SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TYQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 3x3y PHENYLETHYLAMINE
OXIDASE
(Arthrobacter
globiformis) 		6 / 10 THR A 377
TYR A 384
HIS A 431
HIS A 433
HIS A 592
MET A 602
 None
TYQ  A 382 ( 4.2A)
CU  A 701 (-3.2A)
CU  A 701 (-3.2A)
CU  A 701 (-3.0A)
TYQ  A 382 ( 2.9A)
 1.39A 1ivvA-3x3yA:
62.3		 1ivvA-3x3yA:
99.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 3x3y PHENYLETHYLAMINE
OXIDASE
(Arthrobacter
globiformis) 		10 / 10 TYR A 284
THR A 378
ASN A 381
ASP A 383
TYR A 384
VAL A 406
HIS A 431
HIS A 433
HIS A 592
MET A 602
 None
TYQ  A 382 ( 4.0A)
TYQ  A 382 ( 3.4A)
TYQ  A 382 ( 3.5A)
TYQ  A 382 ( 4.2A)
TYQ  A 382 ( 3.9A)
CU  A 701 (-3.2A)
CU  A 701 (-3.2A)
CU  A 701 (-3.0A)
TYQ  A 382 ( 2.9A)
 0.26A 1ivvA-3x3yA:
62.3		 1ivvA-3x3yA:
99.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 3x3y PHENYLETHYLAMINE
OXIDASE
(Arthrobacter
globiformis) 		6 / 10 THR A 377
TYR A 384
HIS A 431
HIS A 433
HIS A 592
MET A 602
 None
TYQ  A 382 ( 4.2A)
CU  A 701 (-3.2A)
CU  A 701 (-3.2A)
CU  A 701 (-3.0A)
TYQ  A 382 ( 2.9A)
 1.44A 1ivvB-3x3yA:
61.5		 1ivvB-3x3yA:
99.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 3x3y PHENYLETHYLAMINE
OXIDASE
(Arthrobacter
globiformis) 		6 / 10 THR A 378
ASP A 383
TYR A 384
VAL A 406
HIS A 592
HIS A 433
 TYQ  A 382 ( 4.0A)
TYQ  A 382 ( 3.5A)
TYQ  A 382 ( 4.2A)
TYQ  A 382 ( 3.9A)
CU  A 701 (-3.0A)
CU  A 701 (-3.2A)
 1.49A 1ivvB-3x3yA:
61.5		 1ivvB-3x3yA:
99.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 3x3y PHENYLETHYLAMINE
OXIDASE
(Arthrobacter
globiformis) 		10 / 10 TYR A 284
THR A 378
ASN A 381
ASP A 383
TYR A 384
VAL A 406
HIS A 431
HIS A 433
HIS A 592
MET A 602
 None
TYQ  A 382 ( 4.0A)
TYQ  A 382 ( 3.4A)
TYQ  A 382 ( 3.5A)
TYQ  A 382 ( 4.2A)
TYQ  A 382 ( 3.9A)
CU  A 701 (-3.2A)
CU  A 701 (-3.2A)
CU  A 701 (-3.0A)
TYQ  A 382 ( 2.9A)
 0.30A 1ivvB-3x3yA:
61.5		 1ivvB-3x3yA:
99.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3x3y PHENYLETHYLAMINE
OXIDASE
(Arthrobacter
globiformis) 		5 / 7 TYR A 284
TYR A 296
ASP A 298
TYR A 384
HIS A 433
 None
TYQ  A 382 ( 4.8A)
None
TYQ  A 382 ( 4.2A)
CU  A 701 (-3.2A)
 0.87A 2pncA-3x3yA:
35.9		 2pncA-3x3yA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3x3y PHENYLETHYLAMINE
OXIDASE
(Arthrobacter
globiformis) 		4 / 6 TYR A 296
ASP A 298
TYR A 384
HIS A 433
 TYQ  A 382 ( 4.8A)
None
TYQ  A 382 ( 4.2A)
CU  A 701 (-3.2A)
 0.90A 2pncB-3x3yA:
39.5		 2pncB-3x3yA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3x3y PHENYLETHYLAMINE
OXIDASE
(Arthrobacter
globiformis) 		5 / 12 ALA A 308
GLY A 254
ALA A 402
GLY A 385
PHE A 386
 None
None
TYQ  A 382 ( 4.8A)
None
None
 1.11A 4r29B-3x3yA:
undetectable		 4r29B-3x3yA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 3x3y PHENYLETHYLAMINE
OXIDASE
(Arthrobacter
globiformis) 		4 / 6 ARG A 133
PHE A 407
ILE A 379
THR A 378
 None
None
TYQ  A 382 ( 4.9A)
TYQ  A 382 ( 4.0A)
 1.04A 5vceA-3x3yA:
undetectable		 5vceA-3x3yA:
22.78