SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TYR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5lmx DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49
(Saccharomyces
cerevisiae) 		5 / 10 TYR M  76
PRO M  94
VAL M  95
VAL M  21
GLY M  24
 TYR  M  76 ( 1.3A)
PRO  M  94 ( 1.1A)
VAL  M  95 ( 0.6A)
VAL  M  21 ( 0.5A)
GLY  M  24 ( 0.0A)
 1.37A 13gsA-5lmxM:
undetectable		 13gsA-5lmxM:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 9 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.41A 1bkfA-5wpiA:
undetectable		 1bkfA-5wpiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 8 THR A  16
ASN A 362
ASP A 397
TYR A 350
 THR  A  16 ( 0.8A)
ASN  A 362 ( 0.6A)
ASP  A 397 ( 0.6A)
TYR  A 350 ( 1.3A)
 1.03A 1bu5B-4kqnA:
undetectable		 1bu5B-4kqnA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		4 / 8 ASP A 151
TRP A 155
TYR A 176
THR A 168
 ASP  A 151 ( 0.6A)
TRP  A 155 ( 0.5A)
TYR  A 176 ( 1.3A)
THR  A 168 ( 0.8A)
 1.07A 1ceaA-2qc5A:
undetectable
1ceaB-2qc5A:
undetectable		 1ceaA-2qc5A:
13.82
1ceaB-2qc5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		4 / 8 ASP A 193
TRP A 197
TYR A 218
THR A 210
 ASP  A 193 ( 0.6A)
TRP  A 197 ( 0.5A)
TYR  A 218 ( 1.3A)
THR  A 210 ( 0.8A)
 1.13A 1ceaA-2qc5A:
undetectable
1ceaB-2qc5A:
undetectable		 1ceaA-2qc5A:
13.82
1ceaB-2qc5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 7 GLY A 149
TYR A 170
ALA A 150
GLU A 168
 GLY  A 149 ( 0.0A)
TYR  A 170 ( 1.3A)
ALA  A 150 ( 0.0A)
GLU  A 168 (-0.5A)
 0.90A 1dmaA-4w65A:
undetectable		 1dmaA-4w65A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 5nh2 UNCHARACTERIZED
PROTEIN
(Bartonella
henselae) 		4 / 7 GLY B  49
ALA B  51
TYR B  50
GLU B  17
 GLY  B  49 ( 0.0A)
ALA  B  51 ( 0.0A)
TYR  B  50 ( 1.3A)
GLU  B  17 ( 0.5A)
 0.85A 1dmaA-5nh2B:
undetectable		 1dmaA-5nh2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		8 / 12 ALA A 144
TYR A 146
TYR A 170
ASP A 172
GLN A 174
GLU A 196
ASP A 198
GLU A 201
 ALA  A 144 ( 0.0A)
TYR  A 146 ( 1.3A)
TYR  A 170 ( 1.3A)
ASP  A 172 ( 0.5A)
GLN  A 174 ( 0.5A)
GLU  A 196 ( 0.6A)
ASP  A 198 (-0.6A)
GLU  A 201 (-0.5A)
 0.36A 1dy4A-5w0aA:
48.5		 1dy4A-5w0aA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		6 / 12 ALA A 144
TYR A 146
TYR A 170
ASP A 198
GLU A 201
ASP A 322
 ALA  A 144 ( 0.0A)
TYR  A 146 ( 1.3A)
TYR  A 170 ( 1.3A)
ASP  A 198 (-0.6A)
GLU  A 201 (-0.5A)
ASP  A 322 ( 0.6A)
 0.76A 1dy4A-5w0aA:
48.5		 1dy4A-5w0aA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 LEU A  76
HIS A  77
LEU A 165
LEU A 169
 None
TYR  A 401 (-3.5A)
None
None
 0.95A 1e7cA-5thhA:
undetectable		 1e7cA-5thhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		8 / 9 TYR A 156
PHE A 184
GLY A 267
ASP A 306
MET A 381
TYR A 383
ASP A 384
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TRP  A 532 ( 0.5A)
 0.84A 1e9lA-5gprA:
42.6		 1e9lA-5gprA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4urs DIGUANYLATE CYCLASE
(Thermotoga
maritima) 		3 / 3 GLU A 170
TYR A 166
PHE A 124
 GLU  A 170 ( 0.6A)
TYR  A 166 ( 1.3A)
PHE  A 124 ( 1.3A)
 0.92A 1eqbB-4ursA:
undetectable		 1eqbB-4ursA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4urs DIGUANYLATE CYCLASE
(Thermotoga
maritima) 		3 / 3 GLU A 170
TYR A 166
PHE A 124
 GLU  A 170 ( 0.6A)
TYR  A 166 ( 1.3A)
PHE  A 124 ( 1.3A)
 0.92A 1eqbA-4ursA:
undetectable		 1eqbA-4ursA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4urs DIGUANYLATE CYCLASE
(Thermotoga
maritima) 		3 / 3 GLU A 170
TYR A 166
PHE A 124
 GLU  A 170 ( 0.6A)
TYR  A 166 ( 1.3A)
PHE  A 124 ( 1.3A)
 0.92A 1eqbD-4ursA:
undetectable		 1eqbD-4ursA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4wji PUTATIVE
CYCLOHEXADIENYL
DEHYDROGENASE AND
ADH PREPHENATE
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 SER A 100
HIS A 193
SER A 189
HIS A 190
 NAP  A 301 ( 2.6A)
TYR  A 302 ( 4.9A)
TYR  A 302 ( 3.8A)
None
 1.31A 1eqbC-4wjiA:
undetectable
1eqbD-4wjiA:
undetectable		 1eqbC-4wjiA:
22.77
1eqbD-4wjiA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4urs DIGUANYLATE CYCLASE
(Thermotoga
maritima) 		3 / 3 GLU A 170
TYR A 166
PHE A 124
 GLU  A 170 ( 0.6A)
TYR  A 166 ( 1.3A)
PHE  A 124 ( 1.3A)
 0.93A 1eqbC-4ursA:
undetectable		 1eqbC-4ursA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1gc7 RADIXIN
(Mus
musculus) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 VAL  A 220 ( 0.6A)
GLY  A 219 ( 0.0A)
LEU  A 218 ( 0.6A)
TYR  A 228 ( 1.3A)
GLY  A 224 ( 0.0A)
 1.01A 1fduA-1gc7A:
undetectable		 1fduA-1gc7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1gc7 RADIXIN
(Mus
musculus) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 VAL  A 220 ( 0.6A)
GLY  A 219 ( 0.0A)
LEU  A 218 ( 0.6A)
TYR  A 228 ( 1.3A)
GLY  A 224 ( 0.0A)
 1.00A 1fduC-1gc7A:
undetectable		 1fduC-1gc7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5ve2 ENOYL-COA HYDRATASE
(Pseudoalteromona
s
atlantica) 		5 / 12 LEU A  35
TYR A  32
GLY A 107
PHE A  60
VAL A  51
 LEU  A  35 ( 0.6A)
TYR  A  32 ( 1.3A)
GLY  A 107 ( 0.0A)
PHE  A  60 ( 1.3A)
VAL  A  51 ( 0.6A)
 1.10A 1fduC-5ve2A:
undetectable		 1fduC-5ve2A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		4 / 6 GLY A  44
LEU A  67
TYR A  65
GLU A  74
 GLY  A  44 (-0.0A)
LEU  A  67 ( 0.6A)
TYR  A  65 ( 1.3A)
GLU  A  74 (-0.6A)
 1.04A 1fduD-3ulkA:
6.5		 1fduD-3ulkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 HIS A  47
GLY A  49
GLY A 187
ASP A 189
GLN A 190
HIS A 223
 None
None
None
None
TYR  A 701 (-3.3A)
None
 0.66A 1ffyA-2cycA:
4.6		 1ffyA-2cycA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 HIS A  70
GLY A 207
ASP A 209
GLN A 210
HIS A 235
 AMP  A 402 (-4.4A)
AMP  A 402 (-3.1A)
AMP  A 402 (-2.8A)
TYR  A 401 ( 3.3A)
AMP  A 402 (-4.0A)
 0.56A 1ffyA-3vgjA:
undetectable		 1ffyA-3vgjA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1wly 2-HALOACRYLATE
REDUCTASE
(Burkholderia
sp.
WS) 		4 / 8 TYR A 219
ILE A 151
HIS A 141
LEU A 137
 TYR  A 219 ( 1.3A)
ILE  A 151 ( 0.7A)
HIS  A 141 ( 1.0A)
LEU  A 137 ( 0.6A)
 0.88A 1fslA-1wlyA:
undetectable		 1fslA-1wlyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 5 THR A  85
LEU A  87
GLY A  90
TYR A 116
 THR  A  85 ( 0.8A)
LEU  A  87 ( 0.6A)
GLY  A  90 ( 0.0A)
TYR  A 116 ( 1.3A)
 1.19A 1gtiF-2qv2A:
undetectable		 1gtiF-2qv2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5gru DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		6 / 12 TYR H 170
GLN H 223
PHE H 232
ASN L  36
ALA L  97
TRP L 106
 TYR  H 170 ( 1.3A)
GLN  H 223 ( 0.6A)
PHE  H 232 ( 1.3A)
ASN  L  36 ( 0.6A)
ALA  L  97 ( 0.0A)
TRP  L 106 ( 0.5A)
 0.74A 1h8sA-5gruH:
21.4		 1h8sA-5gruH:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5gru DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		6 / 12 TYR L 157
GLN L 210
PHE L 219
VAL H  37
ALA H  97
TRP H 119
 TYR  L 157 ( 1.3A)
GLN  L 210 ( 0.6A)
PHE  L 219 ( 1.3A)
VAL  H  37 ( 0.6A)
ALA  H  97 ( 0.0A)
TRP  H 119 ( 0.5A)
 0.72A 1h8sA-5gruL:
13.9		 1h8sA-5gruL:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE
(Thymus
vulgaris) 		4 / 8 LEU A 562
LEU A 482
TYR A 478
SER A 416
 LEU  A 562 ( 0.6A)
LEU  A 482 ( 0.5A)
TYR  A 478 ( 1.3A)
SER  A 416 ( 0.0A)
 1.20A 1hk2A-5c05A:
2.2		 1hk2A-5c05A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2qj6 TOXIN A
(Clostridioides
difficile) 		5 / 12 THR A 256
ARG A 271
LEU A 273
TYR A 250
TYR A 268
 THR  A 256 ( 0.8A)
ARG  A 271 ( 0.6A)
LEU  A 273 ( 0.5A)
TYR  A 250 ( 1.3A)
TYR  A 268 ( 1.3A)
 1.28A 1httC-2qj6A:
undetectable		 1httC-2qj6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2qj6 TOXIN A
(Clostridioides
difficile) 		5 / 12 THR A 256
ARG A 271
LEU A 273
TYR A 250
TYR A 268
 THR  A 256 ( 0.8A)
ARG  A 271 ( 0.6A)
LEU  A 273 ( 0.5A)
TYR  A 250 ( 1.3A)
TYR  A 268 ( 1.3A)
 1.28A 1httD-2qj6A:
undetectable		 1httD-2qj6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1gc7 RADIXIN
(Mus
musculus) 		5 / 11 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 VAL  A 220 ( 0.6A)
GLY  A 219 ( 0.0A)
LEU  A 218 ( 0.6A)
TYR  A 228 ( 1.3A)
GLY  A 224 ( 0.0A)
 1.15A 1iolA-1gc7A:
undetectable		 1iolA-1gc7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A  34
HIS A  42
HIS A  45
GLY A 170
GLN A 173
 TYR  A 401 (-3.4A)
None
None
None
TYR  A 401 (-3.0A)
 0.61A 1jzsA-1j1uA:
0.3		 1jzsA-1j1uA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 11 GLY E  36
HIS E  45
HIS E  48
GLY E 192
ASP E 194
 TYR  E 320 (-3.3A)
None
None
None
None
 0.83A 1jzsA-1tydE:
undetectable		 1jzsA-1tydE:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		6 / 11 GLY E  36
HIS E  48
GLY E 192
ASP E 194
GLN E 195
LEU E 222
 TYR  E 320 (-3.3A)
None
None
None
TYR  E 320 (-3.3A)
None
 0.73A 1jzsA-1tydE:
undetectable		 1jzsA-1tydE:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A  39
HIS A  47
GLY A 187
ASP A 189
GLN A 190
 TYR  A 701 (-3.4A)
None
None
None
TYR  A 701 (-3.3A)
 0.62A 1jzsA-2cycA:
3.0		 1jzsA-2cycA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 11 GLY A  62
HIS A  70
GLY A 207
ASP A 209
GLN A 210
 TYR  A 401 ( 3.3A)
AMP  A 402 (-4.4A)
AMP  A 402 (-3.1A)
AMP  A 402 (-2.8A)
TYR  A 401 ( 3.3A)
 0.62A 1jzsA-3vgjA:
undetectable		 1jzsA-3vgjA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		5 / 11 GLY A 129
HIS A 138
HIS A 141
GLY A 297
ASP A 299
 TYR  A 501 (-3.5A)
None
None
None
None
 0.92A 1jzsA-5ihxA:
undetectable		 1jzsA-5ihxA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		6 / 11 GLY A 129
HIS A 141
GLY A 297
ASP A 299
GLN A 300
LEU A 341
 TYR  A 501 (-3.5A)
None
None
None
TYR  A 501 (-2.9A)
None
 0.78A 1jzsA-5ihxA:
undetectable		 1jzsA-5ihxA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		6 / 11 GLY A 116
HIS A 125
HIS A 128
GLY A 284
ASP A 286
GLN A 287
 TYR  A 501 (-3.6A)
None
None
None
None
TYR  A 501 (-2.8A)
 0.76A 1jzsA-5ijxA:
undetectable		 1jzsA-5ijxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		6 / 11 HIS A 125
HIS A 128
GLY A 284
ASP A 286
GLN A 287
LEU A 330
 None
None
None
None
TYR  A 501 (-2.8A)
None
 0.86A 1jzsA-5ijxA:
undetectable		 1jzsA-5ijxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 310
LEU A 338
GLU A 123
TYR A 317
GLU A 318
 LEU  A 310 ( 0.6A)
LEU  A 338 ( 0.6A)
GLU  A 123 ( 0.6A)
TYR  A 317 ( 1.3A)
GLU  A 318 ( 0.6A)
 1.08A 1kw0A-1wqaA:
undetectable		 1kw0A-1wqaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 SER A 379
LEU A  13
TYR A   6
GLY A 361
 SER  A 379 ( 0.0A)
LEU  A  13 ( 0.6A)
TYR  A   6 ( 1.3A)
GLY  A 361 (-0.0A)
 1.48A 1liiA-5d7wA:
undetectable		 1liiA-5d7wA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		5 / 11 TYR A 315
TYR A 151
GLY A 169
TRP A 190
TYR A 181
 TYR  A 315 ( 1.3A)
TYR  A 151 ( 1.3A)
GLY  A 169 ( 0.0A)
TRP  A 190 ( 0.5A)
TYR  A 181 ( 1.3A)
 1.41A 1lwcA-3qviA:
undetectable		 1lwcA-3qviA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		4 / 6 GLU A 309
ILE A 714
TYR A 713
GLY A 755
 GLU  A 309 ( 0.6A)
ILE  A 714 ( 0.7A)
TYR  A 713 ( 1.3A)
GLY  A 755 ( 0.0A)
 1.05A 1maaB-1v0fA:
undetectable
1maaD-1v0fA:
undetectable		 1maaB-1v0fA:
22.78
1maaD-1v0fA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		3 / 3 PHE A 198
TYR A 382
PRO A 200
 PHE  A 198 ( 1.3A)
TYR  A 382 ( 1.3A)
PRO  A 200 ( 1.1A)
 1.15A 1mcnA-3sagA:
undetectable
1mcnB-3sagA:
undetectable
1mcnP-3sagA:
undetectable		 1mcnA-3sagA:
17.45
1mcnB-3sagA:
17.45
1mcnP-3sagA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		3 / 3 PHE A  21
TYR A  15
PRO A  18
 PHE  A  21 ( 1.3A)
TYR  A  15 ( 1.3A)
PRO  A  18 ( 1.1A)
 1.09A 1mcnA-6gefA:
undetectable
1mcnB-6gefA:
undetectable
1mcnP-6gefA:
undetectable		 1mcnA-6gefA:
undetectable
1mcnB-6gefA:
undetectable
1mcnP-6gefA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 310
LEU A 338
GLU A 123
TYR A 317
GLU A 318
 LEU  A 310 ( 0.6A)
LEU  A 338 ( 0.6A)
GLU  A 123 ( 0.6A)
TYR  A 317 ( 1.3A)
GLU  A 318 ( 0.6A)
 1.17A 1mmkA-1wqaA:
undetectable		 1mmkA-1wqaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 310
LEU A 338
GLU A 123
TYR A 317
GLU A 318
 LEU  A 310 ( 0.6A)
LEU  A 338 ( 0.6A)
GLU  A 123 ( 0.6A)
TYR  A 317 ( 1.3A)
GLU  A 318 ( 0.6A)
 1.20A 1mmtA-1wqaA:
undetectable		 1mmtA-1wqaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 11 LEU A 219
PHE A 114
GLY A 221
VAL A 261
LEU A 317
 None
None
None
TYR  A 888 (-4.7A)
None
 1.15A 1mx1A-2amcA:
undetectable		 1mx1A-2amcA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 6 SER A 180
THR A 179
ASN A 133
LEU A 174
 TYR  A 888 (-2.7A)
None
None
None
 1.36A 1mxdA-2amcA:
undetectable		 1mxdA-2amcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_A_MTXA1278_1
(PTERIDINE REDUCTASE
2)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 10 TYR A 154
LEU A 205
TYR A 161
LEU A 240
THR A 298
 TYR  A 154 ( 1.3A)
LEU  A 205 ( 0.6A)
TYR  A 161 ( 1.3A)
LEU  A 240 ( 0.6A)
THR  A 298 ( 0.8A)
 1.13A 1mxfA-5wo6A:
undetectable		 1mxfA-5wo6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 11 TYR A 154
LEU A 205
TYR A 161
LEU A 240
THR A 298
 TYR  A 154 ( 1.3A)
LEU  A 205 ( 0.6A)
TYR  A 161 ( 1.3A)
LEU  A 240 ( 0.6A)
THR  A 298 ( 0.8A)
 1.13A 1mxfB-5wo6A:
undetectable		 1mxfB-5wo6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 11 TYR A 154
LEU A 205
TYR A 161
LEU A 240
THR A 298
 TYR  A 154 ( 1.3A)
LEU  A 205 ( 0.6A)
TYR  A 161 ( 1.3A)
LEU  A 240 ( 0.6A)
THR  A 298 ( 0.8A)
 1.17A 1mxfC-5wo6A:
undetectable		 1mxfC-5wo6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 11 TYR A 154
LEU A 205
TYR A 161
LEU A 240
THR A 298
 TYR  A 154 ( 1.3A)
LEU  A 205 ( 0.6A)
TYR  A 161 ( 1.3A)
LEU  A 240 ( 0.6A)
THR  A 298 ( 0.8A)
 1.18A 1mxfD-5wo6A:
undetectable		 1mxfD-5wo6A:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 ASN L  36
TRP L  48
TYR L  51
GLY L 102
GLY H 225
 ASN  L  36 ( 0.6A)
TRP  L  48 ( 0.5A)
TYR  L  51 ( 1.3A)
GLY  L 102 ( 0.0A)
GLY  H 225 ( 0.0A)
 1.07A 1ncwH-5gruL:
23.2
1ncwL-5gruL:
15.0		 1ncwH-5gruL:
52.94
1ncwL-5gruL:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 369
TYR A 348
GLU A 373
SER A 224
 ARG  A 369 ( 0.6A)
TYR  A 348 ( 1.3A)
GLU  A 373 ( 0.5A)
SER  A 224 ( 0.0A)
 1.19A 1nx9A-2ogsA:
10.2		 1nx9A-2ogsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ARG A 150
GLU A 156
HIS A 231
SER A 227
 TYR  A 401 (-4.5A)
TYR  A 401 ( 4.5A)
None
None
 1.31A 1nx9A-4ppuA:
undetectable		 1nx9A-4ppuA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 369
TYR A 348
GLU A 373
SER A 224
 ARG  A 369 ( 0.6A)
TYR  A 348 ( 1.3A)
GLU  A 373 ( 0.5A)
SER  A 224 ( 0.0A)
 1.19A 1nx9B-2ogsA:
16.6		 1nx9B-2ogsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ARG A 150
GLU A 156
HIS A 231
SER A 227
 TYR  A 401 (-4.5A)
TYR  A 401 ( 4.5A)
None
None
 1.30A 1nx9B-4ppuA:
undetectable		 1nx9B-4ppuA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 369
TYR A 348
GLU A 373
SER A 224
 ARG  A 369 ( 0.6A)
TYR  A 348 ( 1.3A)
GLU  A 373 ( 0.5A)
SER  A 224 ( 0.0A)
 1.18A 1nx9C-2ogsA:
10.2		 1nx9C-2ogsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ARG A 150
GLU A 156
HIS A 231
SER A 227
 TYR  A 401 (-4.5A)
TYR  A 401 ( 4.5A)
None
None
 1.30A 1nx9C-4ppuA:
undetectable		 1nx9C-4ppuA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 369
TYR A 348
GLU A 373
SER A 224
 ARG  A 369 ( 0.6A)
TYR  A 348 ( 1.3A)
GLU  A 373 ( 0.5A)
SER  A 224 ( 0.0A)
 1.18A 1nx9D-2ogsA:
16.5		 1nx9D-2ogsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ARG A 150
GLU A 156
HIS A 231
SER A 227
 TYR  A 401 (-4.5A)
TYR  A 401 ( 4.5A)
None
None
 1.30A 1nx9D-4ppuA:
undetectable		 1nx9D-4ppuA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 12 GLU A 262
HIS A 239
HIS A 208
HIS A 183
TYR A 155
 GLU  A 262 ( 0.6A)
HIS  A 239 (-1.0A)
HIS  A 208 ( 1.0A)
HIS  A 183 (-1.0A)
TYR  A 155 ( 1.3A)
 1.46A 1o86A-4kqnA:
undetectable		 1o86A-4kqnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 12 GLU A 262
HIS A 239
PHE A  65
HIS A 183
TYR A 155
 GLU  A 262 ( 0.6A)
HIS  A 239 (-1.0A)
PHE  A  65 ( 1.3A)
HIS  A 183 (-1.0A)
TYR  A 155 ( 1.3A)
 1.42A 1o86A-4kqnA:
undetectable		 1o86A-4kqnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 6 ALA A 148
TYR A 146
ILE A 172
GLU A 169
 ALA  A 148 ( 0.0A)
TYR  A 146 ( 1.3A)
ILE  A 172 ( 0.7A)
GLU  A 169 ( 0.6A)
 1.29A 1oniB-1gc7A:
undetectable
1oniC-1gc7A:
undetectable		 1oniB-1gc7A:
17.03
1oniC-1gc7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 206
LEU A 191
TYR A 196
LEU A  33
LEU A 211
 PHE  A 206 ( 1.3A)
LEU  A 191 ( 0.6A)
TYR  A 196 ( 1.3A)
LEU  A  33 ( 0.6A)
LEU  A 211 ( 0.6A)
 1.34A 1p33A-5hfiA:
undetectable		 1p33A-5hfiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 206
LEU A 191
TYR A 196
LEU A  33
LEU A 211
 PHE  A 206 ( 1.3A)
LEU  A 191 ( 0.6A)
TYR  A 196 ( 1.3A)
LEU  A  33 ( 0.6A)
LEU  A 211 ( 0.6A)
 1.33A 1p33B-5hfiA:
undetectable		 1p33B-5hfiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 206
LEU A 191
TYR A 196
LEU A  33
LEU A 211
 PHE  A 206 ( 1.3A)
LEU  A 191 ( 0.6A)
TYR  A 196 ( 1.3A)
LEU  A  33 ( 0.6A)
LEU  A 211 ( 0.6A)
 1.29A 1p33C-5hfiA:
undetectable		 1p33C-5hfiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  66
TYR A  84
GLY A  71
ASN A  90
LEU A  82
 LEU  A  66 ( 0.5A)
TYR  A  84 ( 1.3A)
GLY  A  71 ( 0.0A)
ASN  A  90 ( 0.6A)
LEU  A  82 ( 0.6A)
 1.20A 1pj7A-4mwtA:
1.4		 1pj7A-4mwtA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 TYR A 538
ASP A 540
ASP A 542
LEU A 608
 TYR  A 538 ( 1.3A)
ASP  A 540 (-0.5A)
ASP  A 542 ( 0.5A)
LEU  A 608 ( 0.5A)
 1.19A 1pk2A-4flxA:
undetectable		 1pk2A-4flxA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY E  47
HIS E  48
GLY E 192
ASP E 194
GLN E 195
 None
None
None
None
TYR  E 320 (-3.3A)
 0.70A 1qu2A-1tydE:
4.0		 1qu2A-1tydE:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS E  48
GLY E 192
ASP E 194
GLN E 195
VAL E 223
 None
None
None
TYR  E 320 (-3.3A)
None
 0.73A 1qu2A-1tydE:
4.0		 1qu2A-1tydE:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 HIS A  47
GLY A  49
GLY A 187
ASP A 189
GLN A 190
HIS A 223
 None
None
None
None
TYR  A 701 (-3.3A)
None
 0.66A 1qu2A-2cycA:
4.6		 1qu2A-2cycA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 HIS A  70
GLY A 207
ASP A 209
GLN A 210
HIS A 235
 AMP  A 402 (-4.4A)
AMP  A 402 (-3.1A)
AMP  A 402 (-2.8A)
TYR  A 401 ( 3.3A)
AMP  A 402 (-4.0A)
 0.56A 1qu2A-3vgjA:
undetectable		 1qu2A-3vgjA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		5 / 12 GLY A 140
HIS A 141
GLY A 297
ASP A 299
GLN A 300
 None
None
None
None
TYR  A 501 (-2.9A)
 0.75A 1qu2A-5ihxA:
4.3		 1qu2A-5ihxA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 GLY A 127
HIS A 128
GLY A 284
ASP A 286
GLN A 287
 None
None
None
None
TYR  A 501 (-2.8A)
 0.68A 1qu2A-5ijxA:
undetectable		 1qu2A-5ijxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  47
GLY A  49
ASP A 189
GLN A 190
HIS A 223
 None
None
None
TYR  A 701 (-3.3A)
None
 0.68A 1qu3A-2cycA:
undetectable		 1qu3A-2cycA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 390
ASP A 454
ASN A 456
GLU A 412
 TYR  A 390 ( 1.3A)
ASP  A 454 ( 0.6A)
ASN  A 456 ( 0.6A)
GLU  A 412 ( 0.6A)
 1.03A 1rjdA-2ogsA:
2.7		 1rjdA-2ogsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 6 ASP A 331
TYR A 272
ASN A 279
GLU A 319
 ASP  A 331 ( 0.6A)
TYR  A 272 (-1.3A)
ASN  A 279 ( 0.6A)
GLU  A 319 ( 0.5A)
 1.28A 1rjdA-3o96A:
undetectable		 1rjdA-3o96A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 390
ASP A 454
ASN A 456
GLU A 412
 TYR  A 390 ( 1.3A)
ASP  A 454 ( 0.6A)
ASN  A 456 ( 0.6A)
GLU  A 412 ( 0.6A)
 1.02A 1rjdB-2ogsA:
2.4		 1rjdB-2ogsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 6 ASP A 331
TYR A 272
ASN A 279
GLU A 319
 ASP  A 331 ( 0.6A)
TYR  A 272 (-1.3A)
ASN  A 279 ( 0.6A)
GLU  A 319 ( 0.5A)
 1.28A 1rjdB-3o96A:
undetectable		 1rjdB-3o96A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 390
ASP A 454
ASN A 456
GLU A 412
 TYR  A 390 ( 1.3A)
ASP  A 454 ( 0.6A)
ASN  A 456 ( 0.6A)
GLU  A 412 ( 0.6A)
 1.05A 1rjdC-2ogsA:
3.0		 1rjdC-2ogsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 6 ASP A 331
TYR A 272
ASN A 279
GLU A 319
 ASP  A 331 ( 0.6A)
TYR  A 272 (-1.3A)
ASN  A 279 ( 0.6A)
GLU  A 319 ( 0.5A)
 1.28A 1rjdC-3o96A:
undetectable		 1rjdC-3o96A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKW_A_PNTA225_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 12 GLU A  24
LYS A  28
TYR A  17
GLU A  22
ASN A  67
 GLU  A  24 ( 0.6A)
LYS  A  28 ( 0.0A)
TYR  A  17 ( 1.3A)
GLU  A  22 ( 0.5A)
ASN  A  67 ( 0.6A)
 1.31A 1rkwA-6gefA:
0.0		 1rkwA-6gefA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 3gle PILIN
(Streptococcus
pyogenes) 		4 / 7 GLU A 117
TYR A 128
THR A  50
TYR A  83
 GLU  A 117 ( 0.6A)
TYR  A 128 ( 1.3A)
THR  A  50 ( 0.8A)
TYR  A  83 ( 1.3A)
 1.24A 1rmtB-3gleA:
undetectable		 1rmtB-3gleA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 10 ASN L  36
TRP L  48
TYR L  51
GLY L 102
GLY H 225
 ASN  L  36 ( 0.6A)
TRP  L  48 ( 0.5A)
TYR  L  51 ( 1.3A)
GLY  L 102 ( 0.0A)
GLY  H 225 ( 0.0A)
 1.09A 1ruaH-5gruL:
23.5
1ruaL-5gruL:
20.5		 1ruaH-5gruL:
52.94
1ruaL-5gruL:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 ASN L  36
TRP L  48
TYR L  51
GLY L 102
GLY H 225
 ASN  L  36 ( 0.6A)
TRP  L  48 ( 0.5A)
TYR  L  51 ( 1.3A)
GLY  L 102 ( 0.0A)
GLY  H 225 ( 0.0A)
 1.11A 1rulH-5gruL:
23.1
1rulL-5gruL:
15.0		 1rulH-5gruL:
52.94
1rulL-5gruL:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 ASN L  36
TRP L  48
TYR L  51
GLY L 102
GLY H 225
 ASN  L  36 ( 0.6A)
TRP  L  48 ( 0.5A)
TYR  L  51 ( 1.3A)
GLY  L 102 ( 0.0A)
GLY  H 225 ( 0.0A)
 1.06A 1rumH-5gruL:
23.0
1rumL-5gruL:
15.0		 1rumH-5gruL:
52.94
1rumL-5gruL:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 ASN L  36
TRP L  48
TYR L  51
GLY L 102
GLY H 225
 ASN  L  36 ( 0.6A)
TRP  L  48 ( 0.5A)
TYR  L  51 ( 1.3A)
GLY  L 102 ( 0.0A)
GLY  H 225 ( 0.0A)
 1.07A 1rupH-5gruL:
23.1
1rupL-5gruL:
15.1		 1rupH-5gruL:
52.94
1rupL-5gruL:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Saccharomonospor
a
viridis) 		4 / 7 VAL A 239
VAL A 236
TYR A 304
ARG A 249
 VAL  A 239 ( 0.6A)
VAL  A 236 ( 0.6A)
TYR  A 304 ( 1.3A)
ARG  A 249 ( 0.6A)
 1.21A 1t46A-4jbeA:
undetectable		 1t46A-4jbeA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 10 TYR A 159
HIS A 160
PHE A 340
GLN A 369
GLY A 371
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
GLY  A 371 ( 0.0A)
PHE  A 372 (-1.3A)
 0.37A 1uhoA-3sl5A:
36.4		 1uhoA-3sl5A:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		4 / 5 MET A3999
ALA A4004
ILE A3848
ASP A3721
 TYR  A4000 ( 3.4A)
ALA  A4004 ( 0.0A)
ILE  A3848 ( 0.7A)
ASP  A3721 ( 0.6A)
 1.15A 1upfC-5w6lA:
undetectable		 1upfC-5w6lA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
RHOPTRY NECK PROTEIN
2
(Plasmodium
falciparum;
Plasmodium
vivax) 		4 / 4 MET B2045
ALA A 253
TYR A 251
ILE A 252
 MET  B2045 ( 0.0A)
ALA  A 253 ( 0.0A)
TYR  A 251 ( 1.3A)
ILE  A 252 ( 0.7A)
 1.27A 1upfD-5nqfB:
undetectable		 1upfD-5nqfB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3won DIPEPTIDYL
AMINOPEPTIDASE BII
(Pseudoxanthomona
s
mexicana) 		4 / 7 GLY A 274
PRO A 273
THR A  71
GLY A 655
 None
None
None
TYR  A 802 (-3.8A)
 0.82A 1usqA-3wonA:
undetectable		 1usqA-3wonA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3won DIPEPTIDYL
AMINOPEPTIDASE BII
(Pseudoxanthomona
s
mexicana) 		4 / 7 GLY A 274
PRO A 273
THR A  71
GLY A 655
 None
None
None
TYR  A 802 (-3.8A)
 0.83A 1usqF-3wonA:
undetectable		 1usqF-3wonA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 8 TYR A 419
THR A 323
LEU A 377
MET A 374
 TYR  A 419 ( 1.3A)
THR  A 323 ( 0.8A)
LEU  A 377 ( 0.5A)
MET  A 374 ( 0.0A)
 1.20A 1uw6A-3gnrA:
undetectable
1uw6B-3gnrA:
undetectable		 1uw6A-3gnrA:
17.14
1uw6B-3gnrA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 196
THR A 209
TRP A 203
LEU A   4
 TYR  A 196 ( 1.3A)
THR  A 209 ( 0.8A)
TRP  A 203 ( 0.5A)
LEU  A   4 ( 0.6A)
 1.42A 1uw6A-5hfiA:
undetectable
1uw6B-5hfiA:
undetectable		 1uw6A-5hfiA:
18.70
1uw6B-5hfiA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 8 TYR A 419
THR A 323
LEU A 377
MET A 374
 TYR  A 419 ( 1.3A)
THR  A 323 ( 0.8A)
LEU  A 377 ( 0.5A)
MET  A 374 ( 0.0A)
 1.21A 1uw6D-3gnrA:
undetectable
1uw6E-3gnrA:
undetectable		 1uw6D-3gnrA:
17.14
1uw6E-3gnrA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 8 TYR A 419
THR A 323
LEU A 377
MET A 374
 TYR  A 419 ( 1.3A)
THR  A 323 ( 0.8A)
LEU  A 377 ( 0.5A)
MET  A 374 ( 0.0A)
 1.22A 1uw6G-3gnrA:
undetectable
1uw6H-3gnrA:
undetectable		 1uw6G-3gnrA:
17.14
1uw6H-3gnrA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 8 TYR A 419
THR A 323
LEU A 377
MET A 374
 TYR  A 419 ( 1.3A)
THR  A 323 ( 0.8A)
LEU  A 377 ( 0.5A)
MET  A 374 ( 0.0A)
 1.21A 1uw6P-3gnrA:
undetectable
1uw6Q-3gnrA:
undetectable		 1uw6P-3gnrA:
17.14
1uw6Q-3gnrA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 8 LEU A 377
MET A 374
TYR A 419
THR A 323
 LEU  A 377 ( 0.5A)
MET  A 374 ( 0.0A)
TYR  A 419 ( 1.3A)
THR  A 323 ( 0.8A)
 1.22A 1uw6P-3gnrA:
undetectable
1uw6T-3gnrA:
undetectable		 1uw6P-3gnrA:
17.14
1uw6T-3gnrA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM
(Pseudomonas
aeruginosa) 		4 / 8 TRP A 203
LEU A   4
TYR A 196
THR A 209
 TRP  A 203 ( 0.5A)
LEU  A   4 ( 0.6A)
TYR  A 196 ( 1.3A)
THR  A 209 ( 0.8A)
 1.44A 1uw6P-5hfiA:
undetectable
1uw6T-5hfiA:
undetectable		 1uw6P-5hfiA:
18.70
1uw6T-5hfiA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		6 / 12 MET A  56
TYR A 113
VAL A 115
ASN A 117
TYR A 197
ARG A 233
 MET  A  56 (-0.0A)
TYR  A 113 ( 1.3A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
 1.15A 1wopA-1wsvA:
50.1		 1wopA-1wsvA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		7 / 12 MET A  56
VAL A 115
ASN A 117
TYR A 371
TYR A 197
ARG A 233
TRP A 262
 MET  A  56 (-0.0A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
TYR  A 371 (-1.3A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
TRP  A 262 ( 0.5A)
 1.09A 1wopA-1wsvA:
50.1		 1wopA-1wsvA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 VAL A 115
TYR A 113
ASN A 117
TYR A 197
ARG A 233
 VAL  A 115 (-0.6A)
TYR  A 113 ( 1.3A)
ASN  A 117 (-0.6A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
 1.48A 1wopA-1wsvA:
50.1		 1wopA-1wsvA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		12 / 12 MET A  56
THR A  87
LEU A  88
ILE A 103
VAL A 115
ASN A 117
PHE A 176
MET A 177
TYR A 197
ARG A 233
LEU A 242
TRP A 262
 MET  A  56 (-0.0A)
THR  A  87 ( 0.8A)
LEU  A  88 (-0.6A)
ILE  A 103 (-0.7A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
PHE  A 176 (-1.3A)
MET  A 177 (-0.0A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
LEU  A 242 (-0.6A)
TRP  A 262 ( 0.5A)
 0.02A 1wsvA-1wsvA:
66.6		 1wsvA-1wsvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		3 / 3 ASP A 101
GLU A 204
TYR A 371
 ASP  A 101 (-0.6A)
GLU  A 204 (-0.5A)
TYR  A 371 (-1.3A)
 0.02A 1wsvA-1wsvA:
66.6		 1wsvA-1wsvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		11 / 12 MET A  56
THR A  87
LEU A  88
ILE A 103
VAL A 115
ASN A 117
PHE A 176
MET A 177
TYR A 197
LEU A 242
TRP A 262
 MET  A  56 (-0.0A)
THR  A  87 ( 0.8A)
LEU  A  88 (-0.6A)
ILE  A 103 (-0.7A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
PHE  A 176 (-1.3A)
MET  A 177 (-0.0A)
TYR  A 197 (-1.3A)
LEU  A 242 (-0.6A)
TRP  A 262 ( 0.5A)
 0.19A 1wsvB-1wsvA:
62.3		 1wsvB-1wsvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_B_THHB4001_1
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 4 ASP A 101
GLU A 204
ARG A 233
TYR A 371
 ASP  A 101 (-0.6A)
GLU  A 204 (-0.5A)
ARG  A 233 (-0.6A)
TYR  A 371 (-1.3A)
 0.23A 1wsvB-1wsvA:
62.3		 1wsvB-1wsvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)
(Homo
sapiens) 		5 / 12 GLU A  52
SER A  54
PHE A  61
TYR A  24
ASN A 108
 GLU  A  52 (-0.6A)
SER  A  54 ( 0.0A)
PHE  A  61 ( 1.3A)
TYR  A  24 ( 1.3A)
ASN  A 108 (-0.6A)
 1.05A 1x70A-1szbA:
undetectable		 1x70A-1szbA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 1tza APAG PROTEIN
(Shewanella
oneidensis) 		4 / 8 TYR A  28
PHE A  30
ALA A  56
LEU A 124
 TYR  A  28 ( 1.3A)
PHE  A  30 ( 1.3A)
ALA  A  56 ( 0.0A)
LEU  A 124 ( 0.6A)
 1.14A 1x8vA-1tzaA:
undetectable		 1x8vA-1tzaA:
14.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
HIS A 204
MET A 273
LEU A 319
ASN A 321
THR A 333
ILE A 336
MET A 337
SER A 368
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.54A 1xlxA-3sl5A:
51.0		 1xlxA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 159
HIS A 160
HIS A 204
MET A 273
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
MET  A 273 (-0.0A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.74A 1xlxB-3sl5A:
51.1		 1xlxB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
HIS A 204
MET A 273
THR A 333
ILE A 336
MET A 337
PHE A 340
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
MET  A 273 (-0.0A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.54A 1xlxB-3sl5A:
51.1		 1xlxB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
PHE A 340
MET A 357
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.61A 1xmuA-3sl5A:
51.4		 1xmuA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
PHE A 340
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.44A 1xmuB-3sl5A:
51.1		 1xmuB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 TYR A 159
ASP A 201
ILE A 336
MET A 337
PHE A 340
MET A 357
 TYR  A 159 (-1.3A)
ASP  A 201 ( 0.5A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
 1.47A 1xomA-3sl5A:
53.0		 1xomA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.57A 1xomA-3sl5A:
53.0		 1xomA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
THR A 333
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.59A 1xomB-3sl5A:
52.8		 1xomB-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
THR A 333
ILE A 336
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.54A 1xoqA-3sl5A:
53.5		 1xoqA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
THR A 333
ILE A 336
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.52A 1xoqA-3sl5A:
53.5		 1xoqA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.49A 1xoqB-3sl5A:
53.4		 1xoqB-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.50A 1xoqB-3sl5A:
53.4		 1xoqB-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
MET A 337
PHE A 340
MET A 357
GLN A 369
PHE A 372
ILE A 376
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
ILE  A 376 (-0.6A)
 0.48A 1xosA-3sl5A:
51.3		 1xosA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
MET A 337
PHE A 340
SER A 355
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
SER  A 355 ( 0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.02A 1xosA-3sl5A:
51.3		 1xosA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
ILE A 336
MET A 337
SER A 355
MET A 357
SER A 368
GLN A 369
PHE A 372
ILE A 376
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
ILE  A 376 (-0.6A)
 0.74A 1xotA-3sl5A:
50.9		 1xotA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
ASN A 321
ILE A 336
MET A 337
SER A 355
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.59A 1xotB-3sl5A:
50.9		 1xotB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
ASN A 321
ILE A 336
MET A 337
SER A 355
MET A 357
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.73A 1xotB-3sl5A:
50.9		 1xotB-3sl5A:
84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 LYS A 592
TYR A 594
ARG A 407
TYR A 545
 LYS  A 592 (-0.0A)
TYR  A 594 (-1.3A)
ARG  A 407 ( 0.6A)
TYR  A 545 ( 1.3A)
 1.35A 1xqlA-4flxA:
undetectable
1xqlB-4flxA:
undetectable		 1xqlA-4flxA:
21.34
1xqlB-4flxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 8 LYS A 592
TYR A 594
ARG A 407
TYR A 545
 LYS  A 592 (-0.0A)
TYR  A 594 (-1.3A)
ARG  A 407 ( 0.6A)
TYR  A 545 ( 1.3A)
 1.39A 1xqlA-4flxA:
undetectable
1xqlB-4flxA:
undetectable		 1xqlA-4flxA:
21.34
1xqlB-4flxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 9 GLY A 168
ALA A 171
LEU A 172
TYR A 123
HIS A  77
 None
None
None
None
TYR  A 401 (-3.5A)
 1.13A 1y7iA-5thhA:
undetectable		 1y7iA-5thhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 367
PHE A 377
GLU A 149
GLY A 177
 TYR  A 367 ( 1.3A)
PHE  A 377 ( 1.3A)
GLU  A 149 ( 0.5A)
GLY  A 177 ( 0.0A)
 0.98A 1ykiC-4mwtA:
undetectable
1ykiD-4mwtA:
undetectable		 1ykiC-4mwtA:
16.78
1ykiD-4mwtA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 5 TYR A 160
SER A  72
SER A  59
THR A  23
 TYR  A 160 ( 1.3A)
SER  A  72 ( 0.0A)
SER  A  59 ( 0.0A)
THR  A  23 ( 0.8A)
 1.19A 1yvpA-5ec3A:
undetectable		 1yvpA-5ec3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 6 TYR A 160
SER A  72
SER A  59
THR A  23
 TYR  A 160 ( 1.3A)
SER  A  72 ( 0.0A)
SER  A  59 ( 0.0A)
THR  A  23 ( 0.8A)
 1.17A 1yvpB-5ec3A:
undetectable		 1yvpB-5ec3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		10 / 11 TYR A 156
PHE A 184
GLY A 267
ASP A 306
GLU A 308
MET A 381
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.39A 2a3aA-5gprA:
12.4		 2a3aA-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		8 / 11 TYR A 156
PHE A 184
GLY A 267
TRP A 268
ASP A 306
GLU A 308
MET A 381
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
TRP  A 268 ( 0.5A)
ASP  A 306 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TRP  A 532 ( 0.5A)
 0.65A 2a3aA-5gprA:
12.4		 2a3aA-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		8 / 9 PHE A 184
GLY A 267
GLU A 308
MET A 381
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.47A 2a3aB-5gprA:
43.1		 2a3aB-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1435_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		9 / 11 TYR A 156
PHE A 184
GLY A 267
TRP A 268
ASP A 306
GLU A 308
MET A 381
TYR A 383
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
TRP  A 268 ( 0.5A)
ASP  A 306 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.78A 2a3bA-5gprA:
43.0		 2a3bA-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1435_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		10 / 11 TYR A 156
PHE A 184
GLY A 267
TRP A 268
ASP A 306
MET A 381
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
TRP  A 268 ( 0.5A)
ASP  A 306 ( 0.5A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.57A 2a3bA-5gprA:
43.0		 2a3bA-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		9 / 10 PHE A 184
GLY A 267
ASP A 306
GLU A 308
MET A 381
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.67A 2a3bB-5gprA:
43.1		 2a3bB-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		9 / 12 TYR A 156
TRP A 160
PHE A 184
GLY A 267
ASP A 306
GLU A 308
MET A 381
TYR A 383
TRP A 532
 TYR  A 156 ( 1.3A)
TRP  A 160 ( 0.5A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.72A 2a3cA-5gprA:
12.4		 2a3cA-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		10 / 12 TYR A 156
TRP A 160
PHE A 184
GLY A 267
ASP A 306
MET A 381
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 TYR  A 156 ( 1.3A)
TRP  A 160 ( 0.5A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.44A 2a3cA-5gprA:
12.4		 2a3cA-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		4 / 6 TYR A 716
GLY A 597
SER A 605
ARG A 596
 TYR  A 716 ( 1.3A)
GLY  A 597 ( 0.0A)
SER  A 605 ( 0.0A)
ARG  A 596 ( 0.6A)
 1.24A 2a3cA-1v0fA:
undetectable		 2a3cA-1v0fA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4c9g ADP, ATP CARRIER
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 177
GLY A 192
PHE A 193
ARG A 252
 TYR  A 177 ( 1.3A)
GLY  A 192 (-0.0A)
PHE  A 193 (-1.3A)
ARG  A 252 (-0.6A)
 1.38A 2a3cA-4c9gA:
undetectable		 2a3cA-4c9gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		11 / 12 TRP A 160
PHE A 184
GLY A 267
THR A 269
ASP A 306
GLU A 308
MET A 381
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 TRP  A 160 ( 0.5A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
THR  A 269 ( 0.8A)
ASP  A 306 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.71A 2a3cB-5gprA:
43.1		 2a3cB-5gprA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		4 / 6 TYR A 716
GLY A 597
SER A 605
ARG A 596
 TYR  A 716 ( 1.3A)
GLY  A 597 ( 0.0A)
SER  A 605 ( 0.0A)
ARG  A 596 ( 0.6A)
 1.22A 2a3cB-1v0fA:
undetectable		 2a3cB-1v0fA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		5 / 9 LEU A4016
ALA A4024
TYR A4026
LEU A3897
GLU A3930
 LEU  A4016 ( 0.6A)
ALA  A4024 ( 0.0A)
TYR  A4026 ( 1.3A)
LEU  A3897 ( 0.6A)
GLU  A3930 ( 0.6A)
 1.30A 2azqA-5w6lA:
undetectable		 2azqA-5w6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		4 / 8 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.37A 2bteA-5w0aA:
undetectable		 2bteA-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		4 / 8 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.32A 2bteD-5w0aA:
undetectable		 2bteD-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		4 / 7 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.29A 2bytA-5w0aA:
undetectable		 2bytA-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		4 / 7 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.29A 2bytD-5w0aA:
undetectable		 2bytD-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 7 ASP E  38
GLY E  70
GLY E  71
ASN E 123
 TYR  E 320 (-3.6A)
TYR  E 320 ( 4.9A)
None
TYR  E 320 ( 4.7A)
 0.74A 2c49B-1tydE:
undetectable		 2c49B-1tydE:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		4 / 7 ASP A 118
GLY A 150
GLY A 151
ASN A 214
 TYR  A 501 (-2.9A)
TYR  A 501 ( 3.8A)
None
TYR  A 501 ( 4.4A)
 0.69A 2c49B-5ijxA:
undetectable		 2c49B-5ijxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 11 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.31A 2dg3A-5wpiA:
undetectable		 2dg3A-5wpiA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 3k5s CADHERIN-13
(Gallus
gallus) 		5 / 10 TYR A 112
ALA A 209
ILE A 170
GLU A 190
ILE A 213
 TYR  A 112 ( 1.3A)
ALA  A 209 ( 0.0A)
ILE  A 170 ( 0.7A)
GLU  A 190 ( 0.5A)
ILE  A 213 ( 0.7A)
 1.34A 2dm6A-3k5sA:
undetectable
2dm6B-3k5sA:
undetectable		 2dm6A-3k5sA:
19.02
2dm6B-3k5sA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 9 GLN A 130
GLN A 184
GLY A 229
PHE A  20
PHE A  23
 TYR  A 302 (-4.0A)
TYR  A 302 (-3.5A)
None
NAP  A 301 (-3.6A)
None
 1.02A 2dr6A-5t95A:
2.6		 2dr6A-5t95A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		6 / 12 LEU A 156
GLY A 157
VAL A 164
ALA A 177
MET A 227
TYR A 229
 LEU  A 156 ( 0.6A)
GLY  A 157 ( 0.0A)
VAL  A 164 ( 0.6A)
ALA  A 177 ( 0.0A)
MET  A 227 ( 0.0A)
TYR  A 229 ( 1.3A)
 0.71A 2fumC-3o96A:
24.2		 2fumC-3o96A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 6 TYR A  56
GLY A  21
ASP A  22
ASN A  23
 TYR  A  56 ( 1.3A)
GLY  A  21 ( 0.0A)
ASP  A  22 ( 0.5A)
ASN  A  23 ( 0.6A)
 1.15A 2g72A-3qviA:
undetectable		 2g72A-3qviA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 TYR A 159
HIS A 160
PHE A 340
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.50A 2h42A-3sl5A:
36.2		 2h42A-3sl5A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 TYR A 159
LEU A 319
PHE A 340
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
LEU  A 319 ( 0.6A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.43A 2h42C-3sl5A:
35.9		 2h42C-3sl5A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		5 / 10 TYR A 315
TYR A 151
GLY A 169
TRP A 190
TYR A 181
 TYR  A 315 ( 1.3A)
TYR  A 151 ( 1.3A)
GLY  A 169 ( 0.0A)
TRP  A 190 ( 0.5A)
TYR  A 181 ( 1.3A)
 1.44A 2hndA-3qviA:
undetectable		 2hndA-3qviA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		5 / 10 TYR A 315
TYR A 151
GLY A 169
TRP A 190
TYR A 181
 TYR  A 315 ( 1.3A)
TYR  A 151 ( 1.3A)
GLY  A 169 ( 0.0A)
TRP  A 190 ( 0.5A)
TYR  A 181 ( 1.3A)
 1.44A 2hnyA-3qviA:
undetectable		 2hnyA-3qviA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		3 / 3 LYS A 256
TYR A 138
PRO A 153
 LYS  A 256 ( 0.0A)
TYR  A 138 ( 1.3A)
PRO  A 153 ( 1.1A)
 1.30A 2j9cC-4hneA:
undetectable		 2j9cC-4hneA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3won DIPEPTIDYL
AMINOPEPTIDASE BII
(Pseudoxanthomona
s
mexicana) 		4 / 7 GLY A 274
PRO A 273
THR A  71
GLY A 655
 None
None
None
TYR  A 802 (-3.8A)
 0.86A 2jklA-3wonA:
undetectable		 2jklA-3wonA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3won DIPEPTIDYL
AMINOPEPTIDASE BII
(Pseudoxanthomona
s
mexicana) 		4 / 7 GLY A 274
PRO A 273
THR A  71
GLY A 655
 None
None
None
TYR  A 802 (-3.8A)
 0.86A 2jklC-3wonA:
undetectable		 2jklC-3wonA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3won DIPEPTIDYL
AMINOPEPTIDASE BII
(Pseudoxanthomona
s
mexicana) 		4 / 7 GLY A 274
PRO A 273
THR A  71
GLY A 655
 None
None
None
TYR  A 802 (-3.8A)
 0.88A 2jklD-3wonA:
undetectable		 2jklD-3wonA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 TYR A 297
GLY A 334
PHE A 294
 TYR  A 297 ( 1.3A)
GLY  A 334 (-0.0A)
PHE  A 294 ( 1.3A)
 0.67A 2m2pB-5d7wA:
undetectable		 2m2pB-5d7wA:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1
(Rattus
norvegicus) 		5 / 9 GLY A 316
LEU A 313
TYR A 309
LEU A 291
THR A 286
 GLY  A 316 ( 0.0A)
LEU  A 313 ( 0.5A)
TYR  A 309 ( 1.3A)
LEU  A 291 ( 0.6A)
THR  A 286 ( 0.8A)
 1.03A 2npnA-2pnnA:
undetectable		 2npnA-2pnnA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 12 ALA A  45
ALA A 173
TYR A 136
ILE A  48
LEU A 156
 ALA  A  45 ( 0.0A)
ALA  A 173 ( 0.0A)
TYR  A 136 ( 1.3A)
ILE  A  48 ( 0.6A)
LEU  A 156 ( 0.6A)
 1.05A 2nyrA-1c8xA:
undetectable		 2nyrA-1c8xA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3gle PILIN
(Streptococcus
pyogenes) 		3 / 3 GLY A 186
ARG A 188
TYR A 266
 GLY  A 186 ( 0.0A)
ARG  A 188 ( 0.6A)
TYR  A 266 ( 1.3A)
 0.69A 2opxA-3gleA:
undetectable		 2opxA-3gleA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		3 / 3 GLY A 167
ARG A  39
TYR A 110
 GLY  A 167 ( 0.0A)
ARG  A  39 ( 0.6A)
TYR  A 110 ( 1.3A)
 0.75A 2opxA-5w0aA:
undetectable		 2opxA-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 GLY A 400
TYR A 583
GLY A 586
TRP A 398
GLU A 554
 GLY  A 400 ( 0.0A)
TYR  A 583 ( 1.3A)
GLY  A 586 ( 0.0A)
TRP  A 398 ( 0.5A)
GLU  A 554 ( 0.5A)
 1.02A 2plwA-4flxA:
undetectable		 2plwA-4flxA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 7 PHE A 285
TYR A  87
TYR A  36
THR A  65
 PHE  A 285 ( 1.3A)
TYR  A  87 ( 1.3A)
TYR  A  36 (-1.3A)
THR  A  65 ( 0.8A)
 1.28A 2q6kA-3pu5A:
undetectable		 2q6kA-3pu5A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3ig0 DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		3 / 3 SER A 453
TYR A 524
HIS A 525
 SER  A 453 ( 0.0A)
TYR  A 524 ( 1.3A)
HIS  A 525 ( 1.0A)
 0.74A 2r2vD-3ig0A:
undetectable		 2r2vD-3ig0A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5gru DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 ILE L 217
ASP H 117
GLY H  99
TYR L 176
THR H 103
 ILE  L 217 ( 0.7A)
ASP  H 117 ( 0.6A)
GLY  H  99 ( 0.0A)
TYR  L 176 ( 1.3A)
THR  H 103 ( 0.8A)
 1.47A 2tsrD-5gruL:
undetectable		 2tsrD-5gruL:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		6 / 9 TYR A 156
PHE A 184
GLY A 267
ASP A 306
TYR A 383
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
TYR  A 383 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.93A 2uy4A-5gprA:
18.4		 2uy4A-5gprA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		6 / 9 TYR A 156
PHE A 184
GLY A 267
GLU A 308
TYR A 383
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
GLU  A 308 ( 0.6A)
TYR  A 383 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.52A 2uy4A-5gprA:
18.4		 2uy4A-5gprA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		4 / 8 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.30A 2v0gA-5w0aA:
undetectable		 2v0gA-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		4 / 5 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.38A 2v0gD-5w0aA:
undetectable		 2v0gD-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 368
THR A 367
LEU A 225
THR A 351
 TYR  A 368 ( 1.3A)
THR  A 367 ( 0.8A)
LEU  A 225 ( 0.6A)
THR  A 351 ( 0.8A)
 1.09A 2v0zO-2ogsA:
undetectable		 2v0zO-2ogsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4wji PUTATIVE
CYCLOHEXADIENYL
DEHYDROGENASE AND
ADH PREPHENATE
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 SER A 100
HIS A 193
SER A 189
HIS A 190
 NAP  A 301 ( 2.6A)
TYR  A 302 ( 4.9A)
TYR  A 302 ( 3.8A)
None
 1.31A 2vmyA-4wjiA:
3.6
2vmyB-4wjiA:
4.3		 2vmyA-4wjiA:
23.86
2vmyB-4wjiA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 PRO A 632
GLY A 705
TYR A 716
 PRO  A 632 ( 1.1A)
GLY  A 705 ( 0.0A)
TYR  A 716 ( 1.3A)
 0.65A 2vouB-1v0fA:
undetectable		 2vouB-1v0fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 PRO A 632
GLY A 705
TYR A 716
 PRO  A 632 ( 1.1A)
GLY  A 705 ( 0.0A)
TYR  A 716 ( 1.3A)
 0.66A 2vouC-1v0fA:
undetectable		 2vouC-1v0fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		3 / 3 PRO A 238
GLY A 162
TYR A 244
 PRO  A 238 ( 1.1A)
GLY  A 162 ( 0.0A)
TYR  A 244 ( 1.3A)
 0.72A 2vouC-4w65A:
undetectable		 2vouC-4w65A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		4 / 7 LEU A 406
ASN A 410
LEU A 225
TYR A 426
 LEU  A 406 ( 0.6A)
ASN  A 410 ( 0.6A)
LEU  A 225 ( 0.6A)
TYR  A 426 ( 1.3A)
 1.23A 2w8yA-3ulkA:
undetectable		 2w8yA-3ulkA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 12 TYR A 159
HIS A 160
LEU A 319
ILE A 336
GLU A 339
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
GLU  A 339 ( 0.5A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.01A 2weyA-3sl5A:
37.9		 2weyA-3sl5A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 12 TYR A 159
HIS A 160
LEU A 319
ILE A 336
GLU A 339
PHE A 340
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
GLU  A 339 ( 0.5A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.83A 2weyA-3sl5A:
37.9		 2weyA-3sl5A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 GLY A  62
ILE A 196
ASN A 214
ALA A  96
 TYR  A 401 ( 3.3A)
None
None
TYR  A 401 (-3.6A)
 0.88A 2x0pA-3vgjA:
undetectable		 2x0pA-3vgjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		4 / 4 VAL A 521
TYR A 520
VAL A 417
SER A 382
 VAL  A 521 ( 0.6A)
TYR  A 520 ( 1.3A)
VAL  A 417 ( 0.6A)
SER  A 382 ( 0.0A)
 1.17A 2x45B-5gprA:
undetectable		 2x45B-5gprA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		6 / 11 TYR A 156
PHE A 184
GLY A 267
GLU A 308
TYR A 383
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
GLU  A 308 ( 0.6A)
TYR  A 383 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.74A 2xtkA-5gprA:
19.8		 2xtkA-5gprA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		6 / 10 TYR A 156
PHE A 184
GLY A 267
ASP A 306
TYR A 383
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
TYR  A 383 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.96A 2xtkB-5gprA:
19.7		 2xtkB-5gprA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		6 / 10 TYR A 156
PHE A 184
GLY A 267
GLU A 308
TYR A 383
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
GLU  A 308 ( 0.6A)
TYR  A 383 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.56A 2xtkB-5gprA:
19.7		 2xtkB-5gprA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		4 / 8 THR A 574
TYR A 575
ARG A 568
ILE A 571
 THR  A 574 ( 0.8A)
TYR  A 575 ( 1.3A)
ARG  A 568 ( 0.6A)
ILE  A 571 ( 0.7A)
 1.07A 2xytE-4mtpA:
undetectable		 2xytE-4mtpA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		4 / 8 THR A 574
TYR A 575
ARG A 568
ILE A 571
 THR  A 574 ( 0.8A)
TYR  A 575 ( 1.3A)
ARG  A 568 ( 0.6A)
ILE  A 571 ( 0.7A)
 1.06A 2xytH-4mtpA:
undetectable		 2xytH-4mtpA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 201
VAL A 176
TYR A 183
ILE A  23
 TYR  A 201 ( 1.3A)
VAL  A 176 (-0.6A)
TYR  A 183 ( 1.3A)
ILE  A  23 ( 0.7A)
 1.27A 2xz5B-4rhyA:
undetectable
2xz5E-4rhyA:
undetectable		 2xz5B-4rhyA:
21.70
2xz5E-4rhyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  23
TYR A 201
VAL A 176
TYR A 183
 ILE  A  23 ( 0.7A)
TYR  A 201 ( 1.3A)
VAL  A 176 (-0.6A)
TYR  A 183 ( 1.3A)
 1.31A 2xz5D-4rhyA:
undetectable
2xz5E-4rhyA:
undetectable		 2xz5D-4rhyA:
21.70
2xz5E-4rhyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2qvs CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		3 / 3 TYR B 180
VAL B 156
THR B 179
 TYR  B 180 ( 1.3A)
VAL  B 156 ( 0.6A)
THR  B 179 ( 0.8A)
 0.80A 2ygnA-2qvsB:
undetectable		 2ygnA-2qvsB:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		3 / 3 PRO A 306
GLU A 221
TYR A 290
 PRO  A 306 ( 1.1A)
GLU  A 221 ( 0.6A)
TYR  A 290 ( 1.3A)
 0.79A 2zmbA-5nksA:
undetectable		 2zmbA-5nksA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 7 TYR A 382
PHE A 198
ILE A 202
ASN A 353
 TYR  A 382 ( 1.3A)
PHE  A 198 ( 1.3A)
ILE  A 202 ( 0.7A)
ASN  A 353 ( 0.6A)
 1.24A 2zseA-3sagA:
undetectable		 2zseA-3sagA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2p5d UPF0310 PROTEIN
MJECL36
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 102
TYR A  60
PHE A 108
ILE A 144
ASP A 140
 PHE  A 102 ( 1.3A)
TYR  A  60 ( 1.3A)
PHE  A 108 ( 1.3A)
ILE  A 144 ( 0.7A)
ASP  A 140 ( 0.6A)
 1.33A 2zznB-2p5dA:
undetectable		 2zznB-2p5dA:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		7 / 12 MET A  56
ASP A 101
ILE A 103
VAL A 115
ASN A 117
TYR A 197
ARG A 233
 MET  A  56 (-0.0A)
ASP  A 101 (-0.6A)
ILE  A 103 (-0.7A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
 0.28A 3a8iA-1wsvA:
46.8		 3a8iA-1wsvA:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		6 / 12 MET A  56
ASP A 101
TYR A 113
VAL A 115
ASN A 117
ARG A 233
 MET  A  56 (-0.0A)
ASP  A 101 (-0.6A)
TYR  A 113 ( 1.3A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
ARG  A 233 (-0.6A)
 1.11A 3a8iA-1wsvA:
46.8		 3a8iA-1wsvA:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		8 / 12 MET A  56
ASP A 101
ILE A 103
VAL A 115
ASN A 117
TYR A 197
ARG A 233
TRP A 262
 MET  A  56 (-0.0A)
ASP  A 101 (-0.6A)
ILE  A 103 (-0.7A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
TRP  A 262 ( 0.5A)
 0.32A 3a8iB-1wsvA:
46.2		 3a8iB-1wsvA:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		6 / 12 MET A  56
ASP A 101
TYR A 113
VAL A 115
ASN A 117
ARG A 233
 MET  A  56 (-0.0A)
ASP  A 101 (-0.6A)
TYR  A 113 ( 1.3A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
ARG  A 233 (-0.6A)
 1.12A 3a8iB-1wsvA:
46.2		 3a8iB-1wsvA:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		7 / 12 MET A  56
ILE A 103
VAL A 115
ASN A 117
TYR A 197
ARG A 233
TRP A 262
 MET  A  56 (-0.0A)
ILE  A 103 (-0.7A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
TRP  A 262 ( 0.5A)
 0.44A 3a8iC-1wsvA:
46.4		 3a8iC-1wsvA:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		6 / 12 MET A  56
TYR A 113
VAL A 115
ASN A 117
TYR A 197
ARG A 233
 MET  A  56 (-0.0A)
TYR  A 113 ( 1.3A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
 1.16A 3a8iC-1wsvA:
46.4		 3a8iC-1wsvA:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		8 / 12 MET A  56
ASP A 101
ILE A 103
VAL A 115
ASN A 117
TYR A 197
ARG A 233
TRP A 262
 MET  A  56 (-0.0A)
ASP  A 101 (-0.6A)
ILE  A 103 (-0.7A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
TRP  A 262 ( 0.5A)
 0.39A 3a8iD-1wsvA:
46.3		 3a8iD-1wsvA:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		7 / 12 MET A  56
ASP A 101
TYR A 113
VAL A 115
ASN A 117
TYR A 197
ARG A 233
 MET  A  56 (-0.0A)
ASP  A 101 (-0.6A)
TYR  A 113 ( 1.3A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
 1.12A 3a8iD-1wsvA:
46.3		 3a8iD-1wsvA:
33.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 7 ILE A  54
ILE A 301
LEU A  23
LEU A  15
 TYR  A 356 (-4.5A)
None
None
None
 0.97A 3adxA-3kumA:
undetectable		 3adxA-3kumA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		4 / 8 LYS A  52
GLY A  51
HIS A  98
TYR A  97
 LYS  A  52 ( 0.0A)
GLY  A  51 ( 0.0A)
HIS  A  98 ( 1.0A)
TYR  A  97 ( 1.3A)
 0.82A 3af0A-4g41A:
undetectable		 3af0A-4g41A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		5 / 12 PHE A 301
LEU A 223
GLU A 305
ARG A 149
TYR A 286
 PHE  A 301 ( 1.3A)
LEU  A 223 ( 0.5A)
GLU  A 305 ( 0.6A)
ARG  A 149 ( 0.6A)
TYR  A 286 ( 1.3A)
 1.44A 3apvA-3gnrA:
undetectable		 3apvA-3gnrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		5 / 12 PHE A 301
LEU A 223
GLU A 305
ARG A 149
TYR A 286
 PHE  A 301 ( 1.3A)
LEU  A 223 ( 0.5A)
GLU  A 305 ( 0.6A)
ARG  A 149 ( 0.6A)
TYR  A 286 ( 1.3A)
 1.36A 3apvB-3gnrA:
undetectable		 3apvB-3gnrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3h8m EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens) 		5 / 12 PHE A 944
TYR A 949
VAL A 928
LEU A 989
ARG A 957
 PHE  A 944 ( 1.4A)
TYR  A 949 ( 1.3A)
VAL  A 928 ( 0.6A)
LEU  A 989 ( 0.5A)
ARG  A 957 ( 0.6A)
 1.49A 3apvB-3h8mA:
undetectable		 3apvB-3h8mA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		5 / 12 PHE A 301
LEU A 223
GLU A 305
ARG A 149
TYR A 286
 PHE  A 301 ( 1.3A)
LEU  A 223 ( 0.5A)
GLU  A 305 ( 0.6A)
ARG  A 149 ( 0.6A)
TYR  A 286 ( 1.3A)
 1.43A 3apwB-3gnrA:
undetectable		 3apwB-3gnrA:
16.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARQ_A_DM5A606_1
(CHITINASE A)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		6 / 6 TRP A 268
LYS A 362
ASP A 384
TRP A 389
TYR A 411
ARG A 439
 TRP  A 268 ( 0.5A)
LYS  A 362 ( 0.0A)
ASP  A 384 ( 0.5A)
TRP  A 389 (-0.5A)
TYR  A 411 ( 1.3A)
ARG  A 439 ( 0.6A)
 0.55A 3arqA-5gprA:
55.3		 3arqA-5gprA:
50.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARR_A_PNXA606_1
(CHITINASE A)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		7 / 7 TRP A 268
GLY A 359
LYS A 362
ASP A 384
TRP A 389
TYR A 411
ARG A 439
 TRP  A 268 ( 0.5A)
GLY  A 359 ( 0.0A)
LYS  A 362 ( 0.0A)
ASP  A 384 ( 0.5A)
TRP  A 389 (-0.5A)
TYR  A 411 ( 1.3A)
ARG  A 439 ( 0.6A)
 0.46A 3arrA-5gprA:
56.4		 3arrA-5gprA:
50.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARU_A_PNXA606_1
(CHITINASE A)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		7 / 7 PHE A 309
GLY A 359
LYS A 362
ASP A 384
TRP A 389
TYR A 411
ARG A 439
 PHE  A 309 ( 1.3A)
GLY  A 359 ( 0.0A)
LYS  A 362 ( 0.0A)
ASP  A 384 ( 0.5A)
TRP  A 389 (-0.5A)
TYR  A 411 ( 1.3A)
ARG  A 439 ( 0.6A)
 0.46A 3aruA-5gprA:
56.0		 3aruA-5gprA:
50.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3k5s CADHERIN-13
(Gallus
gallus) 		4 / 7 VAL A  97
ASP A 102
TYR A  73
ILE A  49
 VAL  A  97 ( 0.6A)
ASP  A 102 ( 0.6A)
TYR  A  73 ( 1.3A)
ILE  A  49 ( 0.6A)
 0.79A 3avpA-3k5sA:
undetectable		 3avpA-3k5sA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 TYR A 159
HIS A 160
LEU A 319
PHE A 340
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.55A 3b2rA-3sl5A:
31.7		 3b2rA-3sl5A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 TYR A 159
HIS A 160
LEU A 319
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.45A 3b2rB-3sl5A:
31.6		 3b2rB-3sl5A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 11 LEU A 310
VAL A 265
TYR A 257
LEU A 253
TYR A 249
 LEU  A 310 ( 0.6A)
VAL  A 265 ( 0.6A)
TYR  A 257 ( 1.3A)
LEU  A 253 ( 0.6A)
TYR  A 249 ( 1.3A)
 1.49A 3bgrA-2qv2A:
undetectable
3bgrB-2qv2A:
undetectable		 3bgrA-2qv2A:
20.63
3bgrB-2qv2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 8 TYR A 131
ASN A 177
PHE A 460
TRP A 444
 TYR  A 131 ( 1.3A)
ASN  A 177 (-0.6A)
PHE  A 460 (-1.3A)
TRP  A 444 (-0.5A)
 1.42A 3bjwD-3gnrA:
undetectable		 3bjwD-3gnrA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A  37
GLU A  41
ASP A  81
 TYR  A 701 (-4.6A)
TYR  A 701 ( 4.3A)
None
 0.87A 3bxoA-2cycA:
2.6		 3bxoA-2cycA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A  37
GLU A  41
ASP A  81
 TYR  A 701 (-4.6A)
TYR  A 701 ( 4.3A)
None
 0.82A 3bxoB-2cycA:
undetectable		 3bxoB-2cycA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 1ng0 COAT PROTEIN
(Cocksfoot
mottle
virus) 		5 / 12 TYR A 213
ASN A 206
GLU A 203
ARG A 217
VAL A 214
 TYR  A 213 ( 1.3A)
ASN  A 206 ( 0.6A)
GLU  A 203 ( 0.5A)
ARG  A 217 ( 0.6A)
VAL  A 214 ( 0.6A)
 1.13A 3cb8A-1ng0A:
undetectable		 3cb8A-1ng0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		4 / 8 HIS A  22
GLY A  11
ASN A  23
TYR A  17
 HIS  A  22 ( 1.0A)
GLY  A  11 ( 0.0A)
ASN  A  23 ( 0.6A)
TYR  A  17 ( 1.3A)
 1.40A 3ccfA-1rynA:
undetectable		 3ccfA-1rynA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 3p9w HUMAN VEGF
(Homo
sapiens) 		4 / 5 ILE B  34
PRO B  52
TYR B  52
TYR B  33
 ILE  B  34 ( 0.6A)
PRO  B  52 ( 1.1A)
TYR  B  52 ( 1.3A)
TYR  B  33 ( 1.3A)
 0.77A 3d9lA-3p9wB:
undetectable
3d9lY-3p9wB:
undetectable		 3d9lA-3p9wB:
16.90
3d9lY-3p9wB:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 461
LEU A 422
TYR A 380
LEU A 273
LEU A 450
 PHE  A 461 ( 1.3A)
LEU  A 422 ( 0.6A)
TYR  A 380 ( 1.3A)
LEU  A 273 ( 0.6A)
LEU  A 450 ( 0.6A)
 1.15A 3e23A-4zkeA:
undetectable		 3e23A-4zkeA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 117
TYR A 317
GLY A 119
ASN A 116
 GLY  A 117 ( 0.0A)
TYR  A 317 ( 1.3A)
GLY  A 119 ( 0.0A)
ASN  A 116 ( 0.6A)
 1.08A 3e9rA-1wqaA:
undetectable		 3e9rA-1wqaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 117
TYR A 317
GLY A 119
ASN A 116
 GLY  A 117 ( 0.0A)
TYR  A 317 ( 1.3A)
GLY  A 119 ( 0.0A)
ASN  A 116 ( 0.6A)
 1.09A 3e9rC-1wqaA:
undetectable		 3e9rC-1wqaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		5 / 10 ILE A  24
ILE A  45
GLY A 404
TYR A 395
LEU A 409
 ILE  A  24 ( 0.7A)
ILE  A  45 ( 0.7A)
GLY  A 404 ( 0.0A)
TYR  A 395 ( 1.3A)
LEU  A 409 ( 0.5A)
 1.35A 3elzB-5nksA:
undetectable		 3elzB-5nksA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 9 ILE A 450
TYR A 520
ILE A 522
LYS A 497
GLU A 511
 ILE  A 450 ( 0.7A)
TYR  A 520 ( 1.3A)
ILE  A 522 ( 0.6A)
LYS  A 497 ( 0.0A)
GLU  A 511 ( 0.6A)
 1.04A 3f78A-2vbfA:
3.8		 3f78A-2vbfA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.84A 3fhjA-1j1uA:
19.1		 3fhjA-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fhjA-2cycA:
19.2		 3fhjA-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fhjB-1j1uA:
18.2		 3fhjB-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fhjB-2cycA:
18.2		 3fhjB-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fhjC-1j1uA:
17.5		 3fhjC-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fhjC-2cycA:
17.6		 3fhjC-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fhjD-1j1uA:
19.6		 3fhjD-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fhjD-2cycA:
2.2		 3fhjD-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fhjE-1j1uA:
18.8		 3fhjE-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.00A 3fhjE-2cycA:
2.3		 3fhjE-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fhjF-1j1uA:
19.9		 3fhjF-1j1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fhjF-2cycA:
19.9		 3fhjF-2cycA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.00A 3fi0A-2cycA:
19.3		 3fi0A-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.42A 3fi0B-1j1uA:
18.8		 3fi0B-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fi0C-1j1uA:
19.1		 3fi0C-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 0.98A 3fi0C-2cycA:
19.4		 3fi0C-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.84A 3fi0D-1j1uA:
18.3		 3fi0D-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fi0D-2cycA:
19.4		 3fi0D-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A  34
HIS A  70
ASP A 158
ILE A 159
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
 0.60A 3fi0E-1j1uA:
17.1		 3fi0E-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.42A 3fi0E-1j1uA:
17.1		 3fi0E-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  39
HIS A  76
ASP A 175
ILE A 176
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
 0.87A 3fi0E-2cycA:
18.1		 3fi0E-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.83A 3fi0F-1j1uA:
18.7		 3fi0F-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 0.95A 3fi0F-2cycA:
12.0		 3fi0F-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  34
HIS A  70
ASP A 158
ILE A 159
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
 0.61A 3fi0G-1j1uA:
19.3		 3fi0G-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.41A 3fi0G-1j1uA:
19.3		 3fi0G-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.85A 3fi0H-1j1uA:
18.7		 3fi0H-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 8 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.87A 3fi0I-1j1uA:
18.8		 3fi0I-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.02A 3fi0I-2cycA:
18.9		 3fi0I-2cycA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.84A 3fi0J-1j1uA:
18.9		 3fi0J-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.00A 3fi0J-2cycA:
19.2		 3fi0J-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.84A 3fi0K-1j1uA:
18.1		 3fi0K-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.01A 3fi0K-2cycA:
18.3		 3fi0K-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.82A 3fi0L-1j1uA:
18.2		 3fi0L-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 0.97A 3fi0L-2cycA:
6.8		 3fi0L-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.87A 3fi0M-1j1uA:
2.5		 3fi0M-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.00A 3fi0M-2cycA:
19.1		 3fi0M-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.90A 3fi0N-1j1uA:
19.0		 3fi0N-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.04A 3fi0O-2cycA:
19.2		 3fi0O-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A  34
HIS A  70
ASP A 158
ILE A 159
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
 0.60A 3fi0P-1j1uA:
18.3		 3fi0P-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.45A 3fi0P-1j1uA:
18.3		 3fi0P-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  39
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 0.82A 3fi0P-2cycA:
18.7		 3fi0P-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  39
HIS A  76
ASP A 175
ILE A 176
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
 0.90A 3fi0P-2cycA:
18.7		 3fi0P-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 GLY A  41
HIS A  77
ASP A 173
GLN A 188
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.4A)
TYR  A 401 (-3.0A)
 0.83A 3fi0P-5thhA:
16.9		 3fi0P-5thhA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.86A 3fi0R-1j1uA:
18.3		 3fi0R-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 SER A 180
THR A 179
GLY A 282
GLY A 316
VAL A 261
 TYR  A 888 (-2.7A)
None
TYR  A 888 ( 4.0A)
TYR  A 888 (-3.6A)
TYR  A 888 (-4.7A)
 0.99A 3fzgA-2amcA:
undetectable		 3fzgA-2amcA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 159
HIS A 160
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.52A 3g4lA-3sl5A:
53.4		 3g4lA-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.44A 3g4lA-3sl5A:
53.4		 3g4lA-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
MET A 357
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
MET  A 357 (-0.0A)
PHE  A 372 (-1.3A)
 0.53A 3g4lB-3sl5A:
52.8		 3g4lB-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
 0.46A 3g4lC-3sl5A:
53.0		 3g4lC-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
SER A 368
GLN A 369
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
 0.33A 3g4lD-3sl5A:
52.9		 3g4lD-3sl5A:
98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		11 / 11 TYR A 156
PHE A 184
GLY A 267
TRP A 268
ASP A 306
GLU A 308
MET A 381
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 TYR  A 156 ( 1.3A)
PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
TRP  A 268 ( 0.5A)
ASP  A 306 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.49A 3g6mA-5gprA:
7.2		 3g6mA-5gprA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		5 / 12 VAL A 290
SER A 354
ILE A 187
VAL A 366
TYR A 368
 VAL  A 290 ( 0.6A)
SER  A 354 ( 0.0A)
ILE  A 187 ( 0.7A)
VAL  A 366 ( 0.6A)
TYR  A 368 ( 1.3A)
 0.99A 3g8iA-5gprA:
undetectable		 3g8iA-5gprA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 VAL A 682
ILE A 702
TYR A 701
ILE A 717
 VAL  A 682 ( 0.6A)
ILE  A 702 ( 0.7A)
TYR  A 701 ( 1.3A)
ILE  A 717 ( 0.7A)
 1.00A 3hgxA-4flxA:
1.6		 3hgxA-4flxA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 4gow CALMODULIN
(Homo
sapiens) 		4 / 7 VAL D 142
TYR D 138
LYS D  81
GLU D  83
 VAL  D 142 ( 0.6A)
TYR  D 138 ( 1.3A)
SER  D  81 ( 0.0A)
GLU  D  83 ( 0.5A)
 1.20A 3hs4A-4gowD:
undetectable		 3hs4A-4gowD:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5x7y LIPOCALIN-CAN F 6
ALLERGEN
(Canis
lupus) 		4 / 8 PHE A  93
TYR A 123
PHE A  57
LEU A  72
 PHE  A  93 ( 1.3A)
TYR  A 123 ( 1.3A)
PHE  A  57 (-1.3A)
LEU  A  72 ( 0.6A)
 0.90A 3i45A-5x7yA:
undetectable		 3i45A-5x7yA:
11.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 9 TYR A 159
ASN A 321
ILE A 336
PHE A 340
MET A 357
GLN A 369
PHE A 372
ILE A 376
 TYR  A 159 (-1.3A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
ILE  A 376 (-0.6A)
 0.53A 3iakA-3sl5A:
51.9		 3iakA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 9 TYR A 159
MET A 273
ASN A 321
ILE A 336
PHE A 340
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
MET  A 273 (-0.0A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.73A 3iakA-3sl5A:
51.9		 3iakA-3sl5A:
94.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 4 PRO A 398
TYR A  49
GLY A  47
THR A  46
 PRO  A 398 ( 1.1A)
TYR  A  49 ( 1.3A)
GLY  A  47 ( 0.0A)
THR  A  46 ( 0.8A)
 1.41A 3ib0A-4kqnA:
undetectable		 3ib0A-4kqnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 ALA A  25
ILE A  50
LEU A  66
ILE A  74
TYR A  98
 ALA  A  25 ( 0.0A)
ILE  A  50 ( 0.7A)
LEU  A  66 ( 0.5A)
ILE  A  74 ( 0.7A)
TYR  A  98 ( 1.3A)
 1.27A 3jw3B-6gefA:
undetectable		 3jw3B-6gefA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 9 TYR A 159
HIS A 160
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.01A 3jwqA-3sl5A:
39.2		 3jwqA-3sl5A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 TYR A 159
HIS A 160
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.94A 3jwqB-3sl5A:
39.0
3jwqC-3sl5A:
39.2		 3jwqB-3sl5A:
28.41
3jwqC-3sl5A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 7 TYR A 159
HIS A 160
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.91A 3jwqC-3sl5A:
39.2		 3jwqC-3sl5A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 11 TYR A 159
HIS A 160
PHE A 340
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.01A 3jwqA-3sl5A:
39.2
3jwqD-3sl5A:
38.8		 3jwqA-3sl5A:
28.41
3jwqD-3sl5A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 5jja SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens) 		4 / 8 TYR A 263
TYR A 292
PHE A 211
ILE A 207
 TYR  A 263 ( 1.3A)
TYR  A 292 ( 1.3A)
PHE  A 211 ( 1.3A)
ILE  A 207 ( 0.7A)
 1.06A 3jz0B-5jjaA:
2.1		 3jz0B-5jjaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		3 / 3 ARG A3933
GLU A3821
TYR A3833
 ARG  A3933 ( 0.6A)
GLU  A3821 ( 0.6A)
TYR  A3833 ( 1.3A)
 0.94A 3k37B-5w6lA:
undetectable		 3k37B-5w6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 4 GLY A  58
TYR A  86
GLY A  84
ASP A  83
 GLY  A  58 ( 0.0A)
TYR  A  86 ( 1.3A)
GLY  A  84 ( 0.0A)
ASP  A  83 ( 0.6A)
 1.06A 3kl3A-2ogsA:
2.2		 3kl3A-2ogsA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 GLY A  62
MET A 259
PHE A 353
PHE A 120
 TYR  A 401 ( 3.3A)
None
None
None
 0.94A 3ko0D-3vgjA:
undetectable
3ko0E-3vgjA:
undetectable		 3ko0D-3vgjA:
15.55
3ko0E-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 PHE A 120
GLY A  62
MET A 259
PHE A 353
 None
TYR  A 401 ( 3.3A)
None
None
 0.97A 3ko0B-3vgjA:
undetectable
3ko0J-3vgjA:
undetectable		 3ko0B-3vgjA:
15.55
3ko0J-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 GLY A  62
MET A 259
PHE A 353
PHE A 120
 TYR  A 401 ( 3.3A)
None
None
None
 0.99A 3ko0K-3vgjA:
undetectable
3ko0S-3vgjA:
undetectable		 3ko0K-3vgjA:
15.55
3ko0S-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 7 PHE A 120
GLY A  62
MET A 259
PHE A 353
 None
TYR  A 401 ( 3.3A)
None
None
 0.97A 3ko0K-3vgjA:
undetectable
3ko0S-3vgjA:
undetectable		 3ko0K-3vgjA:
15.55
3ko0S-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 7 PHE A 120
GLY A  62
MET A 259
PHE A 353
 None
TYR  A 401 ( 3.3A)
None
None
 0.96A 3ko0R-3vgjA:
undetectable
3ko0T-3vgjA:
undetectable		 3ko0R-3vgjA:
15.55
3ko0T-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 8 PHE A  38
TYR A  28
ALA A  13
THR A 221
 PHE  A  38 ( 1.3A)
TYR  A  28 ( 1.3A)
ALA  A  13 ( 0.0A)
THR  A 221 ( 0.8A)
 1.06A 3l4dD-1c8xA:
undetectable		 3l4dD-1c8xA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 10 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.30A 3lxiA-3i4kA:
undetectable		 3lxiA-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 11 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.29A 3lxiB-3i4kA:
undetectable		 3lxiB-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 222
ASN A 223
TYR A 202
HIS A 248
TYR A 240
 GLY  A 222 ( 0.0A)
ASN  A 223 ( 0.6A)
TYR  A 202 ( 1.3A)
HIS  A 248 ( 1.0A)
TYR  A 240 ( 1.3A)
 1.32A 3mekA-5nqfA:
undetectable		 3mekA-5nqfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 7 TYR A   7
VAL A  93
VAL A 149
ILE A  96
 TYR  A   7 ( 1.3A)
VAL  A  93 ( 0.6A)
VAL  A 149 ( 0.6A)
ILE  A  96 ( 0.6A)
 1.31A 3ms9B-2vbfA:
undetectable		 3ms9B-2vbfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 7 TYR A  87
VAL A 413
VAL A 400
ILE A 424
 TYR  A  87 ( 1.3A)
VAL  A 413 ( 0.6A)
VAL  A 400 ( 0.6A)
ILE  A 424 ( 0.4A)
 1.30A 3ms9B-4mwtA:
undetectable		 3ms9B-4mwtA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ASP A   6
ILE A  18
VAL A 344
ALA A 117
TYR A 120
 ASP  A   6 (-0.5A)
ILE  A  18 ( 0.5A)
VAL  A 344 ( 0.5A)
ALA  A 117 ( 0.0A)
TYR  A 120 ( 1.3A)
 1.25A 3ohtA-4flxA:
2.2
3ohtB-4flxA:
undetectable		 3ohtA-4flxA:
19.16
3ohtB-4flxA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM
(Pseudomonas
aeruginosa) 		5 / 12 TYR A   8
GLU A  29
ALA A  27
LEU A 207
TRP A 203
 TYR  A   8 ( 1.3A)
GLU  A  29 ( 0.6A)
ALA  A  27 ( 0.0A)
LEU  A 207 ( 0.6A)
TRP  A 203 ( 0.5A)
 1.41A 3ou6D-5hfiA:
undetectable		 3ou6D-5hfiA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6ezy -
(-) 		5 / 12 TYR A  77
GLY A  24
GLY A  81
ASP A  83
LEU A  84
 TYR  A  77 ( 1.3A)
GLY  A  24 ( 0.0A)
GLY  A  81 ( 0.0A)
ASP  A  83 ( 0.6A)
LEU  A  84 ( 0.5A)
 1.13A 3ou7A-6ezyA:
undetectable		 3ou7A-6ezyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  76
ALA A 193
HIS A 185
LEU A 225
ILE A 137
 TYR  A 701 (-3.7A)
None
None
None
None
 1.14A 3ozwB-2cycA:
undetectable		 3ozwB-2cycA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5crc SDEA
(Legionella
pneumophila) 		5 / 9 TYR A  90
ILE A  32
ILE A  93
VAL A  52
ILE A  39
 TYR  A  90 ( 1.3A)
ILE  A  32 ( 0.4A)
ILE  A  93 ( 0.4A)
VAL  A  52 ( 0.6A)
ILE  A  39 ( 0.5A)
 1.24A 3p4wB-5crcA:
undetectable		 3p4wB-5crcA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 2ywy NEW ANTIGEN RECEPTOR
VARIABLE DOMAIN
(Orectolobus
maculatus) 		3 / 3 TYR A  86
TYR A  37
GLU A 101
 TYR  A  86 ( 1.3A)
TYR  A  37 ( 1.3A)
GLU  A 101 ( 0.6A)
 0.85A 3pfgA-2ywyA:
undetectable		 3pfgA-2ywyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 10 ILE A  66
ALA A 101
ILE A  54
ILE A 290
ILE A 277
 None
None
TYR  A 356 (-4.5A)
None
None
 1.11A 3prsA-3kumA:
undetectable		 3prsA-3kumA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 467
GLY A 469
THR A 468
LEU A 477
 TYR  A 467 ( 1.3A)
GLY  A 469 ( 0.0A)
THR  A 468 ( 0.8A)
LEU  A 477 ( 0.6A)
 0.96A 3ps9A-4g9kA:
5.9		 3ps9A-4g9kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 5 TYR A 321
PRO A 371
THR A 425
THR A 393
 TYR  A 321 (-1.3A)
PRO  A 371 ( 1.1A)
THR  A 425 ( 0.8A)
THR  A 393 ( 0.8A)
 1.38A 3q07A-3gnrA:
undetectable		 3q07A-3gnrA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 5 TYR A 321
PRO A 371
THR A 425
THR A 393
 TYR  A 321 (-1.3A)
PRO  A 371 ( 1.1A)
THR  A 425 ( 0.8A)
THR  A 393 ( 0.8A)
 1.34A 3q07B-3gnrA:
undetectable		 3q07B-3gnrA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5crc SDEA
(Legionella
pneumophila) 		5 / 11 TYR A  76
THR A 103
LEU A  78
ALA A  96
THR A  54
 TYR  A  76 ( 1.3A)
THR  A 103 ( 0.8A)
LEU  A  78 ( 0.6A)
ALA  A  96 ( 0.0A)
THR  A  54 ( 0.8A)
 1.25A 3qelA-5crcA:
undetectable
3qelB-5crcA:
undetectable		 3qelA-5crcA:
21.09
3qelB-5crcA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		4 / 5 SER A 180
GLY A 281
GLU B  31
GLU A 279
 TYR  A 888 (-2.7A)
None
None
None
 1.18A 3raeB-2amcA:
1.6
3raeD-2amcA:
undetectable		 3raeB-2amcA:
20.59
3raeD-2amcA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 12 ALA A 107
TYR A 135
LEU A 117
ALA A 282
VAL A 114
 ALA  A 107 ( 0.0A)
TYR  A 135 ( 1.3A)
LEU  A 117 ( 0.6A)
ALA  A 282 ( 0.0A)
VAL  A 114 ( 0.6A)
 1.04A 3rukA-3pu5A:
undetectable		 3rukA-3pu5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 12 PHE A  23
GLY A 128
ASP A 222
GLY A  21
SER A  77
 None
TYR  A 302 ( 3.1A)
TYR  A 302 ( 2.9A)
None
NAP  A 301 (-3.5A)
 1.05A 3sudB-5t95A:
undetectable		 3sudB-5t95A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		4 / 5 TYR A3786
LEU A3958
LYS A3959
ARG A3933
 TYR  A3786 ( 1.3A)
LEU  A3958 ( 0.6A)
LYS  A3959 ( 0.0A)
ARG  A3933 ( 0.6A)
 1.36A 3sudD-5w6lA:
undetectable		 3sudD-5w6lA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 12 PHE A  23
GLY A 128
ASP A 222
GLY A  21
SER A  77
 None
TYR  A 302 ( 3.1A)
TYR  A 302 ( 2.9A)
None
NAP  A 301 (-3.5A)
 1.06A 3sueD-5t95A:
undetectable		 3sueD-5t95A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 TYR A 387
LEU A 185
ARG A 343
 TYR  A 387 ( 1.3A)
LEU  A 185 ( 0.6A)
ARG  A 343 ( 0.6A)
 0.78A 3sufB-2nvvA:
undetectable		 3sufB-2nvvA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		5 / 11 PHE B 338
PHE B 360
PHE B 263
ILE B 300
GLY B 312
 TYR  B 999 (-4.5A)
TYR  B 999 ( 4.8A)
None
None
None
 1.11A 3t3rA-2amcB:
undetectable		 3t3rA-2amcB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 ARG A 204
GLN A 218
PHE A 258
GLY A 281
GLY A 316
 TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.0A)
None
TYR  A 888 (-3.6A)
 0.95A 3tegA-2amcA:
23.2		 3tegA-2amcA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		10 / 12 SER A 180
ARG A 204
GLN A 218
GLU A 220
PHE A 258
PHE A 260
GLY A 282
GLY A 284
ALA A 314
GLY A 316
 TYR  A 888 (-2.7A)
TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.5A)
TYR  A 888 (-3.0A)
TYR  A 888 (-4.5A)
TYR  A 888 ( 4.0A)
None
TYR  A 888 (-3.4A)
TYR  A 888 (-3.6A)
 0.60A 3tegA-2amcA:
23.2		 3tegA-2amcA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		10 / 12 SER A 180
GLN A 183
ARG A 204
GLN A 218
PHE A 258
PHE A 260
GLY A 282
GLY A 284
ALA A 314
GLY A 316
 TYR  A 888 (-2.7A)
None
TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.0A)
TYR  A 888 (-4.5A)
TYR  A 888 ( 4.0A)
None
TYR  A 888 (-3.4A)
TYR  A 888 (-3.6A)
 0.54A 3tegA-2amcA:
23.2		 3tegA-2amcA:
24.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 9 TRP A 149
ARG A 204
VAL A 261
ALA A 314
GLY A 282
 TYR  A 888 (-4.1A)
TYR  A 888 (-3.9A)
TYR  A 888 (-4.7A)
TYR  A 888 (-3.4A)
TYR  A 888 ( 4.0A)
 1.45A 3tehA-2amcA:
42.2		 3tehA-2amcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		9 / 9 TRP A 149
HIS A 178
SER A 180
ARG A 204
GLN A 218
GLU A 220
VAL A 261
ALA A 314
GLY A 316
 TYR  A 888 (-4.1A)
TYR  A 888 (-3.7A)
TYR  A 888 (-2.7A)
TYR  A 888 (-3.9A)
TYR  A 888 (-3.3A)
TYR  A 888 (-3.5A)
TYR  A 888 (-4.7A)
TYR  A 888 (-3.4A)
TYR  A 888 (-3.6A)
 0.48A 3tehA-2amcA:
42.2		 3tehA-2amcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Thermus
thermophilus) 		7 / 7 PRO B 259
HIS B 261
LEU B 286
GLY B 315
GLU B 334
ALA B 356
PHE B 360
 None
TYR  B 999 (-3.6A)
TYR  B 999 (-4.1A)
TYR  B 999 (-3.2A)
TYR  B 999 (-3.5A)
TYR  B 999 (-3.1A)
TYR  B 999 ( 4.8A)
 0.39A 3tehB-2amcB:
60.1		 3tehB-2amcB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		4 / 5 TYR A 117
PHE A 312
PRO A 416
LEU A 419
 TYR  A 117 ( 1.3A)
PHE  A 312 ( 1.3A)
PRO  A 416 ( 1.1A)
LEU  A 419 ( 0.5A)
 1.48A 3tgvC-5nqfA:
undetectable		 3tgvC-5nqfA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		4 / 6 TYR A 117
PHE A 312
PRO A 416
LEU A 419
 TYR  A 117 ( 1.3A)
PHE  A 312 ( 1.3A)
PRO  A 416 ( 1.1A)
LEU  A 419 ( 0.5A)
 1.34A 3tgvD-5nqfA:
undetectable		 3tgvD-5nqfA:
16.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		9 / 9 TYR A 159
LEU A 319
ASN A 321
PRO A 322
THR A 333
ILE A 336
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.46A 3tvxA-3sl5A:
51.5		 3tvxA-3sl5A:
85.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		7 / 7 TYR A 159
ASN A 321
ILE A 336
PHE A 340
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.52A 3tvxB-3sl5A:
51.6		 3tvxB-3sl5A:
85.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 ASP A 118
GLY A 150
GLY A 151
SER A 152
ASN A 214
 TYR  A 501 (-2.9A)
TYR  A 501 ( 3.8A)
None
None
TYR  A 501 ( 4.4A)
 0.88A 3uboA-5ijxA:
2.4		 3uboA-5ijxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		4 / 5 SER A 145
ILE A  16
TYR A 158
GLY A 189
 SER  A 145 (-0.0A)
ILE  A  16 (-0.7A)
TYR  A 158 (-1.3A)
GLY  A 189 (-0.0A)
 1.04A 3uboB-3iccA:
6.9		 3uboB-3iccA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 GLN A  44
PHE A  45
TYR A  82
 GLN  A  44 ( 0.6A)
PHE  A  45 ( 1.3A)
TYR  A  82 ( 1.3A)
 0.97A 3ucjB-1rynA:
undetectable		 3ucjB-1rynA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 GLN A  44
PHE A  45
TYR A  82
 GLN  A  44 ( 0.6A)
PHE  A  45 ( 1.3A)
TYR  A  82 ( 1.3A)
 0.97A 3ucjA-1rynA:
undetectable		 3ucjA-1rynA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 5 TYR A 105
VAL A  54
SER A 304
GLY A  58
 TYR  A 105 ( 1.3A)
VAL  A  54 ( 0.6A)
SER  A 304 ( 0.0A)
GLY  A  58 ( 0.0A)
 1.49A 3v4tA-3i4kA:
undetectable
3v4tD-3i4kA:
undetectable		 3v4tA-3i4kA:
23.42
3v4tD-3i4kA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 12 ALA A 174
TYR A  14
ASP A 128
GLY A 171
ILE A 170
 ALA  A 174 ( 0.0A)
TYR  A  14 (-1.3A)
ASP  A 128 ( 0.5A)
GLY  A 171 ( 0.0A)
ILE  A 170 ( 0.7A)
 1.20A 3vwqA-1c8xA:
undetectable		 3vwqA-1c8xA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 5 ASP A 168
GLU A 167
GLY A 170
TYR A 230
 ASP  A 168 (-0.6A)
GLU  A 167 ( 0.6A)
GLY  A 170 ( 0.0A)
TYR  A 230 (-1.3A)
 1.21A 3w9tB-5d7wA:
undetectable		 3w9tB-5d7wA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 5 GLU A 167
GLY A 170
TYR A 230
GLN A 172
 GLU  A 167 ( 0.6A)
GLY  A 170 ( 0.0A)
TYR  A 230 (-1.3A)
GLN  A 172 ( 0.6A)
 1.46A 3w9tB-5d7wA:
undetectable		 3w9tB-5d7wA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		3 / 3 ASP A 119
GLY A   9
TYR A 121
 ASP  A 119 (-0.6A)
GLY  A   9 (-0.0A)
TYR  A 121 ( 1.3A)
 0.74A 3w9tC-4egsA:
undetectable		 3w9tC-4egsA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 5 ASP A 168
GLU A 167
GLY A 170
TYR A 230
 ASP  A 168 (-0.6A)
GLU  A 167 ( 0.6A)
GLY  A 170 ( 0.0A)
TYR  A 230 (-1.3A)
 1.19A 3w9tE-5d7wA:
undetectable		 3w9tE-5d7wA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		3 / 3 ASP A 119
GLY A   9
TYR A 121
 ASP  A 119 (-0.6A)
GLY  A   9 (-0.0A)
TYR  A 121 ( 1.3A)
 0.74A 3w9tG-4egsA:
undetectable		 3w9tG-4egsA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 155
TYR A 151
ARG A 347
MET A 349
 TYR  A 155 ( 1.3A)
TYR  A 151 ( 1.3A)
ARG  A 347 ( 0.6A)
MET  A 349 ( 0.0A)
 1.49A 3wipC-4mwtA:
undetectable
3wipD-4mwtA:
undetectable		 3wipC-4mwtA:
18.71
3wipD-4mwtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 155
TYR A 151
ARG A 347
MET A 349
 TYR  A 155 ( 1.3A)
TYR  A 151 ( 1.3A)
ARG  A 347 ( 0.6A)
MET  A 349 ( 0.0A)
 1.48A 3wipD-4mwtA:
undetectable
3wipE-4mwtA:
undetectable		 3wipD-4mwtA:
18.71
3wipE-4mwtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		7 / 11 PHE A 184
GLY A 267
ASP A 306
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.80A 3wqvA-5gprA:
43.0		 3wqvA-5gprA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		10 / 11 PHE A 184
GLY A 267
TRP A 268
GLU A 308
MET A 381
TYR A 383
ASP A 384
TYR A 437
ARG A 439
TRP A 532
 PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
TRP  A 268 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
ARG  A 439 ( 0.6A)
TRP  A 532 ( 0.5A)
 0.44A 3wqvA-5gprA:
43.0		 3wqvA-5gprA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		7 / 11 PHE A 184
GLY A 267
ASP A 306
TYR A 383
ASP A 384
TYR A 437
TRP A 532
 PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
ASP  A 306 ( 0.5A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
TRP  A 532 ( 0.5A)
 0.82A 3wqwA-5gprA:
43.0		 3wqwA-5gprA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		10 / 11 PHE A 184
GLY A 267
TRP A 268
GLU A 308
MET A 381
TYR A 383
ASP A 384
TYR A 437
ARG A 439
TRP A 532
 PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
TRP  A 268 ( 0.5A)
GLU  A 308 ( 0.6A)
MET  A 381 ( 0.0A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
TYR  A 437 ( 1.3A)
ARG  A 439 ( 0.6A)
TRP  A 532 ( 0.5A)
 0.47A 3wqwA-5gprA:
43.0		 3wqwA-5gprA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASN E 123
TRP E 126
ASP E  38
 TYR  E 320 ( 4.7A)
None
TYR  E 320 (-3.6A)
 0.85A 4a7tA-1tydE:
undetectable
4a7tF-1tydE:
undetectable		 4a7tA-1tydE:
17.61
4a7tF-1tydE:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		3 / 3 ASN A 227
TRP A 230
ASP A 131
 TYR  A 501 ( 4.6A)
None
TYR  A 501 (-2.9A)
 0.87A 4a7tA-5ihxA:
undetectable
4a7tF-5ihxA:
undetectable		 4a7tA-5ihxA:
17.94
4a7tF-5ihxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		3 / 3 ASN A 214
TRP A 217
ASP A 118
 TYR  A 501 ( 4.4A)
None
TYR  A 501 (-2.9A)
 0.81A 4a7tA-5ijxA:
undetectable
4a7tF-5ijxA:
undetectable		 4a7tA-5ijxA:
17.55
4a7tF-5ijxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		4 / 5 ILE A  46
ILE A 278
TYR A 277
GLU A 279
 ILE  A  46 ( 0.7A)
ILE  A 278 ( 0.7A)
TYR  A 277 ( 1.3A)
GLU  A 279 ( 0.6A)
 1.23A 4a99D-3r9rA:
undetectable		 4a99D-3r9rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 257
GLN A 558
ILE A 557
TYR A 556
 ILE  A 257 ( 0.4A)
GLN  A 558 ( 0.6A)
ILE  A 557 ( 0.4A)
TYR  A 556 ( 1.3A)
 1.25A 4a99D-4zkeA:
undetectable		 4a99D-4zkeA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 5nh2 UNCHARACTERIZED
PROTEIN
(Bartonella
henselae) 		4 / 6 GLY B  49
ALA B  51
TYR B  50
GLU B  17
 GLY  B  49 ( 0.0A)
ALA  B  51 ( 0.0A)
TYR  B  50 ( 1.3A)
GLU  B  17 ( 0.5A)
 0.91A 4ae1A-5nh2B:
undetectable		 4ae1A-5nh2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 HIS A 578
GLY A 580
TYR A 584
GLU A 586
 HIS  A 578 ( 1.0A)
GLY  A 580 ( 0.0A)
TYR  A 584 ( 1.3A)
GLU  A 586 ( 0.5A)
 1.37A 4ae1B-5c6dA:
undetectable		 4ae1B-5c6dA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5gru DIABODY PROTEIN
(Homo
sapiens) 		4 / 5 GLY H  99
TYR H 102
TYR H 100
GLU H 113
 GLY  H  99 ( 0.0A)
TYR  H 102 ( 1.3A)
TYR  H 100 ( 1.3A)
GLU  H 113 ( 0.6A)
 1.20A 4ae1B-5gruH:
3.9		 4ae1B-5gruH:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5ve2 ENOYL-COA HYDRATASE
(Pseudoalteromona
s
atlantica) 		4 / 7 THR A  61
TYR A  32
LEU A  35
PHE A  60
 THR  A  61 ( 0.8A)
TYR  A  32 ( 1.3A)
LEU  A  35 ( 0.6A)
PHE  A  60 ( 1.3A)
 1.33A 4awuA-5ve2A:
undetectable		 4awuA-5ve2A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		4 / 6 TYR A 223
ASP A 203
GLU A 243
LEU A 234
 TYR  A 223 ( 1.3A)
ASP  A 203 ( 0.6A)
GLU  A 243 ( 0.5A)
LEU  A 234 ( 0.6A)
 1.16A 4ax8A-3sl5A:
undetectable		 4ax8A-3sl5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 9 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.28A 4c9kA-3i4kA:
undetectable		 4c9kA-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 9 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.26A 4c9kB-3i4kA:
undetectable		 4c9kB-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 128
LEU A  46
LEU A 101
GLY A 102
 TYR  A 128 ( 1.3A)
LEU  A  46 ( 0.5A)
LEU  A 101 ( 0.6A)
GLY  A 102 ( 0.0A)
 0.82A 4c9nA-2b92A:
undetectable		 4c9nA-2b92A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 8 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.27A 4c9nA-3i4kA:
undetectable		 4c9nA-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		6 / 10 LEU A 156
GLY A 157
GLY A 159
VAL A 164
ALA A 177
TYR A 229
 LEU  A 156 ( 0.6A)
GLY  A 157 ( 0.0A)
GLY  A 159 ( 0.0A)
VAL  A 164 ( 0.6A)
ALA  A 177 ( 0.0A)
TYR  A 229 ( 1.3A)
 0.53A 4ckjA-3o96A:
20.1		 4ckjA-3o96A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pk2 CYCLIN-T1, PROTEIN
TAT
(Homo
sapiens;
Equine
infectious
anemia
virus) 		3 / 3 TYR A  13
THR A 192
GLU A 147
 TYR  A  13 ( 1.3A)
THR  A 192 ( 0.8A)
GLU  A 147 ( 0.6A)
 0.83A 4df3A-2pk2A:
undetectable		 4df3A-2pk2A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 TYR A 282
ARG A 331
SER A 336
 TYR  A 282 ( 1.3A)
ARG  A 331 ( 0.6A)
SER  A 336 ( 0.0A)
 1.07A 4dr2I-2nvvA:
undetectable
4dr2J-2nvvA:
undetectable		 4dr2I-2nvvA:
14.83
4dr2J-2nvvA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 12 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.34A 4drhA-5wpiA:
undetectable		 4drhA-5wpiA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 12 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.29A 4drhD-5wpiA:
undetectable		 4drhD-5wpiA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 11 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.29A 4driA-5wpiA:
undetectable		 4driA-5wpiA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 11 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.33A 4drjA-5wpiA:
undetectable		 4drjA-5wpiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		4 / 6 GLY A 200
VAL A 205
PRO A 172
TYR A 388
 GLY  A 200 ( 0.0A)
VAL  A 205 ( 0.6A)
PRO  A 172 ( 1.1A)
TYR  A 388 ( 1.3A)
 0.84A 4dxuA-3ulkA:
undetectable		 4dxuA-3ulkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 213
TYR A 392
GLY A 196
ALA A 197
LEU A 204
 PHE  A 213 ( 1.3A)
TYR  A 392 ( 1.3A)
GLY  A 196 ( 0.0A)
ALA  A 197 ( 0.0A)
LEU  A 204 ( 0.6A)
 0.98A 4e1gA-2ogsA:
undetectable		 4e1gA-2ogsA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 213
TYR A 392
GLY A 196
ALA A 197
LEU A 204
 PHE  A 213 ( 1.3A)
TYR  A 392 ( 1.3A)
GLY  A 196 ( 0.0A)
ALA  A 197 ( 0.0A)
LEU  A 204 ( 0.6A)
 0.98A 4e1gB-2ogsA:
undetectable		 4e1gB-2ogsA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4lmq IMMUNOGLOBULIN G1
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 TYR E  90
LEU E  80
LEU E  82
ARG E  66
 TYR  E  90 ( 1.3A)
LEU  E  80 ( 0.5A)
LEU  E  82 ( 0.6A)
ARG  E  66 ( 0.6A)
 1.17A 4em2A-4lmqE:
undetectable		 4em2A-4lmqE:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		4 / 8 LEU A 330
THR A 328
VAL A 117
GLY A 127
 None
None
TYR  A 501 ( 4.0A)
None
 0.83A 4eq4B-5ijxA:
undetectable		 4eq4B-5ijxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 9 GLY A 148
VAL A  73
GLU A  68
TYR A  21
GLY A  70
 GLY  A 148 ( 0.0A)
VAL  A  73 ( 0.6A)
GLU  A  68 ( 0.6A)
TYR  A  21 ( 1.3A)
GLY  A  70 ( 0.0A)
 1.24A 4fimA-1vhoA:
undetectable		 4fimA-1vhoA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 9 GLY A 425
VAL A 400
PRO A 398
TYR A  49
GLY A  47
 GLY  A 425 ( 0.0A)
VAL  A 400 ( 0.6A)
PRO  A 398 ( 1.1A)
TYR  A  49 ( 1.3A)
GLY  A  47 ( 0.0A)
 1.26A 4fimA-4kqnA:
undetectable		 4fimA-4kqnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 5 HIS A 423
TYR A 406
GLY A  58
SER A 414
 HIS  A 423 ( 1.0A)
TYR  A 406 ( 1.3A)
GLY  A  58 ( 0.0A)
SER  A 414 ( 0.0A)
 1.30A 4fu8A-2vbfA:
undetectable		 4fu8A-2vbfA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3bpo INTERLEUKIN-13
RECEPTOR ALPHA-1
CHAIN
(Homo
sapiens) 		4 / 7 PHE C 183
TYR C 158
ILE C 213
PRO C 148
 PHE  C 183 ( 1.3A)
TYR  C 158 ( 1.3A)
ILE  C 213 ( 0.6A)
PRO  C 148 ( 1.1A)
 0.78A 4g5jA-3bpoC:
undetectable		 4g5jA-3bpoC:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		4 / 7 PHE A 250
TYR A 172
ILE A 201
PRO A 170
 PHE  A 250 ( 1.3A)
TYR  A 172 ( 1.3A)
ILE  A 201 ( 0.7A)
PRO  A 170 ( 1.1A)
 0.98A 4g5jA-4nonA:
undetectable		 4g5jA-4nonA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A 418
ALA A 124
HIS A 128
TYR A 444
 HIS  A 418 ( 1.0A)
ALA  A 124 ( 0.0A)
HIS  A 128 ( 1.0A)
TYR  A 444 ( 1.3A)
 0.96A 4gboA-2ogsA:
undetectable		 4gboA-2ogsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		4 / 7 PHE C 215
TYR C 211
GLN C 195
PHE C 312
 PHE  C 215 ( 1.3A)
TYR  C 211 ( 1.3A)
GLN  C 195 ( 0.6A)
PHE  C 312 ( 1.3A)
 1.39A 4grqA-3ghgC:
undetectable
4grqC-3ghgC:
undetectable		 4grqA-3ghgC:
13.33
4grqC-3ghgC:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		4 / 7 PHE C 215
TYR C 211
TRP C 227
PHE C 312
 PHE  C 215 ( 1.3A)
TYR  C 211 ( 1.3A)
TRP  C 227 ( 0.5A)
PHE  C 312 ( 1.3A)
 1.29A 4grqA-3ghgC:
undetectable
4grqC-3ghgC:
undetectable		 4grqA-3ghgC:
13.33
4grqC-3ghgC:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		5 / 12 TYR A  73
ILE A 140
ALA A  21
ALA A  32
VAL A  31
 TYR  A  73 ( 1.3A)
ILE  A 140 ( 0.7A)
ALA  A  21 ( 0.0A)
ALA  A  32 ( 0.0A)
VAL  A  31 ( 0.6A)
 1.05A 4hfpD-3iccA:
undetectable		 4hfpD-3iccA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 7 VAL A  31
GLN A  33
TYR A  36
MET A  70
 VAL  A  31 ( 0.6A)
GLN  A  33 ( 0.6A)
TYR  A  36 ( 1.3A)
MET  A  70 ( 0.0A)
 1.16A 4hxyB-3wd7A:
undetectable		 4hxyB-3wd7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 4 LEU A 110
LEU A 105
GLN A 218
GLU A 123
 None
None
TYR  A 888 (-3.3A)
None
 1.15A 4i41A-2amcA:
undetectable		 4i41A-2amcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 8 ALA A 249
LEU A 166
TYR A 378
TYR A 258
 ALA  A 249 ( 0.0A)
LEU  A 166 ( 0.6A)
TYR  A 378 ( 1.3A)
TYR  A 258 ( 1.3A)
 1.16A 4ijiF-1wojA:
undetectable		 4ijiF-1wojA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		9 / 9 ASN A 142
ALA A 144
TYR A 146
TYR A 170
ASP A 172
GLU A 196
ASP A 198
GLU A 201
TRP A 320
 ASN  A 142 ( 0.6A)
ALA  A 144 ( 0.0A)
TYR  A 146 ( 1.3A)
TYR  A 170 ( 1.3A)
ASP  A 172 ( 0.5A)
GLU  A 196 ( 0.6A)
ASP  A 198 (-0.6A)
GLU  A 201 (-0.5A)
TRP  A 320 ( 0.5A)
 0.55A 4ipmA-5w0aA:
48.2		 4ipmA-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3d9a HEAVY CHAIN OF
HYHEL10 ANTIBODY
FRAGMENT (FAB)
(Mus
musculus) 		4 / 5 TYR H 350
ASN H 360
TYR H 359
ILE H 369
 TYR  H 350 ( 1.3A)
ASN  H 360 ( 0.6A)
TYR  H 359 ( 1.3A)
ILE  H 369 ( 0.7A)
 1.00A 4jtpA-3d9aH:
undetectable		 4jtpA-3d9aH:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 6 TYR A 340
THR A 339
PRO A 333
PHE A 345
 TYR  A 340 ( 1.3A)
THR  A 339 ( 0.8A)
PRO  A 333 ( 1.1A)
PHE  A 345 ( 1.3A)
 1.30A 4kf9A-3i4kA:
undetectable		 4kf9A-3i4kA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 TYR A 382
ARG A 354
SER A 353
 TYR  A 382 ( 1.3A)
ARG  A 354 ( 0.6A)
SER  A 353 ( 0.0A)
 1.11A 4khpI-1v0fA:
undetectable
4khpJ-1v0fA:
undetectable		 4khpI-1v0fA:
11.48
4khpJ-1v0fA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		5 / 12 PRO A 372
TYR A 324
GLY A 346
ASN A 326
MET A 345
 PRO  A 372 ( 1.1A)
TYR  A 324 ( 1.3A)
GLY  A 346 ( 0.0A)
ASN  A 326 ( 0.6A)
MET  A 345 ( 0.0A)
 1.34A 4kosA-1v0fA:
undetectable		 4kosA-1v0fA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		5 / 12 PRO A 372
TYR A 324
GLY A 346
ASN A 326
MET A 345
 PRO  A 372 ( 1.1A)
TYR  A 324 ( 1.3A)
GLY  A 346 ( 0.0A)
ASN  A 326 ( 0.6A)
MET  A 345 ( 0.0A)
 1.36A 4kovA-1v0fA:
undetectable		 4kovA-1v0fA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		5 / 12 PRO A 372
TYR A 324
GLY A 346
ASN A 326
MET A 345
 PRO  A 372 ( 1.1A)
TYR  A 324 ( 1.3A)
GLY  A 346 ( 0.0A)
ASN  A 326 ( 0.6A)
MET  A 345 ( 0.0A)
 1.34A 4kowA-1v0fA:
0.0		 4kowA-1v0fA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOX_A_CLSA205_1
(UNCHARACTERIZED
PROTEIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		5 / 11 PRO A 372
TYR A 324
GLY A 346
ASN A 326
MET A 345
 PRO  A 372 ( 1.1A)
TYR  A 324 ( 1.3A)
GLY  A 346 ( 0.0A)
ASN  A 326 ( 0.6A)
MET  A 345 ( 0.0A)
 1.38A 4koxA-1v0fA:
0.0		 4koxA-1v0fA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		5 / 11 PRO A 372
TYR A 324
GLY A 346
ASN A 326
MET A 345
 PRO  A 372 ( 1.1A)
TYR  A 324 ( 1.3A)
GLY  A 346 ( 0.0A)
ASN  A 326 ( 0.6A)
MET  A 345 ( 0.0A)
 1.37A 4koyA-1v0fA:
undetectable		 4koyA-1v0fA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5jvo ARGININE REPRESSOR
(Corynebacterium
pseudotuberculos
is) 		5 / 11 GLY A 113
ALA A 114
ASP A 136
THR A 132
VAL A 139
 None
None
None
TYR  A 201 (-4.3A)
None
 1.10A 4l1aA-5jvoA:
undetectable		 4l1aA-5jvoA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 10 TYR A 296
PHE A  58
VAL A  40
ILE A  38
LYS A  74
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
LYS  A  74 ( 0.0A)
 1.20A 4laxA-5wpiA:
undetectable		 4laxA-5wpiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 10 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.43A 4laxA-5wpiA:
undetectable		 4laxA-5wpiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		4 / 7 LEU A 125
VAL A 127
GLU A  53
TYR A  59
 LEU  A 125 ( 0.6A)
VAL  A 127 ( 0.6A)
GLU  A  53 ( 0.6A)
TYR  A  59 ( 1.3A)
 1.06A 4lb2A-4egsA:
undetectable		 4lb2A-4egsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 406
VAL A 409
LYS A 433
TYR A 497
 LEU  A 406 ( 0.5A)
VAL  A 409 ( 0.6A)
LYS  A 433 ( 0.0A)
TYR  A 497 ( 1.3A)
 1.13A 4lb2A-5svdA:
undetectable		 4lb2A-5svdA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE
(Bacillus
subtilis) 		8 / 11 THR A  84
TYR A 165
ARG A 168
VAL A 174
ILE A 180
SER A 183
MET A 208
LEU A 217
 THR  A  84 ( 0.8A)
TYR  A 165 ( 1.3A)
ARG  A 168 ( 0.6A)
VAL  A 174 ( 0.5A)
ILE  A 180 ( 0.7A)
SER  A 183 ( 0.0A)
MET  A 208 ( 0.0A)
LEU  A 217 ( 0.6A)
 0.63A 4lhmA-5ep8A:
52.9		 4lhmA-5ep8A:
45.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 7 TYR A  37
ILE A 109
ARG A  97
ILE A 100
 TYR  A  37 ( 1.3A)
ILE  A 109 ( 0.6A)
ARG  A  97 ( 0.6A)
ILE  A 100 ( 0.6A)
 0.92A 4lv9B-4flxA:
undetectable		 4lv9B-4flxA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 4wji PUTATIVE
CYCLOHEXADIENYL
DEHYDROGENASE AND
ADH PREPHENATE
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 11 PRO A 151
ASP A 177
HIS A 123
HIS A 181
GLY A 122
 None
None
TYR  A 302 (-3.7A)
None
None
 1.32A 4lxzB-4wjiA:
undetectable		 4lxzB-4wjiA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3h7a SHORT CHAIN
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 9 PRO A 214
VAL A 217
ALA A 218
TYR A 221
GLY A  18
 PRO  A 214 ( 1.1A)
VAL  A 217 ( 0.6A)
ALA  A 218 ( 0.0A)
TYR  A 221 ( 1.3A)
GLY  A  18 ( 0.0A)
 1.05A 4mmbA-3h7aA:
undetectable		 4mmbA-3h7aA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3h7a SHORT CHAIN
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 PRO A 214
VAL A 217
ALA A 218
TYR A 221
GLY A  18
 PRO  A 214 ( 1.1A)
VAL  A 217 ( 0.6A)
ALA  A 218 ( 0.0A)
TYR  A 221 ( 1.3A)
GLY  A  18 ( 0.0A)
 0.89A 4mmdB-3h7aA:
undetectable		 4mmdB-3h7aA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 2cyc TYROSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ASP A 175
VAL A 134
ALA A 121
PHE A  71
 TYR  A 701 (-3.4A)
None
None
TYR  A 701 (-4.4A)
 1.17A 4nedA-2cycA:
undetectable		 4nedA-2cycA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM
(Pseudomonas
aeruginosa) 		5 / 11 PRO A  95
TYR A  10
LEU A  37
LEU A  24
ILE A 127
 PRO  A  95 ( 1.1A)
TYR  A  10 ( 1.3A)
LEU  A  37 ( 0.5A)
LEU  A  24 ( 0.6A)
ILE  A 127 ( 0.7A)
 1.09A 4odrA-5hfiA:
undetectable
4odrB-5hfiA:
undetectable		 4odrA-5hfiA:
18.49
4odrB-5hfiA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA304_1
(CHITOSANASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 4 TYR A 673
ILE A 666
THR A 667
TYR A 701
 TYR  A 673 ( 1.3A)
ILE  A 666 ( 0.7A)
THR  A 667 ( 0.8A)
TYR  A 701 ( 1.3A)
 1.34A 4oltA-4flxA:
undetectable		 4oltA-4flxA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 TYR A 673
ILE A 666
THR A 667
TYR A 701
 TYR  A 673 ( 1.3A)
ILE  A 666 ( 0.7A)
THR  A 667 ( 0.8A)
TYR  A 701 ( 1.3A)
 1.36A 4oltB-4flxA:
undetectable		 4oltB-4flxA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLU A 156
THR A 141
HIS A 145
 TYR  A 401 ( 4.5A)
None
None
 0.78A 4q15A-4ppuA:
undetectable		 4q15A-4ppuA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLU A 156
THR A 141
HIS A 145
 TYR  A 401 ( 4.5A)
None
None
 0.76A 4q15B-4ppuA:
undetectable		 4q15B-4ppuA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5lmx DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49
(Saccharomyces
cerevisiae) 		5 / 11 PHE M  30
GLU M  50
ASP M  39
TYR M  65
GLY M  64
 PHE  M  30 ( 1.3A)
GLU  M  50 ( 0.6A)
ASP  M  39 ( 0.5A)
TYR  M  65 ( 1.3A)
GLY  M  64 ( 0.0A)
 1.31A 4qb9F-5lmxM:
undetectable		 4qb9F-5lmxM:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 10 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.37A 4qt2A-5wpiA:
undetectable		 4qt2A-5wpiA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 10 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.35A 4qt3A-5wpiA:
undetectable		 4qt3A-5wpiA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 TYR A 165
GLN A 162
SER A 132
ASP A 207
 TYR  A 165 ( 1.3A)
GLN  A 162 ( 0.6A)
SER  A 132 ( 0.0A)
ASP  A 207 ( 0.6A)
 1.06A 4qtuB-3wd7A:
undetectable		 4qtuB-3wd7A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 6 TYR A 673
ILE A 666
THR A 667
TYR A 701
 TYR  A 673 ( 1.3A)
ILE  A 666 ( 0.7A)
THR  A 667 ( 0.8A)
TYR  A 701 ( 1.3A)
 1.36A 4qwpA-4flxA:
undetectable		 4qwpA-4flxA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 10 TYR A 594
LEU A 596
LEU A 404
ALA A 560
GLY A 581
 TYR  A 594 (-1.3A)
LEU  A 596 ( 0.6A)
LEU  A 404 (-0.6A)
ALA  A 560 ( 0.0A)
GLY  A 581 ( 0.0A)
 1.50A 4rn6A-4flxA:
undetectable		 4rn6A-4flxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		5 / 11 GLY A 396
PHE A 442
ILE A 174
ASN A 177
TYR A 127
 GLY  A 396 ( 0.0A)
PHE  A 442 ( 1.3A)
ILE  A 174 ( 0.6A)
ASN  A 177 (-0.6A)
TYR  A 127 ( 1.3A)
 1.22A 4rtrA-3gnrA:
undetectable		 4rtrA-3gnrA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		5 / 12 TYR A 102
ILE A  20
GLY A  19
HIS A 228
ILE A 272
 TYR  A 102 ( 1.3A)
ILE  A  20 ( 0.7A)
GLY  A  19 (-0.0A)
HIS  A 228 ( 1.0A)
ILE  A 272 ( 0.7A)
 1.11A 4rvdA-2qc5A:
undetectable		 4rvdA-2qc5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3kbb PHOSPHORYLATED
CARBOHYDRATES
PHOSPHATASE TM_1254
(Thermotoga
maritima) 		3 / 3 GLU A 113
TYR A  19
GLU A  47
 GLU  A 113 ( 0.6A)
TYR  A  19 ( 1.3A)
GLU  A  47 (-0.6A)
 0.82A 4ryaA-3kbbA:
undetectable		 4ryaA-3kbbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 6 TYR A 114
ARG A 150
GLU A 334
LEU A 177
 TYR  A 114 ( 1.3A)
ARG  A 150 ( 0.6A)
GLU  A 334 ( 0.6A)
LEU  A 177 ( 0.6A)
 1.37A 4twdF-2nvvA:
undetectable
4twdG-2nvvA:
undetectable		 4twdF-2nvvA:
21.66
4twdG-2nvvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 12 ASP A 136
TYR A 135
THR A  38
ALA A  90
ALA A 272
 ASP  A 136 ( 0.6A)
TYR  A 135 ( 1.3A)
THR  A  38 ( 0.8A)
ALA  A  90 ( 0.0A)
ALA  A 272 ( 0.0A)
 1.46A 4u15A-3pu5A:
undetectable		 4u15A-3pu5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASN A 111
PHE A 116
TYR A 144
 ASN  A 111 ( 0.6A)
PHE  A 116 ( 1.3A)
TYR  A 144 ( 1.3A)
 0.58A 4u15A-2b92A:
undetectable		 4u15A-2b92A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		3 / 3 ASN A 177
PHE A 442
TYR A  87
 ASN  A 177 (-0.6A)
PHE  A 442 ( 1.3A)
TYR  A  87 ( 1.3A)
 0.68A 4u15A-3gnrA:
undetectable		 4u15A-3gnrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		5 / 12 ASP A 141
THR A 108
ALA A 107
ALA A 106
TYR A 130
 ASP  A 141 (-0.6A)
THR  A 108 ( 0.8A)
ALA  A 107 ( 0.0A)
ALA  A 106 ( 0.0A)
TYR  A 130 ( 1.3A)
 1.39A 4u15B-1rrvA:
undetectable		 4u15B-1rrvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 12 ASP A 136
TYR A 135
THR A  38
ALA A  90
ALA A 272
 ASP  A 136 ( 0.6A)
TYR  A 135 ( 1.3A)
THR  A  38 ( 0.8A)
ALA  A  90 ( 0.0A)
ALA  A 272 ( 0.0A)
 1.40A 4u15B-3pu5A:
undetectable		 4u15B-3pu5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		4 / 7 PHE A 145
PHE A 142
LYS A 213
TYR A 214
 PHE  A 145 ( 1.3A)
PHE  A 142 ( 1.3A)
LYS  A 213 ( 0.0A)
TYR  A 214 ( 1.3A)
 1.42A 4uciB-1txuA:
0.0		 4uciB-1txuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  79
PHE A  74
TYR A  18
HIS A 120
 PHE  A  79 ( 1.3A)
PHE  A  74 ( 1.3A)
TYR  A  18 ( 1.3A)
HIS  A 120 ( 1.0A)
 1.12A 4uciB-5hfiA:
undetectable		 4uciB-5hfiA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU E 172
GLY E 197
ASP E 176
VAL E 139
PHE E 143
 None
None
TYR  E 320 (-3.5A)
None
None
 1.21A 4wnwA-1tydE:
undetectable		 4wnwA-1tydE:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 ASP A 155
ALA A 146
PHE A 151
SER A 153
GLY A 149
 None
None
None
TYR  A 401 ( 4.7A)
TYR  A 401 (-4.8A)
 1.21A 4xp1A-4ppuA:
undetectable		 4xp1A-4ppuA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
PHE A 106
LEU A 313
LEU A  67
TYR A 312
 ILE  A   7 ( 0.7A)
PHE  A 106 ( 1.3A)
LEU  A 313 ( 0.6A)
LEU  A  67 ( 0.5A)
TYR  A 312 ( 1.3A)
 1.26A 4xumA-4mwtA:
undetectable		 4xumA-4mwtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3t7l ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 16
(Homo
sapiens) 		4 / 5 LEU A 790
TYR A 789
ALA A 771
ILE A 804
 LEU  A 790 ( 0.5A)
TYR  A 789 ( 1.3A)
ALA  A 771 ( 0.0A)
ILE  A 804 ( 0.7A)
 0.96A 4y03B-3t7lA:
undetectable		 4y03B-3t7lA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 VAL A 151
TYR A  56
ALA A  59
 VAL  A 151 ( 0.6A)
TYR  A  56 ( 1.3A)
ALA  A  59 ( 0.0A)
 0.29A 4ybnA-3r64A:
undetectable		 4ybnA-3r64A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLU A 156
THR A 141
HIS A 145
 TYR  A 401 ( 4.5A)
None
None
 0.75A 4ydqB-4ppuA:
undetectable		 4ydqB-4ppuA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		3 / 3 ARG A  61
ASP A  59
TYR A 302
 ARG  A  61 ( 0.6A)
ASP  A  59 ( 0.6A)
TYR  A 302 ( 1.3A)
 0.83A 4yo9B-4yzrA:
undetectable		 4yo9B-4yzrA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 3ig0 DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		4 / 6 LYS A 521
GLY A 510
TYR A 524
ALA A 508
 LYS  A 521 ( 0.0A)
GLY  A 510 ( 0.0A)
TYR  A 524 ( 1.3A)
ALA  A 508 ( 0.0A)
 1.00A 4yshB-3ig0A:
undetectable		 4yshB-3ig0A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 3kbb PHOSPHORYLATED
CARBOHYDRATES
PHOSPHATASE TM_1254
(Thermotoga
maritima) 		4 / 6 PHE A 163
GLY A 183
TYR A 182
ALA A 201
 PHE  A 163 ( 1.3A)
GLY  A 183 ( 0.0A)
TYR  A 182 ( 1.3A)
ALA  A 201 ( 0.0A)
 1.22A 4yshB-3kbbA:
undetectable		 4yshB-3kbbA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1
(Saccharomyces
cerevisiae) 		4 / 8 SER C  90
TYR C 163
ALA C 164
PHE C  85
 SER  C  90 ( 0.0A)
TYR  C 163 ( 1.3A)
ALA  C 164 ( 0.0A)
PHE  C  85 ( 1.3A)
 0.85A 5albL-5lmxC:
undetectable		 5albL-5lmxC:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_1
(ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 ILE A  93
THR A  98
TYR A 100
PRO A  82
ASP A 102
 ILE  A  93 ( 0.7A)
THR  A  98 ( 0.8A)
TYR  A 100 ( 1.3A)
PRO  A  82 ( 1.1A)
ASP  A 102 ( 0.6A)
 1.50A 5alcH-2nvvA:
0.0		 5alcH-2nvvA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 7 ASP A 270
TYR A 267
PRO A 268
THR A 266
 ASP  A 270 ( 0.5A)
TYR  A 267 ( 1.3A)
PRO  A 268 ( 1.1A)
THR  A 266 ( 0.8A)
 1.28A 5b6iA-4w65A:
undetectable		 5b6iA-4w65A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 6 ASP A 172
TYR A 188
TYR A 282
LEU A 345
 ASP  A 172 ( 0.6A)
TYR  A 188 ( 1.3A)
TYR  A 282 ( 1.3A)
LEU  A 345 ( 0.6A)
 1.08A 5bmvB-2nvvA:
undetectable		 5bmvB-2nvvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 6 ASP A  67
TYR A  99
TYR A  56
LEU A  20
 ASP  A  67 ( 0.6A)
TYR  A  99 ( 1.3A)
TYR  A  56 ( 1.3A)
LEU  A  20 ( 0.5A)
 1.20A 5bmvB-3qviA:
undetectable		 5bmvB-3qviA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 7 TYR A 295
GLY A 362
SER A 366
LEU A 367
 TYR  A 295 ( 1.3A)
GLY  A 362 ( 0.0A)
SER  A 366 ( 0.0A)
LEU  A 367 ( 0.6A)
 1.10A 5bphB-5ec3A:
undetectable		 5bphB-5ec3A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 222
ASN A 223
TYR A 202
HIS A 248
TYR A 240
 GLY  A 222 ( 0.0A)
ASN  A 223 ( 0.6A)
TYR  A 202 ( 1.3A)
HIS  A 248 ( 1.0A)
TYR  A 240 ( 1.3A)
 1.31A 5ccmA-5nqfA:
undetectable		 5ccmA-5nqfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 9 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.39A 5cp4A-3i4kA:
undetectable		 5cp4A-3i4kA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		5 / 12 GLY A  36
ALA A  35
SER A 215
TYR A 190
GLU A  42
 GLY  A  36 ( 0.0A)
ALA  A  35 ( 0.0A)
SER  A 215 ( 0.0A)
TYR  A 190 ( 1.3A)
GLU  A  42 ( 0.6A)
 1.31A 5cprB-5d7wA:
undetectable		 5cprB-5d7wA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 5 TYR A 210
HIS A 208
LEU A 291
PRO A 214
 TYR  A 210 ( 1.3A)
HIS  A 208 ( 1.0A)
LEU  A 291 ( 0.6A)
PRO  A 214 ( 1.1A)
 1.18A 5csyB-4kqnA:
3.6		 5csyB-4kqnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		5 / 12 LEU A 640
ARG A 672
TYR A 670
TYR A 592
LEU A 607
 LEU  A 640 ( 0.5A)
ARG  A 672 ( 0.6A)
TYR  A 670 ( 1.3A)
TYR  A 592 ( 1.3A)
LEU  A 607 ( 0.5A)
 1.33A 5czyA-1v0fA:
undetectable		 5czyA-1v0fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 TYR A 105
MET A  69
LEU A  38
GLY A 307
ILE A 309
 TYR  A 105 ( 1.3A)
GLY  A  53 ( 3.5A)
LEU  A  38 ( 0.6A)
GLY  A 307 ( 0.0A)
ILE  A 309 ( 0.7A)
 1.03A 5d4uC-3i4kA:
undetectable		 5d4uC-3i4kA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 TYR A 105
ILE A  36
MET A  69
LEU A  38
ILE A 309
 TYR  A 105 ( 1.3A)
ILE  A  36 ( 0.7A)
GLY  A  53 ( 3.5A)
LEU  A  38 ( 0.6A)
ILE  A 309 ( 0.7A)
 0.96A 5d4uD-3i4kA:
undetectable		 5d4uD-3i4kA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 TYR A 105
MET A  69
LEU A  38
GLY A 307
ILE A 309
 TYR  A 105 ( 1.3A)
GLY  A  53 ( 3.5A)
LEU  A  38 ( 0.6A)
GLY  A 307 ( 0.0A)
ILE  A 309 ( 0.7A)
 0.98A 5d4uD-3i4kA:
undetectable		 5d4uD-3i4kA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2ff0 STEROIDOGENIC FACTOR
1
(Mus
musculus) 		3 / 3 TYR A  25
LYS A  38
LYS A  34
 TYR  A  25 ( 1.3A)
LYS  A  38 ( 0.0A)
LYS  A  34 ( 0.0A)
 0.98A 5dbyA-2ff0A:
undetectable		 5dbyA-2ff0A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 169
LEU A 152
ILE A 120
PHE A  71
TYR A 179
 PHE  A 169 ( 1.3A)
LEU  A 152 ( 0.6A)
ILE  A 120 ( 0.7A)
PHE  A  71 ( 1.3A)
TYR  A 179 ( 1.3A)
 1.44A 5dlvA-4rhyA:
undetectable		 5dlvA-4rhyA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		5 / 11 VAL A 469
PHE A 387
ILE A 447
TYR A 410
LEU A 396
 VAL  A 469 ( 0.6A)
PHE  A 387 ( 1.3A)
ILE  A 447 ( 0.7A)
TYR  A 410 ( 1.3A)
LEU  A 396 ( 0.6A)
 1.10A 5e4dB-3sagA:
undetectable		 5e4dB-3sagA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 6 ALA A 253
THR A 252
VAL A 255
TYR A  28
 ALA  A 253 ( 0.0A)
THR  A 252 ( 0.8A)
VAL  A 255 ( 0.6A)
TYR  A  28 ( 1.3A)
 0.97A 5eckA-1c8xA:
undetectable		 5eckA-1c8xA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 6 ALA A 253
THR A 252
VAL A 255
TYR A  28
 ALA  A 253 ( 0.0A)
THR  A 252 ( 0.8A)
VAL  A 255 ( 0.6A)
TYR  A  28 ( 1.3A)
 1.02A 5eckD-1c8xA:
undetectable		 5eckD-1c8xA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6c0w HISTONE H4
(Homo
sapiens) 		4 / 6 THR B  82
ALA B  83
VAL B  87
TYR B  88
 THR  B  82 ( 0.8A)
ALA  B  83 ( 0.0A)
VAL  B  87 ( 0.6A)
TYR  B  88 ( 1.3A)
 0.82A 5ecoA-6c0wB:
undetectable		 5ecoA-6c0wB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 TYR A  39
TYR A  36
GLY A 200
LEU A  77
 TYR  A  39 ( 1.3A)
TYR  A  36 ( 1.3A)
GLY  A 200 ( 0.0A)
LEU  A  77 ( 0.5A)
 0.88A 5esfA-3wd7A:
undetectable		 5esfA-3wd7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 497
LEU A 494
PHE A 490
PHE A 501
GLY A 424
 TYR  A 497 ( 1.3A)
LEU  A 494 ( 0.6A)
PHE  A 490 ( 1.3A)
PHE  A 501 ( 1.3A)
GLY  A 424 ( 0.0A)
 1.11A 5fsaA-5svdA:
undetectable		 5fsaA-5svdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 VAL A 169
LEU A 149
TYR A 145
MET A 122
GLY A 237
 VAL  A 169 ( 0.6A)
LEU  A 149 ( 0.6A)
TYR  A 145 ( 1.3A)
MET  A 122 ( 0.0A)
GLY  A 237 ( 0.0A)
 1.25A 5g6sA-3sl5A:
0.7
5g6sG-3sl5A:
0.0		 5g6sA-3sl5A:
22.85
5g6sG-3sl5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 VAL A 169
LEU A 149
TYR A 145
MET A 122
GLY A 237
 VAL  A 169 ( 0.6A)
LEU  A 149 ( 0.6A)
TYR  A 145 ( 1.3A)
MET  A 122 ( 0.0A)
GLY  A 237 ( 0.0A)
 1.23A 5g6sB-3sl5A:
undetectable
5g6sC-3sl5A:
0.7		 5g6sB-3sl5A:
22.85
5g6sC-3sl5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 MET A 122
GLY A 237
VAL A 169
LEU A 149
TYR A 145
 MET  A 122 ( 0.0A)
GLY  A 237 ( 0.0A)
VAL  A 169 ( 0.6A)
LEU  A 149 ( 0.6A)
TYR  A 145 ( 1.3A)
 1.25A 5g6sB-3sl5A:
undetectable
5g6sC-3sl5A:
undetectable		 5g6sB-3sl5A:
22.85
5g6sC-3sl5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_D_RAUD400_1
(IMINE REDUCTASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 10 VAL A 169
LEU A 149
TYR A 145
MET A 122
GLY A 237
 VAL  A 169 ( 0.6A)
LEU  A 149 ( 0.6A)
TYR  A 145 ( 1.3A)
MET  A 122 ( 0.0A)
GLY  A 237 ( 0.0A)
 1.24A 5g6sD-3sl5A:
0.7
5g6sF-3sl5A:
0.0		 5g6sD-3sl5A:
22.85
5g6sF-3sl5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 VAL A 169
LEU A 149
TYR A 145
MET A 122
GLY A 237
 VAL  A 169 ( 0.6A)
LEU  A 149 ( 0.6A)
TYR  A 145 ( 1.3A)
MET  A 122 ( 0.0A)
GLY  A 237 ( 0.0A)
 1.24A 5g6sE-3sl5A:
0.7
5g6sH-3sl5A:
undetectable		 5g6sE-3sl5A:
22.85
5g6sH-3sl5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		3 / 3 ASP A  68
SER A  58
TYR A  64
 ASP  A  68 ( 0.5A)
SER  A  58 ( 0.0A)
TYR  A  64 ( 1.3A)
 0.66A 5glmA-3qviA:
undetectable		 5glmA-3qviA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GQB_A_GCSA603_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		8 / 8 PHE A 184
GLY A 267
TRP A 268
GLU A 308
TYR A 383
ASP A 384
ARG A 439
TRP A 532
 PHE  A 184 ( 1.3A)
GLY  A 267 ( 0.0A)
TRP  A 268 ( 0.5A)
GLU  A 308 ( 0.6A)
TYR  A 383 ( 1.3A)
ASP  A 384 ( 0.5A)
ARG  A 439 ( 0.6A)
TRP  A 532 ( 0.5A)
 0.27A 5gqbA-5gprA:
67.9		 5gqbA-5gprA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 PRO A 154
LEU A 234
TYR A 201
PHE A  85
 PRO  A 154 ( 1.1A)
LEU  A 234 ( 0.6A)
TYR  A 201 ( 1.3A)
PHE  A  85 ( 1.3A)
 1.26A 5igjA-1gc7A:
undetectable		 5igjA-1gc7A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ASP A 315
ASP A 141
TYR A 311
GLU A 294
TYR A 291
 ASP  A 315 (-0.5A)
ASP  A 141 (-0.5A)
TYR  A 311 ( 1.3A)
GLU  A 294 ( 0.6A)
TYR  A 291 ( 1.3A)
 1.29A 5iqbD-4flxA:
1.3		 5iqbD-4flxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_B_NMYB600_1
(BIFUNCTIONAL AAC/APH)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 10 ASP A 315
ASP A 141
TYR A 311
GLU A 294
TYR A 291
 ASP  A 315 (-0.5A)
ASP  A 141 (-0.5A)
TYR  A 311 ( 1.3A)
GLU  A 294 ( 0.6A)
TYR  A 291 ( 1.3A)
 1.46A 5iqeB-4flxA:
2.5		 5iqeB-4flxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ASP A 315
ASP A 141
TYR A 311
GLU A 294
TYR A 291
 ASP  A 315 (-0.5A)
ASP  A 141 (-0.5A)
TYR  A 311 ( 1.3A)
GLU  A 294 ( 0.6A)
TYR  A 291 ( 1.3A)
 1.32A 5iqeD-4flxA:
2.5		 5iqeD-4flxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 10 ASP A 315
ASP A 141
TYR A 311
GLU A 294
TYR A 291
 ASP  A 315 (-0.5A)
ASP  A 141 (-0.5A)
TYR  A 311 ( 1.3A)
GLU  A 294 ( 0.6A)
TYR  A 291 ( 1.3A)
 1.47A 5iqgB-4flxA:
0.0		 5iqgB-4flxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A 138
LEU A 226
GLY A 276
PRO A 277
LEU A 225
 TYR  A 138 ( 1.3A)
LEU  A 226 ( 0.6A)
GLY  A 276 ( 0.0A)
PRO  A 277 ( 1.1A)
LEU  A 225 ( 0.6A)
 1.32A 5jo9A-2ogsA:
3.9		 5jo9A-2ogsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.85A 5jsdA-4ki5E:
2.5		 5jsdA-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.85A 5jsdB-4ki5E:
undetectable		 5jsdB-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.84A 5jsdC-4ki5E:
undetectable		 5jsdC-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.86A 5jseA-4ki5E:
2.5		 5jseA-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.87A 5jseB-4ki5E:
3.0		 5jseB-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.86A 5jseC-4ki5E:
undetectable		 5jseC-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2qj6 TOXIN A
(Clostridioides
difficile) 		4 / 6 GLY A 129
THR A 128
TYR A 139
GLY A 144
 GLY  A 129 ( 0.0A)
THR  A 128 ( 0.8A)
TYR  A 139 ( 1.3A)
GLY  A 144 ( 0.0A)
 0.91A 5k4pA-2qj6A:
undetectable		 5k4pA-2qj6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 5 LEU A 424
TYR A 423
LEU A 427
TYR A 441
 LEU  A 424 ( 0.6A)
TYR  A 423 ( 1.3A)
LEU  A 427 ( 0.5A)
TYR  A 441 ( 1.3A)
 1.49A 5ki6A-3gnrA:
2.1		 5ki6A-3gnrA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 376
PRO A 377
TYR A 380
ASN A 728
 ASP  A 376 ( 0.6A)
PRO  A 377 ( 1.1A)
TYR  A 380 ( 1.3A)
ASN  A 728 ( 0.6A)
 1.02A 5l1fC-4zkeA:
4.6		 5l1fC-4zkeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 6c0w CENTROMERE PROTEIN N
(Homo
sapiens) 		3 / 3 SER K 156
TYR K 155
TYR K 154
 SER  K 156 ( 0.0A)
TYR  K 155 ( 1.3A)
TYR  K 154 ( 1.3A)
 0.76A 5lakA-6c0wK:
undetectable
5lakI-6c0wK:
undetectable		 5lakA-6c0wK:
undetectable
5lakI-6c0wK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 6c0w CENTROMERE PROTEIN N
(Homo
sapiens) 		3 / 3 SER K 156
TYR K 155
TYR K 154
 SER  K 156 ( 0.0A)
TYR  K 155 ( 1.3A)
TYR  K 154 ( 1.3A)
 0.73A 5lakC-6c0wK:
undetectable
5lakJ-6c0wK:
undetectable		 5lakC-6c0wK:
undetectable
5lakJ-6c0wK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		4 / 6 GLU A 151
PHE A 225
THR A 224
TYR A 237
 GLU  A 151 ( 0.6A)
PHE  A 225 ( 1.3A)
THR  A 224 ( 0.8A)
TYR  A 237 ( 1.3A)
 1.29A 5lrbA-5xluA:
undetectable		 5lrbA-5xluA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1tza APAG PROTEIN
(Shewanella
oneidensis) 		4 / 8 ILE A  52
TYR A 100
THR A  99
ILE A 114
 ILE  A  52 ( 0.4A)
TYR  A 100 ( 1.3A)
THR  A  99 ( 0.8A)
ILE  A 114 ( 0.6A)
 0.70A 5mzrE-1tzaA:
3.3		 5mzrE-1tzaA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 268
GLY A 342
PHE A 333
ALA A 343
TYR A 157
 VAL  A 268 ( 0.6A)
GLY  A 342 ( 0.0A)
PHE  A 333 ( 1.3A)
ALA  A 343 ( 0.0A)
TYR  A 157 ( 1.3A)
 1.11A 5n5dA-1wqaA:
undetectable		 5n5dA-1wqaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 TYR A 592
SER A 610
TRP A 678
 TYR  A 592 ( 1.3A)
SER  A 610 ( 0.0A)
TRP  A 678 ( 0.5A)
 0.98A 5n8jB-1v0fA:
undetectable		 5n8jB-1v0fA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		3 / 3 TYR A 105
SER A 133
TRP A 224
 TYR  A 105 ( 1.3A)
SER  A 133 ( 0.0A)
TRP  A 224 ( 0.5A)
 0.80A 5n8jB-3r9rA:
undetectable		 5n8jB-3r9rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 TYR A 592
SER A 610
TRP A 678
 TYR  A 592 ( 1.3A)
SER  A 610 ( 0.0A)
TRP  A 678 ( 0.5A)
 0.93A 5n8jA-1v0fA:
undetectable		 5n8jA-1v0fA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		3 / 3 TYR A 105
SER A 133
TRP A 224
 TYR  A 105 ( 1.3A)
SER  A 133 ( 0.0A)
TRP  A 224 ( 0.5A)
 0.81A 5n8jA-3r9rA:
undetectable		 5n8jA-3r9rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 TYR A 592
SER A 610
TRP A 678
 TYR  A 592 ( 1.3A)
SER  A 610 ( 0.0A)
TRP  A 678 ( 0.5A)
 0.90A 5n8jD-1v0fA:
undetectable		 5n8jD-1v0fA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		3 / 3 TYR A 105
SER A 133
TRP A 224
 TYR  A 105 ( 1.3A)
SER  A 133 ( 0.0A)
TRP  A 224 ( 0.5A)
 0.85A 5n8jD-3r9rA:
undetectable		 5n8jD-3r9rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)
(Homo
sapiens) 		4 / 7 TYR A  59
GLN A  77
ASP A  50
TYR A 106
 TYR  A  59 ( 1.3A)
GLN  A  77 ( 0.6A)
ASP  A  50 ( 0.6A)
TYR  A 106 ( 1.3A)
 1.37A 5ov9B-1szbA:
undetectable		 5ov9B-1szbA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 7 TYR A 151
TYR A 313
ASP A 316
HIS A 318
 TYR  A 151 ( 1.3A)
TYR  A 313 ( 1.3A)
ASP  A 316 ( 0.6A)
HIS  A 318 ( 1.0A)
 1.48A 5ov9B-3qviA:
undetectable		 5ov9B-3qviA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		4 / 4 VAL A 139
VAL A 108
TYR A 120
GLN A 122
 VAL  A 139 ( 0.6A)
VAL  A 108 ( 0.5A)
TYR  A 120 ( 1.3A)
GLN  A 122 ( 0.6A)
 1.05A 5qggA-5nksA:
undetectable		 5qggA-5nksA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6ezy -
(-) 		4 / 4 VAL A  57
VAL A  56
TYR A   6
GLN A  48
 VAL  A  57 ( 0.6A)
VAL  A  56 ( 0.6A)
TYR  A   6 ( 1.3A)
GLN  A  48 ( 0.6A)
 1.11A 5qggA-6ezyA:
undetectable		 5qggA-6ezyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		4 / 4 VAL A 139
VAL A 108
TYR A 120
GLN A 122
 VAL  A 139 ( 0.6A)
VAL  A 108 ( 0.5A)
TYR  A 120 ( 1.3A)
GLN  A 122 ( 0.6A)
 1.04A 5qgoA-5nksA:
undetectable		 5qgoA-5nksA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6ezy -
(-) 		4 / 4 VAL A  57
VAL A  56
TYR A   6
GLN A  48
 VAL  A  57 ( 0.6A)
VAL  A  56 ( 0.6A)
TYR  A   6 ( 1.3A)
GLN  A  48 ( 0.6A)
 1.14A 5qgoA-6ezyA:
undetectable		 5qgoA-6ezyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		4 / 4 VAL A 139
VAL A 108
TYR A 120
GLN A 122
 VAL  A 139 ( 0.6A)
VAL  A 108 ( 0.5A)
TYR  A 120 ( 1.3A)
GLN  A 122 ( 0.6A)
 1.05A 5qgpA-5nksA:
undetectable		 5qgpA-5nksA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		4 / 4 VAL A 139
VAL A 108
TYR A 120
GLN A 122
 VAL  A 139 ( 0.6A)
VAL  A 108 ( 0.5A)
TYR  A 120 ( 1.3A)
GLN  A 122 ( 0.6A)
 1.06A 5qgqA-5nksA:
undetectable		 5qgqA-5nksA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		4 / 4 VAL A 139
VAL A 108
TYR A 120
GLN A 122
 VAL  A 139 ( 0.6A)
VAL  A 108 ( 0.5A)
TYR  A 120 ( 1.3A)
GLN  A 122 ( 0.6A)
 1.08A 5qhbA-5nksA:
undetectable		 5qhbA-5nksA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 168
GLY A 169
SER A 191
LEU A 192
VAL A 202
 SAH  A 301 (-4.6A)
SAH  A 301 (-3.3A)
TYR  A 220 ( 3.5A)
SAH  A 301 ( 4.1A)
SAH  A 301 (-4.7A)
 0.38A 5twjA-3o7bA:
7.4		 5twjA-3o7bA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 168
GLY A 169
SER A 191
LEU A 192
VAL A 202
 SAH  A 301 (-4.6A)
SAH  A 301 (-3.3A)
TYR  A 220 ( 3.5A)
SAH  A 301 ( 4.1A)
SAH  A 301 (-4.7A)
 0.38A 5twjC-3o7bA:
7.3		 5twjC-3o7bA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		4 / 8 THR A 181
TYR A 180
THR A 176
ARG A 173
 THR  A 181 ( 0.8A)
TYR  A 180 ( 1.3A)
THR  A 176 ( 0.8A)
ARG  A 173 ( 0.6A)
 1.40A 5tzoA-3r9rA:
undetectable		 5tzoA-3r9rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 8 THR A 220
TYR A 219
THR A 203
ARG A 140
 THR  A 220 ( 0.8A)
TYR  A 219 ( 1.3A)
THR  A 203 ( 0.8A)
ARG  A 140 ( 0.6A)
 1.05A 5tzoA-4w65A:
5.6		 5tzoA-4w65A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 8 THR A 220
TYR A 219
THR A 203
ARG A 140
 THR  A 220 ( 0.8A)
TYR  A 219 ( 1.3A)
THR  A 203 ( 0.8A)
ARG  A 140 ( 0.6A)
 1.04A 5tzoB-4w65A:
5.6		 5tzoB-4w65A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 8 THR A 220
TYR A 219
THR A 203
ARG A 140
 THR  A 220 ( 0.8A)
TYR  A 219 ( 1.3A)
THR  A 203 ( 0.8A)
ARG  A 140 ( 0.6A)
 1.05A 5tzoC-4w65A:
5.6		 5tzoC-4w65A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 208
LEU A 224
MET A 139
TYR A 204
 LEU  A 208 ( 0.6A)
LEU  A 224 ( 0.6A)
MET  A 139 ( 0.0A)
TYR  A 204 ( 1.3A)
 1.44A 5uc3A-2b92A:
undetectable		 5uc3A-2b92A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A 418
ALA A 124
HIS A 128
TYR A 444
 HIS  A 418 ( 1.0A)
ALA  A 124 ( 0.0A)
HIS  A 128 ( 1.0A)
TYR  A 444 ( 1.3A)
 0.94A 5uizA-2ogsA:
undetectable		 5uizA-2ogsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 6 ASN E  77
ALA E  24
PRO E  53
TYR E  27
 ASN  E  77 ( 0.6A)
ALA  E  24 ( 0.0A)
PRO  E  53 ( 1.1A)
TYR  E  27 ( 1.3A)
 1.05A 5umd2-4ki5E:
undetectable
5umdF-4ki5E:
undetectable		 5umd2-4ki5E:
17.39
5umdF-4ki5E:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		3 / 3 LEU A 242
ILE A 200
TYR A 210
 LEU  A 242 ( 0.6A)
ILE  A 200 ( 0.7A)
TYR  A 210 ( 1.3A)
 0.63A 5uunB-5d7aA:
undetectable		 5uunB-5d7aA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 7 GLU A  89
ALA A  60
GLY A  58
TYR A  54
 GLU  A  89 ( 0.5A)
ALA  A  60 ( 0.0A)
GLY  A  58 ( 0.0A)
TYR  A  54 ( 1.3A)
 1.02A 5uxdA-2vbfA:
undetectable		 5uxdA-2vbfA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.73A 5v0iA-1j1uA:
19.0		 5v0iA-1j1uA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 1j1u TYROSYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.72A 5v0iB-1j1uA:
19.5		 5v0iB-1j1uA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 275
VAL A 273
LEU A 263
ILE A 240
 TYR  A 275 ( 1.3A)
VAL  A 273 ( 0.6A)
LEU  A 263 ( 0.6A)
ILE  A 240 ( 0.7A)
 0.69A 5v0vA-2ogsA:
undetectable		 5v0vA-2ogsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		4 / 5 TYR A 328
MET A 324
THR A 323
LEU A 320
 TYR  A 328 ( 1.3A)
MET  A 324 ( 0.0A)
THR  A 323 ( 0.8A)
LEU  A 320 ( 0.6A)
 1.15A 5w97J-5xluA:
undetectable		 5w97J-5xluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 8 PRO A 207
LYS A 204
THR A 286
TYR A 279
 PRO  A 207 ( 1.1A)
LYS  A 204 ( 0.0A)
THR  A 286 ( 0.8A)
TYR  A 279 ( 1.3A)
 1.36A 5x2sI-4dlkA:
undetectable
5x2sJ-4dlkA:
undetectable
5x2sK-4dlkA:
undetectable		 5x2sI-4dlkA:
17.77
5x2sJ-4dlkA:
19.82
5x2sK-4dlkA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 6 TYR A 254
GLU A 257
GLY A 252
GLY A 224
 TYR  A 254 ( 1.3A)
GLU  A 257 ( 0.5A)
GLY  A 252 (-0.0A)
GLY  A 224 (-0.0A)
 0.94A 5x7pB-3c3nA:
undetectable		 5x7pB-3c3nA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 5 VAL A  53
ARG A 233
GLY A 196
TYR A 197
 VAL  A  53 ( 0.6A)
ARG  A 233 (-0.6A)
GLY  A 196 (-0.0A)
TYR  A 197 (-1.3A)
 1.03A 5x80A-1wsvA:
undetectable
5x80B-1wsvA:
undetectable		 5x80A-1wsvA:
20.12
5x80B-1wsvA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 5 GLY A 196
TYR A 197
VAL A  53
ARG A 233
 GLY  A 196 (-0.0A)
TYR  A 197 (-1.3A)
VAL  A  53 ( 0.6A)
ARG  A 233 (-0.6A)
 1.10A 5x80C-1wsvA:
undetectable
5x80D-1wsvA:
undetectable		 5x80C-1wsvA:
20.12
5x80D-1wsvA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 222
ASN A 223
TYR A 202
HIS A 248
TYR A 240
 GLY  A 222 ( 0.0A)
ASN  A 223 ( 0.6A)
TYR  A 202 ( 1.3A)
HIS  A 248 ( 1.0A)
TYR  A 240 ( 1.3A)
 1.32A 5xxdA-5nqfA:
undetectable		 5xxdA-5nqfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		3 / 3 SER A 110
HIS A 158
TYR A 116
 SER  A 110 ( 0.0A)
HIS  A 158 ( 1.0A)
TYR  A 116 ( 1.3A)
 1.04A 5y2tA-2hk0A:
undetectable		 5y2tA-2hk0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 12 LEU A 203
ARG A 125
ILE A 172
TYR A 245
ILE A 184
 LEU  A 203 ( 0.5A)
ARG  A 125 ( 0.6A)
ILE  A 172 ( 0.7A)
TYR  A 245 ( 1.3A)
ILE  A 184 ( 0.4A)
 1.21A 5y2tB-5l5nA:
undetectable		 5y2tB-5l5nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 8 TYR A 274
ILE A 347
LEU A 156
ALA A 152
LEU A  45
 TYR  A 274 ( 1.3A)
ILE  A 347 ( 0.7A)
LEU  A 156 ( 0.6A)
ALA  A 152 ( 0.0A)
LEU  A  45 ( 0.6A)
 1.15A 5y7pE-3r6yA:
undetectable		 5y7pE-3r6yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 5 ALA A 411
SER A 414
GLY A  58
TYR A 406
 ALA  A 411 ( 0.0A)
SER  A 414 ( 0.0A)
GLY  A  58 ( 0.0A)
TYR  A 406 ( 1.3A)
 1.27A 5yodB-2vbfA:
undetectable		 5yodB-2vbfA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		4 / 5 HIS C 343
SER C 332
TYR C 211
GLY C 333
 HIS  C 343 ( 1.0A)
SER  C 332 ( 0.0A)
TYR  C 211 ( 1.3A)
GLY  C 333 ( 0.0A)
 1.37A 5yodH-3ghgC:
undetectable		 5yodH-3ghgC:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 10 TYR A 335
LEU A 173
ASP A 172
VAL A 142
GLY A 143
 TYR  A 335 ( 1.3A)
LEU  A 173 ( 0.6A)
ASP  A 172 ( 0.6A)
VAL  A 142 ( 0.6A)
GLY  A 143 ( 0.0A)
 1.47A 5zbdA-2nvvA:
0.0		 5zbdA-2nvvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 10 TYR A 335
LEU A 173
ASP A 172
VAL A 142
GLY A 143
 TYR  A 335 ( 1.3A)
LEU  A 173 ( 0.6A)
ASP  A 172 ( 0.6A)
VAL  A 142 ( 0.6A)
GLY  A 143 ( 0.0A)
 1.43A 5zbdB-2nvvA:
0.0		 5zbdB-2nvvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 6c0w HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HISTONE H4
(Homo
sapiens;
Homo
sapiens) 		5 / 12 TYR B  88
ASN B  64
ALA A  71
ALA A  98
PHE A  67
 TYR  B  88 ( 1.3A)
ASN  B  64 ( 0.6A)
ALA  A  71 ( 0.0A)
ALA  A  98 ( 0.0A)
PHE  A  67 ( 1.3A)
 1.05A 5zw4A-6c0wB:
undetectable		 5zw4A-6c0wB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 159
PHE A  78
ILE A 100
LEU A  98
ALA A 116
 TYR  A 159 ( 1.3A)
PHE  A  78 ( 1.3A)
ILE  A 100 ( 0.6A)
LEU  A  98 ( 0.6A)
ALA  A 116 ( 0.0A)
 1.37A 5zwrB-3c3nA:
undetectable		 5zwrB-3c3nA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)
(Homo
sapiens) 		5 / 12 TYR A  92
THR A  82
LEU A  71
PHE A  49
LEU A  44
 TYR  A  92 ( 1.3A)
THR  A  82 ( 0.8A)
LEU  A  71 ( 0.6A)
PHE  A  49 ( 1.3A)
LEU  A  44 ( 0.6A)
 1.31A 6a93B-1szbA:
undetectable		 6a93B-1szbA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		5 / 10 TYR A 188
ALA A 159
PHE A 162
ALA A 163
LEU A 170
 TYR  A 188 ( 1.3A)
ALA  A 159 ( 0.0A)
PHE  A 162 ( 1.3A)
ALA  A 163 ( 0.0A)
LEU  A 170 ( 0.6A)
 1.26A 6ay4A-1rrvA:
undetectable		 6ay4A-1rrvA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_A_9F2A302_1
(BETA-LACTAMASE)		 1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 PRO A 167
TYR A 169
THR A 233
THR A 234
ASP A 252
 PRO  A 167 ( 1.1A)
TYR  A 169 ( 1.3A)
THR  A 233 (-0.9A)
THR  A 234 ( 0.9A)
ASP  A 252 ( 0.6A)
 1.36A 6b5yA-1wojA:
0.0
6b5yB-1wojA:
undetectable		 6b5yA-1wojA:
18.18
6b5yB-1wojA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_A_9F2A302_1
(BETA-LACTAMASE)		 1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 PRO A 167
TYR A 169
THR A 233
THR A 234
ASP A 252
 PRO  A 167 ( 1.1A)
TYR  A 169 ( 1.3A)
THR  A 233 (-0.9A)
THR  A 234 ( 0.9A)
ASP  A 252 ( 0.6A)
 1.36A 6b68A-1wojA:
0.0
6b68B-1wojA:
0.0		 6b68A-1wojA:
18.18
6b68B-1wojA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_C_9F2C302_1
(BETA-LACTAMASE)		 1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 10 PRO A 167
TYR A 169
THR A 233
THR A 234
ASP A 252
 PRO  A 167 ( 1.1A)
TYR  A 169 ( 1.3A)
THR  A 233 (-0.9A)
THR  A 234 ( 0.9A)
ASP  A 252 ( 0.6A)
 1.35A 6b68C-1wojA:
0.0
6b68D-1wojA:
0.0		 6b68C-1wojA:
18.18
6b68D-1wojA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_A_9F2A302_1
(BETA-LACTAMASE)		 1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 PRO A 167
TYR A 169
THR A 233
THR A 234
ASP A 252
 PRO  A 167 ( 1.1A)
TYR  A 169 ( 1.3A)
THR  A 233 (-0.9A)
THR  A 234 ( 0.9A)
ASP  A 252 ( 0.6A)
 1.33A 6b69A-1wojA:
0.0
6b69B-1wojA:
0.0		 6b69A-1wojA:
18.18
6b69B-1wojA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_C_9F2C302_1
(BETA-LACTAMASE)		 1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 PRO A 167
TYR A 169
THR A 233
THR A 234
ASP A 252
 PRO  A 167 ( 1.1A)
TYR  A 169 ( 1.3A)
THR  A 233 (-0.9A)
THR  A 234 ( 0.9A)
ASP  A 252 ( 0.6A)
 1.36A 6b69C-1wojA:
0.0
6b69D-1wojA:
0.0		 6b69C-1wojA:
18.18
6b69D-1wojA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_C_9F2C302_1
(BETA-LACTAMASE)		 1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 PRO A 167
TYR A 169
THR A 233
THR A 234
ASP A 252
 PRO  A 167 ( 1.1A)
TYR  A 169 ( 1.3A)
THR  A 233 (-0.9A)
THR  A 234 ( 0.9A)
ASP  A 252 ( 0.6A)
 1.38A 6b6aC-1wojA:
0.0
6b6aD-1wojA:
undetectable		 6b6aC-1wojA:
18.18
6b6aD-1wojA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 11 ASP A 178
PRO A 176
ARG A 182
PRO A  82
TYR A 117
 ASP  A 178 ( 0.6A)
PRO  A 176 ( 1.1A)
ARG  A 182 ( 0.6A)
PRO  A  82 ( 1.1A)
TYR  A 117 ( 1.3A)
 1.27A 6bm5A-2nvvA:
undetectable		 6bm5A-2nvvA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1omo ALANINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 7 ALA A 101
THR A 102
TYR A 103
GLN A 296
 ALA  A 101 ( 0.0A)
THR  A 102 ( 0.8A)
TYR  A 103 ( 1.3A)
GLN  A 296 ( 0.6A)
 0.68A 6cduA-1omoA:
0.0
6cduE-1omoA:
0.0		 6cduA-1omoA:
22.70
6cduE-1omoA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1omo ALANINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 GLN A 296
ALA A 101
THR A 102
TYR A 103
 GLN  A 296 ( 0.6A)
ALA  A 101 ( 0.0A)
THR  A 102 ( 0.8A)
TYR  A 103 ( 1.3A)
 0.74A 6cduD-1omoA:
undetectable
6cduE-1omoA:
undetectable		 6cduD-1omoA:
22.70
6cduE-1omoA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1omo ALANINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 7 GLN A 296
ALA A 101
THR A 102
TYR A 103
 GLN  A 296 ( 0.6A)
ALA  A 101 ( 0.0A)
THR  A 102 ( 0.8A)
TYR  A 103 ( 1.3A)
 0.67A 6cduH-1omoA:
undetectable
6cduI-1omoA:
undetectable		 6cduH-1omoA:
22.70
6cduI-1omoA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 3p9w HUMAN VEGF
(Homo
sapiens) 		3 / 3 TYR B  59
GLY B  65
THR B  68
 TYR  B  59 ( 1.3A)
GLY  B  65 ( 0.0A)
THR  B  68 ( 0.8A)
 0.12A 6cjkB-3p9wB:
18.7		 6cjkB-3p9wB:
37.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		4 / 6 TYR A 239
GLU A 242
GLN A 243
LYS A 246
 TYR  A 239 ( 1.3A)
GLU  A 242 ( 0.6A)
GLN  A 243 ( 0.6A)
LYS  A 246 ( 0.0A)
 1.02A 6d8pA-1fxjA:
0.0		 6d8pA-1fxjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		4 / 6 TYR A  48
ASP A 179
VAL A 125
GLU A 178
 TYR  A  48 ( 1.3A)
ASP  A 179 ( 0.6A)
VAL  A 125 ( 0.5A)
GLU  A 178 ( 0.5A)
 1.25A 6djzB-2rciA:
undetectable		 6djzB-2rciA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 6 TRP A  93
LEU A 223
TYR A 143
GLN A 137
 TRP  A  93 ( 0.5A)
LEU  A 223 ( 0.5A)
TYR  A 143 ( 1.3A)
GLN  A 137 ( 0.6A)
 1.39A 6djzC-3gnrA:
undetectable		 6djzC-3gnrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 6 ASN A 234
TYR A 170
VAL A 195
VAL A 198
 ASN  A 234 ( 0.6A)
TYR  A 170 (-1.3A)
VAL  A 195 (-0.6A)
VAL  A 198 ( 0.6A)
 1.27A 6f32B-3c3nA:
undetectable		 6f32B-3c3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 6 ASN B 125
TYR B 127
VAL B 101
VAL B  97
THR B  96
 ASN  B 125 ( 0.6A)
TYR  B 127 ( 1.3A)
VAL  B 101 ( 0.6A)
VAL  B  97 ( 0.6A)
THR  B  96 ( 0.8A)
 1.46A 6f32B-4oudB:
2.9		 6f32B-4oudB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		6 / 10 VAL A 121
LEU A  61
LEU A  59
LEU A  40
TYR A 166
LEU A  75
 VAL  A 121 ( 0.6A)
LEU  A  61 ( 0.6A)
LEU  A  59 ( 0.5A)
LEU  A  40 ( 0.6A)
TYR  A 166 ( 1.3A)
LEU  A  75 ( 0.6A)
 1.13A 6f5uA-4rhyA:
undetectable
6f5uB-4rhyA:
undetectable		 6f5uA-4rhyA:
20.93
6f5uB-4rhyA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 5 ALA A 383
TYR A 467
GLN A 382
ILE A 304
 ALA  A 383 ( 0.0A)
TYR  A 467 ( 1.3A)
GLN  A 382 ( 0.6A)
ILE  A 304 ( 0.7A)
 1.39A 6f6sA-2ogsA:
undetectable
6f6sB-2ogsA:
undetectable		 6f6sA-2ogsA:
10.41
6f6sB-2ogsA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1gc7 RADIXIN
(Mus
musculus) 		3 / 3 TYR A 201
ASP A 197
GLN A 196
 TYR  A 201 ( 1.3A)
ASP  A 197 ( 0.6A)
GLN  A 196 ( 0.6A)
 0.61A 6g1pA-1gc7A:
0.0		 6g1pA-1gc7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		4 / 5 ASN A 732
TYR A 325
GLY A 346
HIS A 743
 ASN  A 732 ( 0.6A)
TYR  A 325 ( 1.3A)
GLY  A 346 ( 0.0A)
HIS  A 743 ( 1.0A)
 1.29A 6gh9A-1v0fA:
undetectable		 6gh9A-1v0fA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2p5d UPF0310 PROTEIN
MJECL36
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A  62
LYS A  20
TYR A  65
 ARG  A  62 ( 0.6A)
LYS  A  20 ( 0.0A)
TYR  A  65 ( 1.3A)
 1.15A 6gnaA-2p5dA:
undetectable		 6gnaA-2p5dA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 ARG A 504
LYS A 502
TYR A 497
 ARG  A 504 (-0.6A)
LYS  A 502 ( 0.0A)
TYR  A 497 ( 1.3A)
 1.33A 6gnaA-4flxA:
1.3		 6gnaA-4flxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2p5d UPF0310 PROTEIN
MJECL36
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A  62
LYS A  20
TYR A  65
 ARG  A  62 ( 0.6A)
LYS  A  20 ( 0.0A)
TYR  A  65 ( 1.3A)
 1.15A 6gnbA-2p5dA:
undetectable		 6gnbA-2p5dA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 ARG A 504
LYS A 502
TYR A 497
 ARG  A 504 (-0.6A)
LYS  A 502 ( 0.0A)
TYR  A 497 ( 1.3A)
 1.33A 6gnbA-4flxA:
1.3		 6gnbA-4flxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 163
TYR A  29
VAL A 283
ARG A 139
GLY A 160
 GLY  A 163 ( 0.0A)
TYR  A  29 ( 1.3A)
VAL  A 283 ( 0.6A)
ARG  A 139 ( 0.6A)
GLY  A 160 ( 0.0A)
 1.01A 6gngA-2ogsA:
5.4		 6gngA-2ogsA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		4 / 5 TYR A 278
VAL A 267
PHE A 311
GLY A 275
 TYR  A 278 ( 1.3A)
VAL  A 267 ( 0.5A)
PHE  A 311 ( 1.3A)
GLY  A 275 ( 0.0A)
 1.32A 6hd4A-1v0fA:
undetectable		 6hd4A-1v0fA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_0
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		5 / 12 PRO A 548
ILE A 571
TYR A 541
HIS A 542
THR A 524
 PRO  A 548 ( 1.1A)
ILE  A 571 ( 0.7A)
TYR  A 541 ( 1.3A)
HIS  A 542 ( 1.0A)
THR  A 524 ( 0.9A)
 1.29A 6hloA-1v0fA:
0.0		 6hloA-1v0fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4wji PUTATIVE
CYCLOHEXADIENYL
DEHYDROGENASE AND
ADH PREPHENATE
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 11 SER A 189
GLY A 122
GLY A  99
ASP A  97
VAL A 105
 TYR  A 302 ( 3.8A)
None
NAP  A 301 (-3.4A)
None
None
 1.26A 6i5zD-4wjiA:
4.3		 6i5zD-4wjiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 THR A 386
ILE A 256
TYR A 257
LEU A 534
MET A 538
 THR  A 386 ( 0.8A)
ILE  A 256 ( 0.7A)
TYR  A 257 ( 1.3A)
LEU  A 534 ( 0.6A)
MET  A 538 ( 0.0A)
 1.30A 6ie8A-2vbfA:
undetectable		 6ie8A-2vbfA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		4 / 5 TYR A 328
MET A 324
THR A 323
LEU A 320
 TYR  A 328 ( 1.3A)
MET  A 324 ( 0.0A)
THR  A 323 ( 0.8A)
LEU  A 320 ( 0.6A)
 1.13A 6nknJ-5xluA:
undetectable		 6nknJ-5xluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		4 / 5 TYR A 328
MET A 324
THR A 323
LEU A 320
 TYR  A 328 ( 1.3A)
MET  A 324 ( 0.0A)
THR  A 323 ( 0.8A)
LEU  A 320 ( 0.6A)
 1.14A 6nknW-5xluA:
undetectable		 6nknW-5xluA:
undetectable