SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TYM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		6 / 12 GLY A 319
SER A 343
GLY A 453
ASP A 455
GLN A 456
PHE A 482
 TYM  A 701 (-3.6A)
TYM  A 701 (-3.6A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
TYM  A 701 (-3.4A)
None
 1.13A 1ffyA-4j75A:
7.4		 1ffyA-4j75A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 HIS A 320
GLY A 319
GLY A 453
ASP A 455
GLN A 456
 TYM  A 701 ( 4.8A)
TYM  A 701 (-3.6A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
TYM  A 701 (-3.4A)
 1.13A 1ffyA-4j75A:
7.4		 1ffyA-4j75A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 11 GLY A 161
HIS A 170
HIS A 173
ASP A 312
GLN A 313
 TYM  A 501 (-3.6A)
None
TYM  A 501 (-4.6A)
TYM  A 501 (-3.2A)
TYM  A 501 (-3.6A)
 0.94A 1jzsA-1r6uA:
undetectable		 1jzsA-1r6uA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A  79
HIS A  87
HIS A  90
ASP A 216
GLN A 217
 TYM  A 400 (-3.4A)
SO4  A 393 (-3.9A)
SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
 1.03A 1jzsA-3jxeA:
2.9		 1jzsA-3jxeA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		6 / 11 GLY A 308
HIS A 317
HIS A 320
GLY A 453
ASP A 455
GLN A 456
 TYM  A 701 (-3.4A)
None
TYM  A 701 ( 4.8A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
TYM  A 701 (-3.4A)
 0.99A 1jzsA-4j75A:
undetectable		 1jzsA-4j75A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		6 / 11 GLY A 308
HIS A 317
SER A 343
GLY A 453
ASP A 455
GLN A 456
 TYM  A 701 (-3.4A)
None
TYM  A 701 (-3.6A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
TYM  A 701 (-3.4A)
 1.15A 1jzsA-4j75A:
undetectable		 1jzsA-4j75A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  87
GLY A  89
HIS A  90
ASP A 216
VAL A 244
 SO4  A 393 (-3.9A)
TYM  A 400 (-3.6A)
SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.9A)
 0.67A 1pg2A-3jxeA:
10.6		 1pg2A-3jxeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 11 HIS A 317
GLY A 319
HIS A 320
GLY A 453
ASP A 455
 None
TYM  A 701 (-3.6A)
TYM  A 701 ( 4.8A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
 0.51A 1pg2A-4j75A:
11.6		 1pg2A-4j75A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  89
HIS A  90
ASP A 216
GLN A 217
VAL A 244
 TYM  A 400 (-3.6A)
SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.9A)
 0.75A 1qu2A-3jxeA:
4.3		 1qu2A-3jxeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  87
GLY A  89
HIS A  90
ASP A 216
VAL A 244
 SO4  A 393 (-3.9A)
TYM  A 400 (-3.6A)
SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.9A)
 1.07A 1qu2A-3jxeA:
4.3		 1qu2A-3jxeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  90
ASP A 216
GLN A 217
PHE A 243
VAL A 244
 SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
None
TYM  A 400 (-3.9A)
 0.85A 1qu2A-3jxeA:
4.3		 1qu2A-3jxeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		6 / 12 GLY A 319
HIS A 320
GLY A 453
ASP A 455
GLN A 456
PHE A 482
 TYM  A 701 (-3.6A)
TYM  A 701 ( 4.8A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
TYM  A 701 (-3.4A)
None
 0.75A 1qu2A-4j75A:
7.5		 1qu2A-4j75A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		6 / 12 GLY A 319
SER A 343
GLY A 453
ASP A 455
GLN A 456
PHE A 482
 TYM  A 701 (-3.6A)
TYM  A 701 (-3.6A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
TYM  A 701 (-3.4A)
None
 1.13A 1qu2A-4j75A:
7.5		 1qu2A-4j75A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 HIS A 320
GLY A 319
GLY A 453
ASP A 455
GLN A 456
 TYM  A 701 ( 4.8A)
TYM  A 701 (-3.6A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
TYM  A 701 (-3.4A)
 1.13A 1qu2A-4j75A:
7.5		 1qu2A-4j75A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 HIS A  87
GLY A  89
HIS A  90
ASP A 216
GLN A 217
VAL A 244
 SO4  A 393 (-3.9A)
TYM  A 400 (-3.6A)
SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.9A)
 1.06A 1qu3A-3jxeA:
5.7		 1qu3A-3jxeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  90
ASP A 216
GLN A 217
PHE A 243
VAL A 244
 SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
None
TYM  A 400 (-3.9A)
 0.95A 1qu3A-3jxeA:
5.7		 1qu3A-3jxeA:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 THR A 160
GLY A 161
GLY A 163
GLN A 194
GLN A 284
 TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 (-3.2A)
 1.01A 2akeA-1r6uA:
56.8		 2akeA-1r6uA:
97.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		12 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
THR A 196
GLU A 199
LYS A 200
GLN A 284
ILE A 307
CYH A 309
GLN A 313
PHE A 317
 TYM  A 501 (-3.8A)
TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 ( 3.8A)
TYM  A 501 (-3.0A)
None
TYM  A 501 (-3.2A)
TYM  A 501 (-4.8A)
TYM  A 501 (-4.8A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.7A)
 0.41A 2akeA-1r6uA:
56.8		 2akeA-1r6uA:
97.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 THR A  78
GLY A  79
GLY A  81
LYS A 117
GLN A 111
GLN A 198
 TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.2A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.2A)
 1.21A 2akeA-3jxeA:
43.4		 2akeA-3jxeA:
43.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		10 / 12 TYR A  77
THR A  78
GLY A  79
GLY A  81
THR A 113
GLU A 116
LYS A 117
GLN A 198
ILE A 211
GLN A 217
 TYM  A 400 (-4.1A)
TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.6A)
TYM  A 400 (-2.7A)
TYM  A 400 (-3.2A)
TYM  A 400 (-3.2A)
None
TYM  A 400 (-3.5A)
 0.42A 2akeA-3jxeA:
43.4		 2akeA-3jxeA:
43.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 THR A 307
GLY A 308
GLY A 310
GLN A 341
GLN A 429
 TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.9A)
TYM  A 701 (-3.1A)
 1.00A 2akeA-4j75A:
51.6		 2akeA-4j75A:
49.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		9 / 12 TYR A 306
THR A 307
GLY A 308
GLY A 310
GLU A 346
LYS A 347
GLN A 429
GLN A 456
PHE A 460
 TYM  A 701 (-4.0A)
TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.0A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.1A)
TYM  A 701 (-3.4A)
TYM  A 701 (-4.7A)
 0.35A 2akeA-4j75A:
51.6		 2akeA-4j75A:
49.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A 194
GLN A 111
TYR A  77
TRP A 221
 None
TYM  A 400 (-4.1A)
TYM  A 400 (-4.1A)
None
 1.48A 2aoxA-3jxeA:
2.3		 2aoxA-3jxeA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 THR A 160
GLY A 161
GLY A 163
GLN A 194
GLN A 284
 TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 (-3.2A)
 0.98A 2azxA-1r6uA:
63.6		 2azxA-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 THR A 160
GLY A 161
GLY A 163
GLN A 284
GLN A 313
 TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.2A)
TYM  A 501 (-3.6A)
 1.04A 2azxA-1r6uA:
63.6		 2azxA-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		12 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
GLN A 284
ILE A 307
CYH A 309
GLN A 313
PHE A 317
 TYM  A 501 (-3.8A)
TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 ( 3.8A)
TYM  A 501 (-3.0A)
TYM  A 501 (-3.2A)
TYM  A 501 (-4.8A)
TYM  A 501 (-4.8A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.7A)
 0.29A 2azxA-1r6uA:
63.6		 2azxA-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 THR A  78
GLY A  79
GLY A  81
GLN A 111
GLN A 198
 TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.2A)
 0.91A 2azxA-3jxeA:
46.6		 2azxA-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 THR A  78
GLY A  79
GLY A  81
GLN A 198
GLN A 217
 TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.2A)
TYM  A 400 (-3.5A)
 1.08A 2azxA-3jxeA:
46.6		 2azxA-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		10 / 12 TYR A  77
THR A  78
GLY A  79
GLY A  81
GLN A 111
THR A 113
GLU A 116
GLN A 198
ILE A 211
GLN A 217
 TYM  A 400 (-4.1A)
TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.6A)
TYM  A 400 (-2.7A)
TYM  A 400 (-3.2A)
None
TYM  A 400 (-3.5A)
 0.25A 2azxA-3jxeA:
46.6		 2azxA-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 THR A 307
GLY A 308
GLY A 310
GLN A 341
GLN A 429
 TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.9A)
TYM  A 701 (-3.1A)
 0.98A 2azxA-4j75A:
51.4		 2azxA-4j75A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 THR A 307
GLY A 308
GLY A 310
GLN A 429
GLN A 456
 TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.1A)
TYM  A 701 (-3.4A)
 1.03A 2azxA-4j75A:
51.4		 2azxA-4j75A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		9 / 12 TYR A 306
THR A 307
GLY A 308
GLY A 310
GLN A 341
GLU A 346
GLN A 429
GLN A 456
PHE A 460
 TYM  A 701 (-4.0A)
TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.9A)
TYM  A 701 (-3.0A)
TYM  A 701 (-3.1A)
TYM  A 701 (-3.4A)
TYM  A 701 (-4.7A)
 0.26A 2azxA-4j75A:
51.4		 2azxA-4j75A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 THR A 160
GLY A 161
GLY A 163
GLN A 194
GLN A 284
 TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 (-3.2A)
 0.97A 2azxB-1r6uA:
63.4		 2azxB-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 THR A 160
GLY A 161
GLY A 163
GLN A 284
GLN A 313
 TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.2A)
TYM  A 501 (-3.6A)
 1.02A 2azxB-1r6uA:
63.4		 2azxB-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		12 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
GLN A 284
ILE A 307
CYH A 309
GLN A 313
PHE A 317
 TYM  A 501 (-3.8A)
TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 ( 3.8A)
TYM  A 501 (-3.0A)
TYM  A 501 (-3.2A)
TYM  A 501 (-4.8A)
TYM  A 501 (-4.8A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.7A)
 0.29A 2azxB-1r6uA:
63.4		 2azxB-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 THR A  78
GLY A  79
GLY A  81
GLN A 111
GLN A 198
 TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.2A)
 0.89A 2azxB-3jxeA:
46.3		 2azxB-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 THR A  78
GLY A  79
GLY A  81
GLN A 198
GLN A 217
 TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.2A)
TYM  A 400 (-3.5A)
 1.07A 2azxB-3jxeA:
46.3		 2azxB-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		10 / 12 TYR A  77
THR A  78
GLY A  79
GLY A  81
GLN A 111
THR A 113
GLU A 116
GLN A 198
ILE A 211
GLN A 217
 TYM  A 400 (-4.1A)
TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.6A)
TYM  A 400 (-2.7A)
TYM  A 400 (-3.2A)
None
TYM  A 400 (-3.5A)
 0.26A 2azxB-3jxeA:
46.3		 2azxB-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 THR A 307
GLY A 308
GLY A 310
GLN A 341
GLN A 429
 TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.9A)
TYM  A 701 (-3.1A)
 0.95A 2azxB-4j75A:
51.5		 2azxB-4j75A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 THR A 307
GLY A 308
GLY A 310
GLN A 429
GLN A 456
 TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.1A)
TYM  A 701 (-3.4A)
 1.01A 2azxB-4j75A:
51.5		 2azxB-4j75A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		9 / 12 TYR A 306
THR A 307
GLY A 308
GLY A 310
GLN A 341
GLU A 346
GLN A 429
GLN A 456
PHE A 460
 TYM  A 701 (-4.0A)
TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.9A)
TYM  A 701 (-3.0A)
TYM  A 701 (-3.1A)
TYM  A 701 (-3.4A)
TYM  A 701 (-4.7A)
 0.24A 2azxB-4j75A:
51.5		 2azxB-4j75A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		11 / 11 TYR A 159
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
GLN A 284
ILE A 307
CYH A 309
GLN A 313
PHE A 317
 TYM  A 501 (-3.8A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 ( 3.8A)
TYM  A 501 (-3.0A)
TYM  A 501 (-3.2A)
TYM  A 501 (-4.8A)
TYM  A 501 (-4.8A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.7A)
 0.33A 2dr2A-1r6uA:
56.8		 2dr2A-1r6uA:
97.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		9 / 11 TYR A  77
GLY A  79
GLY A  81
GLN A 111
THR A 113
GLU A 116
GLN A 198
ILE A 211
GLN A 217
 TYM  A 400 (-4.1A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.6A)
TYM  A 400 (-2.7A)
TYM  A 400 (-3.2A)
None
TYM  A 400 (-3.5A)
 0.27A 2dr2A-3jxeA:
43.4		 2dr2A-3jxeA:
43.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		8 / 11 TYR A 306
GLY A 308
GLY A 310
GLN A 341
GLU A 346
GLN A 429
GLN A 456
PHE A 460
 TYM  A 701 (-4.0A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.4A)
TYM  A 701 (-3.9A)
TYM  A 701 (-3.0A)
TYM  A 701 (-3.1A)
TYM  A 701 (-3.4A)
TYM  A 701 (-4.7A)
 0.24A 2dr2A-4j75A:
51.7		 2dr2A-4j75A:
49.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 ILE A 359
PHE A 340
ILE A 175
PHE A 406
 None
None
TYM  A 501 ( 4.5A)
None
 1.02A 2q6hA-1r6uA:
undetectable		 2q6hA-1r6uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 ILE A 359
PHE A 340
ILE A 175
PHE A 406
 None
None
TYM  A 501 ( 4.5A)
None
 1.02A 2qb4A-1r6uA:
undetectable		 2qb4A-1r6uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		4 / 7 GLY A 308
GLN A 341
PHE A 383
PHE A 438
 TYM  A 701 (-3.4A)
TYM  A 701 (-3.9A)
None
None
 1.14A 2qx4A-4j75A:
undetectable
2qx4B-4j75A:
undetectable		 2qx4A-4j75A:
20.49
2qx4B-4j75A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		4 / 7 GLY A 308
THR A 307
GLN A 456
PHE A 482
 TYM  A 701 (-3.4A)
TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
None
 1.13A 2qx4A-4j75A:
undetectable
2qx4B-4j75A:
undetectable		 2qx4A-4j75A:
20.49
2qx4B-4j75A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 11 HIS A 317
GLY A 319
HIS A 320
GLY A 453
ASP A 455
 None
TYM  A 701 (-3.6A)
TYM  A 701 ( 4.8A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
 0.67A 2x1lA-4j75A:
11.3		 2x1lA-4j75A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 HIS A 317
GLY A 319
HIS A 320
GLY A 453
ASP A 455
 None
TYM  A 701 (-3.6A)
TYM  A 701 ( 4.8A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
 0.62A 2x1lB-4j75A:
11.4		 2x1lB-4j75A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 11 HIS A 317
GLY A 319
HIS A 320
GLY A 453
ASP A 455
 None
TYM  A 701 (-3.6A)
TYM  A 701 ( 4.8A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
 0.67A 2x1lC-4j75A:
11.3		 2x1lC-4j75A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 5 ASP A 312
ILE A 175
PRO A 176
PHE A 177
 TYM  A 501 (-3.2A)
TYM  A 501 ( 4.5A)
TYM  A 501 (-4.4A)
None
 1.24A 3s3vA-1r6uA:
undetectable		 3s3vA-1r6uA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		4 / 7 TYR A 425
PHE A 412
GLN A 456
PHE A 460
 None
None
TYM  A 701 (-3.4A)
TYM  A 701 (-4.7A)
 1.25A 3tvxB-4j75A:
undetectable		 3tvxB-4j75A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 LEU A 330
VAL A 478
PRO A 451
THR A 307
GLY A 310
 None
None
None
TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
 1.22A 4q15A-4j75A:
undetectable		 4q15A-4j75A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 LEU A 330
VAL A 478
PRO A 451
THR A 307
GLY A 310
 None
None
None
TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
 1.25A 4q15B-4j75A:
undetectable		 4q15B-4j75A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 TYR A 316
GLY A 163
GLU A 199
ASP A 197
 None
TYM  A 501 (-3.6A)
TYM  A 501 (-3.0A)
None
 1.21A 5emlA-1r6uA:
undetectable		 5emlA-1r6uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 HIS A 317
GLY A 319
HIS A 320
GLY A 453
ASP A 455
 None
TYM  A 701 (-3.6A)
TYM  A 701 ( 4.8A)
TYM  A 701 (-2.9A)
TYM  A 701 (-3.2A)
 1.01A 5hg0B-4j75A:
6.8		 5hg0B-4j75A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.60A 5qgjA-4j75A:
undetectable		 5qgjA-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.64A 5qgmA-4j75A:
undetectable		 5qgmA-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.62A 5qgnA-4j75A:
undetectable		 5qgnA-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.67A 5qgyA-4j75A:
undetectable		 5qgyA-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.68A 5qgzA-4j75A:
undetectable		 5qgzA-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.66A 5qh0A-4j75A:
undetectable		 5qh0A-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.67A 5qh2A-4j75A:
undetectable		 5qh2A-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.68A 5qh3A-4j75A:
undetectable		 5qh3A-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.66A 5qh7A-4j75A:
undetectable		 5qh7A-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.67A 5qhaA-4j75A:
undetectable		 5qhaA-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 VAL A 477
VAL A 450
GLN A 429
 None
None
TYM  A 701 (-3.1A)
 0.67A 5qhhA-4j75A:
undetectable		 5qhhA-4j75A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 LEU A 330
VAL A 478
PRO A 451
THR A 307
GLY A 310
 None
None
None
TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
 1.26A 5xipA-4j75A:
undetectable		 5xipA-4j75A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 LEU A 330
VAL A 478
PRO A 451
THR A 307
GLY A 310
 None
None
None
TYM  A 701 (-4.6A)
TYM  A 701 (-3.4A)
 1.25A 5xipC-4j75A:
undetectable		 5xipC-4j75A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		6 / 12 ILE A 193
GLY A 161
ASP A 197
ILE A 223
VAL A 457
ILE A 234
 None
TYM  A 501 (-3.6A)
None
None
None
None
 1.43A 6emuA-1r6uA:
undetectable		 6emuA-1r6uA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4j75 TRYPTOPHANYL-TRNA
SYNTHETASE
(Plasmodium
falciparum) 		4 / 8 SER A 313
MET A 316
GLY A 453
SER A 480
 None
None
TYM  A 701 (-2.9A)
TYM  A 701 ( 4.5A)
 0.91A 6giqL-4j75A:
undetectable
6giqP-4j75A:
undetectable
6giqT-4j75A:
undetectable		 6giqL-4j75A:
21.91
6giqP-4j75A:
20.05
6giqT-4j75A:
10.00