39
VAL A  38
VAL A 115
ILE A  85
 None
None
TYU  A1001 (-4.1A)
None
None
 0.99A 3oxwD-2fr5A:
undetectable		 3oxwD-2fr5A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2fr5 CYTIDINE DEAMINASE
(Mus
musculus) 		5 / 11 ARG A 103
GLY A  39
VAL A  38
VAL A 115
ILE A  85
 None
None
TYU  A1001 (-4.1A)
None
None
 0.75A 3oxxB-2fr5A:
undetectable		 3oxxB-2fr5A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2fr5 CYTIDINE DEAMINASE
(Mus
musculus) 		6 / 11 ARG A 103
ALA A  70
GLY A  39
VAL A  38
VAL A 115
ILE A  85
 None
None
None
TYU  A1001 (-4.1A)
None
None
 0.91A 3oxxD-2fr5A:
undetectable		 3oxxD-2fr5A:
19.31